Nanoscience & Nanotechnology

Article Chemistry, Multidisciplinary

Eliciting immunogenic cell death via tumor-associated fibroblast inactivation and autophagy induction with doxorubicin and silybin loaded molecularly imprinted nanosystem

Shiyang Wu, Yan He, Ruiqi Zhou, Chunlin Chen, Dawei Chen, Haiyang Hu

Summary: In this research, LDHA@MIP-DSD nanoparticles were designed to enhance the effectiveness of immunogenic cell death (ICD) in cancer immunotherapy. LDHA@MIP-DSD improved the accessibility of nanodrugs to cancer cells by surface imprinting LDHA and induced autophagy with SLN. The combination of these two effects resulted in optimal immune stimulation and antitumor efficiency.

NANO TODAY (2024)

Article Nanoscience & Nanotechnology

Theoretical design of superhard twinned BC2N

Nan Min, Hui Liang, Hao Chen, Xianqi Song, Dan Zhou, Quan Li

Summary: BC2N is an ideal combination of diamond and boron nitride, which is expected to exhibit better mechanical properties and thermal stability. Recent studies have shown that nanotwinned BC2N has superior energetic stability and mechanical strength compared to single-crystal BC2N. The simulated X-ray diffraction patterns of nanotwinned BC2N match previous experimental data. This research offers insights into the rational design and functional optimization of nanotwinned boron-carbon-nitrogen compounds.

SCRIPTA MATERIALIA (2024)

Article Chemistry, Physical

Ultrathin nanolayer constituted by a natural polysaccharide achieves egg-box structured SnO2 nanoparticles toward efficient and stable perovskite solar cells

Haichao Yang, Wensi Cai, Ming Wang, Saif M. H. Qaid, Zhiyuan Xu, Huaxin Wang

Summary: The introduction of sodium alginate (SA) into perovskite solar cells improves the carrier dynamics, stability, and performance by inhibiting nonradiative recombination and retarded charge dynamics.

NANO ENERGY (2024)

Article Biophysics

Immunity testing against COVID-19 from blood by an IoT-enabled and AI-controlled multiplexed microfluidic platform

Nabil H. Bhuiyan, Joon S. Shim

Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Influence of shear stress on electroactive biofilm characteristics and performance in microbial fuel cells

Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour

Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.

BIOSENSORS & BIOELECTRONICS (2024)

Article Nanoscience & Nanotechnology

Discovery of Ni activated sintering of MoNbTaW predicted by a computed grain boundary diagram

Sashank Shivakumar, Keqi Song, Chunyang Wang, Tianjiao Lei, Huolin L. Xin, Timothy J. Rupert, Jian Luo

Summary: This study investigates the enhanced sintering effect of Ni addition in high-entropy alloy MoNbTaW. The experiments reveal complete grain boundary wetting above the bulk solidus line and suggest the presence of a liquid-like interfacial phase below the line. The calculated GB phase diagram predicts high-temperature GB disordering and rationalizes the observed Ni-activated sintering.

SCRIPTA MATERIALIA (2024)

Article Nanoscience & Nanotechnology

Facile formation of a superalloy-like microstructure in Ni77Ga23 alloys by rapid solidification processing

Yanhui Wang, Jianrong Gao, Lunhua He

Summary: Ni77Ga23 alloys were rapidly solidified and undercooled using glass fluxing treatment. The study indicates that rapid solidification leads to the formation of a disordered solid solution, and high undercoolings result in the formation of an equiaxed microstructure. Within the equiaxed grains, coherent cuboidal precipitates of Ni3Ga phase are dispersed, and HRTEM study reveals the presence of disordered nano-domains in the lattice of Ni3Ga phase.

SCRIPTA MATERIALIA (2024)

Article Biophysics

A long lifetime and highly sensitive wearable microneedle sensor for the continuous real-time monitoring of glucose in interstitial fluid

Sijie Yin, Zhiqiang Yu, Ningning Song, Zhanjun Guo, Wei Li, Jinhang Ma, Xiaoyan Wang, Junyao Liu, Minmin Liang

Summary: Researchers have developed a microneedle-based glucose monitoring skin patch that can continuously and accurately monitor glucose levels in real time, offering high sensitivity and a long lifespan. The results can be displayed on a smartphone.

BIOSENSORS & BIOELECTRONICS (2024)

Article Nanoscience & Nanotechnology

Role of nanostructured Ni surface layer in enhanced Hastelloy alloy diffusion bonding at temperatures far beyond recrystallization

Tong Lin, Chun Li, Yuanhang Chen, Lei Chen, Xiaoqing Si, Junlei Qi, Jian Cao

Summary: Enhanced Hastelloy alloy diffusion bonding was achieved by introducing a nanostructured Ni surface layer. The unique contribution of the nanostructured layer in the evolving microstructure is to promote the formation of diffusion-induced recrystallization at the interface, resulting in a lower bonding temperature and higher strength of the joint.

SCRIPTA MATERIALIA (2024)

Article Chemistry, Applied

Highly porous carbons prepared via water-assisted mechanochemical treatment of cellulose-based materials followed by carbonization and mild activation

Parichart Onsri, Rabindra Dubadi, Laemthong Chuenchom, Decha Dechtrirat, Mietek Jaroniec

Summary: This study presented a facile and eco-friendly mechanochemical treatment of cellulose-based materials, followed by carbonization and mild activation, to obtain highly porous carbons. The chemically activated carbon showed a high CO2 adsorption capacity due to the large volume of ultramicropores. The method can be used for preparing carbon materials with high surface areas and enhanced porosity.

