Health Policy & Services

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Article Economics

Cost-effectiveness of apixaban and rivaroxaban in thromboprophylaxis of cancer patients treated with chemotherapy in Spain

Andres J. Munoz, Laura Ortega, Ana Gutierrez, Enrique Gallardo, Dario Rubio-Rodriguez, Carlos Rubio-Terres, Blanca Moron, Pilar Garcia-Alfonso, Jose Manuel Soria

Summary: This study aimed to assess the cost-utility of thromboprophylaxis with apixaban and rivaroxaban compared to no thromboprophylaxis in ambulatory cancer patients with an intermediate-to-high risk of venous thromboembolism (VTE). The results showed that apixaban and rivaroxaban had similar costs to non-prophylaxis and the difference was not statistically significant, with a clinically insignificant QALY gain.

JOURNAL OF MEDICAL ECONOMICS (2023)

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Article Economics

Out-of-pocket cost by cancer stage at diagnosis in commercially insured patients in the United States

November McGarvey, Matthew Gitlin, Ela Fadli, Karen C. Chung

Summary: This study estimated the out-of-pocket costs experienced by cancer patients at different stages after diagnosis. The findings showed that a higher proportion of out-of-pocket costs were incurred in the first year post-diagnosis and remained relatively high for the following three years. The cumulative mean out-of-pocket costs were generally higher for patients diagnosed at later stages (III/IV) compared to those diagnosed at earlier stages (I/II) across all types of cancer.

JOURNAL OF MEDICAL ECONOMICS (2023)

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Article Economics

The cost-of-illness and burden-of-disease of treatment-resistant depression in Austria

Evelyn Walter, Matthaeus Traunfellner, Martin Gleitsmann, Michaela Zalesak, Christian Helmenstein

Summary: This study aimed to determine the direct medical utilization and cost-of-illness of treatment-resistant depression (TRD) in Austria. The results showed that the direct and indirect costs of TRD patients were high.

JOURNAL OF MEDICAL ECONOMICS (2023)

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Article Health Policy & Services

Improving Access to and Coverage of Rehabilitation Services through the Implementation of Rehabilitation in Primary Health Care: A Case Study from Chile

Vanessa Seijas, Katherina M. Hrzic, Ximena Z. Neculhueque, Carla Sabariego

Summary: Chile successfully integrated rehabilitation into primary health care through the Comprehensive Rehabilitation in PHC Program, improving access, coverage, and equity. Strong governance, financial commitment, and evidence-based planning were the key to achieving this.

HEALTH SYSTEMS & REFORM (2023)

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Article Health Policy & Services

The Promise of Grassroots Approaches to Solving Absenteeism in Primary Health-Care Facilities in Nigeria: Evidence from a Qualitative Study

Obinna Onwujekwe, Prince Agwu, Pallavi Roy, Eleanor Hutchinson, Charles Orjiakor, Martin McKee, Aloysius Odii, Chukwudi Nwokolo, Mushtaq Khan, Susannah Mayhew, Dina Balabanova

Summary: Absenteeism among PHC workers in Nigeria is a major obstacle to achieving UHC. The dominant approach of government-led topdown solutions has not been successful. This paper explores grassroots approaches, highlighting the importance of community resources, philanthropic support, and engaging trained health workers to address absenteeism. However, a holistic response should combine horizontal and vertical measures.

HEALTH SYSTEMS & REFORM (2023)

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Article Health Policy & Services

A Gender-Based and Quasi-Experimental Study of the Catastrophic and Impoverishing Health-Care Expenditures in Mexican Households with Elderly Members, 2000-2020

Edson Servan-Mori, Emanuel Orozco-Nunez, Carlos M. Guerrero-Lopez, J. Jaime Miranda, Stephen Jan, Laura Downey, Emma Feeny, Ileana Heredia-Pi, Laura Flamand, Gustavo Nigenda, Robyn Norton, Rafael Lozano

Summary: Latin America is facing an increasing burden of noncommunicable diseases, which has led to challenges in healthcare delivery and social protection for vulnerable populations. This study examined catastrophic and excessive health care expenditures in Mexican households with and without elderly members, taking into account the gender bias in care-seeking preferences. The findings showed that female-headed households, especially those with elderly members, faced greater risks of catastrophic and excessive health care expenditures compared to male-headed households. This highlights the urgent need for strengthening social protection in health, especially as the burden of noncommunicable diseases continues to grow and is further exacerbated by COVID-19.

