Plant Sciences

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Article Plant Sciences

High-resolution neuraminidase inhibition profiling of Arnebia euchroma (Royle) IM Johnst. based on HR-MS and target isolation: An example study of anti-infectious constituents in traditional Chinese medicine

Yuheng Huang, Xiaoxin Guo, Zhen Wang, Cong Yin, Mu Chen, Jiaming Xie, Ning Li, Zhengchao Tu, Juan Li, Jiaqing Cao, Zhengjin Jiang, Weihuan Huang, Haiyan Tian

Summary: Arnebia euchroma, a traditional Chinese medicine, has potential inhibitory activities on bacterial and viral neuraminidases, making it a promising candidate for anti-infectious drugs. Through high-resolution bioassay profiling, potential active ingredients in A. euchroma were identified and their inhibitory activities on neuraminidases were determined.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Identification of bioactive components on antihemorrhoidal activity of Cistus laurifolius L. using RP-HPLC and LC-QTOF-MS

Sultan Pekacar, Burgin Ozuepek, Esra Kuepeli Akkol, Hakki Tastan, Halil Ersan, Didem Deliorman Orhan

Summary: C. laurifolius is widely used in folk medicine in Anatolia and has been found to possess anti-inflammatory and anti-hemorrhoidal properties.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Xingbei antitussive granules ameliorate cough hypersensitivity in post-infectious cough guinea pigs by regulating tryptase/PAR2/ TRPV1 pathway

Yun Li, Ruiheng Zhao, Mengyuan Zhang, Kunlu Shen, Xin Hou, Bowen Liu, Chunxiao Li, Bingqing Sun, Min Xiang, Jiangtao Lin

Summary: This study demonstrates the significant therapeutic effects of Xingbei antitussive granules (XB) on post-infectious cough (PIC). XB treatment alleviates cough hypersensitivity and inflammatory responses, inhibits the degranulation of mast cells, and ameliorates neurogenic inflammation in PIC guinea pigs. The mechanisms may be associated with the inhibition of Tryptase/PAR2/PKC/TRPV1 and the recovery of respiratory bacterial microbiota.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Safety and antidiabetic activity of Lagenaria siceraria (Molina) Standl. juice in streptozotocin-induced diabetic rats

Manas Jyoti Das, Dipanjan Banerjee, Amartya Banerjee, Sangita Muchahary, Archana Sinha, Debananda Gogoi, Pronobesh Chattopadhyay, Suman Dasgupta, Sankar Chandra Deka

Summary: Lagenaria siceraria (Molina) Standl. Juice has demonstrated promising anti-inflammatory properties as well as the capacity to inhibit the digestion enzymes glucosidase and amylase, opening new avenues for further research into its antidiabetic potential.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Total Glucosides of White Paeony Capsule ameliorates Parkinson's disease-like behavior in MPTP-induced mice model by regulating LRRK2/ alpha-synuclein signaling

Hong-Yan Li, De-Shui Liu, Li-Bo Li, Ying-Bo Zhang, Hai-Ying Dong, Jing-Yan Zhang, Jun-Ping Wang, Ming Jin, Nan Luo, Xiao-Jie Zhang

Summary: This study found that the Total Glucosides of White Paeony Capsule (TGPC) exhibited neuroprotective effects on a mice model of Parkinson's disease (PD). The neuroprotective effects were associated with the prevention of neuroinflammation and neurodegeneration modulated by the LRRK2/alpha-synuclein (alpha-syn) pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Integrated analysis of metabolomic and transcriptomic profiling reveals the effect of Atractylodes oil on Spleen Yang Deficiency Syndrome in rats

Xin Zhan, Yangxin Xiao, Qipan Jian, Yan Dong, Chang Ke, Zhongshi Zhou, Yanju Liu, Jiyuan Tu

Summary: The study demonstrates that Atractylodes oil (AO) can improve the symptoms of Spleen Yang Deficiency Syndrome (SYDS) in rats, and its mechanism of action may be related to the activation of the AMPK/SIRT1/PGC-1 alpha signaling pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Review Plant Sciences

Erythrina velutina Willd.: A review of its traditional uses, phytochemistry, pharmacology, and toxicology

