Review
Cell Biology
Verena Fischer, Melanie Haffner-Luntzer
Summary: Postmenopausal osteoporosis is a systemic disease caused by the loss of bone mass and increased fracture risk, resulting from reduced estrogen levels after menopause. The alterations of immune cells contribute to the development of bone destruction in addition to the direct negative effects of estrogen-deficiency on bone.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Jian Yang, Shasha Hu, Yangyang Bian, Jiangling Yao, Dong Wang, Xiaoqian Liu, Zhengdong Guo, Siyuan Zhang, Lei Peng
Summary: New research has shown that the development of osteoarthritis is influenced by different mechanisms of cell death and types of cytokines. Understanding the interaction between cytokines, cell death processes, and osteoarthritis is crucial for better understanding the pathogenesis and progression of the disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Rachel Shahan, Che-Wei Hsu, Trevor M. Nolan, Benjamin J. Cole, Isaiah W. Taylor, Laura Greenstreet, Stephen Zhang, Anton Afanassiev, Anna Hendrika Cornelia Vlot, Geoffrey Schiebinger, Philip N. Benfey, Uwe Ohler
Summary: This study constructed a comprehensive atlas at single-cell resolution to investigate the gene expression dynamics and transcriptional regulators during Arabidopsis root development. The results revealed tissue trans-differentiation and provided insights into cell identity determination and organ development regulation.
DEVELOPMENTAL CELL
(2022)
Review
Cell Biology
Yanglin Ding, Shuhua Yang
Summary: Temperature fluctuations caused by climate change inhibit plant growth and threaten crop productivity. Understanding how plants defend against temperature stress is crucial for agricultural sustainability and food security.
DEVELOPMENTAL CELL
(2022)
Review
Anatomy & Morphology
Sven Jonckheere, Jamie Adams, Dominic De Groote, Kyra Campbell, Geert Berx, Steven Goossens
Summary: Metastasis, the spread of cancer cells to distant sites, is the primary cause of cancer morbidity and mortality. During the initial stages of metastasis, cancer cells undergo EMT, becoming migratory and invasive mesenchymal-like cells with stem cell properties. Targeting EMT in therapy has the potential to prevent cancer cell invasion and dissemination, reduce cancer stemness, and enhance the effectiveness of chemotherapy.
CELLS TISSUES ORGANS
(2022)
Article
Cell Biology
Jonathan P. Karr, John J. Ferrie, Robert Tjian, Xavier Darzacq
Summary: This Perspective presents a new model for understanding how distal cis-regulatory elements communicate with promoters, diverging from the traditional enhancer-promoter looping paradigm. The model focuses on the coactivator p300 and offers a synthesis of the current literature to support its plausibility.
GENES & DEVELOPMENT
(2022)
Review
Cell Biology
Anita V. Kumar, Joslyn Mills, Louis R. Lapierre
Summary: Efficient proteostasis is crucial for cellular maintenance, and the protein p62 plays a key role as a selective autophagy receptor and also participates in other cellular processes. p62 has context-dependent impacts on aging and diseases, reflecting its involvement in maintaining proteostasis. This review highlights recent advances in understanding p62's functions and mechanisms and its implications on aging and neurodegeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Qian Hu, Wanhui Wei, Daiqian Wu, Fengxing Huang, Mengting Li, Wenjie Li, Jingwen Yin, Yanan Peng, Yuanyuan Lu, Qiu Zhao, Lan Liu
Summary: This study reveals that GCH1/BH4 metabolism is a major factor contributing to the resistance of colorectal cancer cells to erastin-induced ferroptosis. Inhibiting GCH1/BH4 metabolism promotes ferroptosis by activating ferritinophagy, suggesting a novel therapeutic strategy for colorectal cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Xuanhua P. Xie, Dan R. Laks, Daochun Sun, Mungunsarnai Ganbold, Zilai Wang, Alicia M. Pedraza, Tejus Bale, Viviane Tabar, Cameron Brennan, Xiuping Zhou, Luis F. Parada
Summary: This study confirms the existence of quiescent cancer stem cells in glioblastoma that can evade anti-proliferative therapies. By analyzing the functional characteristics of glioblastomas from genetically engineered mice, essential quiescent stem-like cells that can be directly isolated from tumors were identified. A specific gene expression signature related to quiescent cancer stem cells was found in both primary and recurrent human glioblastomas. These findings provide insights into the failure of conventional treatment and lay the foundation for alternative therapies.
DEVELOPMENTAL CELL
(2022)
Review
Cell Biology
Karen M. Ridge, John E. Eriksson, Milos Pekny, Robert D. Goldman
Summary: This review discusses the essential functions of vimentin intermediate filaments (IFs) revealed from studies of Vim(-/-) mice and cells derived from them. It has been found that Vim(-/-) mice and their organs, tissues, and cells exhibit various phenotypes, frequently reflecting altered responses in tissue recovery. Cell-based experiments have confirmed the critical role of vimentin IFs in regulating cell mechanics.
