Article
Biotechnology & Applied Microbiology
Sonaxi Kharb, Sangeeta Yadav, Anshul Singh, Anjana Sarkar, Ravi Tomar
Summary: In this study, 1,3-benzodioxole-tagged dacarbazine derivatives were investigated as microtubule inhibitors for cancer control. The binding potential of these derivatives with tubulin was examined using molecular docking software, and their pharmacokinetic and pharmacological properties were studied. The results showed that Compounds 1 and 2 effectively bind with tubulin protein and have potential as potent anticancer drugs.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Asmaa Saleh, Dalia H. Abdelkader, Thanaa A. El-Masry, Duaa Eliwa, Badriyah Alotaibi, Walaa A. Negm, Engy Elekhnawy
Summary: This study isolated chlorogenic acid (CGA) from Euphorbia milii flowers and prepared CGA nanoparticles using the electrospraying technique in a polyvinyl alcohol (PVA)/poly(lactic-co-glycolic acid) (PLGA) polymeric matrix. The optimized formula (F2) exhibited significant antibacterial activity against Pseudomonas aeruginosa and antiviral activity against HCoV-229E and MERS-CoV. The encapsulation of CGA into electrospray PVA/PLGA nanoparticles shows promise as an antimicrobial agent.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Bingting Li, Jun Zhang, Ning Ma, Weidan Li, Guoxing You, Gan Chen, Lian Zhao, Quan Wang, Hong Zhou
Summary: The study explores the co-administration of haemoglobin-based oxygen carriers (HBOCs) and Doxorubicin (DOX) to enhance chemotherapeutic effectiveness and alleviate the side effects. Results show that the combination significantly improves cytotoxicity and DNA damage in a hypoxic environment. In-vivo experiments demonstrate a stronger tumour suppressive effect and reduced expression of related proteins in the combined treatment group. Additionally, HBOCs effectively reduce splenocardiac toxicity induced by DOX.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yuqing Chen, Yibo Mei, Lijiang Gu, Xing Li, Peng Guo, Lihong Chen, Dalin He
Summary: This study compares the efficacy of ALA-450 nm PDT and ALA-635 nm PDT and finds that ALA-450 nm PDT is more effective in inhibiting cell proliferation and promoting cell apoptosis than ALA-635 nm PDT, possibly through increasing intracellular ROS generation and caspase-dependent apoptosis pathway. In addition, ALA-450 nm PDT significantly inhibits tumor growth and activates cell apoptosis. Therefore, ALA-450 nm PDT may be a promising therapeutic strategy for eradicating HR-HPV infected cells and HR-HPV related diseases.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
R. D. K. Misra, K. P. Misra
Summary: The overview highlights the importance of the synergy between biological sciences and additive manufacturing of cellular structures in the development of cellular structured implants. It emphasizes the potential of additive manufacturing, computer-aided design, and structure-property relationships to address challenges in the biomedical field. It also discusses the limitations of traditional fabrication methods and the benefits of patient-specific design offered by additive manufacturing.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Sanjay, Anshul Sharma, Hae-Jeung Lee
Summary: Carbon quantum dots were synthesized from blue honeysuckle berry fruit extracts using a hydrothermal process. The material exhibited excellent photoluminescence properties and a quantum yield of -35.92%. The study found that the carbon dots had neuroprotective effects and could reverse LPS-induced cytotoxicity and induce anti-inflammatory and antioxidative responses in human microglial cells.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jonas Verstegen, Klaus Guenther
Summary: It has been discovered that certain hydroponically grown plants can synthesize selenium nanoparticles (SeNP) through biosynthesis when exposed to selenite. These SeNP have a narrow size distribution and contain approximately 2 million selenium atoms, proving the possibility of green synthesis of SeNP in both plant extracts and living organisms. This research provides new insights into the biochemistry of selenium in plants and its impact on nutrition, food sciences, and medicine. To the best of our knowledge, this is the first report on the synthesis of elemental nanoparticles, specifically selenium nanoparticles, by living plants.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Mao-ling Sun, Yang Zhong, Xiao-na Li, Jun Yao, Yu-qing Pan
Summary: A feasible HAV detection solution was established by combining RT-MIRA and LFD. The RT-MIRA-LFD method showed high accuracy and rapidness in detecting HAV infection. This method could provide a considerable advantage for diagnosing and controlling HAV infection, especially in regions with limited medical resources.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Piaotao Cheng, Shouhang Gong, Caopei Guo, Ping Kong, Chencheng Li, Chengbing Yang, Tao Zhang, Jiachen Peng
