Physiology

Review Physiology

Breath-holding as model for the evaluation of EEG signal during respiratory distress

Lucas de Jesus Alves Ribeiro, Victor Hugo do Vale Bastos, Marcelo Coertjens

Summary: This study investigates the relationship between cortical activity and the regulation of bulbar respiratory centers during respiratory challenges. The results suggest that a protocol of successive apneas triggers an increase in maximum apnea time, making it a potential model for studying cortical activity during respiratory distress.

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2023)

Review Physiology

Hyperexcitability of muscle spindle afferents in jaw-closing muscles in experimental myalgia: Evidence for large primary afferents involvement in chronic pain

Dar'ya Sas, Fanny Gaudel, Dorly Verdier, Arlette Kolta

Summary: The topic of this review is the emergence of ectopic firing in muscle spindle afferents (MSAs) and its potential role in pathological pain. The review highlights the mechanisms underlying the generation of ectopic firing, such as oscillations supported by a persistent sodium current and regulation of extracellular Ca2+ by astrocytes. The review also discusses the possible cross-talk between MSAs and nociceptors in the periphery.

EXPERIMENTAL PHYSIOLOGY (2023)

Article Physiology

Pain quality patterns in delayed onset muscle soreness of the lower back suggest sensitization of fascia rather than muscle afferents: a secondary analysis study

Andreas Brandl, Jan Wilke, Christoph Egner, Tobias Schmidt, Andreas Schilder, Robert Schleip

Summary: This study aimed to analyze the pain origin of delayed onset muscle soreness (DOMS) in the lower back. The findings revealed that the sensory characteristics of DOMS were similar to electrical stimulation but significantly different from muscle pain, suggesting that DOMS may have a fascial rather than muscular origin.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2023)

Article Biology

Differences in nutritional profile by chronotype among 12-h day shift and night shift nurses

Rachel Faulkner, Teresa Rangel, Rebecca A. Penders, Trisha Saul, Ross Bindler, Lindsey Miller, Marian Wilson

Summary: The impact of preferred chronotype and shift mismatch on nutritional intake and metabolic disease risk among acute care nurses is uncertain. This study found that eveningness nurses had markers of metabolic syndrome and consumed more calories. Mismatched nurses consumed more calories, but this finding was not statistically significant. Further research with larger samples is needed.

CHRONOBIOLOGY INTERNATIONAL (2023)

Article Physiology

Obesity blunts insulin sensitivity improvements and attenuates strength gains following resistance training in nondiabetic men

Ramzi A. Al-Horani, Khaled M. Alsays, Osama Abo Alrob

Summary: The study shows that obesity hinders improvements in insulin sensitivity and attenuates strength gains through resistance training. It suggests that additional strategies, such as caloric restriction, may be needed for improving insulin sensitivity in individuals with obesity.

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2023)

Article Neurosciences

Network-based systematic dissection of exercise-induced inhibition of myosteatosis in older individuals

Hirotaka Iijima, Fabrisia Ambrosio, Yusuke Matsui

Summary: This study used a network medicine paradigm to compare the transcriptomic response of aged muscle to exercise and immobilization, and explored the molecular cascade regulating fat accumulation. The findings suggest that the Pgc-1 alpha -mitochondrial fatty acid oxidation axis is a shared mechanism by which physical activity regulates age-related myosteatosis.

JOURNAL OF PHYSIOLOGY-LONDON (2023)

Article Biology

The moon cycle influences reproductive and productive traits in guinea pigs (Cavia porcellus) from a tropical Andean area

Miguel F. Perea, Estefania A. Fernandez, Juan P. Garzon, Cornelio A. Rosales, Hugo Hernandez-Fonseca, Daniel A. Perdomo, Fernando P. Perea

Summary: The lunar cycle affects various reproductive and productive traits in guinea pigs, such as litter size, mortality, number of pups weaned, and individual and litter weaning weights. This valuable information may have practical applications in the management of guinea pig production systems.

CHRONOBIOLOGY INTERNATIONAL (2023)

Article Nutrition & Dietetics

Families' perception of proposed nutrition screening on admission to pediatric hospitals: a qualitative analysis

Sarah Kocel, Laura E. Carter, Marlis Atkins

Summary: This study explores the potential perceptions, feelings, and opinions of families regarding pediatric nutrition screening during hospital admission. The findings show that nutrition screening may raise sensitive emotions and a lack of understanding of the purpose and questions of the screening. The acceptance of nutrition screening could be limited by the timing and approach.

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM (2023)

Article Biology

Stability of social jetlag and sleep timing into the second year of the Covid-19 pandemic: Results from a longitudinal study of a nationally representative adult sample in Ireland

Sudha Raman, Philip Hyland, Andrew N. Coogan

Summary: The early phase of the COVID-19 pandemic led to significant changes in sleep/wake timing, which persisted into the second year of the pandemic. The study highlights the key roles of working practices and other social factors in shaping social jetlag.

CHRONOBIOLOGY INTERNATIONAL (2023)

Article Psychology, Biological

Effects of resistance exercises on inhibitory control and plasma epinephrine levels: A registered report of a crossover randomized controlled trial

Ting-Yu Lin, Hao-Chien Cheng, Yi-Luen Tsai, Hung-Wen Liu, Tsung-Min Hung

Summary: This study investigates the effects of acute resistance exercise on cognitive performance, addressing previous methodological limitations and finding that it improves congruent reaction time but is not associated with changes in plasma epinephrine levels.

