Immunology

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Article Immunology

K2P2.1 is a regulator of inflammatory cell responses in idiopathic inflammatory myopathies

Christopher Nelke, Thomas Muentefering, Derya Cengiz, Lukas Theissen, Vera Dobelmann, Christina B. Schroeter, Helena Block, Corinna Preu, Alexander P. E. Michels, Stefanie Lichtenberg, Marc Pawlitzki, Steffen Pfeuffer, Niklas Huntemann, Alexander Zarbock, Thorben Briese, Christoph Kittl, Carsten Dittmayer, Thomas Budde, Ingrid E. Lundberg, Werner Stenzel, Sven G. Meuth, Tobias Ruck

Summary: K2P2.1 plays a regulatory role in the autoimmune response of idiopathic inflammatory myopathies (IIMs), by regulating inflammatory cell response, adhesion, and transmigration in both endothelial and skeletal muscle cells. Inhibiting K2P2.1 enhances the inflammatory response, while activating K2P2.1 improves the disease course.

JOURNAL OF AUTOIMMUNITY (2024)

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Article Biochemistry & Molecular Biology

Cytokine profiles and virological markers highlight distinctive immune statuses, and effectivenesses and limitations of NAs across different courses of chronic HBV infection

Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao

Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.

CYTOKINE (2024)

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Article Immunology

Interleukin-15 alters hippocampal synaptic transmission and impairs episodic memory formation in mice

Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola

Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.

BRAIN BEHAVIOR AND IMMUNITY (2024)

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Article Biochemistry & Molecular Biology

Growth hormone-releasing hormone antagonists counteract interferon-γ - induced barrier dysfunction in bovine and human endothelial cells

Saikat Fakir, Nektarios Barabutis

Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.

CYTOKINE (2024)

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Review Biochemistry & Molecular Biology

Immunomodulatory actions of myeloid-derived suppressor cells in the context of innate immunity

Nikoleta Bizymi, Andreas M. Matthaiou, Irene Mavroudi, Aristea Batsali, Helen A. Papadaki

Summary: Myeloid-derived suppressor cells (MDSCs) are innate immune cells that have immunomodulatory properties. They interact extensively with other innate or adaptive immune cells and can either enhance or attenuate immune responses depending on the triggering conditions. However, their positive role in host defense mechanisms is rarely discussed in the literature.

INNATE IMMUNITY (2024)

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Review Immunology

Measurement of brain glutathione with magnetic Resonance spectroscopy in Schizophrenia-Spectrum disorders - A systematic review and Meta-Analysis

Alex J. Murray, Clara S. Humpston, Martin Wilson, Jack C. Rogers, Mohammad Zia Ul Haq Katshu, Peter F. Liddle, Rachel Upthegrove

Summary: Oxidative stress may contribute to the worsening of psychosis and poor outcomes. Glutathione levels in psychosis patients are related to clinical features and spectroscopy protocols. Meta-analysis shows no difference in glutathione levels between total psychosis patients and controls, but reduced levels are seen in patients with stable schizophrenia. Additionally, older studies demonstrate greater reductions in glutathione levels.

BRAIN BEHAVIOR AND IMMUNITY (2024)

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Article Immunology

Fibre-rich diet attenuates chemotherapy-related neuroinflammation in mice

Courtney Cross, Maya Davies, Emma Bateman, Elise Crame, Paul Joyce, Anthony Wignall, Amin Ariaee, Marc A. Gladman, Hannah Wardill, Joanne Bowen

Summary: This study demonstrates that a high fibre diet can alter gut microbiota composition and increase the production of the short-chain fatty acid propionate, thereby reducing neuroinflammation caused by the chemotherapeutic agent 5-fluorouracil (5-FU). The results of this study indicate that dietary fibre has neuroprotective effects in alleviating the neuroimmune changes seen in response to chemotherapy treatment, mediated through the microbiota-gut-brain axis.

BRAIN BEHAVIOR AND IMMUNITY (2024)

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Article Biochemistry & Molecular Biology

Proinflammatory pattern in the lower airways of non-asthmatic obese adolescents

Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler

Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.

CYTOKINE (2024)

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Article Immunology

Probiotic Clostridium butyricum ameliorates cognitive impairment in obesity via the microbiota-gut-brain axis

Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu

Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.

