Article
Economics
Junxing Chay, Joshua Yi Min Tung, Rebecca Jade Su, Edwin Jonathan Aslim, Callix Wong, Georgia Swan, Wei Jin Chua, Henry Sun Sien Ho, Eric Andrew Finkelstein
Summary: This study evaluated the cost-effectiveness of minimally invasive surgical therapies for moderate-to-severe BPH patients in Singapore, finding that WVTT as a first-line treatment is cost-effective for both moderate and severe patients, while PUL is not cost-effective. TURP is cost-effective as a first-line treatment for severe patients only.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Shailja Shah, Katherine Cappell, Robert Sedgley, Corey Pelletier, Rinu Jacob, Machaon Bonafede, Rena Yadlapati
Summary: This study aimed to characterize the cost drivers of patients with Helicobacter pylori (HP) and estimate the cost savings associated with successful eradication compared to failed eradication. The results showed that the healthcare costs of HP patients are influenced by comorbidities and there are significant cost savings for patients with successful HP eradication in specific HP-related conditions.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Yan Wang, Weihua Gao, Xu Han, Jenny Jiang, Belinda Sandler, Xiaoyan Li, Carla Zema
Summary: This study used the Optum Market Clarity database to examine the relationship between New York Heart Association (NYHA) functional class and cardiovascular outcomes in obstructive hypertrophic cardiomyopathy (HCM). The study found that as the NYHA class worsened, the risks of all outcomes increased.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Editorial Material
Economics
Panagiotis Petrou
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Jorge E. Cortes, Delphine Rea, Michael J. Mauro, Diana Tran, Pearl Wang, Kejal Jadhav, Aurore Yocolly, Koji Sasaki
Summary: This study assessed and compared the health care resource utilization (HCRU) rates of asciminib and bosutinib among 3 L+ patients with chronic myeloid leukemia in chronic phase (CML-CP) in the ASCEMBL trial. The results showed that asciminib-treated patients had lower resource utilization compared to bosutinib-treated patients over the long-term.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Sasha Berry, Barrie Chubb, Annabel Acs, Edel Falla, Akanksha Verma, Samuel J. P. Malkin, Barnaby Hunt, Andrew J. Palmer
Summary: The study aimed to investigate the performance of the IQVIA Core Diabetes Model in predicting the outcomes of the SUSTAIN 6 trial and examine the impact of calibration on cost-effectiveness outcomes from a UK healthcare payer perspective. The results showed that once-weekly semaglutide had improved health economic benefits in treating diabetes-related complications compared to placebo plus standard of care, especially after calibration.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Stephane Alexandre Regnier, Xin Ying Lee
Summary: This study conducted a meta-regression analysis on placebo data from clinical trials of anti-calcitonin gene-related peptide (anti-CGRP) monoclonal antibodies for migraine prevention, and found that intravenous administration of placebo led to a higher reduction in monthly migraine days. Additionally, episodic migraine type and a higher proportion of patients with multiple failed preventive treatments were associated with lower efficacy.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Jennifer A. Whitty, Peter Littlejohns, Julie Ratcliffe, Kylie Rixon, Andrew Wilson, Elizabeth Kendall, Paul Burton, Kalipso Chalkidou, Paul A. Scuffham
Summary: This study compared the opinions on prioritizing access to bariatric surgery obtained through a Citizens' Jury (CJ) and a preference elicitation method (Discrete Choice Experiment, DCE). The results showed that the important criteria were similar across the groups, but the order of importance varied. The participants in the CJ had more diverse opinions after deliberation, with a higher priority given to those with comorbidities. This study contributes to understanding the use of different methods for gathering public opinions on healthcare decisions.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Warittakorn Kategeaw, Nontaya Nakkam, Sasisopin Kiertiburanakul, Chonlaphat Sukasem, Wichittra Tassaneeyakul, Nathorn Chaiyakunapruk
Summary: This study evaluated the cost-effectiveness of HLA-B*13:01 screening before co-trimoxazole initiation in HIV-infected patients in Thailand. The findings suggest that this screening strategy may not be cost-effective.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Medicine, General & Internal
Muhammad Muneeb Hassan, Muhammad Ameeq, Farrukh Jamal, Muhammad H. Tahir, John T. Mendy
Summary: This study retrospectively studied 498 COVID-19 patients with tuberculosis and COPD at the DHQ Hospital in Muzaffargarh, Punjab, Pakistan. The results showed that COVID-19 patients with tuberculosis had a higher risk of death and a lower risk of recovery, with a shorter time to death and longer time to recovery.
ANNALS OF MEDICINE
(2023)
Review
Medicine, General & Internal
Yotam Kolben, Henny Azmanov, Ram Gelman, Danna Dror, Yaron Ilan
Summary: Antimicrobial resistance is a significant obstacle caused by the widespread use of antimicrobial agents. This paper presents the establishment of a second-generation AI chronobiology-based approach to prevent further resistance and potentially overcome existing resistance.
ANNALS OF MEDICINE
(2023)
Review
Medicine, General & Internal
Zhu Liu, Shiming Huang, Xiaoli Yuan, Yan Wang, Yannan Liu, Jing Zhou
Summary: Children in developed countries suffer from vitamin D deficiency due to less outdoor exercise and insufficient intake, leading to various pediatric disorders.
