Article
Integrative & Complementary Medicine
Sanjeev Rastogi, Deep Narayan Pandey, Ram Harsh Singh
Summary: The world is facing an unprecedented pandemic of COVID-19 caused by the novel coronavirus. Despite efforts to contain it, the pandemic continues to spread. This article proposes a pragmatic plan for intervention in India, drawing on Traditional Chinese Medicine and Ayurveda, in order to address the lack of clinically-proven prophylaxis and therapeutic strategy. The plan provides graded response measures based on the stage of infection. While there is currently no evidence-based treatment for COVID-19, clinical interventions are necessary. Immediate implementation of the proposed Ayurveda strategy will facilitate learning and generate evidence.
JOURNAL OF AYURVEDA AND INTEGRATIVE MEDICINE
(2022)
Article
Integrative & Complementary Medicine
Rahul Singh, Vijay Kumar Bhardwaj, Jatin Sharma, Rituraj Purohit, Sanjay Kumar
Summary: Tea polyphenols have the potential to inhibit the NSP16 protein of SARS-CoV-2, making them a potential antiviral medication.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2022)
Article
Integrative & Complementary Medicine
Ahmed A. Zaki, Ahmed Ashour, Sameh S. Elhady, Khaled M. Darwish, Ahmed A. Al-Karmalawy
Summary: This study discovered potential antiviral compounds from natural products and investigated their inhibitory activities against SARS-CoV-2 through molecular docking and molecular dynamics simulations. The results showed that these compounds have promising affinity and activity against the M-protein of SARS-CoV-2, suggesting their potential as new drug candidates for treating COVID-19.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2022)
Article
Plant Sciences
Chen Fu, Yifan Wu, Shaojiao Liu, Chaoqin Luo, Yuqiao Lu, Menghan Liu, Lingfeng Wang, Yunling Zhang, Xuemei Liu
Summary: This study aims to investigate the effect of Rehmannioside A on cognitive impairment after ischemia in rats and SH-SY5Y cells, and further evaluate the anti-oxidative and anti-ferroptosis mechanisms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Integrative & Complementary Medicine
Gangarapu Kiran, L. Karthik, M. S. Shree Devi, P. Sathiyarajeswaran, K. Kanakavalli, K. M. Kumar, D. Ramesh Kumar
Summary: The study used in Silico computational studies to analyze the phytoconstituents of Siddha medicine formulations Kabasura Kudineer and JACOM, commonly used in treating viral respiratory infections, and their potential effectiveness against SARS-CoV-2. Molecular docking studies showed that 9 compounds in these formulations had high affinity for the spike protein of SARS-CoV-2. Furthermore, all the phytoconstituents were found to be non-carcinogenic and non-tumorigenic. Based on these findings, a new formulation called SNACKeV was proposed, which could potentially be used for the effective treatment of COVID-19.
