Gastroenterology & Hepatology

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Article Gastroenterology & Hepatology

A Novel cause of Massive Hepatosplenomegaly with Fibrosis in two children: Transient Infantile Hypertriglyceridemia

Shruti Sharma, Yash P. Sharma, Kavita Mardi, Ayushi Agarwal, Mukesh Surya

Summary: This article presents two cases of transient infantile hypertriglyceridemia (TIH) from Himachal Pradesh in North India, with no consanguinity or family history. Diagnosis and management of the disease require comprehensive counseling and monitoring for the patients and their families.

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY (2024)

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Review Gastroenterology & Hepatology

Post-transplantation Lymphoproliferative Disorder (PTLD): In the Liver Transplant Recipient

Asisha M. Janeela, Nambiathayil A. Fouzia, Uday G. Zachariah

Summary: Post-transplantation lymphoproliferative disorders (PTLD) are rare neoplasms that occur in the post-transplantation period. Children undergoing liver transplantation are at higher risk of PTLD. Risk factors include immunosuppression and Epstein-Barr virus status. Diagnosis requires clinical suspicion, radiological evaluation, and tissue biopsy. Risk reduction involves minimizing aggressive immunosuppressive regimens and early treatment.

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY (2024)

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Article Gastroenterology & Hepatology

Autoimmune Hepatitis Pathophysiology

Zhou Yuming, Tang Ruqi, Merrill Eric Gershwin, Ma Xiong

CLINICS IN LIVER DISEASE (2024)

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Article Gastroenterology & Hepatology

Treatment of Primary Biliary Cholangitis including Transplantation

Yasameen Muzahim, Ali Wakil, Mehak Bassi, Nikolaos Pyrsopoulos

CLINICS IN LIVER DISEASE (2024)

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Article Gastroenterology & Hepatology

Primary Sclerosing Cholangitis Epidemiology, Diagnosis, and Presentation

Aalam Sohal, Sanya Kayani, Kris Kowdley

Summary: Primary sclerosing cholangitis (PSC) is an immune-mediated liver disease characterized by inflammation and fibrosis of bile ducts. It is commonly associated with inflammatory bowel disease, especially ulcerative colitis. The natural history of the disease varies among patients, but most will develop cirrhosis.

CLINICS IN LIVER DISEASE (2024)

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Article Gastroenterology & Hepatology

Primary Biliary Cholangitis Pathophysiology

Inbal Houri, Gideon M. Hirschfield

CLINICS IN LIVER DISEASE (2024)

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Article Gastroenterology & Hepatology

Treatment of Autoimmune Hepatitis

Aparna Goel, Paul Kwo

Summary: The goal of autoimmune hepatitis treatment is achieving clinical and biochemical remission. Standard care involves induction treatment with corticosteroids and gradual tapering of steroids. Alternatives to standard therapy can be considered for patients with intolerance or inadequate response. Treatment withdrawal is achievable in less than 20% of patients after 2 years of sustained remission, and liver transplantation should be considered for patients with progressive disease or complications.

CLINICS IN LIVER DISEASE (2024)

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Article Gastroenterology & Hepatology

Systemic Complications of Primary Biliary Cholangitis

Mariana Zapata, Hendrick Pagan-Torres, Marlyn J. Mayo

CLINICS IN LIVER DISEASE (2024)

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Article Gastroenterology & Hepatology

Phenotypes of Primary Sclerosing Cholangitis and Differential Diagnosis

Brian H. Horwich, Douglas T. Dieterich

CLINICS IN LIVER DISEASE (2024)

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Article Gastroenterology & Hepatology

Alcohol-associated liver disease: Epidemiology and management

Helena Hernandez-Evole, Natalia Jimenez-Esquivel, Elisa Pose, Ram on Bataller

Summary: Alcohol is the leading cause of preventable morbidity and mortality worldwide, and the most frequent cause of liver disease. Alcohol-associated liver disease has a complex pathogenesis, with unknown precise mechanisms. Currently, there are no targeted therapies to interfere with the disease's progression, making alcohol abstinence the most effective measure to improve prognosis in patients with this disease.

ANNALS OF HEPATOLOGY (2024)

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Letter Gastroenterology & Hepatology

Schistosomiasis: A neglected cause of liver disease in the Philippines

Alexander M. Sy

ANNALS OF HEPATOLOGY (2024)

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Article Gastroenterology & Hepatology

MZF1 promotes tumour progression and resistance to anti-PD- L1 antibody treatment in hepatocellular carcinoma

Anna Kan, Shuang Liu, Minke He, Dongsheng Wen, Haijing Deng, Lichang Huang, Zhicheng Lai, Yexing Huang, Ming Shi

Summary: This study reveals the correlation between the transcription factor MZF1 and the immune checkpoint molecule PD-L1 in hepatocellular carcinoma (HCC). The overexpression of MZF1 is associated with an immunosuppressive environment and decreased T-cell infiltration in HCC. Mechanistically, MZF1 accelerates PD-L1 ubiquitination via the CDK4 pathway. Inhibition of CDK4 may restore PD-L1 expression and enhance the efficacy of anti-PD-L1 antibodies.

