Article
Hematology
Dan Xu, Jinlong Jiang, Guangsheng He, Haixia Zhou, Chengfu Ji
Summary: This study investigated the expressions of miR-361-3p and KMT2A in AML tissues and cell lines, and identified an advanced target for AML therapy. The results showed low expression of miR-361-3p and high expression of KMT2A. Inhibition of KMT2A prevented AML cells from proliferating, migrating, and invading. KMT2A was also confirmed as a direct target of miR-361-3p and negatively correlated with it.
Article
Hematology
Jing Jing, Yanjun Diao, Xiaoyan Hao, Yuan Zhao, Xiang Cheng, Enliang Hu, Jie Lin, Chong Yuan, Jingyuan Jia, Jiayun Liu
Summary: This study evaluates the consistency of erythrocyte volume parameters between Sysmex-XN9000 and CellaVisionDI-60. The results show that both instruments have good accuracy and consistency in measuring heterogeneity degree. It is suggested to combine Sysmex-XN9000 and CellaVisionDI-60 for comprehensive anisocytosis evaluation in daily work.
Article
Hematology
Liang Liang, Yongjun Xiao, Weilin Guo, Tiantian Xie, Lihong Zheng, Youqiong Li
Summary: Using third-generation sequencing (TGS), a patient with double heterozygous -alpha(4.2I)/-alpha(4.2II) was identified, indicating the ability of TGS to detect different sub-types of the 4.2 kb deletion.
Review
Hematology
Xia Zhu, Weiling Zhang, Yi Zhang, Yizhuo Wang, Huimin Hu, Jing Li, Yan Zhou, Tao Han, Dongsheng Huang
Summary: This study aimed to explore the efficacy of prophylactic pegfilgrastim in preventing febrile neutropenia (FN) in pediatric/adolescent cancer patients. The results showed no significant difference in reducing the rate of FN between pegfilgrastim and conventional methods. However, in patients receiving pegfilgrastim, rates of FN, grade 4 FN, severe neutropenia, and treatment delays due to FN still existed.
Review
Hematology
Jie Wu, Hui Yan, Chunli Xiang
Summary: Wilms' tumor gene 1 (WT1) plays a crucial role in the biological and pathological processes of several human malignancies, especially in hematological malignancies such as leukemia and myelodysplastic syndrome. WT1 overexpression or mutation is commonly found in acute myeloid leukemia patients, and it has been widely regarded as a marker for monitoring minimal residual disease. Many researchers are interested in developing targeted therapy for WT1. This review provides a summary of the functions, correlation with other genes, clinical features, prognosis value, and targeting therapy of WT1 in hematological malignancies.
Article
Hematology
Claire Berger, Sandrine Thouvenin, Aurelie Montmartin, Pauline Noyel, Coline Legendre, Brigitte Tardy-Poncet
Summary: This case report discusses the long-term prophylaxis management of a child with type 3 von Willebrand disease by switching to Wilate. The results showed that the new prophylaxis regimen effectively reduced bleeding episodes and improved the quality of life for both the child and his mother.
Article
Hematology
Chen-Li Li, Cheng Tan, Ling Gao, Yong Chang, Wei-Min Fan
Summary: This study aimed to establish local reference intervals (RIs) for complete blood cell (CBC) counts in newborns. Capillary blood specimens were collected from 497 healthy newborns, and the RIs for 18 CBC parameters were calculated following the guideline. The conformity rate of the RIs in the validation specimens was 90%-100%. Conclusion: Region-specific RIs for CBC parameters in healthy newborns were established to aid in the diagnosis of hematological diseases in neonates.
Article
Hematology
Huihsou Fan, Wenqiang Yan, Lingna Li, Jingyu Xu, Jiahui Liu, Yan Xu, Weiwei Sui, Shuhui Deng, Chenxing Du, Shuhua Yi, Dehui Zou, Lugui Qiu, Gang An
Summary: This study aimed to evaluate whether there is a shift in risk stratification at progression compared to that at diagnosis in patients with MM, and to analyze its prognostic impact. The results showed that re-staging and stage migration have predictive value for prognosis, and patients with deteriorated stage migration or maintained advanced stage at progression may require more individualized treatment.
Article
Hematology
Jiao Wang, Cuiping Wu, Weilun Zhou
Summary: The aim of this study was to identify novel prognostic and therapeutic targets associated with acute myeloid leukemia (AML). The researchers found that circPLXNB2 was highly expressed in AML patients and cells, and it regulated tumor progression through the circPLXNB2/miR-654-3p/CCND1 axis. Therefore, circPLXNB2 may be a new therapeutic target for AML treatment.
Article
Hematology
Lizhu Chen, Ning Tang, Jun Huang, Xiaobao Wei, Qingyan Zhong, Tizhen Yan, Shiqiang Luo
Summary: This study investigated the molecular diagnosis of hemoglobin variants in Z region in Central Guangxi, Southern China using capillary electrophoresis. Ten rare hemoglobin variants were detected, including one newly discovered variant, and the study enriched the data of rare hemoglobin variants in Southern China.
Article
Hematology
Shan Zhang, Yansong Tu, Hurong Lai, Huijun Chen, Huaijun Tu, Jian Li
Summary: Using bioinformatics analysis, PPARG, GNG12, and CD19 were identified as potential biomarkers for predicting CNS relapse in childhood ALL. A risk assessment model was established and survival analysis showed significant association between these genes and risk score with CNS relapse.