Tomi Lois Adetunji, Marvellous Amarachi Acho, Victory Oghenetega Samuel, Chinemerem Ruth Ohoro, Mmbulaheni Ramulondi

Summary: The traditional medicinal uses of Erythrina velutina, combined with modern scientific research, highlight its pharmacological potential and make it a significant candidate for drug development.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

A systematical strategy for quality markers screening of different methods processing Platycodonis radix based on phytochemical analysis and the impact on Chronic Obstructive Pulmonary Disease

Tingting Bai, Jingying Guo, Yaling Deng, Yuqing Zheng, Jie Shang, Peng Zheng, Minmin Liu, Ming Yang, Jinlian Zhang

Summary: This study evaluated the phytochemical composition and pharmacodynamics of Platycodon grandiflorum (PG) and Baihezhijiegeng (BJ). The results showed that BJ has anti-COPD activity by regulating inflammatory mediators and the EGFR/MUC5AC pathway in rats with COPD.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Traditional Chinese medicine for neonatal hypoxic-ischemic encephalopathy: A Bayesian network meta-analysis

Chao Zhang, Jiajia Guo, Huaiqing Yin, Chongjuan Yin, Yurong Peng

Summary: This study conducted a network meta-analysis to investigate the efficacy of Chinese herbal injections (CHIs) combined with traditional symptomatic treatment (TST) for neonatal hypoxic-ischemic encephalopathy (HIE). The results showed that CHIs combined with TST significantly improved treatment performance compared to TST alone, with SXI + TST showing the most preferable improvement.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

YuPingFeng (YPF) upregulates caveolin-1 (CAV1) to alleviate pulmonary fibrosis through the TGF-β1/Smad2 pathway

Xiao Chen, Min Wei, Guo-Dong Li, Qi-Liang Sun, Jia-Qi Fan, Jun-Yi Li, Chun-Mei Yun, Dao-Ming Liu, Hong Shi, Yi-Qing Qu

Summary: The study aims to investigate the therapeutic effects of YPF on pulmonary fibrosis. It was found that YPF may have significant therapeutic potential for pulmonary fibrosis by targeting various compounds and pathways, possibly attributed to its ability to up-regulate CAV1 expression and inhibit pulmonary fibrosis through modulation of the TGF-beta 1/Smad2 signaling pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Effect and pharmacological mechanism of Salvia miltiorrhiza and its characteristic extracts on diabetic nephropathy

Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao

Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Hypericum roeperianum bark extract suppresses breast cancer proliferation via induction of apoptosis, downregulation of PI3K/Akt/mTOR signaling cascade and reversal of EMT

Michel-Gael F. Guefack, Debojit Talukdar, Rimi Mukherjee, Subhabrata Guha, Debarpan Mitra, Depanwita Saha, Gaurav Das, Francois Damen, Victor Kuete, Nabendu Murmu

Summary: Hypericum roeperianum, a traditional medicinal spice, has been found to possess anticancer properties. It inhibits breast cancer progression by regulating mitochondrial apoptosis and epithelial-mesenchymal transition (EMT). The crude extract induces apoptosis and inhibits cell migration by affecting multiple molecular markers. Additionally, it modulates the PI3K/Akt/mToR signaling pathway to suppress EMT. The in vitro and in vivo experiments support the potential use of Hypericum roeperianum in breast cancer therapy.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Effects and mechanism of extracts rich in phenylpropanoids-polyacetylenes and polysaccharides from Codonopsis Radix on improving scopolamine-induced memory impairment of mice

Qi Xie, Xianrun Hu, Xiang Zhao, Zedong Xiang, Qianping Chen, Zhejun Xie, Hanxue Wang, Yonglin Zhao, Xuemei Cheng, Changhong Wang

Summary: This study confirmed the positive effects of the macromolecular portion (POL) and small molecule portion (EPP) from Codonopsis Radix (CR) on improving scopolamine-induced memory impairment. The mechanisms involved the regulation of cholinergic function, enhanced antioxidant defense, and suppression of inflammation.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Chemopreventive potential of hydroethanolic Murraya koenigii leaves extract against DMBA induced breast carcinogenesis: In-silico and in-vivo study

