Pharmacology & Pharmacy

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Article Plant Sciences

Diuretic activity evaluation and chemical composition analysis of Hedyotis scandens extract from Mizoram, India, in rat models

Elizabeth Vanlalruati Ngamlai, R. B. Pradhan, P. C. Lalbiaknii, Vanlalhruaii Ralte, F. Lalnunmawia, P. C. Vanlalhluna, S. K. Mehta

Summary: Hedyotis scandens extract demonstrated significant diuretic effects and was found to be safe for consumption. This study confirms the traditional use of this plant as a diuretic in the Mizoram region. The GC-MS analysis identified several bioactive compounds, including phytol, which is associated with diuretic properties.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Huang-Qi-Jian-Zhong-Tang accelerates healing of indomethacin-induced gastric ulceration in rats via anti-inflammatory and antioxidant mechanisms

Houpan Song, Meng Xiong, Chang Yu, Baoping Ren, Meiqi Zhong, Shunhua Zhou, Qing Gao, Chen Ou, Xiaojuan Wang, Jing Lu, Meiyan Zeng, Xiong Cai, Qinghua Peng

Summary: In this study, the gastroprotective potential of Huang-Qi-Jian-Zhong-Tang (HQJZT) in a rat model of indomethacin-induced gastric ulcer was investigated. The results showed that HQJZT effectively protected the stomach from ulceration by suppressing gastric acid secretion, enhancing antioxidant defenses and blood flow, mitigating proinflammatory cytokines, and inhibiting the activation of NF-kappa B and STAT signaling pathways.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Revealing the mechanism of Zanthoxylum armatum DC. extract-induced liver injury in mice based on lipidomics

Nannan Yang, Jian Zhang, Jiafu Guo, Qiwen Xiang, Yan Huang, Jiayu Wen, Qiuyan Liu, Tingting Hu, Yan Chen, Chaolong Rao

Summary: This study aimed to investigate the potential hepatotoxic mechanism of Z. armatum by analyzing hepatic lipid levels, lipid metabolites and metabolic pathways using lipidomics.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Annickia affinis (Exell) Versteegh & Sosef methanol stem bark extract, potent fractions and isolated Berberine alkaloid target both blood and liver stages of malaria parasites

Nekpen Erhunse, Surekha Kumari, Pooja Anmol, Pooja Singh, Ehimwenma Sheena Omoregie, Agam Prasad Singh, Upendra Sharma, Dinkar Sahal

Summary: This study identified the specialized metabolites responsible for the antiplasmodial activity of Annickia affinis, finding that protoberberine alkaloids isolated from the plant showed excellent antiplasmodial activity, particularly against the blood-stage malaria parasite. Additionally, these compounds also exhibited promising activity against the liver-stage malaria parasite.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Understanding mechanistic aspect of the therapeutic role of herbal agents on neuroplasticity in cerebral ischemic-reperfusion injury

Annu Bangar, Heena Khan, Amarjot Kaur, Kamal Dua, Thakur Gurjeet Singh

Summary: This study aims to gather and highlight the traditional understanding of therapeutic plants and their efficacy in cerebral ischemia-reperfusion injury. It also provides a concise summary and explanation of herbal drugs and their role in improving neuroplasticity. The review of pharmacological activity of polyherbal formulations produced from some of the frequently referenced botanicals for the treatment of cerebral ischemia damage was conducted.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

The anti-liver fibrosis effect of Tibetan medicine (Qiwei Tiexie capsule) is related to the inhibition of NLRP3 inflammasome activation in vivo and in vitro

Shanshan Wang, Fei Ye, Qingjia Ren, Shengnan Sun, Weina Xia, Zhuwei Wang, Haolin Guo, Han Li, Shujing Zhang, Scott Lowe, Meng Chen, Qinghong Du, Weihong Li

Summary: This study confirms the significant anti-liver fibrosis effect of Tibetan medicine QWTX and reveals its mechanism through the inhibition of NLRP3 inflammasome activation.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Essential oil from Ligusticum chuanxiong Hort. Alleviates lipopolysaccharide-induced neuroinflammation: Integrating network pharmacology and molecular mechanism evaluation

