Hematology

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Article Hematology

Outcome of first or second transplantation using unrelated umbilical cord blood without ATG conditioning regimen for pediatric bone marrow failure disorders

Xia Chen, Fang Liu, Yuanyuan Ren, Luyang Zhang, Yang Wan, Wenyu Yang, Xiaojuan Chen, Li Zhang, Yao Zou, Yumei Chen, Xiaofan Zhu, Ye Guo

Summary: Unrelated umbilical cord blood transplantation (UCBT) is an effective alternative treatment for pediatric patients with bone marrow failure. The use of the TBI/BU + FLU + CY conditioning regimen ensures a high engraftment rate for UCBT and overcomes the challenge of graft failure. Secondary salvage use of cord blood transplantation may still be useful for patients who have failed after other transplantation.

BLOOD CELLS MOLECULES AND DISEASES (2024)

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Article Hematology

The role of PKC in X-ray-induced megakaryocyte apoptosis and thrombocytopenia

Fanbi Meng, Shuang Chen, Chunliang Liu, Muhammad Shoaib Khan, Yan Yan, Jun Wan, Yue Xia, Chenglin Sun, Mengnan Yang, Renping Hu, Kesheng Dai

Summary: PKC plays a critical role in regulating megakaryocyte development and platelet production in thrombocytopenia. The inhibition of PKC activation delays and reduces radiation-induced megakaryocyte apoptosis, leading to improved platelet count recovery. This study provides a potential therapeutic target for treating thrombocytopenia.

BLOOD CELLS MOLECULES AND DISEASES (2024)

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Review Hematology

Thrombotic triad in microgravity

Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth

Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.

THROMBOSIS RESEARCH (2024)

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Article Hematology

Trimethylamine-N-oxide (TMAO) and basic fibroblast growth factor (bFGF) are possibly involved in corticosteroid resistance in adult patients with immune thrombocytopenia

Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min

Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.

THROMBOSIS RESEARCH (2024)

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Article Hematology

Driver gene KRAS aggravates cancer-associated stroke outcomes

Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki

Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.

THROMBOSIS RESEARCH (2024)

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Article Hematology

Shock score for prediction of clinical outcomes among stable patients with acute symptomatic pulmonary embolism

Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez

Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.

THROMBOSIS RESEARCH (2024)

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Article Hematology

Bach1 inhibitor HPP-D mediates ?-globin gene activation in sickle erythroid progenitors

Chithra D. Palani, Xingguo Zhu, Manickam Alagar, Otis C. Attucks, Betty S. Pace

Summary: This study evaluated the ability of a novel Bach1 inhibitor, HPP-D, to induce HbF in KU812 cells and primary sickle erythroid progenitors. The results showed that HPP-D increased HbF levels and decreased Bach1 protein levels in both cell types. Furthermore, it enhanced NRF2 binding to the gamma-globin promoter antioxidant response elements, leading to an open chromatin configuration and increased gamma-globin transcription.

BLOOD CELLS MOLECULES AND DISEASES (2024)

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Review Oncology

CpG-biomarkers in tumor tissue and prediction models for the survival of colorectal cancer: A systematic review and external validation study

Tanwei Yuan, Dominic Edelmann, Jakob N. Kather, Ziwen Fan, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Blaeker, Barbara Burwinkel, Hermann Brenner, Michael Hoffmeister

Summary: The study aimed to analyze and validate previously published CpG-methylation-based prognostic biomarkers and prediction models for colorectal cancer (CRC) prognosis. The results showed that the discrimination ability of the models was insufficient and lacked clinical relevance.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2024)

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Article Hematology

Safety of fixed-dose heparin titration boluses in underweight patients

Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter

Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.

THROMBOSIS RESEARCH (2024)

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Letter Hematology

Identification of two de novo variants causing inherited antithrombin deficiency by quantitative analysis of variant alleles

Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita

THROMBOSIS RESEARCH (2024)

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Review Cell Biology

Humanized mouse models for inherited thrombocytopenia studies

Xiaojie Wang, Maoshan Chen, Lanyue Hu, Chengning Tan, Xiaoliang Li, Peipei Xue, Yangzhou Jiang, Peipei Bao, Teng Yu, Fengjie Li, Yanni Xiao, Qian Ran, Zhongjun Li, Li Chen

Summary: This article mainly reviews the development and application of humanized mouse models in studying thrombocytopenia, as well as the existing challenges.

PLATELETS (2023)

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Article Cell Biology

Exploration of risk factors of platelet transfusion refractoriness and its impact on the prognosis of hematopoietic stem cell transplantation: a retrospective study of patients with hematological diseases

Xiaofei Song, Jiaqian Qi, Xueqian Li, Meng Zhou, Jingyi He, Tiantian Chu, Yue Han

Summary: Splenomegaly and JAK gene mutation are independent risk factors for platelet transfusion refractoriness (PTR) in patients with hematological diseases. PTR has a negative impact on the prognosis of patients after transplantation and can hinder platelet reconstitution.

