Gastroenterology & Hepatology

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Review Gastroenterology & Hepatology

BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update

Maria Reig, Alejandro Forner, Jordi Rimola, Joana Ferrer-Fabrega, Marta Burrel, Angeles Garcia-Criado, Robin K. Kelley, Peter R. Galle, Vincenzo Mazzaferro, Riad Salem, Bruno Sangro, Amit G. Singal, Arndt Vogel, Josep Fuster, Carmen Ayuso, Jordi Bruix

Summary: There have been significant advances in the treatment strategies for hepatocellular carcinoma since the last update in 2018. However, some interventions still lack sufficient data for clinical incorporation, and personalized clinical management requires consideration of multiple parameters.

JOURNAL OF HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Global, regional, and national burden of hepatitis B, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

Brittney S. Sheena, Lindsey Hiebert, Hannah Han, Helen Ippolito, Mohsen Abbasi-Kangevari, Zeinab Abbasi-Kangevari, Hedayat Abbastabar, Amir Abdoli, Hiwa Abubaker Ali, Mesafint Molla Adane, Oyelola A. Adegboye, Qorinah Estiningtyas Sakilah Adnani, Shailesh M. Advani, Muhammad Sohail Afzal, Saira Afzal, Mohamad Aghaie Meybodi, Bahman Ahadinezhad, Bright Opoku Ahinkorah, Sajjad Ahmad, Tauseef Ahmad, Sepideh Ahmadi, Haroon Ahmed, Muktar Beshir Ahmed, Tarik Ahmed Rashid, Gizachew Taddesse Akalu, Addis Aklilu, Tayyaba Akram, Hanadi Al Hamad, Fares Alahdab, Adugnaw Zeleke Alem, Dejene Tsegaye Alem, Fadwa Alhalaiqa Naji Alhalaiqa, Robert Kaba Alhassan, Liaqat Ali, Muhammad Ashar Ali, Yousef Alimohamadi, Vahid Alipour, Motasem Alkhayyat, Sami Almustanyir, Rajaa M. Al-Raddadi, Haya Altawalah, Saeed Amini, Hubert Amu, Robert Ancuceanu, Catalina Liliana Andrei, Tudorel Andrei, Amir Anoushiravani, Adnan Ansar, Anayochukwu Edward Anyasodor, Jalal Arabloo, Morteza Arab-Zozani, Ayele Mamo Argaw, Zeleke Gebru Argaw, Muhammad Arshad, Anton A. Artamonov, Tahira Ashraf, Daniel Atlaw, Floriane Ausloos, Marcel Ausloos, Sina Azadnajafabad, Mohammadreza Azangou-Khyavy, Amirhossein Azari Jafari, Ghasem Azarian, Sayna Bagheri, Saeed Bahadory, Atif Amin Baig, Maciej Banach, Nastaran Barati, Amadou Barrow, Abdul-Monim Mohammad Batiha, Diana Fernanda Bejarano Ramirez, Uzma Iqbal Belgaumi, Alemshet Yirga Berhie, Devidas S. Bhagat, Nikha Bhardwaj, Pankaj Bhardwaj, Krittika Bhattacharyya, Vijayalakshmi S. Bhojaraja, Ali Bijani, Antonio Biondi, Belay Boda Abule Bodicha, Hunduma Amensisa Bojia, Archith Boloor, Cristina Bosetti, Dejana Braithwaite, Nikolay Ivanovich Briko, Zahid A. Butt, Luis Alberto Camera, Raja Chandra Chakinala, Promit Ananyo Chakraborty, Jaykaran Charan, Shu Chen, Jee-Young Jasmine Choi, Sonali Gajanan Choudhari, Fazle Rabbi Chowdhury, Dinh-Toi Chu, Sheng-Chia Chung, Paolo Angelo Cortesi, Benjamin C. Cowie, Garland T. Culbreth, Omid Dadras, Xiaochen Dai, Lalit Dandona, Rakhi Dandona, Fernando Pio De la Hoz, Sisay Abebe Debela, Mohammed Gebre Dedefo, Feleke Mekonnen Demeke, Takele Gezahegn G. Demie, Getu Debalkie Demissie, Meseret Derbew Molla, Abebaw