Article
Biophysics
Yusheng Feng, Zhifen Han, Chong Chen, Xuchen Wang, Jing Liu, Yousef Khan, Maobin Xie, Yufeng Chen, Yue Zhang, Gang Li
Summary: A study has developed an intestinal stent loaded with a combination of traditional Chinese medicines for the treatment of intestinal tumors. The stent, made using emulsion electrospinning technology, has a core-shell structure and sustained drug release properties. In vitro tests have shown that the drug-loaded membrane effectively inhibits tumor cell growth.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Chuanchao Tang, Yi Pan, Zheng Wei, Longcai Liu, Jiajie Xu, Wei Han, Yu Cai
Summary: This study systematically compares the photothermal properties of two organic molecules and finds that the side chains of organic molecules have a significant impact on photothermal performance. Linear alkyl chains can increase the absorption onset wavelength and photothermal conversion efficiency, thereby enhancing photothermal properties.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biotechnology & Applied Microbiology
Pattarapol Sittisart, Kitsakorn Locharoenrat
Summary: This study aimed to enhance the specific interactions between human hepatocellular carcinoma cell lines (HepG-2) by preparing and investigating the fluorescence emission properties of the Ag-Au-ICG complex. The complex was prepared via physical adsorption and evaluated for fluorescence spectra. The addition of an optimized dosage of Ag-Au-ICG to HepG-2 resulted in maximum fluorescence signal intensity and enhanced contrast fluorescence. The complex showed low cytotoxicity, making it a potential fluorescence enhancer for liver cancer imaging.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jing Wen, Tong Ren, Jinzhen Zheng, Xing Jiang, Yingxia Li, Xilin Jiang, Xin Jin, Hongying Zhao, Jingwen Li
Summary: Atherosclerosis (AS) is the main pathological basis for cardiovascular and cerebrovascular diseases, significantly affecting human health. Using bioinformatics, 74 key genes were identified that are mainly involved in regulating inflammatory response, chemokine signalling pathway, apoptosis, lipid and AS, Toll-like receptor signalling pathway, etc. Four pivotal genes (TYROBP, ITGB2, ITGAM, and TLR2) were screened as therapeutic targets for AS based on their correlation with immune-related biological functions and signal pathways, as well as infiltration level of immune cells.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yifan Zhang, Jie Zhao, Yusheng Zhao, Xue Bai, Yumin Chen, Yuhan Liu, Yue Zhang, Hui Kong, Huihua Qu, Yan Zhao
Summary: As an autoimmune disease, the incidence of ulcerative colitis (UC) remains high. Carbon dots (CDs), a new type of nanomaterials, show potential as a new treatment for UC. The use of carbonized rhei radix rhizoma (RRR) and extracted CDs (RRR-CDs) display significant anti-ulcerative activity in a UC mouse model. This suggests that RRR-CDs could be a candidate drug for UC treatment, expanding the understanding of the biological activity of CDs and providing a potential solution for difficult clinical diseases.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Chatmani Buachi, Charothar Thammachai, Brian J. Tighe, Paul D. Topham, Robert Molloy, Patchara Punyamoonwongsa
Summary: Bee propolis, a natural substance used in alternative medicine, has limited water solubility which causes skin irritation and immune response when combined with alcohol solvents. To overcome this issue, researchers developed a new drug delivery system based on lipid nanodiscs, which showed improved encapsulation efficiency and non-toxicity in low doses. These nanodiscs can enhance the solubility and therapeutic effects of poorly water-soluble drugs.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Shruti Jain, Ayodeji Olalekan Salau
Summary: Computational modelling is used to solve real-world problems by applying computing techniques. This paper introduces a novel predictive model for studying cell survival/death effects of the ERK protein. The model utilizes Neural Networks and fuzzy systems to analyze ERK samples with various concentrations of input proteins. The results demonstrate the accuracy of the model in predicting ERK protein values.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Elvin Peter Chizenga, Heidi Abrahamse
Summary: Passive techniques for administering photosensitizers (PSs) in photodynamic therapy (PDT) are becoming less viable as concerns about PDT resistance increase. In this study, a multifunctional photosensitizing agent was developed by binding PEGylated Gold Nanoparticles (PEGy-AuNP), anti-E6 monoclonal antibodies (mAbs), and phthalocyanines together. This compound showed enhanced internalization of PS, leading to improved PDT effects.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Ehssan Moglad, Engy Elekhnawy, Walaa A. Negm, Duaa Eliwa, Salwa Sami Younis, Basma Mohamed Elmansory, Sebaey Mahgoub, Eman A. Ahmed, Omnia Momtaz Al-Fakhrany
Summary: This study investigated the antibacterial and anti-Toxoplasma potential of Ficus retusa-derived endophytic fungi, particularly Aspergillus niger. The fungal extract showed antibacterial activity against Klebsiella pneumoniae isolates and disrupted biofilm formation. It also exhibited anti-Toxoplasma effects in vivo, reducing mortality and parasite count in mice.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yanhai Xi, Wenming Pan, Yanyan Liu, Ji Liu, Guohua Xu, Yanguo Su, Daquan Chen, Xiaojian Ye
Summary: Osteoporosis, a common disease in the ageing society, is caused by oxidative stress due to excessive accumulation of reactive oxygen species (ROS). Alpha-lipoic acid (ALA) is an antioxidant that can eliminate excess ROS and inhibit oxidative stress. In this study, PEGylated hollow gold nanoparticles (HGNPs) loaded with ALA were designed to treat osteoporosis. The results showed that mPEG@HGNPs-ALA had good biocompatibility and the ability to reduce oxidative stress.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Reuben Samson Dangana, Reama Chinedu George, Umulkhayr Oyenike Shittu, Femi Kayode Agboola
Summary: The study synthesized and characterized zinc oxide nanoparticles (ZnO NPs) using spinach tree and investigated their potential use as nanofertilizer. The synthesized NPs showed UV-Vis absorption at 378 nm, indicating their identity as ZnO NPs. FT-IR analysis revealed the presence of functional groups of the plant extract on the surface of the NPs. SEM images showed spherical shape, while TEM images showed a distribution size of 100 nm. The application of ZnO NPs as a nano fertilizer on Sorghum bicolour plant resulted in increased shoot leaf length, higher photosynthetic rate, and increased SOD activity.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Sadeka Nujhat, Hannah S. Leese, Mirella Di Lorenzo, Rebecca Bowen, Sandhya Moise
Summary: Gynaecological cancers pose a major global health concern, with inadequate screening and diagnostic methods for ovarian, endometrial, and cervical cancer. Portable and cost-effective lab-on-a-chip (LoC) technologies show promise for mass screening and diagnosis of gynaecological cancers. However, further research and validation are needed before widespread adoption in clinical practice.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Lavanya Nehru, Gayathri Devi Kandasamy, Vanaraj Sekar, Mohammed Ali Alshehri, Chellasamy Panneerselvam, Abdulrahman Alasmari, Preethi Kathirvel
Summary: The biogenic manufacture of ZnONPs using endophytic fungus was studied, and their biological properties were evaluated. The biosynthesized ZnO-NPs were characterized using spectroscopic and microscopic methods and showed potent bioactivity, making them a promising choice for biomedical applications.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Muhammad Asraf Mansor, Mohd Ridzuan Ahmad, Michal Petru, Seyed Saeid Rahimian Koloor
Summary: The electrical characteristics of living cells provide important information about their internal structure and composition changes in the cell membrane. An integrated dual microneedle-microchannel technique is introduced to detect and extract the electrical properties of single cells. This device has the potential to be used for low-cost single-cell screening and detection in developing countries.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