PLATELETS (2023)

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Article Cell Biology

A novel, quantitative clot retraction assay to evaluate platelet function

Wayne T. Muraoka, Prajeeda M. Nair, Daniel N. Darlington, Xiaowu Wu, James A. Bynum, Andrew P. Cap

Summary: This study describes a 96-well-based clot retraction assay that allows for rapid measurement of platelet function and provides quantitative information. The assay is robust to different calcium concentrations and can predict factors affecting platelet function.

PLATELETS (2023)

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Article Cell Biology

Factors influencing platelet isolation: a prospective multicenter study from Western China

Shan Liu, Guishu Yang, Guangqun Zeng, Xihao Zhou, Rong Chen, Bin Chen, Jin Chen, Xiaoxia Wen, Xingmei Zhang, Hanxiao Ren, Ruiling Zu, Dongsheng Wang, Ping Leng, Huaichao Luo

Summary: In this study, a prospective multicenter study was conducted on healthy Han Chinese adults to investigate the factors involved in platelet isolation. The study found that platelet recovery rate was slightly higher at room temperature compared to cold temperature, and it gradually decreased with storage time. Samples within 2 hours of storage had significantly higher recovery rate than samples stored beyond 2 hours (p<0.05). The study also showed that the equipment used in different centers affected the recovery rate. Therefore, it is recommended to perform platelet isolation within two hours of blood draw, hold it at room temperature, and fix the centrifuge models during the extraction process, which will improve the research progress of platelet-based liquid biopsy in cancer.

PLATELETS (2023)

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Review Cell Biology

What can the plasma proteome tell us about platelets and (vice versa)?

Steven Bruzek, Marisol Betensky, Jorge Di Paola, Thomas Diacovo, Neil Goldenberg, Vera Ignjatovic

Summary: Multi-omics approaches help study physiological and pathophysiologic processes. Proteomics focuses on proteins as functional elements, important markers, and therapeutic targets. Plasma and platelet proteomes play crucial roles in understanding diseases like atherosclerosis and cancer. Integration of plasma and platelet proteomics can provide comprehensive insights that studying them separately cannot achieve.

PLATELETS (2023)

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Article Cell Biology

Immature platelets and cardiovascular events in patients with stable coronary artery disease

Oliver Buchhave Pedersen, Sanne Bojet Larsen, Steen Dalby Kristensen, Anne-Mette Hvas, Erik Lerkevang Grove

Summary: Immature platelet markers cannot predict cardiovascular events in stable CAD patients.

PLATELETS (2023)

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Review Cell Biology

F11R/JAM-A: why do platelets express a molecule which is also present in tight junctions?

Piotr Kamola, Anna Babinska, Tomasz Przygodzki

Summary: F11R/JAM-A is a transmembrane protein that plays important roles in tight junction formation and leukocyte transmigration. Its function in blood platelets is not well understood, but it has been shown to regulate platelet adhesion and interact with inflamed vascular walls. Further research is needed to fully understand its role in hemostasis and thrombosis.

PLATELETS (2023)

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Article Cell Biology

Association of immature platelets with perioperative complications in neurosurgery

Aida Anetsberger, Isabell Bernlochner, Bettina Jungwirth, Manfred Blobner, Bernhard Meyer, Eberhard F. Kochs, Dario Bongiovanni, Sebastian Schmid, Clemens Langgartner, Lea Baumgart, Jens Gempt

Summary: This study is the first to show a relationship between immature platelets and therapy-relevant complications in neurosurgical patients. It could be a pilot trial for varied scientific questions including risk stratification of neurosurgical patients. Immature platelets are associated with relevant complications in neurosurgical patients.

PLATELETS (2023)

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Letter Cell Biology

Assessment of whole blood platelet aggregation in patients with cirrhosis: challenges and opportunities

Alberto Zanetto, Elena Campello, Marco Senzolo, Paolo Simioni

PLATELETS (2023)

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Article Cell Biology

Platelet glycogenolysis is important for energy production and function

Kanakanagavalli Shravani Prakhya, Hemendra Vekaria, Danielle M. Coenen, Linda Omali, Joshua Lykins, Smita Joshi, Hammodah R. Alfar, Qing Jun Wang, Patrick Sullivan, Sidney W. Whiteheart

Summary: Activated platelets transition from a low-energy-requiring resting state to a high-energy-demanding state. Glycogen turnover occurs in resting platelets and its degradation is important for platelet functions. Glycogen phosphorylase inhibitors block secretion and clot contraction, but the latter can be reversed with alternative metabolic fuels. Glycogen breakdown contributes to the high energy requirements of platelet function.

PLATELETS (2023)

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