Letter
Cell Biology
Mariangela Scavone, Gian Marco Podda, Armando Tripodi, Marco Cattaneo
Article
Hematology
Michael Serries, Hannah Zenzen, Mario Heine, Tobias Holderried, Peter Brossart, Katjana Schwab
Summary: This study evaluated the outcome and prognostic parameters of patients who underwent allo-HSCT and were admitted to the ICU within the first 30 days after transplantation. The results showed that an APACHE-Score≥20, a SAPS-II-Score≥60, a SOFA-Score≥9, need for mechanical ventilation, and use of vasopressors were associated with increased mortality. This suggests that even older patients requiring long-term mechanical ventilation may benefit from intensive care therapy.
Article
Hematology
Rova Malala Fandresena Randrianarisoa, Valery Refeno, Ny Ony Tiana Florence Andrianandrasana, Fidiarivony Ralison, Hanta Marie Danielle Vololontiana, Florine Rafaramino
Summary: This retrospective study aimed to describe and analyze multiple myeloma in Madagascar, revealing a shorter patient survival and high mortality rate due to comorbidities and limited access to recommended therapies.
Article
Hematology
Lu Dong, Haili Wang, Zefeng Miao, Yanhui Yu, Dongzheng Gai, Guoxiang Zhang, Li Ge, Xuliang Shen
Summary: This study constructed an endoplasmic reticulum stress-related prognostic risk score (RS) model to predict prognosis and performed a preliminary analysis of immune infiltration in acute myeloid leukemia (AML) patients. The RS model effectively predicted prognosis and had clinical implications for AML prognosis, combined with the correlation between different RS groups and the immune microenvironment. The study identified genes and pathways related to ER stress and demonstrated that immune cells have significantly different distributions in different risk groups.
Article
Hematology
Tianxia Deng, Sheng Wang, Zhuonan Ran, Qiulian Liu, Mingxia Wang
Summary: This study aimed to construct a nomogram model for predicting poor prognosis in acute leukemia with trisomy 8. A retrospective analysis was conducted on 244 patients with primary acute leukemia with trisomy 8. The nomogram model showed excellent discrimination and consistency in predicting poor prognosis.
Article
Hematology
Fuyan Han, Nan Sheng, Chenchen Sheng, Jing Meng
Summary: This retrospective study aims to evaluate the diagnostic and prognostic value of haematologic parameters in multiple myeloma (MM). The NLR/ALB ratio (NAR) and NLR/HDL-C ratio (NHR) were compared between newly diagnosed MM patients and healthy controls. The results showed that NAR and NHR are significantly higher in MM patients, and higher levels of NAR and NHR are associated with poorer prognosis. NAR is identified as an independent prognostic factor for MM.
Article
Hematology
Haili Wang, Guoxiang Zhang, Lu Dong, Lu Chen, Li Liang, Li Ge, Dongzheng Gai, Xuliang Shen
Summary: A cuproptosis-related prognostic model was constructed, which may have a potential guiding role in the treatment of multiple myeloma.
Article
Hematology
Olga Benitez-Hidalgo, Marc Bosch Schips, Juan Carlos Juarez Gimenez, Mercedes Gironella
Summary: This study reports the real-world experience of PWHB in a Spanish center using rIX-FP. The results show that after switching to rIX-FP, patients had good bleeding control, significant reduction in infusion rate and factor consumption, and higher plasma factor levels compared to previous treatment.
Article
Hematology
Qian Wang
Summary: In this study, cuprotosis-related lncRNAs were identified as prognostic predictors for acute myeloid leukemia (AML). A risk model was constructed to distinguish high- and low-risk groups, and the high-risk group showed poorer prognosis. Additionally, the high- and low-risk groups differed significantly in immune-related processes and drug sensitivity. These findings provide new insights into lncRNA-based diagnostic and therapeutic strategies for AML.
Article
Hematology
Meijuan Sui, Hong Wei, Xiaohan Shen, Keke Gao, Zhuo Zhang, Qian Zhang
Summary: This study found that higher sulfhydryl compounds contribute to ameliorating ATO-induced leukocytosis and hepatotoxicity in APL patients. For patients with higher sulfhydryl in early stage, close monitoring of liver enzymes is warranted instead of prophylactic applying any hepatoprotective intervention, to maintain ATO efficacy.
Article
Hematology
Shandong Tao, Dan Zhou, Lixiao Song, Yuan Deng, Yue Chen, Banghe Ding, Zhengmei He, Chunling Wang, Liang Yu
Summary: This retrospective analysis suggests that human leukocyte antigen (HLA)-mismatched stem cell microtransplantation (MST) may be an optimal post-remission treatment for patients with favorable- and intermediate-risk acute myeloid leukemia (AML), with shorter neutrophil recovery time and lower relapse incidence.
