Integrative & Complementary Medicine

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Review Plant Sciences

Investigation on wound healing effect of Mediterranean medicinal plants and some related phenolic compounds: A review

Ibrahim Mssillou, Meryem Bakour, Meryem Slighoua, Hassan Laaroussi, Hamza Saghrouchni, Fatima Ez-Zahra Amrati, Badiaa Lyoussi, Elhoussine Derwich

Summary: The review provides an outlook on Mediterranean medicinal plants used in wound healing, as well as summarizes the wound healing effect of polyphenolic compounds and their chemical structures. Furthermore, it discusses the wound healing process, skin structure, and current therapies in wound healing.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

Tanshinone I inhibits doxorubicin-induced cardiotoxicity by regulating Nrf2 signaling pathway

Qianqian Jiang, Xu Chen, Xue Tian, Jingmei Zhang, Siming Xue, Yanyan Jiang, Tiantian Liu, Xiaoping Wang, Qianbin Sun, Yiqin Hong, Chun Li, Dongqing Guo, Yong Wang, Qiyan Wang

Summary: This study demonstrated that Tanshinone I (Tan I) can protect against Doxorubicin-induced cardiotoxicity (DIC) by reducing oxidative stress and maintaining mitochondrial function. This protective effect is mediated by the activation of the nuclear erythroid factor 2-related factor 2 (Nrf2) pathway.

PHYTOMEDICINE (2022)

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Article Plant Sciences

Polyphenols extracted from Enteromorpha clathrata alleviates inflammation in lipopolysaccharide-induced RAW 264.7 cells by inhibiting the MAPKs/NF-?B signaling pathways

Ping Huang, Jingxia Hong, Jie Mi, Bolun Sun, Jinjie Zhang, Chao Li, Wenge Yang

Summary: This study explored the anti-inflammatory activity of Enteromorpha clathrata and its potential mechanism of action. The findings suggest that the polyphenol-enriched organic fraction of E. clathrata could be a potential therapeutic agent for treating inflammatory diseases.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Integrative & Complementary Medicine

Green-synthetized selenium nanoparticles using berberine as a promising anticancer agent

Mohamed S. Othman, Sofian T. Obeidat, Amal H. Al-Bagawi, Mohamed A. Fareid, Alaa Fehaid, Ahmed E. Abdel Moneim

Summary: This study evaluated the potential of green-synthesized selenium nanoparticles (SeNPs) containing berberine (SeNPs-Ber) as an anticancer agent. The results showed that SeNPs-Ber significantly improved survival rate, reduced tumor size, and activated apoptotic cascade in tumor cells. Moreover, SeNPs-Ber reduced oxidative stress and improved histopathological alterations in tumor tissue. These findings suggest that green-synthesized SeNPs-Ber has promising anticancer properties and can be used as supplementary medication during chemotherapy.

JOURNAL OF INTEGRATIVE MEDICINE-JIM (2022)

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Article Plant Sciences

Icariin protects podocytes from NLRP3 activation by Sesn2-induced mitophagy through the Keap1-Nrf2/HO-1 axis in diabetic nephropathy

Xuansheng Ding, Hanzhen Zhao, Chen Qiao

Summary: This study found that ICA can inhibit the activation of NLRP3 inflammasome by increasing Sesn2-induced mitophagy, thus exerting a protective effect.

PHYTOMEDICINE (2022)

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Review Plant Sciences

Pharmacological activities and pharmacokinetics of liquiritin: A review

Junyuan Qin, Junren Chen, Fu Peng, Chen Sun, Yu Lei, Guangru Chen, Gangming Li, Yanpeng Yin, Ziwei Lin, Liujun Wu, Jing Li, Wenxiu Liu, Cheng Peng, Xiaofang Xie

Summary: This review summarizes the pharmacokinetics and pharmacological activities of liquiritin, a flavonoid derived from Radix et Rhizoma Glycyrrhizae. It provides insights into the absorption mechanism, bioavailability, and various pharmacological effects of liquiritin, including its potential applications in Alzheimer's disease, tumor, inflammation, and cardiovascular protection.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Integrative & Complementary Medicine

A Bibliometric Analysis and Visualization of Current Research Trends in Chinese Medicine for Osteosarcoma

Yin Meng-chen, Wang Hong-shen, Yang Xi, Xu Chong-qing, Wang Tao, Yan Yin-jie, Fan Zhao-xiang, Ma Jun-ming, Ye Jie, Mo Wen