HEALTH SYSTEMS & REFORM (2023)

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Article Economics

Health care resource utilization patterns among patients with Parkinson's disease psychosis: analysis of Medicare beneficiaries treated with pimavanserin or other-atypical antipsychotics

Krithika Rajagopalan, Nazia Rashid, Shikhar Kumar, Dilesh Doshi

Summary: This study analyzed PDP patients treated with PIM monotherapy and found that it led to nearly 12% and 7% reductions in all-cause hospitalizations and ER visits compared to other-AAPs.

JOURNAL OF MEDICAL ECONOMICS (2023)

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Review Economics

The impact of transparency constraints on the efficiency of the Russian healthcare system: systematic literature review

Yuriy Timofeyev, Oksana Dremova, Mihajlo Jakovljevic

Summary: This study examines the impact of information availability and accessibility on healthcare outcomes in Russia. It highlights the lack of transparency in the Russian healthcare system and the need for improvement.

JOURNAL OF MEDICAL ECONOMICS (2023)

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Article Economics

Informing a cost-effectiveness threshold for Saudi Arabia

Ahmed Hamdan Al-Jedai, James Lomas, Hajer Yousef Almudaiheem, Yazed Sulaiman H. Al-Ruthia, Shabab Alghamdi, Nancy Awad, Ahlam Alghamdi, Mohammad A. Alowairdhi, Hana Alabdulkarim, Majid Almadi, Reem F. Bunyan, Jessica Ochalek

Summary: This study provides estimates of the cost-effectiveness threshold for the Saudi Arabian healthcare system, aiming to inform decision-making. Using four different approaches, the marginal cost per unit of health produced by the healthcare system is estimated to range from SAR 42,046 to SAR 215,120 per QALY gained. The cost-effectiveness threshold based on the average of estimated health gains is suggested to be in the range of SAR 50,000-75,000 per QALY gained, taking into account health opportunity costs.

JOURNAL OF MEDICAL ECONOMICS (2023)

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Article Economics

An economic evaluation of vagus nerve stimulation as an adjunctive treatment to anti-seizure medications for the treatment of drug resistant epilepsy in the United States

Christopher Raspin, Edward Faught, Jeanne Armand, Francesca Barion, Vicki Pollit, Joanna Murphy, Vanessa Danielson

Summary: This study evaluated the cost-effectiveness of vagus nerve stimulation (VNS) therapy as an adjunct treatment for drug-resistant epilepsy (DRE) in the US Medicare context. The results showed that VNS treatment was associated with a gain of 0.385 QALY and a cost-saving of $109,678 per patient compared to anti-seizure medication (ASM) therapy alone. Sensitivity analyses supported the cost-effectiveness of VNS for DRE treatment.

JOURNAL OF MEDICAL ECONOMICS (2023)

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Article Economics

The cost-effectiveness of a nursing home-based transitional care unit for increasing the potential for independent living in the community among hospitalized older adults

Maya Murmann, Danielle Sinden, Amy T. T. Hsu, Kednapa Thavorn, Anan Bader Eddeen, Annie H. H. Sun, Benoit Robert

Summary: A nursing home-based transitional care unit can reduce hospital length of stay and the risk of subsequent institutionalization among frail, older adults. It is a more cost-effective model of care and allows older adults to stay at home for a longer period without institutional care. This research supports the investment in nursing home-based transitional care programs.

JOURNAL OF MEDICAL ECONOMICS (2023)

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Review Economics

Efficacy of abobotulinumtoxinA versus onabotulinumtoxinA for the treatment of refractory neurogenic detrusor overactivity: a systematic review and indirect treatment comparison

Francisco Cruz, Natalya Danchenko, Kyle Fahrbach, Andreas Freitag, Jialu Tarpey, John Whalen

Summary: This study compared the efficacy and safety of abobotulinumtoxinA (aboBoNT-A) and onabotulinumtoxinA (onaBoNT-A) for the treatment of refractory neurogenic detrusor overactivity (NDO) using an indirect treatment comparison. The results showed that abobotulinumtoxinA may be more effective than onabotulinumtoxinA in reducing the frequency of urinary incontinence episodes. Rating: 8 out of 10.

JOURNAL OF MEDICAL ECONOMICS (2023)

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Review Economics

Targeted literature review of the burden of extraintestinal pathogenic Escherichia Coli among elderly patients in Asia Pacific regions

Norio Ohmagari, Won Suk Choi, Hung-Jen Tang, Petar Atanasov, Xiaobin Jiang, Luis Hernandez Pastor, Yoshikazu Nakayama, Jason Chiang, Kyunghwa Lim, Maria Carmen Nievera

Summary: This study synthesized recent data on the epidemiology, clinical burden, and economic burden of invasive ExPEC disease (IED) in the elderly/high risk populations in China, Japan, South Korea, Taiwan, and Australia. ExPEC was found to be a major cause of bloodstream infections in these regions, with significant associated morbidity and mortality. The study also highlighted the increasing costs related to ExPEC infections, particularly in sepsis cases and due to antimicrobial resistance.