Alemayehu Desta, Deepak Dhamnetiya, Mandira Lamichhane Dhimal, Meghnath Dhimal, Mojtaba Didehdar, Linh Phuong Doan, Fariba Dorostkar, Thomas M. Drake, Fatemeh Eghbalian, Michael Ekholuenetale, Iman El Sayed, Maysaa El Sayed Zaki, Muhammed Elhadi, Mohamed A. Elmonem, Aisha Elsharkawy, Shymaa Enany, Daniel Berhanie Enyew, Ryenchindorj Erkhembayar, Sharareh Eskandarieh, Firooz Esmaeilzadeh, Sayeh Ezzikouri, Hossein Farrokhpour, Getahun Fetensa, Florian Fischer, Masoud Foroutan, Mohamed M. Gad, Abhay Motiramji Gaidhane, Shilpa Gaidhane, Natalie C. Galles, Silvano Gallus, Teferi Gebru Gebremeskel, Eyob Alemayehu Gebreyohannes, Keyghobad Ghadiri, Kazem Ghaffari, Mansour Ghafourifard, Seyyed-Hadi Ghamari, Ahmad Ghashghaee, Ali Gholami, Abdolmajid Gholizadeh, Aima Gilani, Amit Goel, Mahaveer Golechha, Pouya Goleij, Davide Golinelli, Giuseppe Gorini, Yitayal Ayalew Goshu, Max G. Griswold, Mohammed Ibrahim Mohialdeen Gubari, Bhawna Gupta, Sapna Gupta, Veer Bala Gupta, Vivek Kumar Gupta, Rasool Haddadi, Rabih Halwani, Saeed S. Hamid, Samer Hamidi, Asif Hanif, Shafiul Haque, Harapan Harapan, Arief Hargono, Sanam Hariri, Ahmed Hasaballah, S. M. Mahmudul Hasan, Soheil Hassanipour, Hadi Hassankhani, Simon Hay, Khezar Hayat, Golnaz Heidari, Claudiu Herteliu, Demisu Zenbaba Heyi, Kamal Hezam, Ramesh Holla, Mohammad-Salar Hosseini, Mostafa Hosseini, Mehdi Hosseinzadeh, Mihaela Hostiuc, Mowafa Househ, Junjie Huang, Nawfal R. Hussein, Ivo Iavicoli, Segun Emmanuel Ibitoye, Olayinka Stephen Ilesanmi, Irena M. Ilic, Milena D. Ilic, Lalu Muhammad Irham, Jessica Y. Islam, Nahlah Elkudssiah Ismail, Kathryn H. Jacobsen, Farhad Jadidi-Niaragh, Amirreza Javadi Mamaghani, Shubha Jayaram, Ranil Jayawardena, Rime Jebai, Ravi Prakash Jha, Nitin Joseph, Farahnaz Joukar, Billingsley Kaambwa, Ali Kabir, Zubair Kabir, Rohollah Kalhor, Himal Kandel, Tesfaye K. Tesfaye Kanko, Rami S. Kantar, Ibraheem M. Karaye, Bekalu Getnet Kassa, Phillip M. Kemp Bohan, Mohammad Keykhaei, Yousef Saleh Khader, Himanshu Khajuria, Gulfaraz Khan, Imteyaz A. Khan, Junaid Khan, Moien Ab Khan, Javad Khanali, Amir M. Khater, Mahalaqua Nazli Khatib, Mahmoud Khodadost, Abdullah T. Khoja, Omid Khosravizadeh, Jagdish Khubchandani, Gyu Ri Kim, Hanna Kim, Min Seo Kim, Yun Jin Kim, Jonathan M. Kocarnik, Ali-Asghar Kolahi, Rajasekaran Koteeswaran, G. Anil Kumar, Carlo La Vecchia, Dharmesh Kumar Lal, Ivan Landires, Savita Lasrado, Jeffrey Lazarus, Caterina Ledda, Doo Woong Lee, Sang-woong Lee, Yeong Yeh Lee, Miriam Levi, Jiarui Li, Stephen S. Lim, Stany W. Lobo, Platon D. Lopukhov, Joana A. Loureiro, Jennifer H. MacLachlan, Hassan Magdy Abd El Razek, Muhammed Magdy Abd El Razek, Azeem Majeed, Alaa Makki, Mohammad-Reza Malekpour, Reza Malekzadeh, Ahmad Azam Malik, Fariborz Mansour-Ghanaei, Mohammad Ali Mansournia, Francisco Rogerlandio Martins-Melo, Philippa C. Matthews, Walter Mendoza, Ritesh G. Menezes, Tuomo J. Meretoja, Amanual Getnet Mersha, Tomislav Mestrovic, Ted R. Miller, Le Huu Nhat Minh, Andreea Mirica, Seyyedmohammadsadeq Mirmoeeni, Erkin M. Mirrakhimov, Sanjeev Misra, Prasanna