Article
Engineering, Biomedical
Yutong Yang, Yongping Liang, Jueying Chen, Xianglong Duan, Baolin Guo
Summary: This study developed a photo-crosslinked multifunctional antibacterial adhesive hemostatic hydrogel dressing that can disinfect drug-resistant bacteria and promote wound healing. Through various tests, it showed good hemostatic and antibacterial properties, and proved to be more effective than current commercially available dressings in treating infected wounds.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Ines Miranda, Andrews Souza, Paulo Sousa, Joao Ribeiro, Elisabete M. S. Castanheira, Rui Lima, Graca Minas
Summary: This review provides an overview of the properties of PDMS and its applications in the field of micro and nanoengineering. PDMS is widely used in biomedical applications due to its excellent optical, electrical, and mechanical properties, as well as biocompatibility. The introduction of the soft-lithography technique has facilitated the rapid prototyping of micro and nanostructures using PDMS, leading to advances in microfluidics, electronics, and biomedicine.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Engineering, Biomedical
Xuewei Zhang, Xi Chen, Hua Hong, Rubei Hu, Jiashang Liu, Changsheng Liu
Summary: The application of decellularized extracellular matrix (dECM) scaffolds holds enormous potential for tissue regeneration. These scaffolds provide an optimal non-immune environment with native three-dimensional structures and bioactive components, making them an ideal choice for regenerating functional organs/tissues, especially when combined with stem cells.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Mei Zhang, Xiaolin Zhang, Taoran Tian, Qi Zhang, Yuting Wen, Junyao Zhu, Dexuan Xiao, Weitong Cui, Yunfeng Lin
Summary: Gouty arthritis is a common inflammatory arthritis, and controlling inflammation is crucial for prevention. Scientists have synthesized a new material called Cur-TFNAs to enhance the effectiveness and bioavailability of curcumin, a natural anti-inflammatory drug. Cur-TFNAs showed better anti-inflammatory effects in in vivo and in vitro experiments compared with free curcumin.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Amal George Kurian, Rajendra K. Singh, Kapil D. Patel, Jung-Hwan Lee, Hae-Won Kim
Summary: Polymeric hydrogels are fascinating platforms for tissue repair and delivery systems. Methacrylated gelatin (GelMA) is a representative hydrogel formulation that has found various biomedical applications. Recent efforts have focused on combining GelMA with bioactive and functional nanomaterials to enhance its properties and create multifunctional platforms for tissue therapeutics.
BIOACTIVE MATERIALS
(2022)
Review
Engineering, Biomedical
Luke van der Koog, Timea B. Gandek, Anika Nagelkerke
Summary: Liposomes and extracellular vesicles (EVs) are two important nanoparticle drug delivery systems, composed of lipid bilayers and biologically secreted nanoparticles, each with its own advantages. Research has evaluated the differences and similarities in their composition, as well as critical mediators affecting pharmacokinetics; exploring different strategies to tweak their pharmacokinetics further demonstrates the potential advantages of these systems in drug delivery.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Engineering, Biomedical
Tianjiao Zhao, Wei Wu, Lihua Sui, Qiong Huang, Yayun Nan, Jianhua Liu, Kelong Ai
Summary: This article discusses the biology and molecular mechanisms of myocardial ischemia reperfusion injury, and summarizes the application of ROS-based nanoparticles, highlighting the latest advances in nanotechnology research for the treatment of myocardial ischemia reperfusion injury.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Yang Li, Rongzhan Fu, Zhiguang Duan, Chenhui Zhu, Daidi Fan
Summary: A hydrogel with antibacterial and antioxidant properties is developed to treat bacterial-infected wounds. The hydrogel can alleviate the inflammatory response and tissue hypoxia of infected wounds. Additionally, the hydrogel exhibits fast self-healing and shape adaptability.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Xu Xue, Yan Hu, Sicheng Wang, Xiao Chen, Yingying Jiang, Jiacan Su
Summary: Bone tissue engineering provides promising tools for the treatment of bone-related diseases using biomimetic hydrogels. This article discusses the fabrication of biomimetic hydrogels using thermal sensitive polymers, mineral ions, chemically triggered agents, photo crosslinking initiators, and enzyme triggers. These hydrogels accelerate bone regeneration and the article also highlights key factors influencing therapeutic effects.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Jueying Chen, Jiahui He, Yutong Yang, Lipeng Qiao, Juan Hu, Jie Zhang, Baolin Guo
Summary: The development of compressible, stretchable and self-healing hydrogel dressings with good adhesive, antibacterial and angiogenesis properties is needed to promote the regeneration of diabetic wounds in clinical applications.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Hussein M. El-Husseiny, Eman A. Mady, Lina Hamabe, Amira Abugomaa, Kazumi Shimada, Tomohiko Yoshida, Takashi Tanaka, Aimi Yokoi, Mohamed Elbadawy, Ryou Tanaka
Summary: Biomedicine and tissue regeneration have made significant advancements in recent years, opening up possibilities for improving the restoration of impaired tissues and their functions. Smart/stimuli-responsive hydrogels, as three-dimensional bioscaffolds, show great potential in tissue engineering and other biomedical applications. This review focuses on the synthesis schemes and responsiveness mechanisms of smart/stimuli-responsive hydrogels, as well as their potential in tissue engineering and other biomedical applications.
