Ophthalmology

Article Ophthalmology

Vitreomacular interface abnormalities in type 2 macular telangiectasia (MacTel)

Ramesh Venkatesh, Rubble Mangla, Ashit Handa, Sai Prashanti Chitturi, Yash Parmar, Rohini Sangoram, Naresh Kumar Yadav, Jay Chhablani

Summary: This study examines the different types of vitreomacular interface abnormalities (VMIA) seen on optical coherence tomography (OCT) in type 2 macular telangiectasia (MacTel), and discusses the possible reasons for its development. The study finds a high frequency of VMIA in advanced type 2 MacTel eyes, and identifies retinal pigment clumps (RPCs) as a potential factor contributing to the development of anomalous posterior vitreous detachment (PVD), as well as subsequent VMIA and epiretinal membrane (ERM) development.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2023)

Review Ophthalmology

Osmolarity spatial variations on the ocular surface

Hugo Pena-Verdeal, Jacobo Garcia-Queiruga, Noelia Nores-Palmas, Veronica Noya-Padin, Maria J. Giraldez, Eva Yebra-Pimentel

Summary: Maintaining a healthy balance of tear production, preservation, and elimination is crucial for proper eye function. Tear osmolarity and its variations are reliable indicators for diagnosing high-prevalence pathologies such as dry eye disease. However, obtaining tear osmolarity from a specific location may not accurately reflect values in other compartments.

SPEKTRUM DER AUGENHEILKUNDE (2023)

Article Ophthalmology

Posing biases in portraits of people that do not exist

Nicola Bruno

Summary: This article reports on the posing biases in portraits of people. By utilizing applications generating photo-realistic virtual portraits, it was discovered that these biases indeed exist and further shed light on the actual capabilities of generative networks.

PERCEPTION (2023)

Article Ophthalmology

Prevalence and Associated Factors of Pseudoexfoliation Syndrome in an Iranian Elderly Population: The Tehran Geriatric Eye Study

Alireza Hashemi, Payam Nabovati, Hassan Hashemi, Mehdi Khabazkhoob

Summary: The prevalence and associated factors of Pseudoexfoliation syndrome (PEX) in an Iranian elderly population were investigated. The overall prevalence of PEX in this study was 3.63%, and it increased significantly with advancing age. Age and cataracts were the associated factors of PEX.

OPHTHALMIC EPIDEMIOLOGY (2023)

Review Genetics & Heredity

Schimmelpenning-Feuerstein-Mims syndrome with orbital choristoma and KRAS mutation: a current review and novel case report

Lauren B. Yeager, Daniel S. Casper, Armando Del Portillo, Brian P. Marr

Summary: Schimmelpenning-Feurstein-Mims Syndrome (SFMS) is a rare neurocutaneous disorder caused by postzygotic mosaic mutations in the RAS/MAPK pathway. Patients with SFMS present with various systemic findings, and ophthalmic manifestations are commonly observed. This article provides a case report of a rare SFMS case and a review of published cases with identified genetic mutations, highlighting the association between KRAS mutation and orbital choristoma.

OPHTHALMIC GENETICS (2023)

Article Ophthalmology

Knowledge, attitude, and practice (KAP) towards glaucoma among new glaucoma patients and their first-degree relatives: A cross-sectional study in a tertiary eye care centre in Riyadh, Saudi Arabia

Ghadah Mohammed S. Alqahtani, Abdullah T. Al Zahrani, Khabir Ahmad, Alaa Nukhaylan Albalawi, Dana Ahmad Obeid, Sami Al Shahwan

Summary: This study aimed to assess the knowledge, attitude, and practice towards glaucoma among patients making their first visit to the glaucoma clinics, at King Khaled Eye Specialist Hospital in Riyadh, and their first-degree relatives. The results showed limited knowledge about glaucoma.