Jing Zuo, Tian-Hao Zhang, Cheng Peng, Bin-Jie Xu, Ou Dai, Yan Lu, Qin-Mei Zhou, Liang Xiong

Summary: Chuanxiong essential oil alleviates neuroinflammation through the NF-kappa B signaling pathway, providing a theoretical foundation for the clinical application of Chuanxiong essential oil in migraine treatment.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Ethnopharmacological analysis based on Thai traditional medicine theory and anti-inflammatory activity of Sa-Tri-Lhung-Klod remedy as a post-partum anti-inflammatory drug

Janjira Inprasit, Arunporn Itharat, Srisopa Ruangnoo, Krittiya Thisayakorn, Kanmanee Sukkasem, Nuntika Prommee, Wicheian Khoenok, Kanjana Sriyam, Darunee Pahusee, Neal M. Davies

Summary: This study aimed to explore the relationship between taste theory in Thai traditional medicine and the anti-inflammatory effect of Sa-Tri-Lhung-Klod (ST) remedy, as well as its chemical constituents. The results showed that the compounds in ST remedy had potent anti-inflammatory activity and effectively inhibited the production of nitric oxide and prostaglandin E2.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Correction Plant Sciences

Application of omics technology to investigate the mechanism underlying the role of San Hua Tang in regulating microglia polarization and blood-brain barrier protection following ischemic stroke (vol 314,116640, 2023)

Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Review Plant Sciences

The genus Balanophora J. R. Forst. & G. Forst. - Its use in traditional medicine, phytochemistry, and pharmacology: A review

Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu

Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

The oral administration of Lotus corniculatus L. attenuates acute and chronic pain models in male rats

Sajjad Jabbari, Zainul Amiruddin Zakaria, Davoud Ahmadimoghaddam, Saeed Mohammadi

Summary: Lotus corniculatus leaves essential oil (LCEO) has antinociceptive effects and can alleviate both acute and chronic pain. It may act through modulation of opioid, TRPV, dopamine, cannabinoid mechanisms, as well as NO-cGMP-K+ channel, and also inhibit inflammatory processes.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Bidirectional effects of geniposide in liver injury: Preclinical evidence construction based on meta-analysis

Xinyu Zeng, Jiajie Jiang, Simiao Liu, Qichao Hu, Sihan Hu, Jinhao Zeng, Xiao Ma, Xiaomei Zhang

Summary: Geniposide exhibits dual pharmacological activity in liver injury, exerting potent hepatoprotective effects within a specific dose and time range, but also causing liver injury.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Isolation of indole alkaloids and a new norneolignan of hydroethanol extract from the stem barks of Aspidosperma nitidum Benth: Preclinical evaluation of safety and anti-inflammatory and healing properties

Manoela Torres-Rego, Patricia Coelho do Nascimento Nogueira, Sarah Pollyana Dias dos Santos, Alessandra Daniele-Silva, Felipe Franca Cavalcanti, Cinthya Iamile Frithz Brandao de Oliveira, Hugo Alexandre Oliveira Rocha, Matheus de Freitas Fernandes-Pedrosa, Edilberto Rocha Silveira, Renata Mendonca Araujo

Summary: The study aimed to isolate indole alkaloids from the stem barks of Aspidosperma nitidum and investigate their safety, anti-inflammatory, and healing properties. Results showed that the extract exhibited anti-inflammatory and healing effects without cytotoxicity, suggesting its potential use in traditional medicine.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Ruyong formula improves thymus function of CUMS-stimulated breast cancer mice

Bingqian He, Wenqin Guo, Rongzhen Shi, Robert D. Hoffman, Qihan Luo, Yuan-Jia Hu, Jianli Gao