Mithra, Babak Moazen, Ashraf Mohamadkhani, Mokhtar Mohammadi, Shafiu Mohammed, Nagabhishek Moka, Ali H. Mokdad, Jalal Moludi, Sara Momtazmanesh, Lorenzo Monasta, Ghobad Moradi, Maliheh Moradzadeh, Rahmatollah Moradzadeh, Paula Moraga, Ebrahim Mostafavi, Sumaira Mubarik, Malaisamy Muniyandi, Christopher J. L. Murray, Mohsen Naghavi, Mukhammad David Naimzada, Sreenivas Narasimha Swamy, Zuhair S. Natto, Biswa Prakash Nayak, Javad Nazari, Ionut Negoi, Serban Mircea Negru, Seyed Aria Nejadghaderi, Sandhya Neupane Kandel, Huong Lan Thi Nguyen, Che Henry Ngwa, Robina Khan Niazi, Chukwudi A. Nnaji, Jean Jacques Noubiap, Ali Nowroozi, Virginia Nunez-Samudio, Bogdan Oancea, Chimedsuren Ochir, Oluwakemi Ololade Odukoya, In-Hwan Oh, Andrew T. Olagunju, Babayemi Oluwaseun Olakunde, Ahmed Omar Bali, Emad Omer, Stanislav S. Otstavnov, Bilcha Oumer, Jagadish Rao Padubidri, Adrian Pana, Anamika Pandey, Eun-Cheol Park, Fatemeh Pashazadeh Kan, Urvish K. Patel, Uttam Paudel, Ionela-Roxana Petcu, Zahra Zahid Piracha, Richard Charles G. Pollok, Maarten J. Postma, Akram Pourshams, Hossein Poustchi, Mohammad Rabiee, Navid Rabiee, Alireza Rafiei, Sima Rafiei, Pavan Manibettu Raghuram, Mosiur Rahman, Amir Masoud Rahmani, Setyaningrum Rahmawaty, Aashish Rajesh, Priyanga Ranasinghe, Chythra R. Rao, Sowmya J. Rao, Mahsa Rashidi, Mohammad-Mahdi Rashidi, David Laith Rawaf, Salman Rawaf, Reza Rawassizadeh, Negar Rezaei, Aziz Rezapour, Sahba Rezazadeh-Khadem, Jefferson Antonio Buendia Rodriguez, Godfrey M. Rwegerera, Siamak Sabour, Basema Saddik, Mohammad Reza Saeb, Umar Saeed, Amirhossein Sahebkar, Km Saif-Ur-Rahman, Sarvenaz Salahi, Hamideh Salimzadeh, Chethan Sampath, Abdallah M. Samy, Juan Sanabria, Francesco Sanmarchi, Milena M. Santric-Milicevic, Arash Sarveazad, Brijesh Sathian, Monika Sawhney, Abdul-Aziz Seidu, Sadaf G. Sepanlou, Allen Seylani, Saeed Shahabi, Masood Ali Shaikh, Elaheh Shaker, Murad Ziyaudinovich Shakhmardanov, Mohammed Shannawaz, Suchitra M. Shenoy, Jeevan K. Shetty, Pavanchand H. Shetty, Kenji Shibuya, Jae Il Shin, Parnian Shobeiri, Migbar Mekonnen Sibhat, Achintya Dinesh Singh, Jasvinder A. Singh, Surjit Singh, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, Amir Ali Sohrabpour, Suhang Song, Seidamir Pasha Tabaeian, Eyayou Girma Tadesse, Majid Taheri, Mircea Tampa, Ker-Kan Tan, Ahmad Tavakoli, Abdelghani Tbakhi, Belay Negash Tefera, Arash Tehrani-Banihashemi, Habtamu Molla Tesfaw, Rekha Thapar, Aravind Thavamani, Seyed Abolfazl Tohidast, Daniel Nigusse Tollosa, Maria Elena Tosti, Marcos Roberto Tovani-Palone, Eugenio Traini, Mai Thi Ngoc Tran, Indang Trihandini, Biruk Shalmeno Tusa, Irfan Ullah, Marco Vacante, Sahel Valadan Tahbaz, Pascual R. Valdez, Shoban Babu Varthya, Bay Vo, Yasir Waheed, Adisu Birhanu Weldesenbet, Melat Woldemariam, Suowen Xu, Seyed Hossein Yahyazadeh Jabbari, Mehdi Yaseri, Yigizie Yeshaw, Vahit Yigit, Birhanu Wubale Yirdaw, Naohiro Yonemoto, Chuanhua Yu, Ismaeel Yunusa, Mazyar Zahir, Leila Zaki, Mohammad Zamani, Maryam Zamanian, Mikhail Sergeevich Zastrozhin, Theo Vos, John W. Ward, M. Ashworth Dirac