Summary: The study used bioinformatics analysis to uncover the immune situation in osteoarthritis (OA) and explore its underlying immune-related molecular mechanisms. Nine infiltrating immune cells with differential abundance between OA and normal samples were found, along with 42 immune-related function genes. Additionally, 5 hub genes were identified as potential diagnostic biomarkers for OA and may participate in the pathogenesis of OA through interactions with infiltrating immune cells.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Siti Sarah Azman, Muhammad Dain Yazid, Nur Azurah Abdul Ghani, Raja Zahratul Azma Raja Sabudin, Mohd Ramzisham Abdul Rahman, Nadiah Sulaiman
Summary: Endothelial dysfunction is the initial step in the pathogenesis of various cardiovascular diseases, but the underlying mechanisms are still unclear. In this study, a mechanical denudation model of arteries was used to efficiently remove intimal hyperplasia without significantly increasing intima-media thickness after 7 days in culture. This ex-vivo model will be useful in investigating the mechanism of re-endothelialization and preventing intimal hyperplasia at an early stage.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Steve Harakeh, Saber H. Saber, Rajaa Al-Raddadi, Turki Alamri, Soad Al-Jaouni, Mohammed Qari, Yousef Qari, Shafiul Haque, Ayat Zawawi, Soad S. Ali, Zakaria Y. Abd Elmageed, Shaker Mousa
Summary: This study aimed to investigate the therapeutic effects of curcumin nanoparticles (Cur-NPs) coated with PEG/chitosan on liver cancer (LC) cells and elucidate the molecular mechanisms underlying their anti-cancer activity. The results showed that Cur-NPs exhibited cytotoxicity on LC cells at a concentration of 6.25 μg/mL, inhibited cell migration in HepG2 cells at 2.5 μg/mL, and reduced angiogenesis. Furthermore, Cur-NPs promoted apoptosis in HepG2 cells by upregulating Bax and p53 and downregulating Bcl-2 expression.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Min Peng, Jun-Lan Chuan, Gao-ping Zhao, Qiang Fu
Summary: This study aims to modify the surface of high translucent zirconia (HTZ) material using a porous structure and silver nanoparticles to prevent bacterial infection and improve the success rate and longevity of dental implants.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
S. K. Prakash
Summary: In this study, non-toxic mercury nanoparticles Prakasine (PRK-NP) were synthesized and their non-toxicity and potential therapeutic effects on breast cancer were demonstrated through in vitro and in vivo experiments.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xiaofei Zhou, Yuetang Zhuang, Xiaohong Liu, Yaowen Gu, Junting Wang, Yuchen Shi, Li Zhang, Rui Li, Yelin Zhao, Hebing Chen, Jiao Li, Hongjuan Yao, Liang Li
Summary: In this study, researchers designed dasatinib-loaded hybrid exosomes by fusing exosomes derived from human pancreatic cancer cells with liposomes loaded with dasatinib. These hybrid exosomes showed pH-sensitive drug release in acidic conditions and exhibited higher uptake rates and cytotoxicity towards pancreatic ductal adenocarcinoma (PDAC) cells compared to free drug or liposomal formulations. Computational analysis also verified the drug-likeness, ADMET, and protein-ligand binding affinity of dasatinib. These findings suggest that cancer-derived hybrid exosomes could be a potential therapeutic candidate for PDAC treatment.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Rohazila Mohamad Hanafiah, Siti Aisyah Abd Ghafar, Vuanghao Lim, Siti Nor Asma Musa, Fahmi Yakop, Arif Haikal Hairil Anuar
Summary: This study synthesized stable and enhanced antibacterial Strobilanthes crispus-mediated silver nanoparticles (SC-AgNPs). Characterization and analysis revealed that SC-AgNPs exhibited significant antimicrobial activities against Escherichia coli, Pseudomonas aeruginosa, and Streptococcus mutans, and disrupted the gene expression of bacteria.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Shantanu Pande
Summary: Liposomes are versatile nanoparticles used for targeted drug delivery. They are composed of phospholipid molecules and contain substances like peptides, proteins, hormones, enzymes, and drugs. Extrusion technique is commonly used to prepare uniform liposomes and control their size. This review focuses on liposome formulation, drug release, and drug-loading factors.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Correction
Biotechnology & Applied Microbiology
W. Zhang, W. Yu, X. Ding, C. Yin, E. Yang, F. Guo, D. Sun, W. Wang
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Correction
Biotechnology & Applied Microbiology
W. Shuai, K. Zhiguo, D. Wang, L. Tao, P. Zhang, D. Liu, S. Sun, J. Zhong
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Retraction
Biotechnology & Applied Microbiology
Miaomiao Xin, Hongda Liang, Hongyue Wang, Dawei Wen, Liqin Wang, Lei Zhao, Mingshu Sun, Jibo Wang
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Retraction
Biotechnology & Applied Microbiology
Lin Yang, Yanan Yu, Qi Zhang, Xiaoyu Li, Cuiping Zhang, Tao Mao, Siliang Liu, Zibin Tian
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
