Integrative & Complementary Medicine

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Article Plant Sciences

The signaling pathways of traditional Chinese medicine in promoting diabetic wound healing

Xin Zhou, Yanling Guo, Kun Yang, Peng Liu, Jun Wang

Summary: Traditional Chinese medicine (TCM) has shown effective promotion of diabetic wound healing through regulating various signaling pathways, such as maintaining inflammatory balance, inhibiting oxidative stress, and regulating abnormal glucose metabolism. This multi-level and multi-pathway effect of TCM provides ideas for screening core targets in treating diabetic wounds and developing modern innovative drugs.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Integrative & Complementary Medicine

The effects of Lavender and Chamomile essential oil inhalation aromatherapy on depression, anxiety and stress in older community- dwelling people: A randomized controlled trial

Hossein Ebrahimi, Abbas Mardani, Mohammad Hasan Basirinezhad, Azam Hamidzadeh, Fatemeh Eskandari

Summary: Inhalation aromatherapy with lavender and chamomile essential oils can help reduce depression, anxiety, and stress levels in community-dwelling older adults.

EXPLORE-THE JOURNAL OF SCIENCE AND HEALING (2022)

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Article Integrative & Complementary Medicine

Tanshinone IIA: New Perspective on the Anti-Tumor Mechanism of A Traditional Natural Medicine

Wenfeng Zhang, Cun Liu, Jie Li, Yiping Lu, Huayao Li, Jing Zhuang, Xin Ren, Mengmeng Wang, Changgang Sun

Summary: Tanshinone IIA is an effective antineoplastic drug that inhibits tumor cell proliferation and induces apoptosis through multiple signaling pathways. It also has a protective effect on chemotherapy drugs and regulates tumor angiogenesis.

AMERICAN JOURNAL OF CHINESE MEDICINE (2022)

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Review Integrative & Complementary Medicine

Allium cepa: A Treasure of Bioactive Phytochemicals with Prospective Health Benefits

Arka Jyoti Chakraborty, Tanvir Mahtab Uddin, B. M. Redwan Matin Zidan, Saikat Mitra, Rajib Das, Firzan Nainu, Kuldeep Dhama, Arpita Roy, Md. Jamal Hossain, Ameer Khusro, Talha Bin Emran

Summary: This review article discusses the various therapeutic and pharmacological effects of onions, including anti-cancer, anti-diabetic, antioxidant, and hypotensive effects. Onions also have beneficial effects on the digestive, circulatory, and respiratory systems, as well as on the immune system.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Review Plant Sciences

Medicinal plants used against hepatic disorders in Bangladesh: A comprehensive review

Rajib Das, Saikat Mitra, Abu Montakim Tareq, Talha Bin Emran, Md. Jamal Hossain, Ali M. Alqahtani, Yahia Alghazwani, Kuldeep Dhama, Jesus Simal-Gandara

Summary: The study summarizes the processes of hepatotoxicity induced by various toxins and explores identified hepatoprotective plants and their phytoconstituents, providing new directions for treating liver injury. Through literature searches and comprehensive analysis, it is found that a variety of plants offer good pharmacological evidence that can be used in the treatment of hepatic disorders.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

Baicalin suppresses the progression of Type 2 diabetes-induced liver tumor through regulating METTL3/m6A/HKDC1 axis and downstream p-JAK2/STAT1/clevaged Capase3 pathway

Hongpeng Jiang, Qianqian Yao, Yongbo An, Linlin Fan, Jing Wang, Huiying Li

Summary: Baicalin can suppress the progression of T2D-induced liver tumors by regulating the METTL3/m(6)A/HKDC1 axis, indicating its potential application in prevention and treatment of T2D-induced liver cancer.