JOURNAL OF AYURVEDA AND INTEGRATIVE MEDICINE
(2022)
Review
Plant Sciences
Ke Yang, Jing Qiu, Zecheng Huang, Ziwei Yu, Wenjun Wang, Huiling Hu, Yu You
Summary: Schisandra chinensis and Schisandra sphenanthera, known as bei-wuweizi and nan-wuweizi in Chinese respectively, are highly similar plants with traditional uses in Chinese medicine for treating various conditions. They have similar chemical compositions and pharmacological activities, with potential drug interactions due to their inhibitory effects on CYP3A and P-gp. Further research is needed to explore their traditional uses and differences for clinical applications.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Plant Sciences
Minmin Li, Huajuan Jiang, Yule Hao, Kequn Du, Hongling Du, Chuan Ma, He Tu, Yao He
Summary: Radix Rehmanniae (RR) is a traditional Chinese herbal medicine with clinical value and rich resources. It has multiple pharmacological actions and can be used to treat various diseases. RR can be processed into two different products, which have significant changes in properties, taste, efficacy, clinical application, chemical composition, and pharmacological action.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Integrative & Complementary Medicine
Duygu Agaguenduez, Teslime Oezge Sahin, Birsen Yilmaz, Kuebra Damla Ekenci, Sehriban Duyar oezer, Raffaele Capasso
Summary: Cruciferous vegetables, known for their nutritive composition and high dietary fiber content, contain bioactive chemicals that have been shown to prevent cancer, especially colorectal cancer, through various mechanisms.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Integrative & Complementary Medicine
Jing Hong, Xiao-wan Xu, Jing Yang, Jing Zheng, Shu-mei Dai, Ju Zhou, Qing-mei Zhang, Yi Ruan, Chang-quan Ling
Summary: This study investigated the knowledge, attitude, acceptance, and predictors of intention to receive the COVID-19 vaccine among cancer patients in Eastern China. The results showed that factors such as alcohol consumption, income impacted by the COVID-19 pandemic, knowledge of how the vaccine was developed, belief in the safety of the vaccine, willingness to pay for the vaccine, and willingness to recommend others to get vaccinated were associated with vaccine acceptance. On the other hand, factors such as being retired, undergoing multiple therapies of cancer, and worrying that the vaccine might deteriorate the prognosis of cancer were associated with vaccine hesitancy.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Review
Plant Sciences
Uttpal Anand, Champa Keeya Tudu, Samapika Nandy, Kumari Sunita, Vijay Tripathi, Gary J. Loake, Abhijit Dey, Jaroslaw Prockow
Summary: This study compiled and emphasized the traditional herbal knowledge and their applications for treating various skin diseases in India, showing great potential in treating human skin disorders. However, further research and clinical evidence are needed to determine the effectiveness of these plant species in skin condition treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Integrative & Complementary Medicine
Si-Yuan Pan, Qu Nie, Hai-Chuan Tai, Xue-Lan Song, Yu-Fan Tong, Long-Jian-Feng Zhang, Xue-Wei Wu, Zhao-Heng Lin, Yong-Yu Zhang, Du-Yun Ye, Yi Zhang, Xiao-Yan Wang, Pei-Li Zhu, Zhu-Sheng Chu, Zhi-Ling Yu, Chun Liang
Summary: Tea originated in China and has a long history and rich culture. Drinking tea has numerous benefits for physical and mental health, including its potential anti-COVID-19 effects. Tea contains a variety of components and minerals. It is a widely consumed non-alcoholic beverage and contributes to economic growth.
Article
Integrative & Complementary Medicine
P. L. T. Girija, Nithya Sivan
Summary: This is the first case known where a COVID-19 positive patient was treated entirely with Ayurveda, showing the potential and importance of traditional Ayurvedic medicine in combating the disease. Compared with Western medicine and Traditional Chinese Medicine, Ayurveda has its unique role in dealing with epidemics.
JOURNAL OF AYURVEDA AND INTEGRATIVE MEDICINE
(2022)
Review
Integrative & Complementary Medicine
Ali S. Alqahtani, Riaz Ullah, Abdelaaty A. Shahat
Summary: The purpose of this review is to summarize the available antidiabetic medicinal plants in Saudi Arabia, including their phytoconstituents and toxicological findings. A total of 50 plant species belonging to 27 families were found in Saudi Arabia, with Lamiaceae and Moraceae being the most dominant families. The common bioactive constituents of these plants include beta-Amyrin, beta-sitosterol, and oleanolic acid. These plants have shown hypoglycemic effects and further pharmacological research is recommended, along with investigation of the side effects of the active ingredients.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Plant Sciences