MATERIALS TODAY BIO
(2022)
Review
Engineering, Biomedical
Ramya Ramadoss, Rajashree Padmanaban, Balakumar Subramanian
Summary: Enamel remineralization is a challenging process due to the complex organized hierarchical microstructure of enamel and its inability to remodel like other mineralized tissues.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Engineering, Biomedical
Abhimanyu Thakur, Diana Carolina Parra, Pedram Motallebnejad, Marcelo Brocchi, Huanhuan Joyce Chen
Summary: Exosomes are tiny extracellular vesicles that carry various components, such as proteins, lipids, and nucleic acids, and play a crucial role in the malignant progression of cancer. Due to their ability to transport drugs and molecular information, exosomes have been considered as a novel tool for cancer therapeutics.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Sigit Sugiarto, Yihao Leow, Chong Li Tan, Guan Wang, Dan Kai
Summary: The review highlights the potential of utilizing lignin as a versatile biomaterial and discusses the challenges and outlook in developing and enhancing biomaterials through chemical modifications of lignin.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Tong Li, Xian-Mao Lu, Ming-Rong Zhang, Kuan Hu, Zhou Li
Summary: Peptide-based self-assembly nanomaterials, with diverse structures and functionalities, play a significant role in bioapplications. This review provides an overview of the recent advances in peptide-based self-assembly nanostructures, focusing on the driving forces and assembly mechanisms. It also summarizes the synthesis, properties, and applications of functional peptide nanomaterials. The challenges and future prospects of peptide-based nanomaterials are discussed.
BIOACTIVE MATERIALS
(2022)
Review
Nanoscience & Nanotechnology
Md Ishak Khan, M. Imran Hossain, M. Khalid Hossain, M. H. K. Rubel, K. M. Hossain, A. M. U. B. Mahfuz, Muzahidul Anik
Summary: Nanotechnology in cancer treatment has great potential, and the nanostructured drug delivery system can achieve high-efficiency drug delivery to specific cancer sites. Lipid-based NDDS is currently considered the most advanced and effective application field, while polymer-based and inorganic NDDS also have significant potential. However, challenges remain in the practical application of NDDS, such as dosage, stability, and biocompatibility of materials.
ACS APPLIED BIO MATERIALS
(2022)
Article
Engineering, Biomedical
Yunhang Liu, Bolong Xu, Mingzhu Lu, Shanshan Li, Juan Guo, Fangzhou Chen, Xiaolu Xiong, Zhe Yin, Huiyu Liu, Dongsheng Zhou
Summary: Due to increasing antibiotic resistance, alternative antibacterial strategies are urgently needed. This study developed iron-doped carbon dots with photothermal conversion and photoenhanced enzyme-like properties for efficient antibacterial therapy and wound healing. The iron-doped carbon dots killed bacteria by generating heat and reactive oxygen species, and promoted wound healing through preventing infection, enhancing tissue proliferation, and inducing angiogenesis. This study is of great importance for finding new antibacterial approaches.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Chenxi Tu, Huidan Lu, Tong Zhou, Wanying Zhang, Liwen Deng, Wangbei Cao, Zhijian Yang, Zhaolong Wang, Xinyu Wu, Jie Ding, Feng Xu, Changyou Gao
Summary: In this study, a multifunctional hydrogel was designed and prepared for the treatment of diabetic wounds. The hydrogel showed abilities in scavenging ROS, killing bacteria, and protecting cells against oxidative stress. It also promoted wound healing and reduced inflammation.
Article
Engineering, Biomedical
Rui Yu, Meng Li, Zhenlong Li, Guoying Pan, Yuqing Liang, Baolin Guo
Summary: A novel supramolecular poly(N-isopropylacrylamide) hybrid hydrogel dressing with thermal contraction and tissue adhesion properties, as well as multiple mechanical and biological properties, is developed to achieve noninvasive wound closure and enhance wound healing simultaneously.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Engineering, Biomedical
Lu Zhang, Chu-Xin Li, Shuang-Shuang Wan, Xian-Zheng Zhang
Summary: Chemodynamic therapy (CDT) is a novel cancer therapeutic strategy using a Fenton or Fenton-like reaction to generate highly cytotoxic hydroxyl radicals (·OH) from endogenous hydrogen peroxide (H2O2) to kill cancer cells, but its low catalytic efficiency and off-target side effects limit its biomedical application, so various strategies are needed to enhance its therapeutic effect.
ADVANCED HEALTHCARE MATERIALS
(2022)