PHYTOMEDICINE (2022)

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Article Plant Sciences

Crocus sativus (saffron) petals extract and its active ingredient, anthocyanin improves ovarian dysfunction, regulation of inflammatory genes and antioxidant factors in testosterone-induced PCOS mice

Fazeleh Moshfegh, Saeedeh Zafar Balanejad, Khadige Shahrokhabady, Armin Attaranzadeh

Summary: This study examined the effects of saffron petal extract (SPE) and saffron petal anthocyanins (SPA) on ovarian hormones, steroidogenic enzymes, ovarian dysfunction, regulation of anti-inflammatory genes, and antioxidant factors in female PCOS mice. The results suggest that SPE and SPA can improve dysregulation of ovarian steroids, steroidogenic enzymes, antioxidant enzymes and inflammatory markers in PCOS mice, ameliorating symptoms of PCOS.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Review Plant Sciences

Network pharmacology provides a systematic approach to understanding the treatment of ischemic heart diseases with traditional Chinese medicine

Hua-Yi Yang, Mengnan Liu, Pei Luo, Xin-Sheng Yao, Hua Zhou

Summary: Network pharmacology has important applications in deciphering the mechanism of TCM in treating ischemic heart diseases. However, its current application in TCM research is still at a superficial level. By combining artificial intelligence technology and other advanced theories and technologies, and systematically studying the metabolic process and network relationships of TCM from a clinical perspective, network pharmacology may have great potential for development.

PHYTOMEDICINE (2022)

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Article Plant Sciences

Natural products for the treatment of stress-induced depression: Pharmacology, mechanism and traditional use

Wei Dai, Kunmiao Feng, Xiaolei Sun, Lingchuan Xu, Sijia Wu, Khalid Rahmand, Dan Jia, Ting Han

Summary: This review provides insights into the pathological mechanism and animal models of stress-induced depression, as well as natural products with antidepressant activity, shedding light on the potential therapeutic effects and clinical potential of these compounds. Natural products also hold promise as a vital source for future antidepressant drug discovery.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Review Integrative & Complementary Medicine

Propolis: An update on its chemistry and pharmacological applications

Rajib Hossain, Cristina Quispe, Rasel Ahmed Khan, Abu Saim Mohammad Saikat, Pranta Ray, Damira Ongalbek, Balakyz Yeskaliyeva, Divya Jain, Antonella Smeriglio, Domenico Trombetta, Roghayeh Kiani, Farzad Kobarfard, Naheed Mojgani, Parvaneh Saffarian, Seyed Abdulmajid Ayatollahi, Chandan Sarkar, Mohammad Torequl Islam, Dilhun Keriman, Arserim Ucar, Miquel Martorell, Antoni Sureda, Gianfranco Pintus, Monica Butnariu, Javad Sharifi-Rad, William C. Cho

Summary: Propolis, a resinous substance produced by honeybees, has diverse clinical applications and potential health benefits. Recent studies have shown its potential in reducing cancer progression, inhibiting infections, and alleviating related symptoms, but further research is needed to validate its health claims.

CHINESE MEDICINE (2022)

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Article Integrative & Complementary Medicine

Salidroside attenuates neuronal ferroptosis by activating the Nrf2/HO1 signaling pathway in Aβ1-42-induced Alzheimer's disease mice and glutamate-injured HT22 cells

Sixia Yang, Zeping Xie, Tingting Pei, Yi Zeng, Qiaowu Xiong, Hui Wei, Yong Wang, Weidong Cheng

Summary: Salidroside plays a neuroprotective role by inhibiting neuronal ferroptosis in A beta(1-42)-induced AD mice and Glu-injured HT22 cells through activation of the Nrf2/HO1 signaling pathway.

CHINESE MEDICINE (2022)

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Article Plant Sciences

Atractylenolide-1 targets SPHK1 and B4GALT2 to regulate intestinal metabolism and flora composition to improve inflammation in mice with colitis

Linghang Qu, Kun Shi, Jing Xu, Chunlian Liu, Chang Ke, Xin Zhan, Kang Xu, Yanju Liu

Summary: This study investigates the efficacy and mechanism of atractylenolide-1 in treating ulcerative colitis. The results show that atractylenolide-1 significantly improves symptoms and reduces inflammation in mice with colitis. It also regulates the intestinal flora and metabolism, making it a potential drug for colitis treatment.

