Article
Pharmacology & Pharmacy
Ying Wang, Min Xia, Jincheng Lu, Tianyu Wang, Xuan Zhang, Michael Ntim, Bin Wang
Summary: Stress conditions induce increased expression of TIP60, which in turn regulates the release of glutamate and receptor expressions, triggering hypertension.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Weimin Yu, Qian Zhang, Yixiang Qiu, Hui Chen, Xiaoyang Huang, Li Xiao, Gang Xu, Siqi Li, Pingping Hu, Xiaoyong Tong
Summary: The dysfunction of SERCA2 leads to PASMC phenotypic transition and pulmonary vascular remodeling through multiple mechanisms, which can be improved by the SERCA2 agonist CDN1163.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Silvana Nader Nagib, Saeed Abdelwahab, Ghada Essam El-Din Amin, Mohamed Farouk Allam
Summary: This study aimed to determine the prevalence and risk factors of CKD among hypertensive non-diabetic patients attending primary health care centers in Cairo. The study found that the prevalence of CKD among the hypertensive non-diabetic patients was 33%, and it is more common in females, those with primary education and low socioeconomic class, patients with positive family history of CKD, patients with ischemic heart disease, and those using antihypertensive drugs. CKD in these patients leads to significant morbidity and mortality.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Wenhai Guo, Danping Huang, Shaodong Li
Summary: The aim of this study was to investigate whether the intervention with different concentrations of lycopene could attenuate H2O2-induced oxidative stress injury in human vascular endothelial cells (VECs). The results showed that lycopene can alleviate oxidative damage in VECs by reducing intracellular ROS levels, inflammatory factor production, cell adhesiveness, and apoptosis rate under oxidative stress conditions through activation of the SIRT1/Nrf2/HO-1 pathway.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Jieyun You, Xuan Li, Fangjie Dai, Jun Liu, Qi Zhang, Wei Guo
Summary: GSDMD-mediated cell death plays a crucial role in cardiac remodeling induced by pressure overload. Deletion of GSDMD can alleviate cardiomyocyte death, hypertrophy and fibrosis. GSDMD-mediated cell death promotes cardiac remodeling through activation of JNK and p38 signaling pathways.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Li Li, Xiaohui Tong, Zebin Ma, Lei Lv, Haipeng Liu, Guang Liang Chen
Summary: The study investigated the effects of amlodipine-folic acid (amlodipine-FA) preparation on hypertension and cardiovascular in renal hypertensive rats with hyperhomocysteinemia (HHcy), providing experimental basis for the clinical research of amlodipine folic acid tablets.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Ke Peng, Mingliang Wang, Jun Wang, Qiang Wang, De Li, Xiongshan Sun, Yongjian Yang, Dachun Yang
Summary: This study found that nuclear receptor subfamily 1, group D, member 1 (NR1D1) inhibits intimal hyperplasia by suppressing the proliferation and migration of vascular adventitial fibroblasts (AFs) in a mTORC1/beta-catenin-dependent manner.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Qiuhong Jiang, Nan Zhang, Hongyu Zhang, Yongjian Xiao, Xia Zhang, Jing Gao, Yin Liu
Summary: This study aimed to analyze the impact of admission time on major adverse cardiovascular events (MACEs) in patients with acute myocardial infarction (AMI). The occurrence of MACEs was significantly higher in patients admitted during off-hours compared to on-hours. Age, blood glucose level, multivessel disease, and off-hour admission were independent risk factors for in-hospital MACEs, while percutaneous coronary intervention and on-hour admission were protective factors for MACEs 1 year after discharge.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Ping Wang, Guihua Liao, Xi Wu, Rentao Yu, Jun Ma
Summary: Brachial-ankle pulse wave velocity (baPWV) is a clinical indicator of aortic stiffness and a risk predictor of cardiovascular disease. In this study, we examined the correlation of baPWV with body fat-related indicators and assessed whether baPWV can predict these indicators.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Cigdem Ileri, Zekeriya Dogan, Beste Ozben, Latife Bircan, Aycan Acet, Taner Sen
Summary: This study aimed to investigate the effect of timing of fixed dose triple antihypertensive combinations on blood pressure control. The results showed that all patients had good blood pressure control regardless of the timing of drug administration. However, patients taking ARB-based triple antihypertensive pills in the morning had significantly less dipping pattern in blood pressure compared to other groups. Therefore, ARB-based drugs may be taken in the evening to ensure dipping physiology.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Luxun Tang, Qi Cai, Xiao Wang, Xiaoyu Li, Xiuchuan Li, Lianglong Chen, Yongjian Yang
Summary: Canagliflozin has a protective effect on hypobaric hypoxia-induced PAH by inhibiting pulmonary arterial remodeling through suppressing glycolysis and reactivating AMP-activated protein kinase signaling pathway.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Liu Qin, Yanling Ren, Lan Chen, Ye Feng, Shunqing Luo, Ping Zhang, Wei Zhang, Xiaohua Liang
