Plant Sciences

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Article Plant Sciences

Ethnopharmacological analysis based on Thai traditional medicine theory and anti-inflammatory activity of Sa-Tri-Lhung-Klod remedy as a post-partum anti-inflammatory drug

Janjira Inprasit, Arunporn Itharat, Srisopa Ruangnoo, Krittiya Thisayakorn, Kanmanee Sukkasem, Nuntika Prommee, Wicheian Khoenok, Kanjana Sriyam, Darunee Pahusee, Neal M. Davies

Summary: This study aimed to explore the relationship between taste theory in Thai traditional medicine and the anti-inflammatory effect of Sa-Tri-Lhung-Klod (ST) remedy, as well as its chemical constituents. The results showed that the compounds in ST remedy had potent anti-inflammatory activity and effectively inhibited the production of nitric oxide and prostaglandin E2.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Correction Plant Sciences

Application of omics technology to investigate the mechanism underlying the role of San Hua Tang in regulating microglia polarization and blood-brain barrier protection following ischemic stroke (vol 314,116640, 2023)

Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Review Plant Sciences

The genus Balanophora J. R. Forst. & G. Forst. - Its use in traditional medicine, phytochemistry, and pharmacology: A review

Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu

Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

The oral administration of Lotus corniculatus L. attenuates acute and chronic pain models in male rats

Sajjad Jabbari, Zainul Amiruddin Zakaria, Davoud Ahmadimoghaddam, Saeed Mohammadi

Summary: Lotus corniculatus leaves essential oil (LCEO) has antinociceptive effects and can alleviate both acute and chronic pain. It may act through modulation of opioid, TRPV, dopamine, cannabinoid mechanisms, as well as NO-cGMP-K+ channel, and also inhibit inflammatory processes.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Bidirectional effects of geniposide in liver injury: Preclinical evidence construction based on meta-analysis

Xinyu Zeng, Jiajie Jiang, Simiao Liu, Qichao Hu, Sihan Hu, Jinhao Zeng, Xiao Ma, Xiaomei Zhang

Summary: Geniposide exhibits dual pharmacological activity in liver injury, exerting potent hepatoprotective effects within a specific dose and time range, but also causing liver injury.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Isolation of indole alkaloids and a new norneolignan of hydroethanol extract from the stem barks of Aspidosperma nitidum Benth: Preclinical evaluation of safety and anti-inflammatory and healing properties

Manoela Torres-Rego, Patricia Coelho do Nascimento Nogueira, Sarah Pollyana Dias dos Santos, Alessandra Daniele-Silva, Felipe Franca Cavalcanti, Cinthya Iamile Frithz Brandao de Oliveira, Hugo Alexandre Oliveira Rocha, Matheus de Freitas Fernandes-Pedrosa, Edilberto Rocha Silveira, Renata Mendonca Araujo

Summary: The study aimed to isolate indole alkaloids from the stem barks of Aspidosperma nitidum and investigate their safety, anti-inflammatory, and healing properties. Results showed that the extract exhibited anti-inflammatory and healing effects without cytotoxicity, suggesting its potential use in traditional medicine.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Ruyong formula improves thymus function of CUMS-stimulated breast cancer mice

Bingqian He, Wenqin Guo, Rongzhen Shi, Robert D. Hoffman, Qihan Luo, Yuan-Jia Hu, Jianli Gao

Summary: The Ruyong Formula (RYF), a traditional Chinese herbal formula, has been used to treat breast cancer patients with depressive symptoms in China. This study aimed to investigate the pharmacological mechanism of RYF on thymus immune function changes in breast cancer patients with mood disorders.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Research on the mechanism of antidepressive effect of Suanzaoren Decoction through TLR4/MyD88/NF-κB pathway and Wnt/β-catenin pathway

Yiyang Du, Tingxu Yan, Bo Wu, Bosai He, Ying Jia

Summary: This study found that Suanzaoren Decoction (SZRD) can reverse depression-like behavior in rats, reduce inflammation, and increase the expression of BDNF, SYP, and PSD95. Further research revealed that SZRD exerts its antidepressant effect by regulating the TLR4/MyD88/NF kappa B pathway and Wnt/beta-catenin pathway in combination.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Quercetin inhibits mesothelial-mesenchymal transition and alleviates postoperative peritoneal adhesions by blocking the TGF-β1/PI3K/ AKT pathway

Gan Li, Yiwei Ren, Enmeng Li, Kai Deng, Chao Qu, Junxiang Zhang, Li Zhang, Xingjie Wang, Jie Lian, Huayou Zhou, Zijun Wang, Tianli Shen, Xuqi Li, Zhengdong Jiang

Summary: This study found that quercetin in Carthami flos is the key component in preventing postoperative peritoneal adhesions. Quercetin can inhibit the mesothelial-mesenchymal transition (MMT) of mesothelial cells and alleviate postoperative peritoneal adhesions by blocking the TGF-beta 1/PI3K/AKT pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Bioactive metabolites reveal the therapeutic consistency of epimedii folium from multi-plant sources for the treatment of kidney-yang deficiency

Xinguang Sun, Yingfei Li, Juan Li, Haizhen Liang, Jie Zhang, Xiaojuan Chen, Qi Li, Xu Pang, Qianzhi Ding, Juan Song, Baolin Guo, Baiping Ma

Summary: This study aimed to investigate the underlying reasons for the similar pharmacological effects of Epimedii Folium from two botanical sources, Epimedium koreanum and Epimedium wushanense. The results showed that both plant species exhibited similar effects on promoting mating behaviors and testosterone levels in rats. The study also found that Epimedii Folium can regulate testosterone production by reversing expressions of key steroidogenic enzymes in rat Leydig cells.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Efficacy of Trigonella foenum-graecum Linne in an animal model of particulate matter-induced asthma exacerbation