Article
Hematology
N. P. Wildenberg, C. Rossi, A. E. Kulozik, J. B. Kunz
Summary: This article presents a family with the beta-hemoglobin variant Hb Santa Juana (HBB:c.326A>G, beta 108(G10) Asn>Ser), also known as Hb Serres, spanning three generations. All affected family members had an abnormal hemoglobin fraction as detected by HPLC, but had normal blood count without signs of anemia or hemolysis. Oxygen affinity (p(50) (O-2) = 31.9-40.4 mmHg) was decreased in all probands, compared to 24.9-28.1 mmHg in unaffected individuals. Clinical symptoms likely related to the hemoglobin variant included cyanosis during anesthesia, while other complaints such as shortness of breath or dizziness were less clearly linked with the hemoglobin variant.
Article
Hematology
Haimin Chen, Nian Zhou, Haotian Shi, Wenjun Yu, Lixia Wu, Fan Zhou
Summary: This study explored the clinical features and outcomes of patients with multiple myeloma harboring 1q21+ gene abnormality. The results showed that 1q21+ was associated with higher ISS stage, elevated lactate dehydrogenase, lower levels of hemoglobin and platelets, and coexistence of del(13q). Patients with 1q21+ had shorter progression-free survival and overall survival, and 1q21+ was identified as an independent adverse prognostic factor.
Article
Hematology
Huihan Zhao, Yu He, Zhongqing Li, Yanlu Huang, Yanping Ying, Zhaoquan Huang
Summary: This study evaluated the characteristics of patients with hematological malignancies and SARS-CoV-2 infection and analyzed the risk factors for severity and mortality. The study found that acute myeloid leukemia and primary hematological disease in active state were independent risk factors for severe SARS-CoV-2 infection, and patients with AML had a higher risk of non-survival compared to patients with other types of HM. Additionally, waiting 14 days for chemotherapy initiation after negative SARS-CoV-2 testing was unnecessary.
Article
Hematology
Norihiro Ueda, Harumi Kato, Seiichi Kato, Toko Saito, Hiroyuki Tachibana, Masamitsu Yanada, Hirofumi Taji, Takeshi Kodaira, Waki Hosoda, Kazuhito Yamamoto
Summary: The management of a case of CHL following primary refractory GZL after a failed auto-HCT, showing favorable response to first-line CHL-directed chemoradiotherapy consisting of BV plus AVD followed by irradiation, is reported. This case may provide insights for treatment decisions in similar cases and for further exploration in future studies.
Article
Hematology
Zhiyou Yu, Yao Yao, Yanming Zhang, Jia Chen, Yang Xu, Shengli Xue, Huiying Qiu, Xiaowen Tang, Yue Han, Suning Chen, Aining Sun, Depei Wu, Ying Wang
Summary: Adult patients with newly diagnosed de novo acute myeloid leukemia (AML) with poor prognosis, known as type 1 primary refractory (REF1), were retrospectively analyzed to evaluate the impact of different salvage regimens on their response and overall survival (OS). The study found no significant difference in outcome among traditional salvage regimens in REF1 patients and suggested that G-CSF primed less intensive chemotherapy could serve as an alternative to intensive chemotherapy, while allo-HSCT is essential for long-term survival.
Article
Hematology
Xiaomei Chen, Chao Li, Yulian Wang, Suxia Geng, Maozhi Xiao, Lingji Zeng, Chengxin Deng, Minming Li, Xin Huang, Jianyu Weng, Xin Du, Peilong Lai
Summary: This study explores the role of ferroptosis in Myelodysplastic Neoplasms (MDS) and identifies several prognostic ferroptosis-related genes. These genes show diagnostic and prognostic significance in MDS, and provide insights into potential therapeutic avenues for this condition.
Article
Hematology
Xian Li, Aiqi Zhao, Huifang Jiang, Ying Lu, Jing Le, Yaping Xie, Meiwei Hu, Hui Zeng, Jianzhi Zhao, Mei Zhou, Hui Zhou, Lili Chen, Weiguo Zhu, Guifang Ouyang, Huiqing Qiu, Songfu Jiang, Qunyi Guo, Wenbin Qian, Yun Liang
Summary: Patients with hematologic malignancies are at a higher risk of severe COVID-19 due to their immunodeficiency. A retrospective study of 289 patients in Zhejiang Province showed that older age, comorbid conditions, and active antineoplastic therapy were associated with increased risk of severe COVID-19. Patients with severe disease had abnormal levels of lymphocytes and inflammatory markers, and a significant proportion experienced persistent symptoms. The effectiveness of inactivated vaccines in these patients was uncertain.
Article
Hematology
Adcharee Kongruang, Nittaya Limsuwanachot, Sutada Magmuang, Prapatsorn Areesirisuk, Pimjai Niparuck, Teerapong Siriboonpiputtana, Budsaba Rerkamnuaychoke
Summary: This study aimed to investigate the feasibility of using an FDA-approved commercial ddPCR assay for measuring BCR::ABL1 in CML patients undergoing TKI therapy. The results showed that ddPCR has high sensitivity and can detect residual disease more effectively compared to standard RQ-PCR.
Article
Cell Biology
Qi-Rui Li, Hua-Zhen Xu, Rong-Cheng Xiao, Bin Liu, Tian-Qi Ma, Ting-Ting Yu, Liu-Gen Li, Mei-Fang Wang, Li Zhao, Xiao Chen, Tong-Fei Li
Summary: The present study demonstrates the use of photodynamic action to activate drug-loaded platelets for controlled drug release and anti-tumor therapy.
