Materials Science, Biomaterials

Article Materials Science, Biomaterials

Antifibrotic properties of hyaluronic acid crosslinked polyisocyanide hydrogels

Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer

Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.

BIOMATERIALS ADVANCES (2024)

Article Engineering, Biomedical

Effect of final temperature and heating rate on the mechanical and optical properties of a zirconia veneering ceramic

Andrea Coldea, Mustafa Borga Donmez, Bogna Stawarczyk

Summary: This study evaluates the impact of firing temperature and heating rate on the properties of zirconia veneering ceramic. The results indicate that translucency, hardness, and fracture toughness are affected by the tested parameters, while shrinkage and flexural strength are not affected.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2024)

Review Biophysics

Novel microneedle platforms for the treatment of wounds by drug delivery: A review

Heng An, Zhen Gu, Zhe Huang, Tong Huo, Yongxiang Xu, Yaozhong Dong, Yongqiang Wen

Summary: This study systematically summarizes and analyzes the manufacturing methods and limitations of different microneedles, as well as the latest research advances in pain management, drug delivery, and healing promotion. It presents the challenges and opportunities for the clinical applications of microneedles in external wound repair and management.

COLLOIDS AND SURFACES B-BIOINTERFACES (2024)

Article Biophysics

Mesoporous silica-stabilized magnetite nanoparticles with peroxidase-like activities for sensitively detecting cholesterol in animal-derived foods

Xueqin Wang, Chuan Liu, Haizhen Tao, Hongjuan Jing, Ruifang Li, Yingyuan Zhao, Xuyang Chen, Xuanping Zhao, Junyan Liu, Huiru Zhang, Na Li

Summary: In this study, a method using inorganic nanozyme-based magnetic mesoporous silica nanoparticles for highly sensitive detection of cholesterol in animal-derived food was reported. The method combines catalytic oxidation and cholesterol oxidase to achieve visual colorimetric detection of cholesterol with a low detection limit.

COLLOIDS AND SURFACES B-BIOINTERFACES (2024)

Article Biophysics

Propelling CuCo-based nanozyme design to new heights through triple enzyme-like power for high-efficiency bacterial eradication

Zheng Liu, Ruibang Wu, Yulin Jiang, Lin Qi, Jiangshan Liu, Meixuan Du, Jing Wang, Limin Liu, Ganjun Feng, Li Zhang

Summary: This study developed copper/cobalt-based metal sulfide nanoparticles with peroxidase-like, oxidase-like, and glutathione depletion activities, which showed remarkable antibacterial effects in vitro and efficient bacteria elimination in treating bacteria-infected wounds. This new antibacterial nanozyme has great potential in non-antibiotic treatment of bacterial infections.

COLLOIDS AND SURFACES B-BIOINTERFACES (2024)

Article Engineering, Biomedical

A bi-layered asymmetric membrane loaded with demineralized dentin matrix for guided bone regeneration

Wan-Hang Zhou, Yan-Fei Li

Summary: The DPP bilayer membranes prepared in this study exhibited notable biological safety and osteogenic activity in vitro, and have the potential to be a prospective candidate for guided bone regeneration (GBR) approach in the future.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2024)

Article Biophysics

Mechanically robust, transparent, and UV-shielding composite of Na-Alginate and maleic acid-functionalized boron nitride nanosheets with improved antioxidant property

Timo Elo, Vijay Singh Parihar, Abhijit Bera, Farzin Javanshour, Minna Kellomaki, Rama Layek

Summary: Maleic acid functionalized boron nitride nanosheets (BNNS-MA)/Na-Alginate composite with enhanced properties has been fabricated for the first time. The composite was driven by homogenous nano-integrations and chemistry of compatibilization. Compared to Na-Alginate, the BNNS-MA/Na-Alginate composites show significant enhancements in mechanical, UV-blocking, and antioxidant properties.

COLLOIDS AND SURFACES B-BIOINTERFACES (2024)

Article Biophysics

Cytotoxicity studies and antibacterial modification of poly(ethylene 2,5-furandicarboxylate) nonwoven

Mariia Svyntkivska, Tomasz Makowski, Roza Pawlowska, Dorota Kregiel, Ele L. de Boer, Ewa Piorkowska

Summary: Novel PEF nonwovens were successfully produced by solution electrospinning and further modification, showing excellent performance. The hydrophilicity of the nonwovens was improved by sodium hydroxide treatment, and silver particles were deposited on the fiber surfaces through two-step modification with compounds and silver ions, exhibiting good antibacterial activity.

