Article
Engineering, Biomedical
Yutong Yang, Yongping Liang, Jueying Chen, Xianglong Duan, Baolin Guo
Summary: This study developed a photo-crosslinked multifunctional antibacterial adhesive hemostatic hydrogel dressing that can disinfect drug-resistant bacteria and promote wound healing. Through various tests, it showed good hemostatic and antibacterial properties, and proved to be more effective than current commercially available dressings in treating infected wounds.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Y. Pathak, A. Tiwari, S. Stalin, S. Singh, P. K. Shukla
Summary: The COVID-19 infection is rapidly spreading, but there is a limited availability of testing kits. Thus, the development of COVID-19 testing kits is an ongoing area of research. Recent studies have shown that chest CT images can be used for COVID-19 testing and classification, but predicting bilateral changes poses challenges. In this paper, a deep transfer learning technique is employed along with cost-sensitive attributes to address the issues with noisy and imbalanced COVID-19 dataset. Experimental results demonstrate the effectiveness of the proposed deep transfer learning-based COVID-19 classification model compared to other supervised learning models.
Article
Engineering, Biomedical
N. Narayan Das, N. Kumar, M. Kaur, V Kumar, D. Singh
Summary: This paper discusses the use of real-time polymerase chain reaction (RT-PCR) and radiological imaging techniques (such as chest X-rays and CT scans) for detecting and diagnosing COVID-19. Chest X-rays are preferred due to their availability, lower cost, and lower ionizing radiation compared to CT scans. The paper aims to develop an automated deep transfer learning-based approach using the extreme version of the Inception (Xception) model for COVID-19 detection in chest X-rays.
Article
Engineering, Biomedical
Ines Miranda, Andrews Souza, Paulo Sousa, Joao Ribeiro, Elisabete M. S. Castanheira, Rui Lima, Graca Minas
Summary: This review provides an overview of the properties of PDMS and its applications in the field of micro and nanoengineering. PDMS is widely used in biomedical applications due to its excellent optical, electrical, and mechanical properties, as well as biocompatibility. The introduction of the soft-lithography technique has facilitated the rapid prototyping of micro and nanostructures using PDMS, leading to advances in microfluidics, electronics, and biomedicine.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Engineering, Biomedical
Guoyingre Gu, Ningbin Zhang, Haipeng Xu, Shaoting Lin, Yang Yu, Guohong Chai, Lisen Ge, Houle Yang, Qiwen Shao, Xinjun Sheng, Xiangyang Zhu, Xuanhe Zhao
Summary: A soft and lightweight neuroprosthetic hand that offers simultaneous myoelectric control and tactile feedback outperformed a conventional rigid neuroprosthetic hand in speed and dexterity. The soft neuroprosthetic hand has the potential to help individuals with limb loss regain control and touch sensation.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Xuewei Zhang, Xi Chen, Hua Hong, Rubei Hu, Jiashang Liu, Changsheng Liu
Summary: The application of decellularized extracellular matrix (dECM) scaffolds holds enormous potential for tissue regeneration. These scaffolds provide an optimal non-immune environment with native three-dimensional structures and bioactive components, making them an ideal choice for regenerating functional organs/tissues, especially when combined with stem cells.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Hao Guan, Mingxia Liu
Summary: This paper surveys the recent advances of domain adaptation methods in medical image analysis, presents the motivation of introducing domain adaptation techniques to tackle domain heterogeneity issues in medical image analysis, and reviews the recent domain adaptation models in various medical image analysis tasks.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Computer Science, Interdisciplinary Applications
Richard J. Chen, Ming Y. Lu, Jingwen Wang, Drew F. K. Williamson, Scott J. Rodig, Neal Lindeman, Faisal Mahmood
Summary: This study proposes an interpretable strategy for multimodal fusion of histology image and genomic features for survival outcome prediction. The results on glioma and clear cell renal cell carcinoma datasets demonstrate that this approach improves the prognostic determinations.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Engineering, Biomedical
Mei Zhang, Xiaolin Zhang, Taoran Tian, Qi Zhang, Yuting Wen, Junyao Zhu, Dexuan Xiao, Weitong Cui, Yunfeng Lin
Summary: Gouty arthritis is a common inflammatory arthritis, and controlling inflammation is crucial for prevention. Scientists have synthesized a new material called Cur-TFNAs to enhance the effectiveness and bioavailability of curcumin, a natural anti-inflammatory drug. Cur-TFNAs showed better anti-inflammatory effects in in vivo and in vitro experiments compared with free curcumin.
