Article
Biochemistry & Molecular Biology
Cristina Tortolini, Valeria Gigli, Antonio Angeloni, Federico Tasca, Nguyen T. K. Thanh, Riccarda Antiochia
Summary: The development of a novel voltammetric immunosensor for the detection of salivary MMP-8 at the point-of-care is described. The sensor showed good performance and comparable results to the conventional ELISA method when tested in real saliva samples. This biosensor is single-use, cost-effective, and requires a small quantity of test medium and a short preparation time.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Mengjiao Zhu, Yu Liu, Meiyue Wang, Tao Liu, Zhenyu Chu, Wanqin Jin
Summary: Early rapid diagnosis of COVID-19 is crucial for reducing the risk of severe symptoms and loss of lung function. Researchers have proposed an ultrafast and ultrasensitive DNA sensor that can accurately detect the virus in a short period of time, with outstanding selectivity.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Miao Liu, Yuwei Wang, Shanshan Tang, Wei Wang, Axin Liang, Aiqin Luo
Summary: An unlabeled ratiometric molecular imprinted electrochemiluminescence sensor was developed for the determination of trace uric acid using MXene@NaAsc, CdSe@ZnS quantum dots, and molecularly imprinted polymer composites modified glass carbon electrode. This sensor, with easy preparation, great selectivity, and excellent sensitivity, successfully detected uric acid in human serum.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Charlotte Da Silva, Camille Lamarche, Carole Pichereaux, Emmanuelle Mouton-Barbosa, Gauthier Demol, Sebastien Boisne, Etienne Dague, Odile Burlet-Schiltz, Flavien Pillet, Marie-Pierre Rols
Summary: Low-energy electron beams (LEEB) are a safe and practical sterilization solution for industrial applications. To address the limitations of LEEB, we developed a low-energy pulsed electron beam generator (LEPEB) that can effectively and efficiently eradicate bacteria in a wide range of industrial applications.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Niloufar Fattahi, Jeffrey Reed, Evan Heronemus, Priyasha Fernando, Ryan Hansen, Prathap Parameswaran
Summary: In this study, polyethylene glycol hydrogels were developed as protective coatings for electroactive biofilms, improving their viability under low resource conditions and ammonia-N shocks.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Daniel Dobrovodsky, Ales Danhel, Daniel Renciuk, Jean-Louis Mergny, Miroslav Fojta
Summary: In this study, N-methyl mesoporphyrin IX (NMM) was utilized as a voltammetric probe for the electrochemical detection of G4s. The detection of NMM was achieved by cyclic voltammetry on a hanging mercury drop electrode (HMDE) with a limit of detection (LOD) of 40 nM. The reduction signal of NMM was found to be significantly higher when G4 oligodeoxynucleotides (G4 ODNs) were present compared to single- or double-stranded ODNs or unfolded ODNs capable of forming G4s. Gradual transition from unstructured single strand to G4, induced by increasing concentrations of the G4 stabilizing K+ ions, was detected for the first time using electrochemical methods. Circular dichroism spectroscopy provided support for the obtained results. This work expands on the utilization of electrochemical probes for DNA secondary structure recognition and offers a proof of principle for the development of novel electroanalytical methods for nucleic acid structure studies.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Rimsha B. Jamal, Ulrich Bay Gosewinkel, Elena E. Ferapontova
Summary: Pathogen-triggered infections are a severe global threat to human health. Researchers have developed a fast and inexpensive electrocatalytic aptamer assay for the specific and ultrasensitive detection of E. coli, allowing for timely treatment and prevention. The method is fast, sensitive, and can be used in field and point-of-care applications for analysis of bacteria in the human environment.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Fatima-Zahra Ait-Itto, James A. Behan, Mathieu Martinez, Frederic Barriere
Summary: This study investigated the feasibility of using ancient marine sediments as inoculum for bioanode development in microbial fuel cells (MFC). The results showed the presence of two exoelectrogenic bacterial genera in these iron-rich sediments and confirmed that the development of the bioanode derived from the native microbiota. This study has important implications for understanding the role of these bacteria in broader paleoenvironmental phenomena.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Issa Fall, Bastien Doumeche, Sofiene Abdellaoui, Caroline Remond, Harivony Rakotoarivonina, Marjorie Ochs
Summary: This article presents a novel electrochemical tool based on lignin-coated paper electrodes for the detection and characterization of ligninolytic activity. The suitability of this method has been demonstrated using a catalaseperoxidase isolated from Thermobacillus xylanilyticus.
