Psychiatry

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Article Clinical Neurology

A multivariate cognitive approach to predict social functioning in recent onset psychosis in response to computerized cognitive training

Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic

Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2024)

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Article Clinical Neurology

Associations of resilience, white matter topological organization, and cognitive functions in first-episode, drug-naive schizophrenia patients: A moderated mediation analysis

Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei

Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2024)

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Article Clinical Neurology

Executive functioning trajectories and their prospective association with inflammatory biomarkers in schizophrenia and non-psychiatric comparison participants

David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee

Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2024)

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Article Clinical Neurology

The contribution of polyamine pathway to determinations of diagnosis for treatment-resistant depression: A metabolomic analysis

Zerui You, Chengyu Wang, Xiaofeng Lan, Weicheng Li, Dewei Shang, Fan Zhang, Yanxiang Ye, Haiyan Liu, Yanling Zhou, Yuping Ning

Summary: This study reveals the metabolic differences between patients with treatment-resistant depression (TRD), first-episode drug-naive major depressive disorder (DN-MDD), and healthy controls (HCs), and identifies potential biomarkers. The analysis of metabolic pathways suggests that changes or imbalances in polyamine metabolism and energy metabolism may be primary altered pathways associated with depression.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2024)

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Article Clinical Neurology

MDMA-assisted psychotherapy for PTSD: Growing evidence for memory effects mediating treatment efficacy

Mesud Sarmanlu, Kim P. C. Kuypers, Patrick Vizeli, Timo L. Kvamme

Summary: The use of MDMA in conjunction with psychotherapy for posttraumatic stress disorder (PTSD) has gained renewed interest in recent years. Although clinical trials have shown promising results, the mechanism underlying this treatment is still unclear. This article explores the potential influence of MDMA's mnemonic effects on the efficacy of the treatment, based on recent preclinical and clinical evidence. The findings are corroborated by research from cognitive psychology and psychopharmacology, and recommendations for future research are provided.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2024)

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Article Clinical Neurology

The exploration of neuroinflammatory mechanism by which CRHR2 deficiency induced anxiety disorder

Shuyi Deng, Anqi Guo, Zhengwei Huang, Kaiyu Guan, Ya Zhu, Cheekai Chan, Jianfang Gui, Cai Song, Xi Li

Summary: This study investigates the mechanism of anxiety-like behavior caused by CRHR2 deficiency. The results show that CRHR2 deficiency leads to dysfunction of the HPA axis, enhanced neuroinflammation, and reductions in n-3 PUFAs and monoamine neurotransmitters.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2024)

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Article Clinical Neurology

Changes in neurotrophic signaling pathways in brain areas of the chronic mild stress rat model of depression as a signature of ketamine fast antidepressant response/non-response

Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi

Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2024)

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Review Clinical Neurology

Effectiveness of rTMS and tDCS treatment for chronic TBI symptoms: A systematic review and meta-analysis

Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler

Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2024)

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Article Clinical Neurology

An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders

Alejandro Borrego-Ruiz, Juan J. Borrego

Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2024)

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Article Clinical Neurology

Cerebral and cerebellar correlates of social cognitive impairment in schizophrenia

Jerillyn Kent, Amy Pinkham

Summary: Social cognition refers to the ways individuals perceive, process, and use information about others. Impairments in social cognition are commonly found in schizophrenia spectrum illnesses and have an impact on functional outcomes. This review summarizes the research on brain networks and cerebellar contributions to social cognitive impairments in this population, while highlighting current knowledge gaps and future directions.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2024)

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Article Clinical Neurology

Unilateral anterior capsulotomy combined with deep brain stimulation for Parkinson's disease psychosis and motor dysfunctions

Fang Wang, Lulin Dai, Yixin Pan, Peng Huang, Chencheng Zhang, Bomin Sun, Dianyou Li

Summary: This study evaluated the feasibility of unilateral anterior capsulotomy combined with subthalamic nucleus deep brain stimulation (STN-DBS) in managing advanced Parkinson's disease patients with psychosis. The results showed significant improvement in psychosis symptoms, motor symptoms, and quality of life after the combined treatment.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2024)

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Review Clinical Neurology

To what extent does white matter map to cognition in bipolar disorder? A systematic review of the evidence

Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen

Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2024)

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Article Clinical Neurology

Doxycycline diminishes the rewarding and psychomotor effects induced by morphine and cocaine

Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes

Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2024)

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Article Neurosciences

A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes

Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney

Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.

BIOLOGICAL PSYCHIATRY (2024)

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Article Neurosciences

Dentate Gyrus Microstructure Is Associated With Resilience After Exposure to Maternal Stress Across Two Human Cohorts

Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner

Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.

BIOLOGICAL PSYCHIATRY (2024)

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Review Clinical Neurology

Epidemical trends and risk factors of PTSD in parents of critically ill children: Evidence from both meta-analysis and subgroup analysis

Xiangyuan Chu, Xiu Dai, Ping Yuan, Guojia Qi, Xiuquan Shi

Summary: The prevalence of PTSD among parents of critically ill children is high, with a significantly higher prevalence in mothers than fathers. The risk factors for parental PTSD include positive acute stress disorder screening, disease severity, perceived stress, unemployed status, and length of hospital stay.

JOURNAL OF AFFECTIVE DISORDERS (2024)

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Article Clinical Neurology

Sex differences in prevalence and clinical correlates of suicide attempts in first-episode and drug-naïve patients with anxious depression in a Chinese Han population: A large-scale cross-sectional study

Guoshuai Luo, Hongyun Ma, Shuo Wang, Cong Yao, Yaxi Li, Daliang Sun, Xiangyang Zhang

Summary: This study found no sex differences in the prevalence of suicide attempts among patients with anxious depression. The severity of anxiety symptoms and abnormalities in thyroid function were associated with an increased risk for suicide attempts in both male and female patients with anxious depression, while the severity of depression symptoms was only associated with suicide attempts in females.

JOURNAL OF AFFECTIVE DISORDERS (2024)

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Article Clinical Neurology

Disrupted synaptic homeostasis and partial occlusion of associative long-term potentiation in the human cortex during social isolation

Peng Zhang, Juan Yan, Jiao Wei, Yane Li, Chuancai Sun

Summary: The study indicates that social isolation disrupts synaptic homeostasis and occludes associative LTP-like plasticity in the human cortex, decreasing behavior performance related to declarative memory.

JOURNAL OF AFFECTIVE DISORDERS (2024)

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Article Clinical Neurology

Association between the triglyceride-glucose index and suicidal ideation: A nationwide cross-sectional survey

Yoo Jeong Lee, Sooyeon Lee, In Cheol Hwang, Hong Yup Ahn

Summary: This study investigated the relationship between insulin resistance and suicidal ideation, and found that the TyG index was significantly associated with suicidal ideation in women, especially in the low-risk group for suicide.

JOURNAL OF AFFECTIVE DISORDERS (2024)

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Article Clinical Neurology

Baseline depression severity as moderator on depression outcomes in psychotherapy and pharmacotherapy

Anna Troeger, Clara Miguel, Marketa Ciharova, Nino de Ponti, Gueldehan Durman, Pim Cuijpers, Eirini Karyotaki

Summary: This study aimed to compare the effects of psychotherapy and pharmacotherapy for adult depression and examine the association between baseline depression severity and treatment outcome. The results showed no significant difference between psychotherapy and pharmacotherapy, and baseline depression severity was not significantly associated with treatment outcome.

JOURNAL OF AFFECTIVE DISORDERS (2024)

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