Review
Medicine, Research & Experimental
Mehrdad Hashemi, Rezvaneh Aparviz, Marzie Beickzade, Mahshid Deldar Abad Paskeh, Simin Khorsand Kheirabad, Zeinab Khazaei Koohpar, Amir Moravej, Hossein Dehghani, Hamidreza Saebfar, Mohammad Arad Zandieh, Shokooh Salimimoghadam, Mohsen Rashidi, Afshin Taheriazam, Maliheh Entezari, Saeed Samarghandian
Summary: This review explores the potential applications of small interfering RNA (siRNA) and short hairpin RNA (shRNA) in the treatment of gastric cancer. It highlights the ability of siRNA to reduce the proliferation and invasion of gastric cancer cells and induce chemosensitivity. However, the unmodified siRNA faces challenges in translational potential. The role of nanostructures in facilitating siRNA delivery to gastric cancer cells and suppressing tumor progression is emphasized. The translation of these findings into clinical trials holds promise for advancing the treatment of gastric cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Yi Jiang, Shenjia Gao, Zhaoyuan Chen, Xiaoqiang Zhao, Jiahui Gu, Han Wu, Yun Liao, Jun Wang, Wankun Chen
Summary: Sepsis is a severe inflammatory response caused by an imbalanced host reaction to infection, and lung injury is one of its most common complications. Pyroptosis, a specific programmed cell death, can either reduce tissue damage or result in excessive cell death, leading to severe consequences.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Fan Wen, Dandan Liu, Mingming Wang, Shujie Zhang, Wenhua Kuang, Lixia Yuan, Jigang Wang, Gang Liu
Summary: This study investigates the ovarian toxicity of Celastrol and its underlying mechanism. It is found that Celastrol directly binds to high mobility group box 1 and interferes with its biological function to regulate p21 transcription, leading to apoptosis of granulosa cells and premature ovarian insufficiency.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Yifan Chen, Hanwei Yin, Jing Sun, Guozhou Zhang, Ying Zhang, Huihui Zeng
Summary: This study demonstrates that butaselen is a potential drug for the treatment of pulmonary fibrosis by inhibiting the NF-κB/TGF-β1/Smads signaling pathway. Additionally, butaselen and dexamethasone have a synergistic effect in inhibiting pulmonary fibrosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Shan shan Lei, Bo Li, Xiao wen Huang, Xu pin Wang, Shan Xiong, Rui Duan, Lin zi Li
Summary: The main component of Epimedium brevicornum, EBPC1, was found to promote osteogenesis during diabetes osteoporosis and inhibit apoptosis by regulating Bax/Bcl2. This study reveals the potential application of Epimedium brevicornum in the treatment of bone diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Yuting Qu, Sisi Qin, Zhihui Yang, Zhuolin Li, Qinhao Liang, Ting Long, Weiyun Wang, Dan Zeng, Qing Zhao, Zehua Dai, Qing Ni, Fei Zhao, Wootae Kim, Jing Hou
Summary: DNA repair is an essential mechanism in cells for protecting against DNA damage. Dysfunctions in this repair pathway are closely associated with cancer development and progression, but also offer opportunities for targeted therapy. Recent research has focused on developing DNA repair inhibitors, such as PARP1 inhibitors, which have shown promising results in treating breast cancer. This review summarizes the research progress and clinical implementation of targeted treatments for the DNA repair pathway, specifically focusing on BRCA and BRCAness.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Jia-Ying Chien, Jhih-Wei Ciou, Yun Yen, Shun-Ping Huang
Summary: M01 holds therapeutic potential by modulating Nrf2 and TXNIP/NLRP3 inflammasome pathways in retinal and optic nerve ischemic damage-related diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Patrick Diaba-Nuhoho
Summary: This article reviews the role and potential mechanisms of PHF5A in tumorigenesis, and discusses its importance and prospects in the treatment of different cancer types.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Hammad Ullah, Alessandro Di Minno, Roberto Piccinocchi, Daniele Giuseppe Buccato, Lorenza Francesca De Lellis, Alessandra Baldi, Hesham R. El-Seedi, Shaden A. M. Khalifa, Gaetano Piccinocchi, Xiang Xiao, Roberto Sacchi, Maria Daglia
Summary: This study assessed the effectiveness and tolerability of supplementing a normal diet with a multi-enzyme blend obtained from fungal fermentation in functional dyspepsia. The results showed improvement in quality of life, sleep quality, and a decrease in pain severity after supplementation with digestive enzymes. Overall, treatment with digestive enzymes was found to be effective and well-tolerated in reducing functional dyspepsia symptoms.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Peng Xiong, Yu-Yun Zheng, Jian-Ming Ouyang
Summary: By studying the Chinese medicine Pocoa (PCPs) with different carboxyl group (-COOH) contents, it was found that PCPs can inhibit oxidative damage and inflammatory response of renal epithelial cells, and this inhibitory effect is enhanced with the increase of carboxyl group content.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Yun Lu, Lan Chen, Zhouxue Wu, Ping Zhou, Jie Dai, Jianmei Li, Qian Wen, Yu Fan, Fancai Zeng, Yue Chen, Shaozhi Fu