BIOELECTROCHEMISTRY
(2024)
Article
Chemistry, Analytical
Ying Li, Pengyue Song, Qingbin Xu, Wenjuan Wu, Nan Long, Jiabo Wang, Lidong Zhou, Ruile Pan, Weijun Kong
Summary: An electrochemiluminescence (ECL) aptasensor with aptamer, N-doped carbon dots (NCDs), and DNA tetrahedral nanostructure (DTN) was developed for ultra-sensitive detection of aflatoxin B1 (AFB1). The sensor exhibited excellent sensitivity, with a low detection limit and wide linear concentration range, as well as high accuracy and recovery in spiked Coix seed matrices. The successful application of the sensor in actual samples confirmed its practicality as a universal platform for trace contaminant detection by altering aptamers.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Chemistry, Analytical
Ragu Sasikumar, Byungki Kim
Summary: In recent years, there has been an increase in the number of patients with prostate cancer, leading to a greater need for monitoring and detecting the anticancer drug, flutamide, in the human body. Researchers have developed a novel electrocatalyst based on Alg-Cys-AuNPs for the detection of flutamide, which exhibits excellent detection performance and is suitable for real-time industrial applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Zhen Wang, Yanhao Li, Xiangnan He, Rui Yan, Zhemin Li, Yadong Jiang, Xian Li
Summary: In this study, an improved deep BRNN model was developed to solve the cross-sensitivity problem of chemical gas sensor array, achieving a recognition accuracy of 98.93%.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jinju Xu, Chaoying Tong, Yuanxin Cao, Ziyi Qin, Chunhui Liao, Yuxia Chen, Shuyun Shi, Ying Guo
Summary: In this study, a dual-channel foldable microfluidic paper-based parallel enzymatic reaction system was fabricated for simultaneous detection of AChE and alpha-Glu, as well as screening inhibitors. The developed platform provides a convenient, efficient, sensitive, and specific method for point-of-care testing of disease and development of drugs.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Chemistry, Analytical
S. Madanan Anju, Susan Varghese, K. Abraham Merin, Ali Ibrahim Shkhair, Greeshma Rajeevan, Geneva Indongo, Sony George
Summary: Researchers have developed a novel nano couple platform for detecting cardiac biomarkers. By utilizing immunocomplex formation between antigen and antibody, the pre-quenched fluorescence of monoclonal antibody conjugated nano fluorophore was successfully lighted up. This system selectively detects the presence of cardiac troponin-T (cTnT) by giving an enhanced fluorescence signal proportional to the concentration of cTnT antigen, achieved by disrupting the direct contact of the cluster and two-dimensional sheet through specific antigen-antibody interaction forming an immunocomplex.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yibiao Jin, Donghao Hu, Jiamiao Yin, Kuangshi Sun, Lijun Chen, Shujuan Liu, Fuyou Li, Qiang Zhao
Summary: In this study, an iridium-based probe decorated with a p-nitrophenyl group was designed and investigated for the detection and imaging of nitroreductase (NTR). The probe showed selective and precise detection of NTR using photoluminescence lifetime imaging (PLIM) within living cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Hong Ran Tao, Hang Yan, Zhe Sun, Ya Bin Cui, Nian Bing Li, Hong Qun Luo
Summary: In this study, a ratiometric fluorescence DNA nanozipper was developed for highly sensitive detection of ATP. The sensing strategy showed a linear response to ATP concentration and could detect low concentrations, demonstrating promising application potential in biological samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jianhua Fan, Xiaohua Li, Cheng Ma, Qun Wang, Changchao Zhang, Lu Wang, Yang Xia, Zhiwu Han
Summary: In this study, a new type of flexible sensory electronic device is developed, which demonstrates excellent performance in high-intensity and high-stretchability scenarios. By employing a combination of flexible materials and biomimetic design, researchers successfully achieved a substrate with high mechanical strength and large elongation capacity, along with impressive electrical conductivity. Based on this innovation, they established an online testing platform for human-machine interaction that can accommodate substantial deformations at joint interfaces, allowing for synchronization and emulation of extensive tensile movements between mechanical prosthetics and human articulations.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