Article
Hematology
Kang Chen, Xiaohan Ning, Xiaohong Yan, Lingling Song
Summary: This study investigated the role and mechanism of action of circ_0104700 in the pathogenesis of acute myeloid leukemia (AML). The results showed that circ_0104700 was highly expressed in AML patients and cell lines. Functional analysis demonstrated that depletion of circ_0104700 reduced cell viability and induced apoptosis in MV-4-11 and Kasumi-1 cells. Mechanistically, circ_0104700 acted as a competing endogenous RNA of miR-665, leading to enhanced MCM2 expression in AML cells.
Article
Hematology
Junyue Fang, Ruihao Zhang, Xianghua Lin, Ying Xu, Kezhi Huang, Phei Er Saw
Summary: In this study, the expression of T cell activation markers and quantity of Tregs in AML patients were investigated. The results showed abnormal activation markers of T cells and Tregs may be involved in the pathological mechanism of AML. Furthermore, CD8(+) CD38(+) T cells and CD8(+) HLA-DR+ T cells could be potential markers for relapsed-refractory AML patients, and Tregs can be used as clinical indicators to evaluate prognosis for AML patients.
Review
Hematology
Jinlong Ma, Jiaheng Guan, Baoan Chen
Summary: This article reports a rare case of de nove Philadelphia (Ph)-positive myelodysplastic syndromes (MDS) transforming into chronic myeloid leukemia (CML) and rapidly progressing to acute myeloid leukemia (AML). The patient experienced relapse during treatment and died subsequently. In addition, the clinical features and outcomes of another 16 adult cases of MDS with de nove Ph-positive were reviewed.
Article
Hematology
Natsuki Hirose, Takayoshi Tachibana, Akihiko Izumi, Shuku Sato, Noriyuki Tadera, Yotaro Tamai, Heiwa Kanamori, Masatsugu Tanaka, Hideaki Nakajima
Summary: This study aimed to evaluate the safety and efficacy of FLT3 inhibitors before and after allogeneic HCT in relapsed/refractory AML patients with FLT3-mutation positive. The results showed that eight out of ten patients achieved hematological remission at HCT, with a median time of 79 days. Post-HCT, patients started maintenance therapy with a median duration of 390 days. Adverse events were observed, but with sufficient attention to safety, this therapy is expected to prevent disease relapse.
Article
Hematology
Zeling Chen, Jing Xu, Ping Ye, Xiaoqin Xin
Summary: This study found a reverse association between serum calcium levels and anaemia risk in US adults, indicating that lower serum calcium levels are associated with increased risk of anaemia. Additionally, a non-linear relationship between serum calcium and anaemia risk was observed. Further prospective studies are needed to confirm these findings.
Article
Hematology
Qiuping Zeng, Haoyan Ren, Cui Liu, Ting Liu, Yongwu Xie, Xiufu Tang
Summary: The objective of this study was to investigate the association between single nucleotide polymorphisms (SNPs) in inflammatory genes and the susceptibility to childhood leukemia. Sixteen studies were included, and the meta-analysis indicated that CXCL12 rs1801157, TLR6 rs5743810, IL-10 rs1800871, rs1800872, and MIF rs755622 polymorphisms were associated with the risk of childhood leukemia.
Article
Hematology
Joerg Hoffmann, Georg Schliesser, Andreas Neubauer
Summary: In refractory autoimmune hemolytic anemia (AIHA), the use of abatacept, a fusion protein with a CTLA-4 domain, may be a reasonable approach to overcome therapy resistance. Combined with additional immunosuppressive medication such as azathioprine, abatacept can lead to a long-lasting increase in hemoglobin levels.
Article
Hematology
Tabea Sutter, Marcus Schittenhelm, Thomas Volken, Thomas Lehmann
Summary: The objective of this study was to investigate the impact of treatment choice on survival, transfusion needs, and hospitalizations in patients over 64 years old with newly diagnosed AML. Retrospective analysis of patients diagnosed with AML between 2017 and 2020 in a regional healthcare network in Switzerland revealed that patients in the HMA + VEN treatment group had significantly better overall survival, shorter hospital stays, and lower transfusion needs.
Article
Hematology
Karin Mayer, Michael Serries, Corinna Hahn-Ast, Savita Bisht, Peter Brossart, Georg Feldmann
Summary: This study retrospectively analyzed the treatment outcomes of acute myeloid leukemia (AML) patients above 65 years of age treated at a university center in Germany. The results showed that intensive chemotherapy and allogenic stem cell transplantation benefitted the survival of AML patients aged 65 and above. Combining ECOG scores and HCT-CI scores can help predict patient outcomes more accurately.