PHYTOMEDICINE (2022)

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Review Plant Sciences

History, phytochemistry, experimental pharmacology and clinical uses of honey: A comprehensive review with special reference to Unani medicine

Sadia Nikhat, Mohammad Fazil

Summary: This review covers the historical uses of honey in traditional and modern medicine, highlighting its biological activities and various health benefits. Research suggests that honey has potential therapeutic value in alleviating multiple diseases and lifestyle disorders.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

Oleic acid alleviates LPS-induced acute kidney injury by restraining inflammation and oxidative stress via the Ras/MAPKs/PPAR-γ signaling pathway

Beibei Zhang, Mengnan Zeng, Yangyang Wang, Meng Li, Yuanyuan Wu, Ruiqi Xu, Qinqin Zhang, Jufang Jia, Yanjie Huang, Xiaoke Zheng, Weisheng Feng

Summary: OA effectively ameliorated renal function, alleviated inflammatory response and oxidative stress, transformed apoptotic, MAPK and PPAR-gamma signaling pathways in AKI mice, regulated metabolisms of phenylalanine, purine, sphingolipid, taurine, and hypotaurine. Moreover, the role of OA in NRK-52e injury was blocked by FTS.

PHYTOMEDICINE (2022)

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Article Plant Sciences

β-Caryophyllene suppresses ferroptosis induced by cerebral ischemia reperfusion via activation of the NRF2/HO-1 signaling pathway in MCAO/R rats

Qingwen Hu, Tianrui Zuo, Ling Deng, Sha Chen, Shengwei Liu, JingDong Liu, Xuan Wang, Xiaomei Fan, Zhi Dong

Summary: This study suggests that ferroptosis plays a critical role in the pathogenesis of acute ischemic stroke. β-Caryophyllene (BCP) has neuroprotective effects by regulating ferroptosis and activating the NRF2/HO-1 signaling pathway to improve cerebral ischemia injury.

PHYTOMEDICINE (2022)

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Article Plant Sciences

Compound Tongluo Decoction inhibits endoplasmic reticulum stress-induced ferroptosis and promoted angiogenesis by activating the Sonic Hedgehog pathway in cerebral infarction

Zhen Hui, Sulei Wang, Jianxiang Li, Jingqing Wang, Zhennian Zhang

Summary: This study investigated the potential mechanism by which Compound Tongluo Decoction (CTLD) alleviates cerebral infarction using rat and cell models. The results showed that CTLD could inhibit ferroptosis induced by endoplasmic reticulum stress and promote angiogenesis by activating the Sonic Hedgehog pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

The relevance of quantitative ethnobotanical indices for ethnopharmacology and ethnobotany

Marco Leonti

Summary: Ethnobotanical indices used in ethnopharmacology may not accurately reflect the efficacy or discovery of drugs, lack statistical rigor and theoretical validation, and cannot fully describe the cultural value and importance of herbal medicines.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

Huangqin decoction ameliorates DSS-induced ulcerative colitis: Role of gut microbiota and amino acid metabolism, mTOR pathway and intestinal epithelial barrier

Mu-xia Li, Min-yao Li, Jun-xuan Lei, Yu-zhu Wu, Ze-hao Li, Lin-ming Chen, Chang-lin Zhou, Ji-yan Su, Guo-xin Huang, Xiao-qi Huang, Xue-bao Zheng

Summary: Huangqin decoction (HQD) exhibits anti-inflammatory effects on DSS-induced colitis in mice by regulating gut microbiota and amino acid metabolism, activating the mTOR signaling pathway, and protecting intestinal mucosal barrier integrity.

PHYTOMEDICINE (2022)

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Article Plant Sciences

Berberine regulates short-chain fatty acid metabolism and alleviates the colitis-associated colorectal tumorigenesis through remodeling intestinal flora

Shihai Yan, Jiayin Chang, Xuehui Hao, Jiang Liu, Xiying Tan, Zhirong Geng, Zhilin Wang

Summary: The study found that berberine can alleviate the occurrence of colitis-associated colorectal tumors by altering the composition of intestinal flora. Berberine increases beneficial bacteria and levels of short-chain fatty acids, reducing inflammation and the risk of cancer.

PHYTOMEDICINE (2022)

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Review Plant Sciences

Antiviral and Virucidal Properties of Essential Oils and Isolated Compounds - A Scientific Approach

Juergen Reichling

Summary: Essential oils and essential oil compounds possess antiviral and virucidal activities, inhibiting viral replication in host cells and showing promising results in in vitro and in vivo studies on different viruses.

PLANTA MEDICA (2022)

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