Review
Cell Biology
Chloe E. George, Christine V. Saunders, Alex Morrison, Tom Scorer, Sarah Jones, Nina C. Dempsey
Summary: A review of the history, function, and advantages of platelet concentrates, comparing cold-stored platelets with room temperature platelets and discussing their limitations.
Article
Hematology
Mohammad S. Afana, Mohammad Abu-Tineh, Awni Alshurafa, Ahmed K. Yasin, Khalid Ahmed, Mohammed Abdulgayoom, Mohamed A. Yassin
Summary: Sickle cell disease (SCD) is a common hematological disease with various complications. The treatment options for SCD are limited. Acute chest syndrome (ACS) is a challenging complication in SCD prevention. Crizanlizumab, a monoclonal antibody, improves blood flow in SCD patients by preventing sickle cell adhesion to endothelium. However, its effectiveness in ACS prevention is not well evaluated. This case report presents a 23-year-old SCD patient with recurrent ACS who showed significant improvement when treated with Crizanlizumab.
Article
Hematology
Zhen-min Ren, Wu-jiao Li, Zhi-hao Xing, Xiao-ying Fu, Ju-yan Zhang, Yun-sheng Chen, De-fa Li
Summary: This study aims to explore the application value of third-generation sequencing (TGS) in the diagnosis of rare thalassemia in children with anemia. The results show that TGS can accurately detect the genotypes of rare thalassemia, which is especially important for clinical diagnosis.
Article
Hematology
Xiaoli Xu, Minjian Xiong, Haiyan Ye, Yonglei Qi, Ying Zhao
Summary: This study analyzed the gene sequencing results of an elderly AML patient and found high expression of tumor-related genes in monocytes and hematopoietic stem cells. These genes may play a role in the progression and heterogeneity of AML, impacting patient treatment and prognosis.
Article
Hematology
Ke Tong, Yan Meng, Luying Zhang, Xiaoying Lei, Xianmin Guan, Li Xiao, Jie Yu, Ying Dou
Summary: This study investigated the clinical characteristics, risk factors, and survival prognosis of pericardial effusion (PE) after haematopoietic stem cell transplantation (HSCT) in children. Retrospective analysis of clinical data from children who underwent HSCT at the Children's Hospital Affiliated with Chongqing Medical University from January 2016 to December 2022 was conducted. The study found that PE usually occurred within 100 days after HSCT and was associated with GVHD grade, abnormal pre-HSCT electrocardiogram, HVOD, pulmonary infection, and EBV infection. PE had a significant negative effect on overall survival (OS) rate.
Article
Hematology
Na Wang, Hongkai Lu, Linzhang Li, Ming Gong, Yongtong Cao
Summary: We report a case of a 25-year-old female patient with severe autoimmune hemolytic anemia complicating hereditary spherocytosis, triggered by respiratory syncytial virus infection. The patient's hemoglobin level was very low and multiple anti-red blood cell antibodies were detected, making blood matching difficult. Combination therapy with glucocorticoids and cyclosporine effectively increased the hemoglobin level and relieved the anemia symptoms.
Article
Hematology
Hanneda A. Fomukong, Mayen Kalu, Idowu A. Aimola, Abdullahi B. Sallau, Halima Bello-Manga, Flore E. Gouegni, Joy U. Ameloko, Zeenat K. Bello, Alfa U. David, Reuben S. Baba
Summary: By analyzing single-cell RNA sequencing data, it was found that the erythroid population is heterogeneous, with a distinct sub-cell type constituting stress erythroids. This finding has important implications for our understanding of steady-state and stress erythropoiesis.
Article
Hematology
Yaxuan Cao, Jianming Luo
Summary: This study reports the discovery of two novel HBB gene deletion mutants and describes their clinical characteristics and genetic analysis methods. When the blood phenotype and clinical presentation do not match the genotype, the presence of new mutants should be considered and further testing should be conducted to ensure accurate diagnosis.
Article
Hematology
A. J. Gerard Jansen, Vickie Mcdonald, Adrian Newland, Mervyn Morgan, Mieke Bastiaanse, Koo Wilson, Daniel Eriksson, Emma Geldman, Owen Daykin-Pont, Samantha Prince, Jaap Jan Zwaginga
Summary: The study investigated patient experience and preference towards thrombopoietin-receptor agonists (TPO-RAs) in the treatment of immune thrombocytopenia (ITP) in the Netherlands. Patients preferred orally delivered therapies, less frequent dosing, and treatments without food restrictions. The study provides insights for improving the quality of life of ITP patients on TPO-RAs.
Article
Hematology
Honghui Wang, Hui Bi, Muran Yang, Xiuli Wang, Chuanju Song, Wen Yang, Yacan Wang, Dongmei Xie, Huiting Li, Zeping Zhou
Summary: This study investigated the differences in intestinal flora between ITP patients and healthy controls, and identified the correlation between intestinal flora and Th1/Th2 imbalance. It was found that changes in the intestinal flora of ITP patients may be related to inflammation and immunity. Additionally, the study revealed the association between intestinal flora and bleeding scores as well as platelet counts. Functionally, the intestinal flora of ITP patients showed alterations in motility, chemotaxis, membrane transport, and metabolism.
Article
Hematology
Min Li, Xiaojuan Li, Xiaohong Lu, Mingqin Zhong, Lin Wang, Mingze Song, Feng Xue
Summary: The study evaluated the analytical performance of automated analysers in haematology laboratories using the sigma metric and selected the best analyser as the reference. The results showed that all parameters of the automated analysers met satisfactory levels at the normal control level. However, the platelet count by Instrument G performed poorly at the low control level, while Instrument H performed the best.