ANNALS OF MEDICINE
(2023)
Review
Medicine, General & Internal
Bartosz Fialek, Charles De Roquetaillade, Michal Pruc, Alla Navolokina, Francesco Chirico, Jerzy Robert Ladny, Frank William Peacock, Lukasz Szarpak
Summary: A comprehensive literature search found a correlation between MR-proADM levels and mortality in COVID-19 patients. The use of MR-proADM may aid in risk stratification, evaluating potential therapy escalation, predicting complications or clinical deterioration, and avoiding unnecessary hospital admissions.
ANNALS OF MEDICINE
(2023)
Article
Medicine, General & Internal
Zhao Zhan, Shi-jin Liu, Yi-ran Zhang, Zhi-long Liu, Xiao-xu Zhao, Ding Hui, Yun-long Pan, Jing-hua Pan
Summary: This study investigated the role of the high endothelial venules/tertiary lymphoid structures (HEV/TLS) in colorectal cancer (CRC) and found that it is associated with a favorable prognosis and the anti-tumor immune microenvironment.
ANNALS OF MEDICINE
(2023)
Article
Medicine, General & Internal
Shuang-Nan Zhou, Da-Wei Jv, Xiang-Fei Meng, Jing-Jing Zhang, Chun Liu, Ze-Yi Wu, Na Hong, Yin-Ying Lu, Ning Zhang
Summary: This study developed a clinical decision support tool based on machine learning to predict the prognosis of intrahepatic cholangiocarcinoma. Three models were established using data from the SEER database and a hospital, with a concordance index ranging from 0.67 to 0.73. The models can help clinicians make optimal treatment decisions.
ANNALS OF MEDICINE
(2023)
Review
Medicine, General & Internal
John Sheppard, Bridgitte Shen Lee, Laura M. Periman
Summary: Dry eye disease is a multifactorial disorder characterized by tear film imbalance, which can lead to inflammation and damage of the ocular surface. It affects 5% to 50% of the worldwide population and can be caused by various factors such as ocular and systemic diseases, medications, and environmental conditions. The management of this chronic disease involves both pharmacologic and nonpharmacologic interventions, with primary care clinicians playing a crucial role in diagnosis, education, and referral. It is important for healthcare professionals to be aware of the etiology and treatment options of dry eye disease.
ANNALS OF MEDICINE
(2023)
Review
Medicine, General & Internal
Zhimin He, Jialin Zhang, Jianzhong Ma, Lei Zhao, Xiaodong Jin, Hongbin Li
Summary: The R-spondin protein family, consisting of RSPO1-4, regulates tumor development and progression in addition to its role as agonists of the Wnt/beta-catenin pathway. Aberrant expression of RSPOs is associated with tumorigenesis and their expression is correlated with anticancer immune cell signatures. The potential therapeutic value of RSPOs in cancer medicine has been investigated, but the precise molecular mechanism and role of RSPOs in cancer remains unclear.
ANNALS OF MEDICINE
(2023)
Article
Medicine, General & Internal
Li Xue, Biao Wang, Jianhong Zhu, Qian He, Fang Huang, Wei Wang, Li Tao, Yan Wang, Nan Xu, Ni Yang, Li Jin, Hua Zhang, Ning Gao, Ke Lei, Yanping Zhang, Chaoliang Xiong, Jing Lei, Ting Zhang, Yan Geng, Ming Li
Summary: This study aimed to investigate the key circRNAs related to rheumatoid arthritis (RA) by identifying differentially expressed circRNAs (DEcircRNAs) in peripheral blood mononuclear cells (PBMCs) from RA patients compared to controls and osteoarthritis (OA) patients. Real-time PCR validation and correlation analysis with laboratory indices were also performed. The functional annotation of host genes of the DEcircRNAs in RA revealed their involvement in metabolic pathways, ECM-receptor interaction, and the PI3K-Akt signalling pathway. These findings contribute to a better understanding of the role of circRNAs in the specific mechanism underlying RA.
ANNALS OF MEDICINE
(2023)
Article
Medicine, General & Internal
Xingxing Chen, Jiajia Lu, Qi Xu, Bin Chen, Lijun Shen
Summary: A study discovered that a folate shortage may increase the risk of hepatic steatosis. The relationship between serum folate and controlled attenuation parameter (CAP) was investigated among 3606 participants from the National Health and Nutrition Examination Survey (NHANES). The findings showed a negative correlation between serum folate and CAP, particularly in males and whites. Among whites, the association followed a U-shaped curve at a specific blood folate level.
ANNALS OF MEDICINE
(2023)
Article
Medicine, General & Internal
Silvia Santos Monteiro, Tiago S. Santos, Liliana Fonseca, Miguel Saraiva, Fernando Pichel, Clara Pinto, Maria T. T. Pereira, Joana Vilaverde, Maria C. C. Almeida, Jorge Dores
Summary: This study evaluated the association between deviation from appropriate gestational weight gain and adverse maternofetal outcomes in women with gestational diabetes. The results showed that inappropriate gestational weight gain was associated with increased risk of large-for-gestational-age infants and macrosomia. This suggests that weight management is important in addition to glycemic control in women with gestational diabetes.
ANNALS OF MEDICINE
(2023)