Summary: Breast cancer is a disease characterized by insidious onset, rapid progression, easy recurrence, and metastasis. Conventional therapies are ineffective, therefore, combination therapy with tumor microenvironment-responsive nanoplatforms is being considered for targeted treatment. A study presented a bioactive hybrid nanoparticle for synergistic chemotherapy and photothermal therapy, which showed good photothermal conversion efficiency and targeted drug delivery to the tumor’s hypoxic regions. The controlled release of the drugs in the tumor microenvironment resulted in effective anti-tumor effects with minimal side effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Francisco Madrid-Gambin, David Fabregat-Safont, Alex Gomez-Gomez, Eulalia Olesti, Natasha L. Mason, Johannes G. Ramaekers, Oscar J. Pozo
Summary: Psychedelics are hallucinogen drugs that alter consciousness. There is renewed interest in using them for mental health disorders, but further research is needed to understand their biological effects, mechanism of action, and metabolism. Metabolic and metabolomics studies can help with this. Metabolic studies determine the drug's main metabolites, while metabolomics can shed light on the biological processes and therapeutic potential of psychedelics.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Adrian Urbano, Judith Plaza, Cesar Picado, Fernando de Mora
Summary: Analytical and functional comparison is crucial for assessing the similarity or difference between versions of a biological medicine. In this study, we compared the human IgE binding features of different lots and versions of omalizumab, an anti-human IgE monoclonal antibody, and found that monoclonal antibodies with the same amino acid sequence but produced in different cell sources exhibited slightly different binding and neutralizing features. These findings demonstrate the importance of such comparisons in evaluating biosimilar candidates and new anti-IgE agents.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Jingru Ma, Wenhai Wang, Wenbin Zhang, Dexin Xu, Jian Ding, Fang Wang, Xia Peng, Dahai Wang, Yanwei Li
Summary: This review provides an update on the techniques and clinical studies of cell treatment for coronary heart disease (CHD), with a focus on the emerging efficacy of stem cell treatment. It specifically examines and comments on current breakthroughs in cell treatment for CHD, including the most effective types of cells, transport modalities, engineering, and biochemical approaches used in this context. It aims to help researchers distill this information and design future studies to overcome the challenges faced by this revolutionary approach for CHD.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Ying Jie Ma, Raffaella Parente, Hang Zhong, Yi Sun, Cecilia Garlanda, Andrea Doni
Summary: The complement system is an important immune defense system that is activated upon recognition of pathogenic microorganisms or altered self-cells by pattern recognition molecules. Recent evidence suggests that pentraxins cooperate with effector PRMs to enhance complement activation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Yaosheng Xiao, Xunlu Xie, Zhixi Chen, Guoqiang Yin, Weihao Kong, Jianguo Zhou
Summary: ATF4 plays a crucial role in maintaining bone homeostasis and inhibiting the development of osteoporosis. It promotes bone formation and inhibits bone resorption.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Jeshma Ravindra, U. G. Yathisha, Dechamma Pandyanda Nanjappa, Krithika Kalladka, Rasik Dhakal, Anirban Chakraborty, Gunimala Chakraborty
Summary: Garlic is an important ingredient in Indian cuisine and its most abundant component, allicin, has been studied for its antimicrobial and antioxidant properties. This study aimed to develop a simple method for allicin extraction from fresh garlic and evaluate its properties in zebrafish, including antioxidant, anti-proliferative, pro-apoptotic, and anti-angiogenic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Jia Yao Phuah, Brian M. Maas, Aimin Tang, Ying Zhang, Luzelena Caro, Radha A. Railkar, Michael D. Swanson, Yu Cao, Hankun Li, Brad Roadcap, Andrew P. Catchpole, Antonios O. Aliprantis, Kalpit A. Vora
Summary: The study found that Clesrovimab has a strong ability to penetrate into the nasal epithelial lining fluid and has higher RSV neutralization activity, which may provide better protection against RSV infection in infants.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Songhyun Lim, Hee Ra Jung, Hyelim Lee, Yeonjeong Chu, Hyejin Kim, Eunha Kim, Sanghee Lee
Summary: In this study, the researchers found that modulating STING through microtubule-destabilizing agents specifically induced type I IFN responses in human monocytes. These findings revealed the versatile regulation of MDA in STING-mediated immunity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Liying Luo, Yuying Cai, Yanyun Jiang, Yingying Gong, Chunyang Cai, Dongwei Lai, Xiao Jin, Zhiqiang Guan, Qinghua Qiu
Summary: Diabetic retinopathy (DR) is the leading cause of end-stage eye disease. Pipecolic acid, as a metabolite, may impede the progression of DR by inhibiting the YAP-GPX4 signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