Summary: This study estimated the global, regional, and national prevalence of HBV, as well as mortality and DALYs due to HBV in 2019. It found a decline in HBV infection rates in different age groups, but an increase in HBV-related deaths. Many countries have reached the target for HBV infection rates in children, but targets for reducing deaths and cases have not been met, and progress needs to be accelerated to achieve the 2030 goals.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Baveno VII - Renewing consensus in portal hypertension

Roberto de Franchis, Jaime Bosch, Guadalupe Garcia-Tsao, Thomas Reiberger, Cristina Ripoll

Summary: The Baveno VII workshop focused on personalized care for portal hypertension in patients with compensated cirrhosis or cACLD, discussing various aspects including diagnosis, treatment, and prevention measures in 9 main topics, resulting in a series of consensus recommendations.

JOURNAL OF HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Gut microbiome and health: mechanistic insights

Willem M. de Vos, Herbert Tilg, Matthias Van Hul, Patrice D. Cani

Summary: The gut microbiota plays a crucial role in regulating host health and its deviations are linked with various diseases. Understanding the molecular aspects of the gut microbiota's influence on health can lead to the development of novel therapies.

GUT (2022)

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Article Gastroenterology & Hepatology

Endoscopic submucosal dissection for superficial gastrointestinal lesions: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022

Pedro Pimentel-Nunes, Diogo Libanio, Barbara A. J. Bastiaansen, Pradeep Bhandari, Raf Bisschops, Michael J. Bourke, Gianluca Esposito, Arnaud Lemmers, Roberta Maselli, Helmut Messmann, Oliver Pech, Mathieu Pioche, Michael Vieth, Bas L. A. M. Weusten, Jeanin E. van Hooft, Pierre H. Deprez, Mario Dinis-Ribeiro

Summary: This guideline provides recommendations for the evaluation and treatment of superficial gastrointestinal lesions. It suggests that experienced endoscopists should use high definition white-light and chromoendoscopy for evaluation and recommends endoscopic submucosal dissection for most lesions. Different treatment approaches are suggested for specific situations. The guideline also provides recommendations for post-resection surveillance and treatment.

ENDOSCOPY (2022)

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Review Gastroenterology & Hepatology

The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis

Kiarash Riazi, Hassan Azhari, Jacob H. Charette, Fox E. Underwood, James A. King, Elnaz Ehteshami Afshar, Mark G. Swain, Stephen E. Congly, Gilaad G. Kaplan, Abdel-Aziz Shaheen

Summary: The prevalence and incidence of non-alcoholic fatty liver disease (NAFLD) are significantly increasing worldwide, with higher rates in men compared to women. Greater awareness and cost-effective risk stratification strategies are needed to address the growing burden of NAFLD.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Advancing the global public health agenda for NAFLD: a consensus statement

Jeffrey Lazarus, Henry E. Mark, Quentin M. Anstee, Juan Pablo Arab, Rachel L. Batterham, Laurent Castera, Helena Cortez-Pinto, Javier Crespo, Kenneth Cusi, M. Ashworth Dirac, Sven Francque, Jacob George, Hannes Hagstrom, Terry T-K Huang, Mona H. Ismail, Achim Kautz, Shiv Kumar Sarin, Rohit Loomba, Veronica Miller, Philip N. Newsome, Michael Ninburg, Ponsiano Ocama, Vlad Ratziu, Mary Rinella, Diana Romero, Manuel Romero-Gomez, Jorn M. Schattenberg, Emmanuel A. Tsochatzis, Luca Valenti, Vincent Wai-Sun Wong, Yusuf Yilmaz, Zobair M. Younossi, Shira Zelber-Sagi

