Article
Immunology
Maya F. Amjadi, Maxwell H. Parker, Ryan R. Adyniec, Zihao Zheng, Alex M. Robbins, S. Janna Bashar, Michael F. Denny, Sara S. Mccoy, Irene M. Ong, Miriam A. Shelef
Summary: Rheumatoid factors (RFs) are polyreactive antibodies that can bind disease-specific epitopes. Recent studies have found that RFs in COVID-19 can bind novel IgG epitopes, which provides new insights into the mechanism of RFs.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Ingrid Reverte, Claudia Marchetti, Sara Pezza, Soami F. Zenoni, Giorgia Scaringi, Laura Ferrucci, Ginevra D'Ottavio, Annabella Pignataro, Diego Andolina, Marcello Raspa, Ferdinando Scavizzi, Marco Venniro, Leslie A. Ramsey, Cornelius Gross, Daniele Caprioli, Davide Ragozzino
Summary: In this study, the role of microglia in neuroadaptations in NAc synapses during cocaine withdrawal was investigated. Microglia depletion prevented cocaine-induced changes in dendritic spines and the accumulation of CP-AMPAR, and also prevented conditioned hyperlocomotion. These results suggest that microglia could be a promising therapeutic target for preventing relapse in substance abuse.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Cell Biology
Jeffrey Maslanka, Gretel Torres, Jennifer Londregan, Naomi Goldman, Daniel Silberman, John Somerville, James E. Riggs
Summary: This study investigates the immunobiology of the peritoneum in ovarian cancer, revealing reduced B1 cells in the ascites and selective loss of B1 and marginal zone B cell subsets in the spleen. These findings suggest a correlation between the depletion of B cell subsets and the influx of myeloid-derived suppressor cells during ovarian cancer.
CELLULAR IMMUNOLOGY
(2024)
Article
Immunology
Yilei Zhang, Guojun Chen, Siyi Zhou, Lingru He, Olalekan Opeyemi Ayanniyi, Qianming Xu, Zhenyu Yue, Congshan Yang
Summary: The development of the Animal Parasitic Diseases and Drugs Database (APDDD) provides a comprehensive and intuitive tool for studying animal parasitic diseases and antiparasitic drugs, allowing users to understand the relationships between parasitic diseases, drugs, and targeted genes more effectively.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Emma Corley, Saahithh Redddi Patlola, Aodan Laighneach, Aiden Corvin, Ross McManus, Marcus Kenyon, John P. Kelly, Declan P. Mckernan, Sinead King, Brian Hallahan, Colm Mcdonald, Derek W. Morris, Gary Donohoe
Summary: Recent studies have found a negative association between childhood trauma and cognitive functioning in patients with schizophrenia. This study aimed to test the hypothesis that physical neglect is associated with cognitive ability, and that this association is mediated by inflammatory response and moderated by genetic risk for schizophrenia. The results showed that inflammatory response mediated the association between physical neglect and cognitive functioning, and genetic risk for schizophrenia moderated the direct pathway between physical neglect and non-social cognitive functioning.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Hilal Uensal, Canan Caka, Hacer Neslihan Bildik, Saliha Esenboga, Alphan Kupesiz, Baris Kuskonmaz, Duygu Uckan Cetinkaya, Mirjam van Der Burg, Ilhan Tezcan, Deniz Cagdas
Summary: The study investigated the demographic, clinical, laboratory, follow-up, and treatment characteristics of 21 patients with Major Histocompatibility Complex Class II (MHC-II) deficiency. It was found that patients with Bare Lymphocyte Syndrome (BLS) exhibited clinical findings similar to severe combined immunodeficiency (SCID), and the flow cytometric MHC-II expression study played a crucial role in the diagnosis, differential diagnosis, early hematopoietic stem cell transplantation (HSCT), and post-HSCT follow-up.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Fatma Gonca Kocanci, Azize Yasemin Goksu Erol, Fatma Yildiz, Hamiyet Eciroglu
Summary: Calcineurin inhibitors, such as pimecrolimus, have been found to have preventive effects against neuroinflammation and apoptotic pathways, which are underlying mechanisms in neurodegenerative diseases. This study demonstrated that pimecrolimus exerts neuroprotective effects by inhibiting inflammation and oxidative stress, making it a potential treatment option for neurodegenerative diseases.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Ngan Pan Bennett Au, Tan Wu, Gajendra Kumar, Yuting Jin, Yolanda Yuen Tung Li, Shun Lam Chan, Joseph Ho Chi Lai, Kannie Wai Yan Chan, Kwan Ngok Yu, Xin Wang, Chi Him Eddie Ma
Summary: This study found that low-dose ionizing radiation (LDIR) reduces brain lesion size and reverses motor deficits in traumatic brain injury (TBI) and stroke. Transcriptomic analysis revealed LDIR-induced upregulation of anti-inflammatory and phagocytosis-related genes, and downregulation of pro-inflammatory cytokines. Live-cell assays confirmed the increased chemotactic and phagocytic capacities of microglia after LDIR. Furthermore, LDIR promoted axonal projections and brain activity recovery months after stroke. These findings suggest that LDIR could be a promising therapeutic strategy for TBI and stroke.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nadia Soliman, Franziska Denk
Summary: This article summarizes the challenge of poor translatability of pre-clinical studies in pain research and provides practical and constructive solutions, including increasing heterogeneity in animal studies, pre-registration, and enhancing statistical training.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Fisheries
Mengjiao Guo, Jiaqi Zhang, Mingtao Li, Xiaorong Zhang, Yantao Wu
Summary: rNLRC3 negatively regulates the NF -KB signaling pathway induced by P. multocida in rabbits by inhibiting the activation of NF -KB, reducing the expression of inflammatory cytokines, and interacting with rTRAF4 and rTRAF6. The NACHT-LRR domain is the functional domain of rNLRC3. These findings provide insights into the important role of rNLRC3 in combating P. multocida infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Immunology
Niall M. Pollock, Jason P. Fernandes, Jenilee Woodfield, Eman Moussa, Brittyne Hlavay, William G. Branton, Melinda Wuest, Nazanin Mohammadzadeh, Laura Schmitt, Jason R. Plemel, Olivier Julien, Frank Wuest, Christopher Power
Summary: Neuroinflammation, demyelination, and neuro-axonal damage are key factors in the progression of multiple sclerosis. The activation of GSDMD in the central nervous system contributes to inflammatory demyelination and neuroaxonal injury, providing insights into the pathogenesis and potential therapeutic strategies for progressive multiple sclerosis.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Pinfang Kang, Peng Dong
Summary: The circMETTL14(11)S/METTL14/CXCR4 axis aggravates endothelial inflammation and atherosclerosis (AS).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Review
Immunology
Meichen Ma, Yuanyuan Xie, Jianhua Liu, Lina Wu, Yong Liu, Xiaosong Qin
Summary: Interleukin-21 (IL-21) is an important effector and messenger molecule in the immune system, with pleiotropic effects on innate and adaptive immune responses. It plays a role in regulating natural killer, T, and B cells. IL-21 also has anti-tumor effects and can enhance the effectiveness of other anti-tumor agents. Understanding the biology of IL-21 in the tumor microenvironment and reducing its toxic and side effects is crucial for maximum benefits in anti-tumor treatment strategies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