COLLOIDS AND SURFACES B-BIOINTERFACES (2024)

Article Engineering, Biomedical

Multiscale homogenisation of diffusion in enzymatically-calcified hydrogels

Marc Graham, Sandra Klinge

Summary: This study investigates the macroscopic diffusion behavior of heterogeneous gels using a homogenization method in a finite element framework. Two materials, calcifying PDMA and PAAm, were studied, and the results show that the diffusivity of PDMA has a strong nonlinear dependence on the solute molecule radius.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2024)

Article Engineering, Biomedical

A novel capsid-XL32-derived adeno-associated virus serotype prompts retinal tropism and ameliorates choroidal neovascularization

Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin

Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.

BIOMATERIALS (2024)

Article Biophysics

A repertoire of nanoengineered short peptide-based hydrogels and their applications in biotechnology

Ipsita Sahu, Priyadarshi Chakraborty

Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.

COLLOIDS AND SURFACES B-BIOINTERFACES (2024)

Article Biophysics

Advances of polymer microspheres and its applications for enhanced oil recovery

Saya Shagymgereyeva, Bauyrzhan Sarsenbekuly, Wanli Kang, Hongbin Yang, Sarsenbek Turtabayev

Summary: This review provides an overview of the application of polymer microspheres in enhancing oil recovery levels in heterogeneous reservoirs. The specific structural and behavioral traits of different types of polymer microspheres, as well as their preparation methods and performance evaluation, are discussed. The current challenges and possible improvements in the functional application of polymer microspheres are also considered. This review will assist researchers in advancing the development of polymer microspheres for increased oil recovery in an economically and ecologically sustainable manner.

COLLOIDS AND SURFACES B-BIOINTERFACES (2024)

Review Biophysics

Current applications of solid lipid nanoparticles and nanostructured lipid carriers as vehicles in oral delivery systems for antioxidant nutraceuticals: A review

Maxius Gunawan, Veerakiet Boonkanokwong

Summary: Lipid nanoparticles have been used to enhance the delivery of antioxidants in the gastrointestinal tract, overcoming challenges such as low solubility and stability. These nanoparticles can improve the bioavailability and effectiveness of antioxidant compounds, making them valuable in nutraceutical formulations.

COLLOIDS AND SURFACES B-BIOINTERFACES (2024)

Article Biophysics

High doses of hydroxyapatite nanoparticle (nHAP) impairs microcirculation in vivo

Aline Oliveira da Silva de Barros, Eduardo Ricci-Junior, Luciana Magalhaes Rebelo Alencar, Pierre Basilio Almeida Fechine, Davino Machado Andrade Neto, Eliete Bouskela, Ralph Santos-Oliveira

Summary: Nanoparticles have become widely used in electronics, medicine, and cosmetics, leading to daily exposure to a significant amount of nanoparticles. This study focused on the impact of a high dosage of hydroxyapatite nanoparticles on microvessels. The results showed that topical administration of these nanoparticles caused significant destruction of venules, arterioles, and capillaries. However, systemic administration did not affect microcirculation but altered biochemical parameters in the blood samples. These findings suggest the need for further investigation into the effects of nanoparticles on microcirculation and overall body homeostasis.

COLLOIDS AND SURFACES B-BIOINTERFACES (2024)

Article Biophysics

Self-assembled and dynamic bond crosslinked herb-polysaccharide hydrogel with anti-inflammation and pro-angiogenesis effects for burn wound healing

Hongfu Wu, Tao Wang, Yinru Liang, Liji Chen, Ziyi Li

Summary: This study developed a naturally derived hydrogel for the treatment of burn wounds. The hydrogel exhibited anti-inflammatory and proangiogenic properties, and accelerated wound healing.

COLLOIDS AND SURFACES B-BIOINTERFACES (2024)

Letter Materials Science, Biomaterials

Reply to concerns on Rodrigues et al., Investigation of plasma treatment on UHMWPE surfaces: Impact on physicochemical properties, sterilization and fibroblastic adhesion

Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli

BIOMATERIALS ADVANCES (2024)

Article Materials Science, Biomaterials

Radial matrix constraint influences tissue contraction and promotes maturation of bi-layered skin equivalents

Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro

Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.

BIOMATERIALS ADVANCES (2024)

Article Materials Science, Biomaterials

Synthesis of bioactive hemoglobin-based oxygen carrier nanoparticles via metal-phenolic complexation

Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau

Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.

BIOMATERIALS ADVANCES (2024)

Article Materials Science, Biomaterials

MMP inhibition as a novel strategy for extracellular matrix preservation during whole liver decellularization

Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad

Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.

BIOMATERIALS ADVANCES (2024)

Article Biophysics

Impact of the physical properties of contact lens materials on the discomfort: role of the coefficient of friction

D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione

Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.

COLLOIDS AND SURFACES B-BIOINTERFACES (2024)