Summary: Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease that affects a significant portion of the global adult population, but has received little attention from the global public health community. This has led to a lack of inclusion of NAFLD in national and international strategies and policies for non-communicable diseases, highlighting the need for a more comprehensive public health response to the disease.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

ECCO Guidelines on Therapeutics in Ulcerative Colitis: Medical Treatment

Tim Raine, Stefanos Bonovas, Johan Burisch, Torsten Kucharzik, Michel Adamina, Vito Annese, Oliver Bachmann, Dominik Bettenworth, Maria Chaparro, Wladyslawa Czuber-Dochan, Piotr Eder, Pierre Ellul, Catarina Fidalgo, Gionata Fiorino, Paolo Gionchetti, Javier P. Gisbert, Hannah Gordon, Charlotte Hedin, Stefan Holubar, Marietta Iacucci, Konstantinos Karmiris, Konstantinos Katsanos, Uri Kopylov, Peter L. Lakatos, Theodore Lytras, Ivan Lyutakov, Nurulamin Noor, Gianluca Pellino, Daniele Piovani, Edoardo Savarino, Francesco Selvaggi, Bram Verstockt, Antonino Spinelli, Yves Panis, Glen Doherty

JOURNAL OF CROHNS & COLITIS (2022)

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Article Gastroenterology & Hepatology

Global burden of primary liver cancer in 2020 and predictions to 2040

Harriet Rumgay, Melina Arnold, Jacques Ferlay, Olufunmilayo Lesi, Citadel J. Cabasag, Jerome Vignat, Mathieu Laversanne, Katherine A. McGlynn, Isabelle Soerjomataram

Summary: The burden of liver cancer varies across the world, and it is a major cause of death in many countries. The number of liver cancer cases and deaths is predicted to increase, with a significant rise expected by 2040.

JOURNAL OF HEPATOLOGY (2022)

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Review Gastroenterology & Hepatology

The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review

Zobair M. Younossi, Pegah Golabi, James M. Paik, Austin Henry, Catherine Van Dongen, Linda Henry

Summary: A comprehensive meta-analysis was conducted to assess the global and regional prevalence, incidence, and mortality of non-alcoholic fatty liver disease (NAFLD). The results showed that the global prevalence of NAFLD is 30% and increasing, highlighting the need for urgent and comprehensive strategies to raise awareness and address NAFLD on local, regional, and global levels.

HEPATOLOGY (2023)

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Article Gastroenterology & Hepatology

ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease

Philip O. Katz, Kerry B. Dunbar, Felice H. Schnoll-Sussman, Katarina B. Greer, Rena Yadlapati, Stuart Jon Spechler

Summary: This article provides updated recommendations and practical guidance for the evaluation and management of GERD, including pharmacologic, lifestyle, surgical, and endoscopic management. The use of proton pump inhibitors (PPIs) has raised concerns about long-term safety and overprescribing. New data regarding surgical and endoscopic interventions have also emerged.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2022)

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Article Gastroenterology & Hepatology

Global change in hepatitis C virus prevalence and cascade of care between 2015 and 2020: a modelling study