PSYCHOPHYSIOLOGY (2023)

Article Behavioral Sciences

Ventral wing hairs provide tactile feedback for aerial prey capture in the big brown bat, Eptesicus fuscus

Brittney L. Boublil, Chao Yu, Grant Shewmaker, Susanne Sterbing, Cynthia F. Moss

Summary: This study found that the microscopic hairs on the wing membranes of bats are involved in airflow sensing for flight control and provide mechanosensory feedback for prey capture and flight.

JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY (2023)

Article Neurosciences

Functional coupling between Piezo1 and TRPM4 influences the electrical activity of HL-1 atrial myocytes

Yang Guo, Delfine Cheng, Ze-Yan Yu, Teresa Schiatti, Andrea Y. Chan, Adam P. Hill, Remi Peyronnet, Michael P. Feneley, Charles D. Cox, Boris Martinac

Summary: The TRPM4 and Piezo1 channels play important roles in cardiac hypertrophy. This study used an in vitro model to investigate the effect of Piezo1-TRPM4 coupling on cardiac action potential frequency. The results show that Piezo1 activation influences action potential frequency, and this influence is regulated by TRPM4. This study provides in vitro evidence of a functional coupling between Piezo1 and TRPM4 in a cardiomyocyte-like cell line. The coupling of a mechanosensitive Ca2+ permeable channel and a Ca2+-activated TRP channel may have a ubiquitous role in mechanosensory transduction.

JOURNAL OF PHYSIOLOGY-LONDON (2023)

Review Physiology

Targeted genetic therapies for inherited disorders that affect both cardiac and skeletal muscle

Yiangos Psaras, Christopher N. Toepfer

Summary: Skeletal myopathies and ataxias with secondary cardiac involvement are complex and progressive diseases. As life expectancy increases, it is necessary to develop targeted therapies to address the evolving cardiac pathologies.

EXPERIMENTAL PHYSIOLOGY (2023)

Article Nutrition & Dietetics

Adapting the Planetary Health Diet Index for children and adolescents

Carolina Venegas Hargous, Liliana Orellana, Claudia Strugnell, Camila Corvalan, Steven Allender, Colin Bell

Summary: This study advances methods for measuring adherence to sustainable healthy diets among children and adolescents and shows the effectiveness of the adapted index through comparisons and associations with diet characteristics in a sample of Chilean children.

INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY (2023)

Article Nutrition & Dietetics

GLP-1 response during pregnancy: variations between trimesters and associations with appetite sensations and usual energy intake

Inis Auclair Mangliar, Anne-Sophie Plante, Myriam Chabot, Claudia Savard, Simone Lemieux, Andreanne Michaud, S. John Weisnagel, Felix Camirand Lemyre, Alain Veilleux, Anne-Sophie Morisset

Summary: Further research is needed to understand the hormonal regulation of food intake during pregnancy and its relationship with energy intake. This study found differences in GLP-1 and appetite sensation responses between trimesters, but few associations were observed between GLP-1, appetite sensations, and usual energy intake.

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM (2023)

Article Pharmacology & Pharmacy

SCH772984 ameliorates lipopolysaccharide-induced hypoglycemia in mice through reversing MEK/ERK/Foxo1-mediated gluconeogenesis suppression

Yirong Wang, Shuyun Qing, Jing Yang, Dehui Qian

Summary: This study revealed that LPS inhibits gluconeogenesis and induces hypoglycemia through the MEK/ERK/Foxo1 signaling pathway, and an ERK inhibitor can reverse this process effectively. These findings provide a novel therapeutic target for LPS-induced hypoglycemia.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2023)

Article Nutrition & Dietetics

Options for substantiating protein content claims for conventional foods

James D. House, Andre Brodkorb, Mark Messina, Michelle Braun, Elaine S. Krul

Summary: In Canada and the United States, data supporting the quality of protein is required for front-of-package protein content claims. However, the current method of measuring protein quality through animal testing is inconsistent with global efforts to reduce animal usage for regulatory purposes. This article presents four alternative options to replace animal testing for determining protein quality and encourages regulatory agencies to consider these approaches for substantiating protein content claims, especially for plant-based foods.

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM (2023)

Article Physiology

Lectin-mediated, time-efficient, and high-yield sorting of different morphologically intact nephron segments

Jessica Roskosch, Uyen Huynh-Do, Stefan Rudloff

Summary: The article introduces a novel method for isolating nephron segments, using low-cost fluorophore-conjugated lectins or agglutinins (Flaggs) combined with flow sorting. This method allows for the simultaneous separation of different nephron segments with preserved 3D morphology from mouse or human samples in a short time. The method is simple, straightforward, cost-effective, and widely applicable, providing high amounts of pure and morphologically intact renal tubule materials for nephron segment-specific research.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2023)

Article Physiology

Analysis of Sprint Ski Mountaineering Performance

Alessandro Fornasiero, Simone Fornoni, Alexa Callovini, Beatrice Todesco, Aldo Savoldelli, Federico Schena, Hans-Christer Holmberg, Barbara Pellegrini, Lorenzo Bortolan

Summary: This study examined the contribution of uphill sections, transitions, and final descent to overall finishing time in ski mountaineering sprint competitions. The results showed that uphill and transition times were closely correlated with finishing time, with uphill explaining a significant portion of the variation. The study also found that top-ranked skiers performed better on uphill sections, while those eliminated showed a tendency for decline. These insights are valuable for training for the 2026 Winter Olympics.

INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE (2023)

Article Biophysics

Revisiting Masselot et al. (2023): assessing the share of excess mortality linked to cold and hot weather in Europe

Alberto Boretti

Summary: Excess mortality attributed to cold weather is significantly higher than that linked to hot weather, highlighting the greater health risks and vulnerabilities associated with cold weather.

INTERNATIONAL JOURNAL OF BIOMETEOROLOGY (2023)