Article
Cell Biology
Sagar S. Matharu, Cassidy S. Nordmann, Kurtis R. Ottman, Rahul Akkem, Douglas Palumbo, Denzel R. D. Cruz, Kenneth Campbell, Gail Sievert, Jamie Sturgill, James Z. Porterfield, Smita Joshi, Hammodah R. Alfar, Chi Peng, Irina D. Pokrovskaya, Jeffrey A. Kamykowski, Jeremy P. Wood, Beth Garvy, Maria A. Aronova, Sidney W. Whiteheart, Richard D. Leapman, Brian Storrie
Summary: Platelets contribute to COVID-19 clinical manifestations, especially microclotting in the pulmonary vasculature. A 3D ultrastructural approach revealed that COVID-19 patient platelets have denser packing of organelles and are smaller in size compared to healthy controls, with little difference in platelet activation. The findings suggest that factors outside of platelets may play a more significant role in COVID-19 complications.
Article
Hematology
Yoko Edahiro, Keita Kirito, Akihiko Gotoh, Katsuto Takenaka, Yuka Sugimoto, Norio Komatsu, Kazuya Shimoda
Summary: This Japanese cross-sectional survey examined the symptoms, daily living activities, and treatment needs of patients with polycythemia vera (PV) as perceived by patients and physicians. The study found that PV symptoms significantly impacted patients' daily living, with work, leisure activities, and family life being the most affected areas. There were also differences in symptom perception, treatment needs, and communication between physicians and patients.
Article
Hematology
Yu Zhu, Jinli Jian, Yujie Niu, Xiaoxiao Yang, Yuancheng Guo, Long Zhao, Bei Liu
Summary: This study investigates the potential of a NAD(+) metabolism-related lncRNA signature as a prognostic biomarker for acute myeloid leukemia (AML). Transcriptome profiles and clinical data of AML patients were obtained from The Cancer Genome Atlas (TCGA) database. NAD(+) metabolism-related lncRNAs were identified and a predictive model was constructed. The model showed good predictive power and outperformed other markers in terms of prognosis.
Article
Hematology
Juan Carlos Olivares-Gazca, Maria de Lourdes Pastelin-Martinez, Merittzel Abigail Montes-Robles, Moises Manuel Gallardo-Perez, Edgar J. Hernandez-Flores, Max Robles-Nasta, Daniela Sanchez-Bonilla, Guillermo J. Ruiz-Delgado, Guillermo J. Ruiz-Arguelles
Summary: To address the issue of unavailable HLA-matched donors for ethnic minorities and multiethnic families, we conducted a study on haploidentical hematopoietic stem cell transplantation (Haplo-HSCT). The results showed that outpatient transplantation using peripheral blood stem cells can be performed safely and significantly reduces costs.
Article
Hematology
Wenzhi Zhang, Jianxin Dun, Hui Li, Jingzhen Liu, Hongbo Chen, Hui Yu, Jiawei Xu, Fen Zhou, Yining Qiu, Jinjin Hao, Qun Hu, Xiaoyan Wu
Summary: In non-DS-AMKL, patients with acquired trisomy 21 (+21) have lower platelet counts at onset compared to those without +21, but there are no significant differences in remission rates and prognosis. Non-DS-AMKL has a younger onset age and is often associated with anemia, bleeding, lymph node enlargement, lower white blood cell count, and complex karyotype. Patients with delayed diagnosis often present with thrombocytopenia or pancytopenia initially.
Article
Hematology
Manjun Zhao, Yang Zhang, Jin Yang, Lei Chen, Ziying Zhang, Huaquan Wang, Zonghong Shao, Limin Xing
Summary: The DNA methylation pattern of B cells in patients with autoimmune hemolytic anemia (AIHA) differs from that of healthy controls, with a higher proportion of hypo-methylation regions. Genes related to differentially methylated regions (DMRs) are mainly involved in specific signaling pathways.
Article
Hematology
Jing-Ying Zou, Si-Man Huang, Hai-Xia Zhoub, Ming-Zhu Xu, Ai-Ning Sun, De-Pei Wu, Sheng-Li Xue, Tong-Tong Zhang
Summary: This retrospective study summarized the effectiveness of combining Venetoclax and BCR-ABL1 TKI for the treatment of Ph+ leukemias. The results showed that this combination therapy achieved a high overall response rate and most patients had sustained disease remission during the one-year follow-up. This approach may be a feasible strategy for Ph+ leukemias, but further prospective studies are needed to evaluate its safety and efficacy.
Article
Hematology
Weiyue Fang, Hongdou Lin, Junyi Chen, Wenjian Guo
Summary: This study aimed to establish a novel signature of necroptosis-related genes to enhance our understanding of molecular heterogeneity in leukemia. By analyzing gene expression profiles and clinical features from TCGA and GEO databases, four genes (FADD, PLA2G4A, PYCARD, and ZBP1) were identified as independent risk factors affecting the prognosis of AML patients. Risk scores were calculated based on the coefficients of these four genes, and a nomogram was constructed using clinical characteristics and risk scores. CellMiner was also used to identify potential drugs and analyze the correlations between genes and drug sensitivity.
Article
Hematology
Junjie Cao, Xiaodong Xu, Ying Lu, Tiantian Wang, Dong Chen, Shuangyue Li, Xuhui Liu, Peipei Ye, Zhong-zheng Zheng, Renzhi Pei
Summary: To overcome the high relapse rate in post-transplantation cyclophosphamide (PTCy) treatment, an intensified conditioning regimen combining fludarabine, enhanced dose of cytarabine, busulfan, cyclophosphamide, anti-thymocyte globulin (ATG) and PTCy was used. The results showed that the incidence of grade II-IV acute graft versus host disease (GVHD) was significantly lower in the intensified conditioning group. In addition, the positive rate of minimal residual disease after transplantation was also significantly reduced.
