Review
Plant Sciences
Lirong Wang, Shujing Chen, Suyi Liu, Abdulmumin Muhammad Biu, Yuli Han, Xingyue Jin, Chunxiao Liang, Yang Liu, Jin Li, Shiming Fang, Yanxu Chang
Summary: This review comprehensively summarizes the research progress in botany, traditional medical use, processing method, phytochemistry, pharmacological activity, quality control, pharmacokinetics, and toxicology of Gardeniae Fructus (GF), providing a scientific basis for its rational application and future research. More than 215 compounds have been isolated and identified from GF, with various pharmacological effects. Improved processing methods can alleviate side effects and toxic reactions. GF has a wide range of potential applications in treating diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chien-Yun Hsiang, Hsin-Yi Lo, Guan-Ling Lu, Pei-Yung Liao, Tin-Yun Ho
Summary: This study identified a novel heat-stable ACE inhibitory peptide, CS-1, in corn silk extract. CS-1 interacted with the zinc-binding motif of ACE, leading to the inhibition of ACE activity and a subsequent decrease in blood pressure in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiaqi Fu, Yuqin Liang, Donghua Yu, Yu Wang, Fang Lu, Shumin Liu
Summary: This study aimed to investigate the role of Radix Saposhnikoviae (RS), which is designed as a guide drug for Huangqi Chifeng decoction (HQCF), in improving lipid metabolism in atherosclerosis (AS) patients. The results showed that HQCF can reduce atherosclerotic lesions in the aorta and lipid accumulation in the liver, potentially by activating the AMPK pathway to regulate lipid transport and metabolic function. These effects can be attributed to the guidance and synergism of RS.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Biochemical Research Methods
Neetu Raghav, Seema Parveen, Simleen Kaur, Selwyn A. Wilson David, Hyesuk Kong, James L. Kenney, Rajesh K. Gupta
Summary: This study evaluated the use of solid medium in sterility testing. Results showed that the sterility test using Schaedler blood agar (SBA) was more sensitive and faster in detecting microorganisms compared to the current compendial method, particularly in samples containing thimerosal. The sterility test using solid medium could be completed in 7 days without any additional technology.
Article
Biochemical Research Methods
Arnaud Marchant, Pierre Van Damme, Stanley Plotkin, Pieter Neels, Maria Cristina Cassetti, Jakob Cramer, Marion F. Gruber, David Goldblatt, Deborah King, Wendy Hartig-Merkel, Joris Vandeputte
Summary: A meeting was held in February 2023 by international organizations to discuss correlates of protection against COVID-19, reviewing evidence and identifying knowledge gaps. Neutralizing antibodies and T lymphocytes are believed to play a significant role in protection, but further studies are needed to consolidate the evidence and evaluate other potential factors.
Article
Substance Abuse
Atefeh Bakhtazad, Afsaneh Asgari Taei, Fatemeh Parvizi, Mehdi Kadivar, Maryam Farahmandfar
Summary: This study found that repeated morphine pretreatment can reverse the impairment of spatial learning and memory caused by ethanol, and this effect may be explained by the modulation of CaMKII and BDNF expressions in the hippocampus and amygdala.
Article
Biochemical Research Methods
Loushambam Samananda Singh
Summary: Antibiotic resistance has become a major concern for global public health, and phage therapy is seen as an alternative for treating multidrug resistant bacterial infections. Nano-emulsion encapsulation is described as the best approach to maintain phage efficacy.
Article
Clinical Neurology
Hannah Meijs, Helena Voetterl, Alexander T. Sack, Hanneke van Dijk, Bieke De Wilde, Jan Van Hecke, Peter Niemegeers, Evian Gordon, Jurjen J. Luykx, Martijn Arns
Summary: This study used a polygenic score (PGS) and electroencephalography (EEG) data analysis to identify potential predictors for treatment outcomes in major depressive disorder (MDD). The results suggest the existence of a stable EEG network related to antidepressant-response that has potential as a predictor for MDD treatment, particularly in the case of venlafaxine.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Pei Liu, Xiao-ying Tan, Huang-qin Zhang, Ke-lei Su, Er-xin Shang, Qing-ling Xiao, Sheng Guo, Jin-ao Duan
Summary: The study aims to investigate the optimal combination ratio of Trichosanthis Pericarpium - Trichosanthis Radix (TP-TR) and its anti-inflammatory active ingredients in the treatment of cough. Through zebrafish and mouse models, the study found that TP-TR at a ratio of 1:2 exhibited superior anti-inflammatory effects and identified several anti-inflammatory active ingredients. Furthermore, network pharmacology and intestinal flora sequencing validated the anti-inflammatory components of TP-TR and revealed its potential regulatory effects on gut microbes.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Song-Yi Lin, Chia-Lin Chang, Kuo-Tong Liou, Yao-Kai Kao, Yea-Hwey Wang, Cher-Chia Chang, Terry B. J. Kuo, Hung-Tse Huang, Cheryl C. H. Yang, Chia-Ching Liaw, Yuh-Chiang Shen
Summary: This study investigates the molecular mechanisms of the action of Achyranthes aspera using an integrative approach and aims to provide a comprehensive understanding of its protective effects and underlying signaling networks.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