Summary: Through bibliometric analysis and visualization tools, this study illustrates the research framework, overall knowledge structure, and development trends of Chinese medicine treatment for osteosarcoma. The results show that the field is still in its early stages, with imbalanced distribution of research and weak cooperation. Basic research is dominant, and exploring the molecular mechanism of Chinese medicine in preventing and treating osteosarcoma may become a key focus in the future.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2022)

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Article Plant Sciences

Moringa oleifera Lam. seed extract protects kidney function in rats with diabetic nephropathy by increasing GSK-3β activity and activating the Nrf2/HO-1 pathway

Ying Wen, Yanyang Liu, Qi Huang, Rong Liu, Jing Liu, Fengyu Zhang, Shao Liu, Yueping Jiang

Summary: Experimental evidence suggests that Moringa oleifera seed extract has therapeutic effects on diabetic nephropathy in rats, potentially through activating the GSK-3 beta and Nrf2/HO-1 pathways to exert antioxidant and anti-renal fibrosis activities.

PHYTOMEDICINE (2022)

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Article Plant Sciences

Biosynthesis and cytotoxic effect of silymarin-functionalized selenium nanoparticles induced autophagy mediated cellular apoptosis via downregulation of PI3K/Akt/mTOR pathway in gastric cancer

Xiao-Jie Mi, Han Sol Choi, Haribalan Perumalsamy, Rajeshkumar Shanmugam, Lakshmi Thangavelu, Sri Renukadevi Balusamy, Yeon-Ju Kim

Summary: Si-SeNPs were successfully synthesized via green synthesis mediated by silymarin. The study investigated the anticancer mechanisms of Si-SeNPs, which showed significant efficacy in inhibiting gastric cancer cells while being non-toxic to normal cells.

PHYTOMEDICINE (2022)

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Article Plant Sciences

Perillyl alcohol attenuates rheumatoid arthritis via regulating TLR4/NF-κB and Keap1/Nrf2 signaling pathways: A comprehensive study onin-vitro and in-vivo experimental models

Eswara Rao Puppala, Siddhi Jain, Pritam Saha, Mahesh Rachamalla, N. P. Syamprasad, Sai Sudha Yalamarthi, Md. Abubakar, Antra Chaudhary, D. Chamundeswari, U. S. N. Murty, Jagadeesh Kumar Gangasani, V. G. M. Naidu

Summary: This study aimed to evaluate the anti-inflammatory effects of perillyl alcohol (POH) on rheumatoid arthritis. The results demonstrated that POH suppressed inflammation and oxidative stress through regulating signaling pathways in both in vitro and in vivo experiments. These findings suggest the potential therapeutic effects of POH in rheumatoid arthritis.

PHYTOMEDICINE (2022)

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Article Plant Sciences

Ligustilide attenuates ischemic stroke injury by promoting Drp1-mediated mitochondrial fission via activation of AMPK

Qian Wu, Jiao Liu, Zhiguo Mao, Liyu Tian, Ning Wang, Guangyun Wang, Yang Wang, Saiwang Seto

Summary: Ligustilide (LIG) improves mitochondrial function and reduces damage caused by ischemic stroke. LIG activates the AMPK signaling pathway to induce mitochondrial fission and mitophagy, thereby protecting against nerve damage.

PHYTOMEDICINE (2022)

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Article Plant Sciences

Quercetin-3-Rutinoside alleviates radiation-induced lung inflammation and fibrosis via regulation of NF-ΚB/TGF-β1 signaling

Savita Verma, Ajaswrata Dutta, Akshu Dahiya, Namita Kalra

Summary: The study found that Quercetin-3-Rutinoside (Q-3-R) can protect against radiation-induced lung injury by regulating NF-Kappa B/TGF-beta 1 signaling pathway, scavenging free radicals, preventing perivascular infiltration, and prolonged inflammatory cascade. This may have potential therapeutic effects on lung damage caused by planned or unplanned radiation exposure.