Sarah Blach, Norah A. Terrault, Frank Tacke, Ivane Gamkrelidze, Antonio Craxi, Junko Tanaka, Imam Waked, Gregory J. Dore, Zaigham Abbas, Ayat R. Abdallah, Maheeba Abdulla, Alessio Aghemo, Inka Aho, Ulus S. Akarca, Abduljaleel M. Alalwan, Marianne Alanko Blome, Said A. Al-Busafi, Soo Aleman, Abdullah S. Alghamdi, Waleed K. Al-Hamoudi, Abdulrahman A. Aljumah, Khalid Al-Naamani, Yousif M. Al Serkal, Ibrahim H. Altraif, Anil C. Anand, Motswedi Anderson, Monique Andersson, Kostas Athanasakis, Oidov Baatarkhuu, Shokhista R. Bakieva, Ziv Ben-Ari, Fernando Bessone, Mia J. Biondi, Abdul Rahman N. Bizri, Carlos E. Brandaoo Mello, Krestina Brigida, Kimberly A. Brown, Robert S. Brown, Philip Bruggmann, Maurizia R. Brunetto, Dana Busschots, Maria Buti, Maia Butsashvili, Joaquin Cabezas, Chungman Chae, Viktorija Chaloska Ivanova, Henry Lik Yuen Chan, Hugo Cheinquer, Kent Jason Cheng, Myeong Eun Cheon, Cheng Hung Chien, Rong Nan Chien, Gourdas Choudhuri, Peer Brehm Christensen, Wan Long Chuang, Vladimir Chulanov, Laura E. Cisneros, Barbara Coco, Fernando A. Contreras, Markus Cornberg, Matthew E. Cramp, Javier Crespo, Fuqiang Cui, Chris W. Cunningham, Lucy Dagher Abou, Olav Dalgard, Doan Y. Dao, Victor De Ledinghen, Moutaz F. Derbala, Keshab Deuba, Karan Dhindsa, Samsuridjal Djauzi, Sylvia Drazilova, Ann Sofi Duberg, Mohammed Elbadri, Manal H. El-Sayed, Gamal Esmat, Chris Estes, Sameera Ezzat, Martti A. Farkkila, Laurent Ferradini, Maria Lucia G. Ferraz, Paulo R. Abrao Ferreira, Tajana Filipec Kanizaj, Robert Flisiak, Sona Frankova, James Fung, Amiran Gamkrelidze, Edward J. Gane, Virginia Garcia, Javier Garcia-Samaniego, Manik Gemilyan, Jordan Genov, Liliana S. Gheorghe, Pierre M. Gholam, Adrian Goldis Null, Magnus Gottfredsson, Richard T. Gray, Jason Grebely, Michael Gschwantler, Behzad Hajarizadeh, Saeed S. Hamid, Waseem Hamoudi, Angelos Hatzakis, Margaret E. Hellard, Sayed Himatt, Harald Hofer, Irena Hrstic, Bela Hunyady, Petr Husa, Azra Husic-Selimovic, Wasim S. M. Jafri, Martin Janicko, Naveed Z. Janjua, Peter Jarcuska, Jerzy Jaroszewicz, Anna Jerkeman, Agita Jeruma, Jidong Jia, Jon G. Jonasson, Martin Kaberg, Kelly D. E. Kaita, Kulpash S. Kaliaskarova Null, Jia Horng Kao, Omor T. Kasymov, Angela Kelly Hanku, Faryal Khamis, Jawad Khamis, Aamir G. Khan, Lekey Khandu, Ibtissam Khoudri, Knut B. Kielland, Do Young Kim, Nicolas Kodjoh, Loreta A. Kondili, Mel Krajden, Henrik Bygum Krarup, Pavol Kristian, Jisoo A. Kwon, Martin Lagging, Wim Laleman, Wai Cheung Lao, Daniel Lavanchy, Pablo Lazaro, Jeffrey Lazarus, Alice U. Lee, Mei Hsuan Lee, Michael K. K. Li, Valentina Liakina, Young Suk Lim, Arthur Love, Boris Luksic, Shepherd Mufudzi Machekera, Abraham O. Malu, Rui T. Marinho, Mojca Maticic, Hailemichael D. Mekonnen, Maria Cassia Mendes-Correa, Nahum Mendez-Sanchez, Shahin Merat, Berhane Redae Meshesha, Havard Midgard, Mike Mills, Rosmawati Mohamed, Ellen Mooneyhan, Christophe Moreno, David H. Muljono, Beat Mullhaupt, Erkin Musabaev, Gaetan Muyldermans, Yvonne Ayerki Nartey, Marcelo C. M. Naveira, Francesco Negro, Alexander Nersesov, Richard Njouom, Renovat Ntagirabiri, Zuridin S. Nurmatov, Solomon A. Obekpa, Stephen Oguche, Sigurdur Olafsson, Janus P. Ong, Ohene K. Opare-Sem, Mauricio Orrego, Anne L. Ovrehus, Calvin Q. Pan, George Papatheodoridis, Markus Peck-Radosavljevic, Mario G. Pessoa, Richard O. Phillips, Nikolay Pimenov, Dijana Plaseska-Karanfilska, Nishi N. Prabdial-Sing, Pankaj Puri, Huma Qureshi Null, Aninda Rahman, Alnoor Ramji, Devin M. Razavi-Shearer, Kathryn Razavi-Shearer, Ezequiel Ridruejo, Cielo Y. Rios-Hincapie, S. M. Shahriar Rizvi, Geert K. M. M. Robaeys, Lewis R. Roberts, Stuart K. Roberts, Stephen D. Ryder, Shakhlo Sadirova, Umar Saeed, Rifaat Safadi, Olga Sagalova, Sanaa S. Said, Riina Salupere, Faisal M. Sanai, Juan F. Sanchez-Avila, Vivek A. Saraswat, Christoph Sarrazin, Gulya Sarybayeva, Carole Seguin-Devaux, Ala Sharara, Mahdi Sheikh, Abate B. Shewaye, William Sievert, Kaarlo Simojoki, Marieta Y. Simonova, Mark W. Sonderup, C. Wendy Spearman, Jan Sperl, Rudolf E. Stauber, Catherine A. M. Stedman, Tung Hung Su, Anita Suleiman, Vana Sypsa, Natalia Tamayo Antabak, Soek Siam Tan, Tammo L. Tergast, Prem H. Thurairajah, Ieva Tolmane, Krzysztof Tomasiewicz, Maia Tsereteli, Benjamin S. C. Uzochukwu, David A. M. C. Van de Vijver, Daniela K. van Santen, Hans Van Vlierberghe, Berend Van Welzen, Thomas Vanwolleghem, Patricia Velez-Moller, Federico Guillermo Villamil, Adriana Vince, Yasir Waheed, Nina Weis, Vincent W. S. Wong, Cesar G. Yaghi, Kakharman Yesmembetov, Ayman Yosry, Man Fung Yuen, Evy Yunihastuti, Stefan Zeuzem, Eli Zuckerman, Homie A. Razavi

