Review
Endocrinology & Metabolism
Hedi L. Claahsen-van der Grinten, Phyllis W. Speiser, S. Faisal Ahmed, Wiebke Arlt, Richard J. Auchus, Henrik Falhammar, Christa E. Fluck, Leonardo Guasti, Angela Huebner, Barbara B. M. Kortmann, Nils Krone, Deborah P. Merke, Walter L. Miller, Anna Nordenstrom, Nicole Reisch, David E. Sandberg, Nike M. M. L. Stikkelbroeck, Philippe Touraine, Agustini Utari, Stefan A. Wudy, Perrin C. White
Summary: Congenital adrenal hyperplasia is a group of autosomal recessive disorders affecting cortisol biosynthesis, with the most common form caused by steroid 21-hydroxylase deficiency due to mutations in CYP21A2. Recent developments include advancements in understanding steroidogenic pathways, improvements in diagnostic measurements, and exploration of alternative medications and treatments for CAH patients.
Article
Endocrinology & Metabolism
Guido Rindi, Ozgur Mete, Silvia Uccella, Olca Basturk, Stefano La Rosa, Lodewijk A. A. Brosens, Shereen Ezzat, Wouter W. de Herder, David S. Klimstra, Mauro Papotti, Sylvia L. Asa
Summary: In this review, the changes and features of neuroendocrine neoplasms (NENs) in the 2022 WHO Classification of Endocrine and Neuroendocrine Tumors are detailed. The consolidation of nomenclature distinguishing different neoplasms and the importance of Ki67 as a tool for classification and grading are emphasized. The clinical relevance of proper classification and the tools available to pathologists for accurate classification are explained. The article also discusses the differential diagnoses and theranostic biomarkers for NENs, as well as the role of pathologists in identifying precursor lesions and applying molecular immunohistochemistry.
ENDOCRINE PATHOLOGY
(2022)
Review
Endocrinology & Metabolism
Vasanti S. Malik, Frank B. Hu
Summary: Studies have shown that habitual consumption of sugar-sweetened beverages is associated with an increased risk of obesity and type 2 diabetes. Global efforts are needed to reduce the intake of these beverages and alleviate the burden of obesity and chronic diseases.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Sylvia L. Asa, Ozgur Mete, Arie Perry, Robert Y. Osamura
Summary: This review summarizes the changes in the 5th Edition of the WHO Classification of Endocrine and Neuroendocrine Tumors related to the pituitary gland, including the classification of pituitary lobe tumors and the detailed subtyping based on tumor cell lineage, cell type, and characteristics.
ENDOCRINE PATHOLOGY
(2022)
Review
Endocrinology & Metabolism
Roger Bouillon, Despoina Manousaki, Cliff Rosen, Katerina Trajanoska, Fernando Rivadeneira, J. Brent Richards
Summary: The review highlights that vitamin D supplementation in vitamin D-replete adults does not provide significant health benefits, but vitamin D deficiency should be corrected. The vitamin D supplementation can prevent and cure nutritional rickets in infants and children.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Summary: The American Diabetes Association (ADA) Standards of Medical Care in Diabetes provide comprehensive guidelines and tools for diabetes care. These standards are regularly updated by a professional committee to ensure their relevance and accuracy.
Article
Endocrinology & Metabolism
Summary: The American Diabetes Association (ADA) Standards of Medical Care in Diabetes provide clinical practice recommendations, treatment goals, and evaluation tools. The standards are updated by a professional committee and include a detailed introduction and evidence grading system.
Article
Endocrinology & Metabolism
Summary: The American Diabetes Association (ADA) Standards of Medical Care in Diabetes is a set of clinical practice recommendations that provides guidelines and evaluation tools for diabetes care. It is updated annually by the ADA Professional Practice Committee, and readers are invited to comment on the standards on the professional website.
Review
Endocrinology & Metabolism
Joao A. Amorim, Giuseppe Coppotelli, Anabela P. Rolo, Carlos M. Palmeira, Jaime M. Ross, David A. Sinclair
Summary: Organismal ageing leads to cellular function loss and systemic deterioration, making individuals more vulnerable to death. Mitochondria play a crucial role not only as energy suppliers but also in the development of ageing-associated diseases. Evidence suggests that ageing and age-related diseases are closely related to imbalances in energy supply and demand, which can be alleviated through various interventions.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Sjaak Pouwels, Nasser Sakran, Yitka Graham, Angela Leal, Tadeja Pintar, Wah Yang, Radwan Kassir, Rishi Singhal, Kamal Mahawar, Dharmanand Ramnarain
Summary: Given the increasing prevalence of diabetes and obesity worldwide, the deleterious effects of non-alcoholic fatty liver disease (NAFLD) are becoming a growing challenge for public health. NAFLD is closely associated with metabolic disorders and can range from mild forms to severe forms with potential liver failure. Advanced fibrosis is a major predictor of morbidity and liver-related mortality. Diagnosis of NAFLD is established through liver biopsy and treatment options include weight loss, dietary modification, and addressing underlying metabolic syndrome.