JHEP REPORTS (2024)

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Editorial Material Gastroenterology & Hepatology

Peginterferon as Part of a Functional Cure Strategy for Hepatitis B: Is the Juice Worth the Squeeze?

Tiange P. Zhang, Norah A. Terrault

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY (2024)

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Review Gastroenterology & Hepatology

Factors Affecting and Promoting Health-related Quality of Life in Patients With Liver Cirrhosis: An Underestimated Domain in Patient Care

Siddheesh Rajpurohit, Balaji Musunuri, Pooja B. Mohan, Ganesh Bhat, Shiran Shetty

Summary: This study identified various factors affecting and promoting HRQoL in patients with liver cirrhosis, including age, gender, income, BMI, psychological factors, and complications. Physical exercise, liver transplant, stem cell therapy, and some medications were associated with improved HRQoL. More intervention trials and consideration of HRQoL in medical therapy are recommended.

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY (2024)

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Article Gastroenterology & Hepatology

Role of Computed Tomography Perfusion in Patients with Liver Cirrhosis and Hepatocellular Carcinoma

Kartik P. Ganga, Pankaj Gupta, Naveen Kalra, Arunanshu Behra, Rakesh Kapoor, Ajay Duseja, Yogesh Chawla, Manavjit S. Sandhu

Summary: This study aimed to evaluate the association between CT perfusion parameters in cirrhotic patients with and without HCC. The results showed that even the remote background liver parenchyma in patients with HCC had increased hepatic arterial perfusion. The perfusion parameters were also found to be significantly altered with increasing severity of cirrhosis.

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY (2024)

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Article Gastroenterology & Hepatology

Liver Severity Score-Based Modeling to Predict Six-Week Mortality Risk Among Hospitalized Cirrhosis Patients With Upper Gastrointestinal Bleeding

Rochelle Wong, Adam Buckholz, Kaveh Hajifathalian, Catherine Ng, Evan Sholle, Gaurav Ghosh, Russell Rosenblatt, Brett E. Fortune

Summary: This study aims to evaluate and recalibrate the accuracy of Child-Turcotte-Pugh (CTP) and Model-for-End-Stage-Liver Disease (MELD) scores in predicting six-week mortality risk. The results showed that both CTP and MELD-based models have excellent discrimination in predicting six-week mortality for all types of bleeding sources, but only the CTP-based model demonstrates calibration for all bleeding etiology.

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY (2024)

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Article Gastroenterology & Hepatology

Trends of Costs and Admission Rates Among Patients Admitted With Autoimmune Hepatitis: Analysis of US Hospitals Using the NIS Database

David U. Lee, Kimberly Schuster, Aneesh Bahadur, Sophie Schellhammer, Reid Ponder, Emma Mitchell-Sparke, Gregory H. Fan, Harrison Chou, Ki J. Lee, Zurabi Lominadze

Summary: Autoimmune hepatitis is a major cause of chronic liver disease in the United States. This study provides insights into the incidence, mortality, and cost implications of this condition using a national database. The findings show an increase in admissions related to autoimmune hepatitis from 2016 to 2019, particularly among patients with hepatic complications.

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY (2024)

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Editorial Material Gastroenterology & Hepatology

INASL Consensus on Management of HCC: Navigating an Evolving Field

Amit G. Singal, Anjana Pillai, Neehar D. Parikh

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY (2024)

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Letter Gastroenterology & Hepatology

Liver Stiffness Measurement by Acoustic Radiation Force Impulse (ARFI) Post Variceal Bleeding Predicts Further Decompensation in Cirrhosis

Akash Roy, Usha Goenka, Mahesh K. Goenka

Summary: Acoustic radiation force impulse elastography, a method for liver stiffness measurement, can predict future decompensation in patients with cirrhosis. It is comparable to transient elastography and has additional benefits for obese patients and those with ascites.

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY (2024)

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Article Gastroenterology & Hepatology

Rectal Bleed in a Child With Abernathy Malformation- Endovascular Management

Aman Y. Khan, Tara P. Tripathy, Donboklang Lynser, Akash Handique, C. Daniala

Summary: Abernathy malformations are rare congenital conditions that cause metabolic abnormalities and varices. Interventional radiology plays a crucial role in diagnosis and treatment, providing comprehensive management.

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY (2024)

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