MICROPOROUS AND MESOPOROUS MATERIALS (2024)

Article Biophysics

3D superstructure based metabolite profiling for glaucoma diagnosis

Minsu Jang, Jonghoon Shin, You Hwan Kim, Tae-Young Jeong, Soojin Jo, Sung-Jo Kim, Vasanthan Devaraj, Joonhee Kang, Eun-Jung Choi, Ji Eun Lee, Jin-Woo Oh

Summary: Metabolome analysis using 3D superstructures has been applied for glaucoma diagnosis, providing comprehensive information and accurate classification of patients. The advantages of 3D superstructures, including high hotspot density, excellent signal repeatability, and thermal stability, enable versatile metabolic analysis and disease diagnosis.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Exploration of aminopeptidase N as new biomarker for early diagnosis of thyroid cancer

Lanlan Xu, Mo Ma, Jingkang Li, Dianfeng Dai, Dejiang Gao, Pinyi Ma, Qiong Wu, Daqian Song

Summary: This study developed an ultra-sensitive probe, LAN-apn, to investigate the expression level of APN in thyroid cancer and evaluate its potential as a biomarker. The results suggest that APN may become a new biomarker for thyroid cancer diagnosis.

BIOSENSORS & BIOELECTRONICS (2024)

Article Biophysics

Biohybrid tongue based on hypothalamic neuronal network-on-a-chip for real-time blood glucose sensing and assessment

Chunlian Qin, Qunchen Yuan, Mengxue Liu, Liujing Zhuang, Lizhou Xu, Ping Wang

Summary: This study proposes a biohybrid tongue based on hypothalamic neuronal network coupled with microelectrode array for real-time glucose perception. Hypothalamic neuronal cultures were cultivated on a two-dimensional brain-on-chip device, enabling the formation of neuronal networks and electrophysiological signal detection. The study investigates the endogenous expression of sweet taste receptors in hypothalamic neuronal cells and explores the spike signal response to sucrose and glucose stimulation. The biohybrid tongue provides insights into glucose sensing mechanisms and hypothalamic neuronal function.

BIOSENSORS & BIOELECTRONICS (2024)

Article Chemistry, Applied

Preparation and catalytic performance of the supported Ti-MWW zeolites

Shaoxiang Xu, Meihua Zhu, Pengming Huang, Shengao Zheng, Yujie Qiao, Yuan Liang, Xiangshu Chen, Hidetoshi Kita

Summary: In this study, nano-sized titanium silicalites were successfully synthesized on alpha-Al2O3 pellets by secondary hydrothermal synthesis, with NH4F doping improving the catalytic performance of supported Ti-MWW zeolites. Reaction conditions and the amount of Ti-MWW zeolites have significant effects on the phenol hydroxylation efficiency.

MICROPOROUS AND MESOPOROUS MATERIALS (2024)

Article Chemistry, Applied

Imide-functionalized Cu-MOF: Biomimetic peroxidase activity and detection of hydrogen peroxide and ascorbic acid

Shuai Wang, Yu Fei Wang, Wen Na Jiao, Jing Jin, Yong Heng Xing, Feng Ying Bai, Li Xian Sun

Summary: The synthesis of MOF with imide-functionalized aromatic conjugated carboxylic acid ligands has been a hot topic. A novel biomimetic peroxidase material (Cu-BDCPPI) was designed, synthesized and characterized. It showed catalytic activity similar to natural peroxidase enzymes and can be used for the detection of H2O2 and AA.

MICROPOROUS AND MESOPOROUS MATERIALS (2024)

Article Chemistry, Applied

Tunable thermoelectric performance in metal-organic framework Ni(BDC) studied by first principles

Suiting Ning, Ziye Zhang, Ni Hu, Ningjie Lv, Man Jiang, Ning Qi, Zhiquan Chen

Summary: Metal-organic frameworks (MOFs) have low lattice thermal conductivity, making them advantageous for thermoelectric applications. However, their low electrical conductivity hinders their thermoelectric performance. In this work, the electrical conductivity of MOFs is improved by infiltrating pillar molecules into layered MOFs. This strategy significantly increases the electrical conductivity and suggests that MOFs have potential as thermoelectric materials.

MICROPOROUS AND MESOPOROUS MATERIALS (2024)

Article Nanoscience & Nanotechnology

Intermittent tensile deformation of silver microcastings: Influence of the strain rate

Luciano Borasi, Andreas Mortensen

Summary: We found that the strain rate does not have a significant impact on the flow stress, work hardening, or strain to fracture of cast silver specimens. Plastic deformation mainly occurs through local slip bursts of variable amplitude.

SCRIPTA MATERIALIA (2024)

Article Biophysics

Cheap and portable paper chip with terrific oxidase-like activity and SERS enhancement performance for SERS-colorimetric bimodal detection of intracellular glutathione

Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li

Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.

BIOSENSORS & BIOELECTRONICS (2024)

Review Biophysics

Protease detection in the biosensor era: A review

Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov

Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.

BIOSENSORS & BIOELECTRONICS (2024)

Article Nanoscience & Nanotechnology

Massive transformations in titanium alloys: Role of relative orientation of adjacent parent grains

S. L. Lu, D. Han, D. Y. Qin, T. Song, D. Qiu, M. Brandt, H. P. Tang, M. Qian

Summary: Massive transformations occur in titanium alloys, resulting in patch-like massive phases that traverse the parent prior-beta grain boundaries. The formation of these phases always occurs when two neighboring prior-beta grains share or nearly share a {110} pole. These phases display concentrated {0001} poles and tend to decompose into ultrafine alpha-beta lamellae.

SCRIPTA MATERIALIA (2024)