JOURNAL OF MEDICAL ECONOMICS (2023)

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Correction Economics

Burden of illness associated with overweight and obesity in patients hospitalized with COVID-19 in the United States: analysis of the premier healthcare database from April 1, 2020 to October 31, 2020 (vol 26, pg 376, 2023)

N. Kim, A. Aly, C. Craver, W. T. Garvey

JOURNAL OF MEDICAL ECONOMICS (2023)

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Article Health Policy & Services

The Politics of Health Policy Agenda Setting in India: The Case of the PMJAY Program

Anuska Kalita, Kevin Croke

Summary: In 2018, India's Prime Minister announced a new health insurance program, Pradhan Mantri Jan Arogya Yojana (PMJAY), aiming to cover over 500 million people. This paper analyzes the emergence of PMJAY on India's political and policy agendas by comparing its presence to previous health programs and applying Kingdon's Multiple Streams Framework. The study reveals that PMJAY gained more media attention but not necessarily more prominence in parliamentary debates or the health budget.

HEALTH SYSTEMS & REFORM (2023)

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Review Economics

The impact of vaccination and outpatient treatment on the economic burden of Covid-19 in the United States omicron era: a systematic literature review

Vicki Pierre, Florin Draica, Manuela Di Fusco, Jingyan Yang, Solange Nunez-Gonzalez, Joanna Kamar, Santiago Lopez, Mary M. Moran, Jennifer Nguyen, Piedad Alvarez, Ashley Cha-Silva, Meghan Gavaghan, Alon Yehoshua, Naomi Stapleton, Heather Burnett

Summary: This study aims to identify and synthesize evidence on how COVID-19 interventions, such as vaccines and outpatient treatments, have impacted healthcare resource use and costs in the US. The systematic literature review included 58 studies, which showed that vaccination and outpatient treatment significantly reduced the risk of hospitalization and other healthcare resource utilization among COVID-19 patients.

JOURNAL OF MEDICAL ECONOMICS (2023)

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Article Economics

Cost-efficiency analysis of conversion to biosimilar filgrastim for supportive cancer care and resultant expanded access analysis to supportive care and early-stage HER2+breast cancer treatment in Saudi Arabia: simulation study

Consuela Cheriece Yousef, Mansoor Ahmed Khan, Hind Almodaimegh, Majed Alshamrani, Meteb Al-Foheidi, Hana AlAbdalkarim, Ahmed AlJedai, Anjum Naeem, Ivo Abraham

Summary: This study estimated the cost-efficiency of converting patients in Saudi Arabia from reference Neupogen and Neulastim to two filgrastim biosimilars (Nivestim, Zarzio), and the budget-neutral expanded access to supportive and therapeutic care. The number-needed-to-convert to provide treatment to one patient was also determined.

JOURNAL OF MEDICAL ECONOMICS (2023)

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Article Economics

Breast cancer-related mortality in Central and Eastern Europe: years of life lost and productivity costs

Goran Bencina, Nour Chami, Robert Hughes, Georgie Weston, Carl Baxter, Adam Maciejczyk, Lazar Popovic, Eugenia Karamousouli, Stina Salomonsson

Summary: This study estimated the years of life lost (YLL) and productivity losses due to breast cancer deaths in nine Central and Eastern European countries. The results showed that premature death from breast cancer leads to substantial YLL and productivity losses, exceeding 259 million euros in 2019 alone. These findings provide important evidence for resource allocation priorities in breast cancer prevention, screening, and treatment.

JOURNAL OF MEDICAL ECONOMICS (2023)

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Editorial Material Economics

Advancing towards a worldwide healthcare system in the post-COVID-19 era: benefits and barriers to international collaboration in healthcare

Ahmad Z. Al Meslamani

JOURNAL OF MEDICAL ECONOMICS (2023)

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Article Economics

Evaluating process utilities for the treatment burden of chemotherapy in multiple myeloma in Japan: a time trade-off valuation study

Tadao Ishida, Mayuko Nakakoji, Tatsunori Murata, Fujio Matsuyama, Shinsuke Iida

Summary: This study used the time trade-off (TTO) method to estimate the process utilities of treatment options for patients with relapsed/refractory multiple myeloma (RRMM) in Japan. The impact of treatment options on health state utilities, particularly in relation to process utilities, was found to be significant.

JOURNAL OF MEDICAL ECONOMICS (2023)

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