BMC ENDOCRINE DISORDERS
(2022)
Review
Endocrinology & Metabolism
Chander K. Negi, Pavel Babica, Lola Bajard, Julie Bienertova-Vasku, Giovanni Tarantino
Summary: NAFLD is the most common form of chronic liver disease worldwide, with current treatment options including dietary restrictions and lifestyle modification. It is closely associated with metabolic disorders such as obesity, type 2 diabetes, and dyslipidemia, with various pharmacological approaches being considered in clinical management.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Review
Endocrinology & Metabolism
Dunya Tomic, Jonathan E. Shaw, Dianna J. Magliano
Summary: The traditional complications of diabetes mellitus have been well-known, but emerging evidence suggests the existence of a different set of complications. Cancer and dementia have become the leading causes of death in people with diabetes, replacing vascular disease. Additionally, diabetes has been linked to a range of comorbidities, including cognitive decline, functional disability, affective disorders, obstructive sleep apnoea, and liver disease. There is currently no comprehensive review summarizing the burden and risks of these emerging complications.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Article
Cell Biology
Daniel Q. Huang, Amit G. Singal, Yuko Kono, Darren J. H. Tan, Hashem B. El-Serag, Rohit Loomba
Summary: Liver cancer epidemiology is changing due to factors such as increasing alcohol consumption, rising obesity rates, and advancements in hepatitis B and C treatment. The Global Burden of Disease study estimated global and regional trends in liver cancer burden, revealing a 25% increase in liver cancer deaths between 2010 and 2019. Non-alcoholic steatohepatitis (NASH) and alcohol were found to have the fastest growing death rates, while hepatitis B and C showed declines. Urgent measures are needed globally to address metabolic risk factors and slow the growing burden of NASH-associated liver cancer, particularly in the Americas.
Review
Endocrinology & Metabolism
Jan Martel, Shih-Hsin Chang, Yun-Fei Ko, Tsong-Long Hwang, John D. Young, David M. Ojcius
Summary: This article discusses the protective role of the intestinal barrier against gut microbes, food antigens, and toxins, as well as key factors associated with disease development and inflammation. In addition to known intestinal diseases, recent research indicates that intestinal barrier and microbiota dysbiosis may be closely linked to the development of metabolic, autoimmune, and aging-related disorders.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Endocrinology & Metabolism
Nuha A. ElSayed, Grazia Aleppo, Vanita R. Aroda, Raveendhara R. Bannuru, Florence M. Brown, Dennis Bruemmer, Billy S. Collins, Marisa E. Hilliard, Diana Isaacs, Eric L. Johnson, Scott Kahan, Kamlesh Khunti, Jose Leon, Sarah K. Lyons, Mary Lou Perry, Priya Prahalad, Richard E. Pratley, Jane Jeffrie Seley, Robert C. Stanton, Robert A. Gabbay
Review
Cell Biology
Samuel Klein, Amalia Gastaldelli, Hannele Yki-Jarvinen, Philipp E. Scherer
Summary: The accumulation of excessive body fat can lead to type 2 diabetes, and the risk of type 2 diabetes increases with an increase in body mass index. The global increase in obesity has therefore resulted in a corresponding increase in the prevalence of type 2 diabetes. The mechanisms linking obesity and type 2 diabetes involve complex changes in b cell function, adipose tissue biology, and multi-organ insulin resistance, which can be improved or even normalized through weight loss.
Review
Endocrinology & Metabolism
Hiba Jebeile, Aaron S. Kelly, Grace O'Malley, Louise A. Baur
Summary: This review provides an overview of the current knowledge on child and adolescent obesity, including its epidemiology, causes, assessment considerations, and management approaches. Prevalence of obesity had plateaued in high-income countries but increased in low-income and middle-income countries before the COVID-19 pandemic. However, weight gain among children and adolescents has increased during the pandemic. Obesity is associated with various health issues and premature mortality. The development and persistence of obesity can be explained by a bio-socioecological framework. The first-line treatment approaches involve family-based behavioral interventions addressing diet, physical activity, sedentary behaviors, and sleep quality. Additional therapies such as intensive dietary approaches, pharmacotherapy, and metabolic and bariatric surgery are emerging, but access to them is limited. Personalized treatment approaches and their translation to clinical practice still require further research.
LANCET DIABETES & ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Celia L. Gregson, David J. Armstrong, Jean Bowden, Cyrus Cooper, John Edwards, Neil J. L. Gittoes, Nicholas Harvey, John Kanis, Sarah Leyland, Rebecca Low, Eugene McCloskey, Katie Moss, Jane Parker, Zoe Paskins, Kenneth Poole, David M. Reid, Mike Stone, Julia Thomson, Nic Vine, Juliet Compston
Summary: The National Osteoporosis Guideline Group (NOGG) has revised the UK guideline for the assessment and management of osteoporosis and the prevention of fragility fractures in postmenopausal women and older men. This comprehensive guideline provides recommendations based on systematic reviews, meta-analyses, and randomized controlled trials. It has been accredited by NICE and endorsed by international organizations.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Endocrinology & Metabolism
Summary: The American Diabetes Association (ADA) Standards of Medical Care in Diabetes provides guidelines and tools for diabetes care and evaluation of quality of care. The standards are updated by a multidisciplinary expert committee.
Review
Endocrinology & Metabolism
Shin-Hae Lee, Shi-Young Park, Cheol Soo Choi
Summary: Insulin resistance, characterized by reduced responsiveness of insulin-targeting tissues to physiological levels of insulin, is a key pathogenic component of many metabolic diseases. This review summarizes the functions of insulin in glucose metabolism and discusses the mechanisms proposed for insulin resistance, such as ectopic lipid accumulation, endoplasmic reticulum stress, and inflammation. Potential therapeutic strategies for addressing insulin resistance are also suggested.
DIABETES & METABOLISM JOURNAL
(2022)
