Correction
Genetics & Heredity
Qian Xia Lin, Yong ' An Jiang, Fang Zhou, Yong Ping Zhang
Article
Genetics & Heredity
Yang Chen, Zhiyuan Bao, Fan Yao, Yan Liu, Bohao Zhao, Xinsheng Wu
Summary: This study identified PRKACB as a potential novel target gene of HOXC13, contributing to the regulation of proliferation and apoptosis in DPCs. ChIP-Seq analysis revealed the genes and pathways associated with HOXC13-regulated hair follicle development.
Article
Genetics & Heredity
Parul Tyagi, Mrinalini Prasad, Shivangi Mathur, Rajiv Ranjan
Summary: This study aimed to identify candidate genes associated with diosgenin biosynthesis in Tribulus terrestris through whole transcriptome profiling. The majority of unigenes related to the biosynthesis of diosgenin exhibited up-regulation in the fruit, leaf, and root tissues. The differential expression of selected genes was validated through qRT-PCR. Additionally, the study discovered a large number of unigenes related to transcription factors and containing simple sequence repeats (SSR).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Haiyu Chen, Xinke Zhang, Guoshuai Zhang, Zhi Zhang, Guoxu Ma, Zhaocui Sun, Chang Liu, Linfang Huang
Summary: This study successfully obtained the chloroplast genome of Nepeta bracteata using Next-generation sequencing. The genome consists of 130 genes and exhibits a typical quadripartite structure. Comparative analysis with other species from the Nepeta genus identified five hypervariable regions. Phylogenetic analysis showed a close relationship between N. bracteata and Nepeta stewartiana. These findings enrich the resources available for chloroplast genomes in the Nepeta genus and highlight the potential of hypervariable regions as molecular markers.
Article
Genetics & Heredity
Benshui Shu, Yanzheng Lin, Yuting Huang, Luyang Liu, Xueming Cai, Jintian Lin, Jingjing Zhang
Summary: This study reveals the significant inhibitory effect of Toosendanin (TSN) on the growth of Spodoptera frugiperda larvae and identifies key genes involved in hormone and cuticle formation regulation. These findings lay the foundation for further research on the molecular toxicological mechanism of TSN in S. frugiperda larvae.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Arthur Mathes, Merve Busra Duman, Alexander Neumann, Gergana Dobreva, Thomas Schmidt
Summary: The study found that treatment with S-adenosylmethionine (SAM) can alter the methylation profiles of H3K4me3 and H3K27me3 in prostate cancer cells, regulating the biological processes and gene expression associated with cancer, and exhibiting anticancer effects.
Article
Genetics & Heredity
Aneeshkumar Gopalakrishnan Arimbasseri, Ashutosh Shukla, Ashis Kumar Pradhan, Purnima Bhargava
Summary: Covalent modifications, such as histone acetylations, are associated with transcriptionally active chromatin regions. Pol III-transcribed genes are repressed under stress conditions, and this repression is linked to increased histone acetylations. A nucleosome in the upstream region of the SNR6 gene plays a regulatory role during repression, with different dynamics of H3K9 and H3K14 acetylations. The increase in acetylations on this nucleosome may be part of the signaling mechanisms preparing cells for stress-related repression and reactivation.
Article
Genetics & Heredity
Gurjit Singh, InSug O-Sullivan, Arivarasu Natarajan Anbazhagan, K. C. Ranjan, Zeba Farooqui, Kaige Ma, Jun Wang, Fackson Mwale, Gina Votta-Velis, Benjamin Bruce, C. Ronald Kahn, Andre J. van Wijnen, Hee-Jeong Im
Summary: Pain is the main symptom of osteoarthritis, and protein kinase C8 plays a critical role in osteoarthritis-related pain. Both global knockout and sensory neuron-specific knockout of PKC8 exacerbate osteoarthritis-related pain, and this is associated with specific pain mediators.