Rakshandha Saini, Nitin Sharma, Oluwole Solomon Oladeji, Anuradha Sourirajan, Kamal Dev, Gokhan Zengin, Mohamed El-Shazly, Vikas Kumar
Summary: Phyllanthus emblica, also known as Indian gooseberry, has been widely used in traditional medicine for its medicinal and nutritional benefits. Studies have shown that it possesses a variety of pharmacological activities, including antimicrobial, antioxidant, anti-inflammatory, and anti-diabetic effects. Toxicological studies have indicated the safety of the fruit even at high doses. Further research is needed to explore the mechanisms of action and potential applications of the bioactive compounds found in Phyllanthus emblica.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Plant Sciences
Yang Liu, Bao-Guo Li, Yu-Hua Su, Ruo-Xi Zhao, Peng Song, Hui Li, Xin-Hai Cui, Hong-Mei Gao, Run-Xiang Zhai, Xian-Jun Fu, Xia Ren
Summary: This review provides an overview of the application of traditional Chinese medicine (TCM) in the treatment of ulcerative colitis (UC). Through regulating inflammatory cytokines, intestinal flora, immune system, and protecting the intestinal mucosa, TCM has shown therapeutic effects in treating UC.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Plant Sciences
Yu-Ying Chen, Qiu-Ping Liu, Pei An, Min Jia, Xin Luan, Jian-Yuan Tang, Hong Zhang
Summary: Ginsenoside Rd is an active compound with broad pharmacological effects that can reduce neurological damage and provide neuroprotection. It exerts its effects through anti-inflammatory, antioxidant, anti-apoptotic, inhibition of Ca2+ influx, and protection of mitochondria pathways, inhibiting excitatory toxicity, regulating nerve growth factors, and promoting nerve regeneration.
Review
Plant Sciences
Qiang Sun, Ting Gong, Maolun Liu, Shan Ren, Han Yang, Sha Zeng, Hui Zhao, Li Chen, Tianqi Ming, Xianli Meng, Haibo Xu
Summary: Shikonin, a major phytochemical component of Lithospermum erythrorhizon, shows promising therapeutic effects on various diseases by regulating multiple signaling pathways. However, its pharmacokinetics reveal low oral bioavailability and potential toxicological effects, such as nephrotoxicity and skin allergies. Clinical trials validating its pharmacodynamics and pharmacokinetics are limited, with potential for pharmaceutical innovation to develop shikonin-based drugs for clinical use.
Article
Plant Sciences
Wuai Zhou, Huan Zhang, Xin Wang, Jun Kang, Wuyan Guo, Lihua Zhou, Huiyun Liu, Menglei Wang, Ruikang Jia, Xinjun Du, Weihua Wang, Bo Zhang, Shao Li
Summary: The mechanism of action (MoA) of traditional Chinese patent medicine Moluodan (MLD) for treating chronic atrophic gastritis (CAG) was elucidated using a network pharmacology approach. Computational analysis showed that the target profiles of MLD compounds covered most bio-molecules reported in literature and the MoA of MLD covered most types of MoA of western drugs for CAG. MLD treatment involved the regulation of various biological functional modules, and experimental validation confirmed its inhibitory effects on cell proliferation, promotion of cell apoptosis and differentiation, reduction of inflammation, and promotion of lipid droplet accumulation in MNNG-induced GES-1 cells.
Review
Plant Sciences
Sun Hee Hyun, Kiran D. Bhilare, Gyo In, Chae-Kyu Park, Jong-Hoon Kim
Summary: Asian ginseng or Korean ginseng, Panax ginseng, has been traditionally used in Korea and China for the treatment of various diseases. Its main active component, ginsenoside, is known for its pharmacological effects such as antioxidant, anti-inflammatory, and anti-diabetic properties, which can prevent cardiovascular diseases and oxidative stress-related damage.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Plant Sciences
Qian Xie, Hongyan Li, Rong Ma, Mihong Ren, Yong Li, Jinxiu Li, Hai Chen, Zhuoping Chen, Daoyin Gong, Jian Wang
Summary: In this study, the therapeutic effects of Coptis chinensis Franch and Magnolia officinalis on TNBS-induced ulcerative colitis in rats were investigated. It was found that these herbal medicines could improve disease indicators, reduce colonic mucosal damage, and regulate intestinal flora. They also showed anti-inflammatory effects and protected the integrity of the tight junction, indicating their potential in preventing intestinal barrier damage.