PHYTOMEDICINE (2022)

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Review Plant Sciences

Aconitum carmichaelii Debeaux: A systematic review on traditional use, and the chemical structures and pharmacological properties of polysaccharides and phenolic compounds in the roots

Yu-Ping Fu, Yuan-Feng Zou, Fei-Yi Lei, Helle Wangensteen, Kari Tvete Inngjerdingen

Summary: This article provides a systematic overview of the phytochemical and pharmacological studies of Aconitum carmichaelii, focusing on polysaccharides and phenolic compounds. Polysaccharides from A. carmichaelii roots have shown various biological effects and have potential for future applications. More research is needed to better understand the pharmacological effects and molecular mechanisms of the identified phenolic compounds.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Review Integrative & Complementary Medicine

Phenolic compounds and antimicrobial properties of mint and thyme

Mohsen Soleimani, Ahmad Arzani, Vida Arzani, Thomas H. Roberts

Summary: Mint and thyme have various medicinal benefits including digestive, antiseptic, antispasmodic, antirheumatic, expectorant, antiallergic, antitussive, antioxidant, and antimicrobial activities. The phenolic compounds in these plants are the most abundant secondary metabolites and have potential health-promoting properties.

JOURNAL OF HERBAL MEDICINE (2022)

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Article Plant Sciences

UPLC-ESI-MS/MS profiling of the underground parts of common Iris species in relation to their anti-virulence activities against Staphylococcus aureus

Mona M. Okba, Passent M. Abdel Baki, Mohammed Abu-Elghait, Amr M. Shehabeldine, Moshera M. El-Sherei, Amal E. Khaleel, Mohamed A. Salem

Summary: The study aims to explore the chemical composition and virulence inhibition potential of three common Iris species. The results showed that Iris plants have inhibitory effects on the hemolytic activity of Staphylococcus aureus, but do not significantly affect the biofilm formation of methicillin resistant and sensitive strains.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Review Plant Sciences

Research progress of anthocyanin prebiotic activity: A review

Muwen Wang, Zuoyong Zhang, Hanju Sun, Shudong He, Shuyun Liu, Tao Zhang, Lei Wang, Gang Ma

Summary: The review summarizes the prebiotic activity of anthocyanins and discusses physical and molecular modification methods to improve their biological activities. The results show that anthocyanins play a significant role in promoting the growth of probiotics, inhibiting the growth of harmful bacteria, and improving the intestinal environment. Physical embedding and molecular modification are effective methods to enhance the prebiotic activity of anthocyanins.

PHYTOMEDICINE (2022)

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Article Plant Sciences

Molecular mechanism of the anti-inflammatory effects of plant essential oils: A systematic review

Qian Zhao, Liyun Zhu, Sunan Wang, Yongsheng Gao, Fei Jin

Summary: This review investigates the anti-inflammatory effects of plant essential oils (PEOs) and explores the underlying mechanisms and clinical trials associated with their anti-inflammatory effects. The results show that PEOs can target and inhibit multiple dysregulated signaling pathways associated with inflammation, suggesting their potential as anti-inflammatory agents.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

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Article Plant Sciences

Medicinal Plants for Anti-neurodegenerative diseases in West Africa

Emmanuel Ayodeji Ayeni, Yuzhou Gong, Hao Yuan, Yikao Hu, Xiaolin Bai, Xun Liao

Summary: This review provides an overview of major neurodegenerative diseases and the use of medicinal plants in managing these diseases in West Africa. It highlights the potential neuroprotective effects of various plant families and their chemical compounds, suggesting them as natural sources for anti-neurodegenerative drug discovery.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

Ganluyin ameliorates DSS-induced ulcerative colitis by inhibiting the enteric-origin LPS/TLR4/NF-cB pathway

Taoxiu Xiong, Xiang Zheng, Ke Zhang, Hansong Wu, Yingjie Dong, Fuchen Zhou, Bingbing Cheng, Linzi Li, Wanfeng Xu, Jie Su, Jiahui Huang, Zetian Jiang, Bo Li, Beibei Zhang, Guiyuan Lv, Suhong Chen

Summary: The study found that Ganluyin (GLY) exerts an anti-ulcerative colitis (UC) effect by improving the colonic mucosal barrier, inhibiting the enteric-origin lipopolysaccharide (LPS)/toll-like receptor (TLR)4/nuclear factor-kappa B (NF-κB) inflammatory pathway, and restoring the homeostasis of the intestinal flora in UC mice. These findings lay a strong foundation for GLY as a potential treatment for UC.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

Coptis chinensis and dried ginger herb combination inhibits gastric tumor growth by interfering with glucose metabolism via LDHA and SLC2A1

Min Fu, Yanju Liu, Huanbo Cheng, Kang Xu, Guangzhong Wang

Summary: The combination of Coptis chinensis and dried ginger inhibits the proliferation, migration, and invasion of gastric cancer cells by regulating glucose metabolism through LDHA and SLC2A1 genes, thus suppressing tumorigenesis.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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