EUROPEAN JOURNAL OF OPHTHALMOLOGY (2023)

Article Ophthalmology

Baseline characteristics of eyes with early residual fluid post loading phase of aflibercept therapy in neovascular AMD: PRECISE study report 3

Shruti Chandra, Sarega Gurudas, Ian Pearce, Martin Mckibbin, Ajay Kotagiri, Geeta Menon, Benjamin J. L. Burton, James Talks, Anna Grabowska, Faruque Ghanchi, Richard Gale, Andrea Giani, Victor Chong, Ching Ning Taffeta Chen, Luke Nicholson, Sridevi Thottarath, Swati Chandak, Sobha Sivaprasad

Summary: The study aimed to compare the baseline characteristics in patients with and without early residual fluid (ERF) after aflibercept loading phase (LP) in patients with treatment naive neovascular age related macular degeneration (nAMD). The study found that increased central subfield thickness (CST) and the presence of intraretinal fluid (IRF) and subretinal fluid (SRF) at baseline were the main determinants of ERF.
Article Ophthalmology

Longitudinal changes in crystalline lens thickness and power in children aged 6-12 years old

Hassan Hashemi, Mehdi Khabazkhoob, Elham Azizi, Rafael Iribarren, Carla Lanca, Andrzej Grzybowski, Jos J. Rozema, Mohammad Hassan Emamian, Akbar Fotouhi

Summary: The study found that the crystalline lens power decreases and thickness slightly increases in 6 to 12-year-old children over a three-year period. These changes are associated with refractive errors, place of residence, age, gender, and outdoor activity time.
Article Ophthalmology

The effect of axial length on the short-term outcomes of cataract surgery combined with ab interno trabeculotomy

Hiroki Goto, Megumi Honjo, Takashi Omoto, Makoto Aihara

Summary: Phaco-LOT is an effective treatment for open-angle glaucoma regardless of axial length. However, long-AL eyes have a lower postoperative IOP decrease and higher incidence of early postoperative IOP spike.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2023)

Article Genetics & Heredity

Case report: ocular manifestations of a gain-of-function mutation in CLCN6, a newly diagnosed disease

Lawrencia Kimera, Sameera Nadimpalli, Sudhi Kurup, F. Sessions Cole, Russell Huang, Kathleen Sisco, Hantamalala Ranay Ranaivo, Marwan Shinawi, Patricia Dickson, Ali Mian, Margaret Reynolds

Summary: This article reports the ophthalmic findings of a new disease caused by a mutation in the CLCN6 gene. The gene is involved in important cellular functions such as cell-volume regulation and acidification of intracellular organelles. The patient with the mutation displayed abnormal optic nerve appearance and progressive vision loss. The mutation is also associated with significant developmental delay and neurodegeneration.

OPHTHALMIC GENETICS (2023)

Article Ophthalmology

Access to eye care among adults from an underserved community in Aotearoa New Zealand

Jaymie T. Rogers, Himal Kandel, Matire Harwood, Telusila Vea, Joanna Black, Jacqueline Ramke

Summary: Cost is a major barrier to accessing eye health services in New Zealand. The barriers and facilitators expressed by this underserved community can inform efforts to improve eye health access in New Zealand through people-centred service designs.

CLINICAL AND EXPERIMENTAL OPTOMETRY (2023)

Article Ophthalmology

Clinical outcomes of stromal lenticule rotation to correct mixed astigmatism

Xiyu Sun, Di Shen, Haixiang Jiang, Yani Wang, Rui Wang, Wei Wei

Summary: This study investigates a novel surgical technique, stromal lenticule rotation, for correcting mixed astigmatism and evaluates its initial clinical outcomes. The results show that this technique is safe and effective in improving visual acuity and correcting refractive error.

EUROPEAN JOURNAL OF OPHTHALMOLOGY (2023)

Article Ophthalmology

What to expect from primary inferior oblique overaction after esotropia surgery

Paulo Freitas-da-Costa, Helio Alves, Renato Santos-Silva, Fernando Falcao-Reis, Jorge Breda, Augusto Magalhaes

Summary: This study evaluates the variation in ocular motility pattern in patients with primary inferior oblique muscle overaction after esotropia surgery. The results show that graded anterior transposition of the inferior oblique muscle effectively normalizes versions, but contralateral overaction often becomes manifest after unilateral IO surgery.