BIOACTIVE MATERIALS
(2022)
Review
Engineering, Biomedical
Sang Min Won, Le Cai, Philipp Gutruf, John A. Rogers
Summary: This Review Article discusses recent progress in the development of miniaturized and ultralightweight devices for neuroengineering, which are wireless, battery-free, and fully implantable. These devices can restrict natural motions and prevent social interactions in animal models, limiting their utility in behavioural neuroscience research. However, advanced neural interfaces with optical, electrical, or fluidic functionality have emerged, capable of combining recording and stimulation modalities for closed-loop applications in basic studies or the treatment of abnormal physiological processes.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Computer Science, Artificial Intelligence
Huisi Wu, Shihuai Chen, Guilian Chen, Wei Wang, Baiying Lei, Zhenkun Wen
Summary: The study introduces a novel skin lesion segmentation method named FAT-Net, which integrates transformer branch and feature adaptation module to capture long-range dependencies and enhance feature fusion. Experimental results demonstrate the superior accuracy and inference speed of FAT-Net on four public datasets compared to state-of-the-art methods.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Engineering, Biomedical
Farshad Tehrani, Hazhir Teymourian, Brian Wuerstle, Jonathan Kavner, Ravi Patel, Allison Furmidge, Reza Aghavali, Hamed Hosseini-Toudeshki, Christopher Brown, Fangyu Zhang, Kuldeep Mahato, Zhengxing Li, Abbas Barfidokht, Lu Yin, Paul Warren, Nickey Huang, Zina Patel, Patrick P. Mercier, Joseph Wang
Summary: The study presents a fully integrated wearable array of microneedles for wireless and continuous real-time sensing of metabolites in interstitial fluid. The device shows robust analytical performance and good correlation with gold-standard measurements.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Engineering, Biomedical
Amal George Kurian, Rajendra K. Singh, Kapil D. Patel, Jung-Hwan Lee, Hae-Won Kim
Summary: Polymeric hydrogels are fascinating platforms for tissue repair and delivery systems. Methacrylated gelatin (GelMA) is a representative hydrogel formulation that has found various biomedical applications. Recent efforts have focused on combining GelMA with bioactive and functional nanomaterials to enhance its properties and create multifunctional platforms for tissue therapeutics.
BIOACTIVE MATERIALS
(2022)
Review
Engineering, Biomedical
Luke van der Koog, Timea B. Gandek, Anika Nagelkerke
Summary: Liposomes and extracellular vesicles (EVs) are two important nanoparticle drug delivery systems, composed of lipid bilayers and biologically secreted nanoparticles, each with its own advantages. Research has evaluated the differences and similarities in their composition, as well as critical mediators affecting pharmacokinetics; exploring different strategies to tweak their pharmacokinetics further demonstrates the potential advantages of these systems in drug delivery.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Engineering, Biomedical
Tianjiao Zhao, Wei Wu, Lihua Sui, Qiong Huang, Yayun Nan, Jianhua Liu, Kelong Ai
Summary: This article discusses the biology and molecular mechanisms of myocardial ischemia reperfusion injury, and summarizes the application of ROS-based nanoparticles, highlighting the latest advances in nanotechnology research for the treatment of myocardial ischemia reperfusion injury.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Yang Li, Rongzhan Fu, Zhiguang Duan, Chenhui Zhu, Daidi Fan
Summary: A hydrogel with antibacterial and antioxidant properties is developed to treat bacterial-infected wounds. The hydrogel can alleviate the inflammatory response and tissue hypoxia of infected wounds. Additionally, the hydrogel exhibits fast self-healing and shape adaptability.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Xu Xue, Yan Hu, Sicheng Wang, Xiao Chen, Yingying Jiang, Jiacan Su
Summary: Bone tissue engineering provides promising tools for the treatment of bone-related diseases using biomimetic hydrogels. This article discusses the fabrication of biomimetic hydrogels using thermal sensitive polymers, mineral ions, chemically triggered agents, photo crosslinking initiators, and enzyme triggers. These hydrogels accelerate bone regeneration and the article also highlights key factors influencing therapeutic effects.
BIOACTIVE MATERIALS
(2022)
Article
Computer Science, Artificial Intelligence
Bas H. M. Van der Velden, Hugo J. Kuijf, Kenneth G. A. Gilhuijs, Max A. Viergever
Summary: This survey examines the applications of explainable artificial intelligence (XAI) in deep learning-based medical image analysis. It introduces a framework for classifying deep learning-based medical image analysis methods based on XAI criteria. The survey also categorizes and investigates XAI techniques in medical image analysis according to the framework and anatomical location. The paper concludes by discussing future opportunities for XAI in medical image analysis.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Engineering, Biomedical
Liqian Wang, Xuejun Wang, Yungen Wu, Mingquan Guo, Chenjian Gu, Changhao Dai, Derong Kong, Yao Wang, Cong Zhang, Di Qu, Chunhai Fan, Youhua Xie, Zhaoqin Zhu, Yunqi Liu, Dacheng Wei
Summary: A self-assembled DNA-based system immobilized on a liquid-gated graphene field-effect transistor enables the electromechanical detection of ultralow levels of unamplified ions, nucleic acids, small molecules, and proteins in biofluids. This technology has been successfully applied to create an integrated and portable device for the rapid detection of SARS-CoV-2 RNA in COVID-19 patients, without the need for RNA extraction or amplification.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Engineering, Biomedical
Jueying Chen, Jiahui He, Yutong Yang, Lipeng Qiao, Juan Hu, Jie Zhang, Baolin Guo
Summary: The development of compressible, stretchable and self-healing hydrogel dressings with good adhesive, antibacterial and angiogenesis properties is needed to promote the regeneration of diabetic wounds in clinical applications.
ACTA BIOMATERIALIA
(2022)