Summary: This study aims to evaluate the burden of hepatitis C virus (HCV) in 2020 and forecast the burden by 2030. Using literature review, Delphi process, and mathematical modelling, it estimated the global prevalence of viraemic HCV infection to be 0.7% in 2020, corresponding to 56.8 million infections. The findings suggest that the current efforts are not on track to achieve the global elimination targets by 2030.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome

Qin Liu, Joyce Wing Yan Mak, Qi Su, Yun Kit Yeoh, Grace Chung-Yan Lui, Susanna So Shan Ng, Fen Zhang, Amy Y. L. Li, Wenqi Lu, David Shu-Cheong Hui, Paul K. S. Chan, Francis K. L. Chan, Siew C. Ng

Summary: This study investigated the link between gut microbiome composition and post-acute COVID-19 syndrome. The results showed that the gut microbiome of patients with long-term complications of COVID-19 differed significantly from that of non-COVID-19 controls and patients without post-acute COVID-19 syndrome.

GUT (2022)

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Review Gastroenterology & Hepatology

Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms

Patrice D. Cani, Clara Depommier, Muriel Derrien, Amandine Everard, Willem M. de Vos

Summary: This article reviews the discovery of Akkermansia muciniphila and its association with health and disease. Studies have shown that A. muciniphila can improve health through various mechanisms and comparisons are made with other next-generation beneficial microorganisms.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2021

Anne F. Peery, Seth D. Crockett, Caitlin C. Murphy, Elizabeth T. Jensen, Hannah P. Kim, Matthew D. Egberg, Jennifer L. Lund, Andrew M. Moon, Virginia Pate, Edward L. Barnes, Courtney L. Schlusser, Todd H. Baron, Nicholas J. Shaheen, Robert S. Sandler

Summary: Gastrointestinal diseases in the United States result in significant healthcare utilization and expenditures, with millions of healthcare encounters and hundreds of thousands of deaths each year. To address this burden, focused clinical and public health efforts, along with increased research funding, are necessary.

GASTROENTEROLOGY (2022)

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Article Gastroenterology & Hepatology

Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN

Eileen Morgan, Melina Arnold, A. Gini, V Lorenzoni, C. J. Cabasag, Mathieu Laversanne, Jerome Vignat, Jacques Ferlay, Neil Murphy, Freddie Bray

Summary: Colorectal cancer is the third most common cancer worldwide, with the highest incidence rates in Australia/New Zealand and Europe, and the lowest rates in Africa and Southern Asia. The burden of colorectal cancer is projected to increase by 2040, with the majority of cases predicted to occur in high HDI countries.