BMC OPHTHALMOLOGY (2023)

Article Ophthalmology

Correlation of contrast sensitivity with ganglion cell/inner plexiform layer thickness and damage location in glaucoma with varying severity

Ruiqi Pang, Jieting Peng, Qing Zhang, Kai Cao, Zhong-Lin Lu, Ningli Wang

Summary: This study aimed to investigate the correlation between contrast sensitivity and macular region ganglion cell/inner plexiform layer (GC/IPL) thickness and damage location in open-angle glaucoma (OAG). The study found that GC/IPL thinning in all sectors of the macular region in OAG was correlated with contrast sensitivity impairment, with the inferior temporal sector being the least affected. Contrast sensitivity was found to be a useful indicator for evaluating the severity of early, moderate, and advanced glaucoma, but not pre-perimetric glaucoma.
Article Ophthalmology

Lower eyelid position before and after blepharoptosis repair

Tatsuya Yunoki, Mitsuya Otsuka, Hitoshi Yamazaki, Atsushi Hayashi

Summary: This study examined the changes in lower eyelid position after blepharoptosis surgery and identified factors that influence the outcome. The results showed that lower eyelid scleral show can be improved after blepharoptosis surgery in cases associated with prostaglandin analogs.

ORBIT-THE INTERNATIONAL JOURNAL ON ORBITAL DISORDERS-OCULOPLASTIC AND LACRIMAL SURGERY (2023)

Review Ophthalmology

Artificial Intelligence for Multiple Sclerosis Management Using Retinal Images: Pearl, Peaks, and Pitfalls

Shadi Farabi Maleki, Milad Yousefi, Sayeh Afshar, Siamak Pedrammehr, Chee Peng Lim, Ali Jafarizadeh, Houshyar Asadi

Summary: Multiple sclerosis (MS) is a complex autoimmune disease characterized by inflammatory processes, demyelination, neurodegeneration, and axonal damage within the central nervous system (CNS). The integration of artificial intelligence (AI), particularly machine learning (ML) and deep learning (DL) algorithms, with optical coherence tomography (OCT) has shown promise in enhancing MS diagnosis, monitoring disease progression, and revolutionizing patient care. AI-driven approaches have remarkable abilities in accurately detecting and classifying MS-related abnormalities, predicting disease progression, and aiding in personalized treatment planning.

SEMINARS IN OPHTHALMOLOGY (2023)

Article Ophthalmology

Development and validation of a deep learning model to predict axial length from ultra-wide field images

Yunzhe Wang, Ruoyan Wei, Danjuan Yang, Kaimin Song, Yang Shen, Lingling Niu, Meiyan Li, Xingtao Zhou

Summary: This study validates the feasibility of using a deep learning model to predict axial length for myopic patients from ultra-wide field images, and demonstrates that the model predicts with high accuracy.
Article Ophthalmology

Efficacy of part-time patching in preventing recurrence after bilateral lateral rectus recession in children with intermittent exotropia

Jae Yong Han, Jinu Han, Sueng-Han Han

Summary: This study evaluates the efficacy of part-time patching in preventing recurrence after bilateral lateral rectus recession in patients with intermittent exotropia. The study found that part-time patching can effectively maintain the surgical outcome and delay the need for reoperation. Patients with a recurrence of 7 to 10 PD showed better results.

BMC OPHTHALMOLOGY (2023)

Article Ophthalmology

Seven-year outcomes of combined treatment of anti-vascular endothelial growth factor with photodynamic therapy for polypoidal choroidal vasculopathy; according to polypoidal lesion regression

Junwoo Lee, Kiyoung Kim, Eung Suk Kim, Seung-Young Yu, Min Seok Kang

Summary: In patients with polypoidal choroidal vasculopathy (PCV), the regression of polypoidal lesion one year after anti-VEGF combined with verteporfin PDT treatment is associated with favorable long-term visual prognosis and the maintenance of good visual acuity.

BMC OPHTHALMOLOGY (2023)

Article Ophthalmology

Improving access to eye care in low and middle-income countries - challenges, opportunities, and the way forward

Srinivas Marmamula, Vijay Kumar Yelagondula, Rajashekar Varada, Rohit C. Khanna

Summary: Vision loss is a significant public health challenge affecting a large number of people worldwide. Low and middle income countries (LMICs) have a higher prevalence of vision loss compared to high-income countries. This paper discusses the barriers to accessing eye care services in LMICs and explores potential strategies, including the use of technology, to improve access. The study suggests that providing free eye care, reducing costs, and enhancing access to cataract surgery can improve accessibility. However, there is a lack of research on access to refraction services for refractive errors and other conditions, which needs to be addressed in future studies.

EXPERT REVIEW OF OPHTHALMOLOGY (2023)