Summary: The Ruyong Formula (RYF), a traditional Chinese herbal formula, has been used to treat breast cancer patients with depressive symptoms in China. This study aimed to investigate the pharmacological mechanism of RYF on thymus immune function changes in breast cancer patients with mood disorders.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Research on the mechanism of antidepressive effect of Suanzaoren Decoction through TLR4/MyD88/NF-κB pathway and Wnt/β-catenin pathway

Yiyang Du, Tingxu Yan, Bo Wu, Bosai He, Ying Jia

Summary: This study found that Suanzaoren Decoction (SZRD) can reverse depression-like behavior in rats, reduce inflammation, and increase the expression of BDNF, SYP, and PSD95. Further research revealed that SZRD exerts its antidepressant effect by regulating the TLR4/MyD88/NF kappa B pathway and Wnt/beta-catenin pathway in combination.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Quercetin inhibits mesothelial-mesenchymal transition and alleviates postoperative peritoneal adhesions by blocking the TGF-β1/PI3K/ AKT pathway

Gan Li, Yiwei Ren, Enmeng Li, Kai Deng, Chao Qu, Junxiang Zhang, Li Zhang, Xingjie Wang, Jie Lian, Huayou Zhou, Zijun Wang, Tianli Shen, Xuqi Li, Zhengdong Jiang

Summary: This study found that quercetin in Carthami flos is the key component in preventing postoperative peritoneal adhesions. Quercetin can inhibit the mesothelial-mesenchymal transition (MMT) of mesothelial cells and alleviate postoperative peritoneal adhesions by blocking the TGF-beta 1/PI3K/AKT pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Bioactive metabolites reveal the therapeutic consistency of epimedii folium from multi-plant sources for the treatment of kidney-yang deficiency

Xinguang Sun, Yingfei Li, Juan Li, Haizhen Liang, Jie Zhang, Xiaojuan Chen, Qi Li, Xu Pang, Qianzhi Ding, Juan Song, Baolin Guo, Baiping Ma

Summary: This study aimed to investigate the underlying reasons for the similar pharmacological effects of Epimedii Folium from two botanical sources, Epimedium koreanum and Epimedium wushanense. The results showed that both plant species exhibited similar effects on promoting mating behaviors and testosterone levels in rats. The study also found that Epimedii Folium can regulate testosterone production by reversing expressions of key steroidogenic enzymes in rat Leydig cells.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Efficacy of Trigonella foenum-graecum Linne in an animal model of particulate matter-induced asthma exacerbation

Eun-Young Kim, Hoyeon Park, Eom Ji Kim, Seung Hoon Lee, Jun Won Choi, Jonghyun Kim, Hyuk-Sang Jung, Youngjoo Sohn

Summary: This study demonstrates the efficacy of Trigonella foenum-graecum Linne (TFG) in alleviating PM-induced inflammatory response in bronchial epithelial cells and an animal model of asthma exacerbation.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Revealing the improvement of diabetes by Si Wei Jiang Huang Tang San through ERK/HIF1α signaling pathway via network pharmacology

Tianshu Xu, Ping He, So Namwangdu, Chunyang Xu, Biyu Hou, Peng Ma, Zijing Wang, Li Zhang, Guanhua Du, Tse Ring, Tengfei Ji, Guifen Qiang

Summary: Residents in Urumqi region are warned to prepare for heavy rain that may cause floods and mudslides, and take measures to reduce possible losses.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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Article Plant Sciences

Chemical profiling of Shengmai injection, tissue distribution and pharmacokinetic characteristics of ginsenosides after intravenous dosing Shengmai injection in rats with cerebral ischemia

Huanhuan Wang, Liying Tang, Shaowei Hu, Xixian Kong, Yi Ouyang, Dong Zhang, Yi Zhang, Shihuan Tang, Hongwei Wu, Hongjun Yang

Summary: This study revealed the ingredients, tissue distribution, and pharmacokinetic characteristics of Shengmai injection (SMI). The study found that ginsenosides were the main active compounds in SMI and had high exposure in different tissues. The pharmacokinetic evaluation showed different elimination rates for different types of ginsenosides.

JOURNAL OF ETHNOPHARMACOLOGY (2024)

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