GUT (2023)

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Review Gastroenterology & Hepatology

2019 Global NAFLD Prevalence: A Systematic Review and Meta-analysis

Michael H. Le, Yee Hui Yeo, Xiaohe Li, Jie Li, Biyao Zou, Yuankai Wu, Qing Ye, Daniel Q. Huang, Changqing Zhao, Jie Zhang, Chenxi Liu, Na Chang, Feng Xing, Shiping Yan, Zi Hui Wan, Natasha Sook Yee Tang, Maeda Mayumi, Xinting Liu, Chuanli Liu, Fajuan Rui, Hongli Yang, Yao Yang, Ruichun Jin, Richard H. X. Le, Yayun Xu, David M. Le, Scott Barnett, Christopher Donald Stave, Ramsey Cheung, Qiang Zhu, Mindie H. Nguyen

Summary: This study aimed to determine the global and regional prevalence trends of NAFLD. The results showed that the overall prevalence of NAFLD is increasing, despite regional variations. South America and North America have the highest prevalence rates. The study suggests that policy makers should increase awareness of NAFLD and promote healthy lifestyle environments to reverse this trend.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report

Peter Malfertheiner, Francis Megraud, Theodore Rokkas, Javier P. Gisbert, Jyh-Ming Liou, Christian Schulz, Antonio Gasbarrini, Richard H. Hunt, Marcis Leja, Colm O'Morain, Massimo Rugge, Sebastian Suerbaum, Herbert Tilg, Kentaro Sugano, Emad M. El-Omar

Summary: Helicobacter pylori infection is recognized as an infectious disease and requires optimized management to prevent complications and gastric cancer. Continuous updates in treatment strategies and testing methods are necessary due to rising antibiotic resistance and the impact on gut microbiota.

GUT (2022)

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Article Gastroenterology & Hepatology

High-Fat Diet Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites

Jia Yang, Hong Wei, Yunfei Zhou, Chun-Ho Szeto, Chuangen Li, Yufeng Lin, Olabisi O. Coker, Harry Cheuk Hay Lau, Anthony W. H. Chan, Joseph J. Y. Sung, Jun Yu

Summary: High-fat diet drives colorectal tumorigenesis in mice by inducing gut microbial dysbiosis, metabolomic dysregulation with elevated lysophosphatidic acid, and gut barrier dysfunction. Antibiotics can attenuate the promoting effect of high-fat diet on colorectal tumorigenesis.

GASTROENTEROLOGY (2022)

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Article Gastroenterology & Hepatology

Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis

Ferenc Emil Mozes, Jenny A. Lee, Emmanuel Anandraj Selvaraj, Arjun Narayan Ajmer Jayaswal, Michael Trauner, Jerome Boursier, Celine Fournier, Katharina Staufer, Rudolf E. Stauber, Elisabetta Bugianesi, Ramy Younes, Silvia Gaia, Monica Lupsor-Platon, Salvatore Petta, Toshihide Shima, Takeshi Okanoue, Sanjiv Mahadeva, Wah-Kheong Chan, Peter J. Eddowes, Gideon M. Hirschfield, Philip Noel Newsome, Vincent Wai-Sun Wong, Victor de Ledinghen, Jiangao Fan, Feng Shen, Jeremy F. Cobbold, Yoshio Sumida, Akira Okajima, Joern M. Schattenberg, Christian Labenz, Won Kim, Myoung Seok Lee, Johannes Wiegand, Thomas Karlas, Yusuf Yilmaz, Guruprasad Padur Aithal, Naaventhan Palaniyappan, Christophe Cassinotto, Sandeep Aggarwal, Harshit Garg, Geraldine J. Ooi, Atsushi Nakajima, Masato Yoneda, Marianne Ziol, Nathalie Barget, Andreas Geier, Theresa Tuthill, M. Julia Brosnan, Quentin Mark Anstee, Stefan Neubauer, Stephen A. Harrison, Patrick M. Bossuyt, Michael Pavlides

Summary: Liver biopsy is still necessary for fibrosis staging in patients with non-alcoholic fatty liver disease. This study evaluated the diagnostic performance of liver stiffness measurement, FIB-4 Index, and NAFLD Fibrosis Score, and showed that sequential combinations of markers can reduce the need for liver biopsies.

GUT (2022)

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