Eun-Young Kim, Hoyeon Park, Eom Ji Kim, Seung Hoon Lee, Jun Won Choi, Jonghyun Kim, Hyuk-Sang Jung, Youngjoo Sohn

Summary: This study demonstrates the efficacy of Trigonella foenum-graecum Linne (TFG) in alleviating PM-induced inflammatory response in bronchial epithelial cells and an animal model of asthma exacerbation.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Revealing the improvement of diabetes by Si Wei Jiang Huang Tang San through ERK/HIF1α signaling pathway via network pharmacology

Tianshu Xu, Ping He, So Namwangdu, Chunyang Xu, Biyu Hou, Peng Ma, Zijing Wang, Li Zhang, Guanhua Du, Tse Ring, Tengfei Ji, Guifen Qiang

Summary: Residents in Urumqi region are warned to prepare for heavy rain that may cause floods and mudslides, and take measures to reduce possible losses.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Chemical profiling of Shengmai injection, tissue distribution and pharmacokinetic characteristics of ginsenosides after intravenous dosing Shengmai injection in rats with cerebral ischemia

Huanhuan Wang, Liying Tang, Shaowei Hu, Xixian Kong, Yi Ouyang, Dong Zhang, Yi Zhang, Shihuan Tang, Hongwei Wu, Hongjun Yang

Summary: This study revealed the ingredients, tissue distribution, and pharmacokinetic characteristics of Shengmai injection (SMI). The study found that ginsenosides were the main active compounds in SMI and had high exposure in different tissues. The pharmacokinetic evaluation showed different elimination rates for different types of ginsenosides.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

An integrated strategy for rapid discovery and identification of the potential effective fragments of polysaccharides from Saposhnikoviae Radix

Jie Li, Chang Zhou, Shu-jin Jing, Yan-yan Jiang, Bin Liu

Summary: This study explored the activity of degraded polysaccharides in Saposhnikoviae Radix and identified potential effective fragments. By establishing chromatographic fingerprints using HPLC and evaluating immunomodulatory activity, the study screened out potential effective fragments based on spectrum-effect relationship analysis. Using LC-IT-TOF MS, the chemical structure of these fragments was elucidated. This study provides an experimental foundation for the exploration of active fragments from macromolecular components.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Zhisou powder displays therapeutic effect on chronic bronchitis through inhibiting PI3K/Akt/HIF-1α/VEGFA signaling pathway and reprograming metabolic pathway of arachidonic acid

Yahui Dong, Yang Liu, Jie Tang, Jiahui Du, Xuzhen Zhuang, Song Tan, Ye Yang, Dengke Yin

Summary: This study aimed to explore the potential mechanism of Zhisou Powder in the treatment of chronic bronchitis by combining UPLC-Q-Exactive-Orbitrap-MS, network pharmacology, metabonomics, and experiment verification.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Jianpi Shengqing Huazhuo Formula improves abnormal glucose and lipid metabolism in obesity by regulating mitochondrial biogenesis

Wenkai Wang, Shanshan Chen, Shuting Xu, Guangyi Liao, Weihao Li, Xiao Yang, Tingting Li, Huifen Zhang, Huanhuan Huang, Yuqing Zhou, Huafeng Pan, Chuanquan Lin

Summary: JSH has been found to have a good effect on obese patients with early abnormal glucose and lipid metabolism. It can reduce body weight, improve glucose and lipid metabolism, and alleviate liver damage in both clinical observations and animal experiments.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Characterization of the glucuronidating pathway of pectolinarigenin, the major active constituent of the Chinese medicine Daji, in humans and its influence on biological activities

Peiqi Liu, Qian Li, Guanghao Zhu, Tiantian Zhang, Dongzhu Tu, Feng Zhang, Moshe Finel, Yuqi He, Guangbo Ge

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Review Plant Sciences

Review of traditional uses, phytochemistry and pharmacology of Tibetan Medicine tangchong

Tianru Wang, Qiuyue Li, Ziyu Zhou, Jia Liu, Yiwen Tao, Yi Zhang, Yong Zeng, Sanyin Zhang, Jinsong Su

Summary: This review provides a comprehensive analysis of tangchong, a group of plants from the Solanaceae family used in traditional Tibetan medicine. It summarizes the traditional usage, chemical composition, pharmacology, toxicology, and quality control measures of these plants. The review highlights the significant value of tangchong as an ethnomedicinal resource, with pharmacological activities primarily linked to its alkaloid content.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Kinsenoside from Anoectochilus roxburghii (Wall.) Lindl. suppressed oxidative stress to attenuate aging-related learning and memory impairment via ERK/Nrf2 pathway

Yu Xiao, Changsong Duan, Pushuang Gong, Qi Zhao, Xin hui Wang, Fang Geng, Jin Zeng, Tianfeng Luo, Yisha Xu, Junning Zhao

Summary: This study explored the protective property of aqueous extract of Anoectochilus roxburghii on aging and aging-related learning and memory impairment. The findings showed that the extract alleviated low growth rate, abnormal brain, liver, and thymus indexes, and decline in learning and memory capability of aging mice.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Essential oil from Inula japonica Thunb. And its phenolic constituents ameliorate pulmonary injury and fibrosis in bleomycin-treated mice

Fan Wei, Yuzhen Yin, Jie Li, Yibo Chang, Shuyuan Zhang, Wenyu Zhao, Xiaochi Ma

Summary: Inula japonica essential oil (EOI) shows potential therapeutic effects on pulmonary injury and fibrosis in mouse models. EOI can inhibit inflammatory response, regulate redox equilibrium, and suppress pulmonary fibrosis by mediating the TGF-beta/Smad and PI3K/Akt signaling pathways.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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