Article
Economics
Krithika Rajagopalan, Nazia Rashid, Dilesh Doshi
Summary: Pimavanserin is the only FDA approved atypical antipsychotic for Parkinson's Disease Psychosis, while other off-label antipsychotics like quetiapine are also used. Comparative analysis shows that PIM monotherapy results in lower hospitalizations compared to QUE.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Wentao Tang, Keigo Hanada, Yoshiharu Motoo, Hiroyuki Sakamaki, Takaaki Oda, Kazuyuki Furuta, Hikaru Abutani, Satoru Ito, Kiichiro Tsutani
Summary: This study examined the potential impact of comprehensive genomic profiling (CGP) testing before standard of care (SoC) on medical costs and clinical outcomes in untreated patients with advanced or recurrent biliary tract cancer (BTC), non-squamous non-small cell lung cancer (NSQ-NSCLC), or colorectal cancer (CRC) in Japan between 2022 and 2026. The results showed that CGP testing before SoC can increase the detection of druggable alterations and improve treatment rates with matched therapies in these cancer types.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Robert Cowan, Alit Stark-Inbar, Liron Rabany, Dagan Harris, Maya Vizel, Alon Ironi, Julio R. R. Vieira, Michelle Galen, Christina Treppendahl
Summary: The use of the Remote Electrical Neuromodulation (REN) device for migraine prevention has been found to significantly reduce headaches and symptoms, decrease healthcare visits and absenteeism, and result in cost savings. This has important clinical and financial incentives for patients, health insurance systems, and employers.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Heidi C. Waters, Robert Stellhorn, Maelys Touya, Heather Fitzgerald, Sandipan Bhattacharjee, Leslie Citrome
Summary: This study evaluates the impact of early initiation of aripiprazole once-monthly (AOM) on healthcare resource utilization, risk of hospitalization, and healthcare costs in patients with schizophrenia. The results indicate that patients who initiate AOM early have lower hospitalization rates and healthcare costs compared to those who initiate it later.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Letter
Economics
Camille Rochmann, Marie Fournier, Judy Hull, Maria Perichon, Ruth Pulikottil-Jacob
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Fabian P. Alvarez, Pierre Chevalier, Matthias Borms, Helene Bricout, Catia Marques, Anu Soininen, Tatu Sainio, Christine Petit, Caroline de Courville
Summary: In order to improve the protection provided by the standard dose influenza quadrivalent vaccine (SDQIV), a high-dose vaccine (HDQIV) has been developed specifically for adults aged 60 and older who are at higher risk of complications. This study aimed to determine the cost-effectiveness of HDQIV compared to SDQIV in three European countries (Belgium, Finland, and Portugal). The results showed that HDQIV resulted in improved health outcomes and was cost-effective in all three countries. Overall, the study highlights the importance of considering HDQIV as a viable option for preventing influenza in high-risk populations.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Anisha M. Patel, Eunice Chang, Caleb Paydar, Sheila R. Reddy
Summary: This study aimed to provide more recent data on healthcare utilization and costs in Huntington's disease (HD) patients. The results showed that HD patients had higher healthcare utilization and costs compared to non-HD patients, and the costs tended to increase with disease progression.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Philip Cornford, Caolan Halpin, Jelena Sassmann, Ian Frankcom, Saran Braybrook
Summary: This study provides a solution for the National Health Service (NHS) in England to alleviate pressures by switching from monthly or 3-monthly hormone therapy to 6-monthly therapy. This change can reduce costs and time required for treatment, leading to improved overall efficiency and economic benefits for the system.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Vicente Escudero-Vilaplana, Roberto Collado-Borrell, Javier De Castro, Amelia Insa, Alex Martinez, Elena Fernandez, Ivana Sullivan, Andres Flores, Natalia Arrabal, David Carcedo, Alba Manzaneque
Summary: This study evaluated the cost-effectiveness of adjuvant atezolizumab in early-stage NSCLC patients with PD-L1 expression >= 50% and without mutations in EGFR or ALK rearrangements in Spain. The results showed that adjuvant treatment with atezolizumab had better effectiveness in terms of life years and quality-adjusted life years compared to best supportive care, but at a higher cost. Sensitivity analysis showed that adjuvant atezolizumab is cost-effective in the majority of simulations, considering the commonly considered cost-effectiveness threshold.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Review
Economics
Liang Wang, Thomas G. Poder
Summary: This study conducted a systematic review of the methods and strategies used in SF-6D studies to elicit values and model the dimensions. The results showed that the value sets for SF-6D differed between countries, highlighting the need to consider cultural and economic differences when developing value sets for more countries.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Kruti Joshi, Dominic Pilon, Aditi Shah, Christopher Holiday, Swapna Karkare, Maryia Zhdanava