Article
Genetics & Heredity
Martin L. Katz, James Cook, Charles H. Vite, Rebecca S. Campbell, Lyndon M. Coghill, Leslie A. Lyons
Summary: This article describes a neurologic evaluation of a 6-month-old cat with progressive motor impairment. Whole genome sequence analysis identified a mutation in the MANBA gene that resulted in the loss of beta-mannosidase activity and caused beta-mannosidosis. Postmortem examination revealed significant accumulation of vacuolar inclusions in the cat's brain tissue.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Review
Genetics & Heredity
Mohammad Housini, Begum Dariya, Nadia Ahmed, Alyssa Stevens, Hope Fiadjoe, Ganji Purnachandra Nagaraju, Riyaz Basha
Summary: Colorectal cancer is a serious global health issue with high incidence and mortality rates. Early diagnosis and effective therapeutic strategies are urgently needed. This review article focuses on the dysregulated signaling pathways, genetic and epigenetic alterations, and crucial biomarkers of CRC, and provides information on relevant clinical trials.
Article
Genetics & Heredity
Aline Portantiolo Lettnin, Eduardo Felipe Wagner, Mariana Teixeira Santos Figueiredo Salgado, Andres Delgado Canedo, Vivian Mary Rumjanek, Gilma Santos Trindade, Ana Paula de Souza Votto
Summary: The present study aimed to evaluate the expression profile of genes related to stem cells characteristics during the acquisition of multidrug resistance phenotype in chronic myeloid leukemia. The results showed a direct relationship between the expression of ABCB1 and OCT4 genes in drug-resistant cells, and an inverse relationship between the expression of ALOX5 and ABCB1 genes.
Article
Genetics & Heredity
Xiaohu Wang, Rui Wang, Shang He, Yuting Weng, Baofeng Lan, Liqin Zhou, Hui Yang
Summary: The aim of this study was to isolate and identify native Bacillus from citrus fruits with inhibition phenotypes to Penicillium sp. Results showed that Bacillus velezensis wr8 could produce antifungal compounds to inhibit the growth of Penicillium sp. and suppress disease development on citrus fruits. Additionally, antimicrobial compounds were also produced to inhibit the growth of Escherichia coli.
Article
Genetics & Heredity
Nuket Bilgen, Mervenur Guvendi, Efe Sezgin, Huseyin Can, Ahmet Efe Koseoglu, Sedef Erkunt Alak, Mert Doskaya, Cemal Un
Summary: This study investigated the mitochondrial DNA diversity in random bred cats from various regions across Turkey and compared it with the mitochondrial DNA profiles of Turkish Angora and Turkish Van breeds. The analysis identified nine 'universal' mitochondrial DNA profiles and one 'outlier' profile in random bred cats. The haplotype structure in random bred cats showed remarkable diversity compared to Turkish Angora and Van breeds. Overall, this study expands our understanding of the feline genetic landscape in Turkey and lays the foundation for future research on the evolutionary trajectories and genetic legacies of these feline populations.
Review
Genetics & Heredity
Zohreh Harsij, Zahra Ghafoorzadeh, Elahe Goharian
Summary: A biotechnological revolution is triggered by the versatility, accuracy, and efficiency of CRISPR-Cas systems. Diagnosing nucleic acid biomarkers using CRISPR is a highly sensitive method. It can detect a wide range of infectious and non-infectious diseases, mutations, and CRISPR deletions associated with genetic disorders. Additionally, this technology has applications in protein and micromolecule testing. However, despite its many contributions to biomedical science, CRISPR technology has negative impacts on the health of living organisms, environmental conditions, and population structures.
Article
Genetics & Heredity
Niloufar Salimian, Maryam Peymani, Kamran Ghaedi, Mehrdad Hashemi, Ebrahim Rahimi
Summary: This study evaluated changes in the expression levels of collagen family genes related to EMT and metastasis in gastric, breast, and colorectal cancers, identifying COL11A1 and COL1A1 as common diagnostic biomarkers for these three types of cancer.
Article
Genetics & Heredity
Shanshan Han, Qiong Wang, Meiqi Cheng, Yue Hu, Pei Liu, Wanle Hou, Liang Liang
Summary: USH2A gene mutations are the main cause of Usher syndrome type 2 and non-syndromic RP. This study investigated the pathological mechanisms of RP using a zebrafish model and found that the knockout of ush2a may affect vesicle transport, leading to structural and functional damage of photoreceptor cells.