Summary: In this study, a nested case-control study was conducted to explore the potential lipid metabolites related to the relationship between nut dietary and blood pressure. The results identified four lipid metabolites that are negatively associated with hypertension in children, which might serve as useful biomarkers for predicting childhood hypertension. Mediation analysis further revealed that two of these lipid metabolites function as mediating variables between nut intake and blood pressure levels. This study provides scientific evidence that nut consumption induces beneficial changes in lipid metabolism, reducing the risk of hypertension in children.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Li Dong, Jing Liu, Yan Qin, Wen-Juan Yang, Liang Nie, Hua-Ning Liu, Qing-Hua Hu, Yu Sun, Wen-Yan Cao
Summary: This study investigates the correlation between coronary artery disease (CAD) and ambulatory arterial stiffness index (AASI) in patients with H-type hypertension and coronary heart disease (CHD). The results show that AASI is significantly increased in patients with H-type hypertension and CHD, and it is associated with the severity of CAD.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Weiqiang Wu, Yanjuan Chen, Kuangyi Wu, Huancong Zheng, Guanzhi Chen, Xianxuan Wang, Zegui Huang, Zefeng Cai, Zhiwei Cai, Zhichao Chen, Yulong Lan, Shuohua Chen, Shouling Wu, Youren Chen
Summary: This study found that a high non-HDL-C concentration is associated with an increased risk of cardiovascular disease (CVD) in individuals with hypertension. Prolonged exposure to a high non-HDL-C concentration also increases the risk. Therefore, achieving target blood pressure and non-HDL-C concentrations can help reduce the risk of CVD in individuals with hypertension.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Yancui Sun, Ying Zhang, Fei Liu, Xiaojie Liu, Tesfaldet H. Hidru, Xiaolei Yang, Yinong Jiang
Summary: This study found that the circadian rhythm of blood pressure is associated with arterial stiffness and endothelial dysfunction in patients with essential hypertension. The results showed that baPWV was highest in the reverse dipping group, followed by the non-dipper and dipper groups. Additionally, endothelial function improved with increased nocturnal blood pressure decline. Therefore, a decrease in nighttime systolic blood pressure may be associated with endothelial function and arterial stiffness.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Pharmacology & Pharmacy
Jun Hou, Keji Lu, Peiwen Chen, Peng Wang, Jing Li, Jiali Yang, Qing Liu, Qiang Xue, Zhaobing Tang, Haifeng Pei
Summary: This review provides an overview of the relationship between high-altitude hypoxia and heart rate variability (HRV), summarizing the mechanisms of diseases caused by hypoxia and changes in HRV across various systems. The study also discusses pharmaceutical interventions and aims to provide research ideas for in-depth studies on HRV.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Jyrki Taurio, Jenni Koskela, Marjatta Sinisalo, Antti Tikkakoski, Onni Niemela, Mari Hamalainen, Eeva Moilanen, Manoj Kumar Choudhary, Jukka Mustonen, Pasi Nevalainen, Ilkka Porsti
Summary: In this study, we examined the association of 24-hour urine sodium excretion with haemodynamics and volume status in 510 normotensive and never-treated hypertensive subjects. The results showed that high sodium excretion was associated with increased extracellular fluid volume, while low sodium intake was associated with increased risk of cardiovascular events. The volume of extracellular fluid was mainly determined by body size, but was also moderately influenced by sodium intake. No differences were found in urinary sodium excretion and extracellular water volume between normotensive and hypertensive participants.
Editorial Material
Peripheral Vascular Disease
Jens Jordan, Italo Biaggioni, Guido Grassi, Artur Fedorowski, Kazuomi Kario
Article
Peripheral Vascular Disease
Christian Beger, Astrid Mayerboeck, Konrad Klein, Theresa Karg, Kai M. Schmidt-Ott, Olaf Randerath, Florian P. Limbourg
Summary: This study assessed the current practice of blood pressure measurement and associated values in German medical practices. The findings suggest that blood pressure control is insufficient and measurements are often not performed according to guideline recommendations.
Review
Obstetrics & Gynecology
Petra M. van Baar, Jeske M. Bij M. de Weg, Eibert A. ten Hove, Linda J. Schoonmade, Lidewij van de Mheen, Eva Pajkrt, Christianne J. M. de Groot, Marjon A. de Boer
Summary: This systematic review found that multifetal pregnancy reduction (MFPR) from triplet to twin is associated with a lower risk of hypertensive disorders of pregnancy (HDP) compared to ongoing triplets. The risk of HDP is also decreased after MFPR from higher-order to twin pregnancies. These findings can inform the decision-making process of MFPR by considering individual risk factors of HDP.
HYPERTENSION IN PREGNANCY
(2023)