Summary: This study aimed to describe the real-world use of esketamine intranasal spray and healthcare outcomes among patients with treatment-resistant depression in the United States. The majority of patients completed the induction phase of esketamine treatment, and most dosing intervals were longer than recommended. Mental health-related inpatient and emergency department costs decreased after esketamine initiation.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Ryan O'Reilly, Hong Lu, Jeffrey C. C. Kwong, Allison McGeer, Teresa To, Beate Sander
Summary: The present study aimed to determine the short- and long-term healthcare costs associated with community-acquired pneumonia (CAP) from the healthcare payer perspective in Ontario, Canada. Through a retrospective population-based matched cohort study, it was found that CAP is associated with significantly increased acute and long-term healthcare costs compared to unexposed subjects. This study highlights the burden of CAP in both the inpatient and outpatient setting, and will inform strategic healthcare planning for future interventions and healthcare programs.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Elliot B. Tapper, Machaon Bonafede, Jesse Fishman, Stephen Dodge, Keith Miller, Ni Zeng, Dave Lewandowski, Alina Bogdanov
Summary: This study aimed to determine the burden of comorbidities, hospitalization, and healthcare costs among patients with NASH in the US. The results showed that higher FIB-4 scores were associated with increased healthcare costs and risk of hospitalization.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Medicine, General & Internal
Yipin Liu, Kai Hong, Wenjuan Weng, Shuangyi Huang, Tianbiao Zhou
Summary: VEGF levels are associated with the risk of chronic kidney disease (CKD), especially in more severe cases. The VEGF +936C/T T allele is not associated with CKD risk.
LIBYAN JOURNAL OF MEDICINE
(2023)
Article
Economics
Umakanth Vudumula, Mausam Patidar, Kapil Gudala, Elizabeth Karpf, Nicholas Adlard
Summary: This study evaluated the impact of early vs delayed ofatumumab initiation and the long-term clinical, societal, and economic outcomes of ofatumumab vs teriflunomide in RMS patients. The results suggest that early initiation of ofatumumab is an effective and cost-saving strategy for improving outcomes in RMS patients. Furthermore, patients receiving ofatumumab for 10 years are projected to have comparatively better outcomes than those receiving teriflunomide.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Oralee J. Varnado, Wenyu Ye, Xiaojuan Mi, Russel Burge, Jerry Hall
Summary: Migraine causes indirect costs due to missed time or reduced productivity at home and work, which can be alleviated by treatment with galcanezumab. This study evaluated the indirect cost savings in patients with episodic or chronic migraine receiving galcanezumab compared to placebo. The results showed significant cost savings in patients with episodic migraine, but not in patients with chronic migraine, suggesting that the disease burden may affect the cost savings.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Ahmed Swidan, Gihan Hamdy Elsisi, Mohamed M. M. Ibrahim, Mohammad Aljazzar, Hossameldin Tawfik Sallam
Summary: A cost-effectiveness study was conducted to evaluate the use of dapagliflozin as an add-on therapy for CKD patients with or without type-2 diabetes. The results showed that dapagliflozin + ramipril was both more cost-effective and improved quality of life compared to ramipril alone. This study only focused on the DAPA-CKD cohort.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Economics
Damian M. May, Jeffrey L. Neul, Ambika Satija, Wendy Y. Cheng, Neema Lema, Andra Boca, Patrick Lefebvre, Jesus Eric Pina-Garza
Summary: This study examines the decision-making and management strategies of physicians in diagnosing and treating patients with Rett syndrome (RTT) in the US. The findings indicate that most physicians use symptom evaluation and genetic testing for RTT diagnosis, with the goal of improving quality of life for patients and caregivers. Clinical practice guidelines are commonly used to monitor progress, but there is an unmet need for novel therapies that target multiple symptoms associated with RTT.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Medicine, General & Internal
Eman Yousef Moursi, Pacint Elsayed Moez, Ehab Mostafa Hassouna, Eman Zakareya Elkemary, Geilan Mahmoud Marei, Mohammed Said Sayed Shater, Mai Hesham Mohammed Badrah
Summary: This study investigates the serum molecular profile of nonalcoholic fatty liver disease (NAFLD) among patients diagnosed with type 2 diabetes (T2DM). The results show that MALAT1 expression is upregulated in both NAFLD and T2DM patients, suggesting it may be an early diagnostic marker for both diseases. Additionally, MEG3 expression is higher in NAFLD patients compared to those with T2DM, indicating it could be a potential predictive biomarker for early T2DM detection among NAFLD-diagnosed patients.
ALEXANDRIA JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Donia Elsaid Fathi Zaghamir, Ateya Megahed Ibrahim
Summary: By conducting an intervention study, the knowledge and practices of nursing students regarding nutrition and dietary habits can be improved. Therefore, it is essential to implement well-structured training programs on nutrition and promote healthy diet habits for medical faculties, paramedics, and applied health institutions in Saudi Arabia.
LIBYAN JOURNAL OF MEDICINE
(2023)