BRAIN BEHAVIOR AND IMMUNITY (2024)

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Article Immunology

An integral blood-brain barrier in adulthood relies on microglia-derived PDGFB

Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi

Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.

BRAIN BEHAVIOR AND IMMUNITY (2024)

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Article Immunology

Comprehensive immunoprofiling of neurodevelopmental disorders suggests three distinct classes based on increased neurogenesis, Th-1 polarization or IL-1 signaling

Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath

Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).

BRAIN BEHAVIOR AND IMMUNITY (2024)

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Article Immunology

Longitudinal study of traumatic-stress related cellular and cognitive aging

Erika J. Wolf, Mark W. Miller, Sage E. Hawn, Xiang Zhao, Sara E. Wallander, Beth McCormick, Christine Govan, Ann Rasmusson, Annjanette Stone, Steven A. Schichman, Mark W. Logue

Summary: Traumatic stress is associated with accelerated epigenetic age and increased risk for dementia. The advanced epigenetic age might be linked to dementia-associated biomarkers. Externalizing comorbidity is associated with accelerated epigenetic age, which in turn is associated with subsequent increases in neuropathology and inflammatory markers. Advanced epigenetic age and neuropathology biomarkers are associated with worse cognitive function.

BRAIN BEHAVIOR AND IMMUNITY (2024)

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Retraction Fisheries

撤稿声明: The M2 macrophages induce autophagic vascular disorder and promote mouse sensitivity to urethane-related lung carcinogenesis (Retraction of Vol 59, art no 2532, 2016)

G. -g. Li, Z. -z. Guo, X. -f. Ma, N. Cao, S. -n. Geng, Y. -q. Zheng, M. -j. Meng, H. -h. Lin, G. Han, G. -j. Du

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2024)

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Article Biochemistry & Molecular Biology

Glycosaminoglycan-induced proinflammatory cytokine levels as disease marker in mucopolysaccharidosis

Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen

Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.

CYTOKINE (2024)

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Article Immunology

Is Brucella excreted in cattle faeces? - Evidence from Punjab, India

V. Sharma, P. Kaur, R. S. Aulakh, R. Sharma, R. Verma, B. B. Singh

Summary: Brucellosis is a neglected zoonosis that affects animals and people in the underdeveloped world. This study aimed to isolate and identify Brucella species from faeces of sero positive cattle in Punjab, India. Fourteen Brucella species were isolated, with 11 identified as Brucella abortus and 3 identified as Brucella melitensis. The study highlights the potential risk of animal faeces for animal and human health and emphasizes the need for careful handling of faeces from seropositive cattle.

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES (2024)

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Article Biochemistry & Molecular Biology

Acacetin protects against sepsis-induced acute lung injury by facilitating M2 macrophage polarization via TRAF6/NF-κB/COX2 axis

Binbin Chang, Zhang Wang, Hui Cheng, Tingyuan Xu, Jieyu Chen, Wan Wu, Yizhi Li, Yong Zhang

Summary: Acacetin can attenuate sepsis-induced ALI by inhibiting the inflammatory response and promoting macrophage polarization. This study is of great significance for the development of new treatments for sepsis-induced ALI.

INNATE IMMUNITY (2024)

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Letter Immunology

Comment on Cheng et al.'s Risk factors for poor COVID-19 outcomes in patients with psychiatric disorders

Wei -Min Chu, Hsin-En Ho, James Cheng-Chung Wei

BRAIN BEHAVIOR AND IMMUNITY (2024)

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Article Immunology

No indication of aberrant neutrophil extracellular trap release in indolent or advanced systemic mastocytosis

Axel Rosell, Cecilia Karlstrom, Joakim S. Dahlin, Daryl Boey, Monika Klimkowska, Kajsa Ax, Charlotte Thalin, Johanna Ungerstedt

Summary: There is no evidence of global increase in neutrophil extracellular trap release in patients with systemic mastocytosis.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2024)

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Article Immunology

Chemogenetic approaches reveal dual functions of microglia in seizures

Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu

Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.

BRAIN BEHAVIOR AND IMMUNITY (2024)

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Editorial Material Immunology

Toward an effective Staphylococcus vaccine: why have candidates failed and what is the next step?

Chih-Ming Tsai, Jr Caldera Jr, Irshad A. A. Hajam, George Y. Y. Liu

EXPERT REVIEW OF VACCINES (2023)

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