Shilpa Sadwal, Sanjay Bharati, Zahid Ahmad Dar, Sarvnarinder Kaur

Summary: The hydroethanolic extract of Murraya koenigii leaves (HEMKLE) shows chemopreventive effects against DMBA-induced breast cancer in rats, likely due to the presence of various phytochemicals.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Di-Huang-Yin-Zi regulates P53/SLC7A11 signaling pathway to improve the mechanism of post-stroke depression

Zhou Yang, Yongxia Jiang, Yang Xiao, Lihui Qian, Yongqu Jiang, Yue Hu, Xiaoli Liu

Summary: The study demonstrates that DHYZ extract can alleviate symptoms and enhance functional capability of rats with post-stroke depression (PSD) by suppressing ferroptosis through the P53/SLC7A11/GPX4 pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

The anticonvulsant effect of saiga horn on febrile seizures by regulating brain serotonin content and inhibiting neuroinflammation

Jinhu Li, Xiang Yao, Yurou Wu, Chengwei Wang, Jincheng Yang, Chunjie Wu

Summary: The study demonstrated that Saiga antelope horn (SAH) has a significant anticonvulsant effect on the febrile seizure (FS) rat model. The mechanism may be related to the increase in tryptophan content and up-regulation of the expression of the ER-13/TPH2/5HT signaling pathway in the brain of FS rats, resulting in an increase in brain serotonin (5-HT) content and a decrease in IL-113 and TNF-a content in the brain.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Review Plant Sciences

Efficacy and potential mechanisms of the main active ingredients of astragalus mongholicus in animal models of liver fibrosis: A systematic review and meta-analysis

Lijuan Dan, Yanwei Hao, Hongfei Song, Tianyuan Wang, Jia Li, Xiaoyan He, Yue Su

Summary: This systematic review and meta-analysis demonstrated the effective role of the main active ingredients of Astragalus mongholicus in preclinical studies of liver fibrosis. The main active ingredients were found to lower levels of various indicators associated with liver fibrosis through mechanisms such as attenuation of oxidative stress, modulation of inflammatory response, and inhibition of collagen production. However, caution should be taken due to significant heterogeneity and poor study quality.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Isomaculosidine facilitates NLRP3 inflammasome activation by promoting mitochondrial reactive oxygen species production and causes idiosyncratic liver injury

Wei Shi, Tingting Liu, Huijie Yang, Jia Zhao, Ziying Wei, Yujiao Huang, Zhiyong Li, Hui Li, Longxin Liang, Xiaorong Hou, Yuanyuan Chen, Yuan Gao, Zhaofang Bai, Xiaohe Xiao

Summary: DC can induce idiosyncratic HILI through the activation of NLRP3 inflammasome. This study aims to investigate the mechanism of DC-induced idiosyncratic HILI and identify the susceptible component.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Lanhuashen stimulates the positive cross-regulation mediated by the S1P axis to ameliorate the disorder of glucolipid metabolism induced by the high sucrose diet in Drosophila melanogaster

Gengyuan Yu, Mo Sun, Tonghua Zhang, Haoran Xu, Jiaqi Wang, Wanting Ye, Peng Wang, Shiyun Zhang, Chenning Zhang, Yikun Sun

Summary: Herba Wanlenbergiae (Lanhuashen) is a traditional Chinese medicine derived from Wahlenbergia marginata. This study found that extracts of Herba Wanlenbergiae can regulate glucolipid metabolism and improve the disorder seen in type 2 diabetes mellitus. The extracts were shown to activate the PI3K-Akt signaling pathway and inhibit lysosome-mediated apoptosis, leading to improved glucolipid metabolism.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Cholinergic signaling of muscarinic receptors directly involves in the neuroprotection of muscone by inducing Ca2+antagonism and maintaining mitochondrial function

Gang Shen, Zongyuan Zhou, Yanlei Guo, Li Li, Jin Zeng, Jianbo Wang, Junning Zhao

Summary: Muscone ameliorates neuronal damage through cholinergic signaling of muscarinic receptors, reducing mitochondrial dysfunction and oxidative stress. This study provides a promising therapeutic target for the treatment of stroke-induced nerve injury, offering potential benefits for stroke patients.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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