GENES & DEVELOPMENT
(2022)
Article
Cell Biology
Keke Xia, Hai-Xi Sun, Jie Li, Jiming Li, Yu Zhao, Lichuan Chen, Chao Qin, Ruiying Chen, Zhiyong Chen, Guangyu Liu, Ruilian Yin, Bangbang Mu, Xiaojuan Wang, Mengyuan Xu, Xinyue Li, Peisi Yuan, Yixin Qiao, Shijie Hao, Jing Wang, Qing Xie, Jiangshan Xu, Shiping Liu, Yuxiang Li, Ao Chen, Longqi Liu, Ye Yin, Huanming Yang, Jian Wang, Ying Gu, Xun Xu
Summary: This study presents a single-cell spatial transcriptome profiling technique called scStereo-seq, which successfully characterized the transcriptomic differences between upper and lower epidermal cells in Arabidopsis leaves. The study also discovered cell-type-specific gene expression gradients and spatial developmental trajectories of vascular cells and guard cells.
DEVELOPMENTAL CELL
(2022)
Review
Cell Biology
Wen Gao, Lin Guo, Yan Yang, Yu Wang, Shuang Xia, Hui Gong, Bi-Kui Zhang, Miao Yan
Summary: Nrf2 and NF-kappa B are important regulators of oxidative stress and inflammation in the body, and there is crosstalk between them. Drug-induced organ toxicity has become a focus of research in clinical practice, and it is urgent to find protective drugs to alleviate this injury. Evidence suggests that modulating both Nrf2 and NF-kappa B pathways can alleviate drug-induced organ toxicity. Therefore, exploring the crosstalk mechanism between Nrf2 and NF-kappa B is of great importance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Ionel Sandovici, Aikaterini Georgopoulou, Vicente Perez-Garcia, Antonia Hufnagel, Jorge Lopez-Tello, Brian Y. H. Lam, Samira N. Schiefer, Chelsea Gaudreau, Fatima Santos, Katharina Hoelle, Giles S. H. Yeo, Keith Burling, Moritz Reiterer, Abigail L. Fowden, Graham J. Burton, Cristina M. Branco, Amanda N. Sferruzzi-Perri, Miguel Constancia
Summary: This study demonstrates the vital role of endothelial and fetus-derived IGF2 in the expansion of the feto-placental microvasculature and trophoblast morphogenesis. It reveals that fetal signals play an important role in controlling placental development and highlights the significance of the imprinted Igf2-Igf2r axis in matching placental development to fetal growth.
DEVELOPMENTAL CELL
(2022)
Review
Cell Biology
Liza O'Donnell, Lee B. Smith, Diane Rebourcet
Summary: Sertoli cells play essential roles in spermatogenesis, supporting germ cell development and regulating other testis somatic cells. They are crucial for maintaining the stem cell niche, facilitating meiosis and spermiogenesis, and regulating androgen production.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Lin Lin, Mu-Xin Zhang, Lei Zhang, Dan Zhang, Chao Li, Yun-lun Li
Summary: Atherosclerosis is a chronic inflammatory disorder characterized by plaque buildup in arteries, with vascular cell injury playing a key role. Dysregulation of autophagy, pyroptosis, and ferroptosis are closely related to atherosclerosis development and plaque stability, highlighting potential pharmacological strategies for addressing atherogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Qi Zhang, Hang Qu, Yinghui Chen, Xueyang Luo, Chong Chen, Bing Xiao, Xiaowei Ding, Pengjun Zhao, Yanan Lu, Alex F. Chen, Yu Yu
Summary: This study discovered that ferroptosis, a programmed iron-dependent cell death mechanism, serves as a mechanism in statin-induced myopathy, and specifically identified atorvastatin as the statin that could lead to ferroptosis in human cardiomyocytes and murine skeletal muscle cells. The study highlights the importance of understanding the underlying pathophysiological mechanism of atorvastatin-induced myopathy and suggests that targeting ferroptosis could be a protective strategy for clinical application.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Li Yang, Jeremy E. Wilusz, Ling-Ling Chen
Summary: Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes as well as from the processing of cellular RNAs. Recent studies have revealed that many protein-coding genes can undergo backsplicing, leading to widespread expression of circular RNAs (circRNAs) in eukaryotic cells. circRNAs play various roles in gene regulation, acting as noncoding RNAs or encoding functional peptides. They are involved in physiological processes including early development, immune responses, neurogenesis, and tumorigenesis.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Xin Sun, Anne-Karina Perl, Rongbo Li, Sheila M. Bell, Eniko Sajti, Vladimir V. Kalinichenko, Tanya Kalin, Ravi S. Misra, Hitesh Deshmukh, Geremy Clair, Jennifer Kyle, Laura E. Crotty Alexander, Jorge A. Masso-Silva, Joseph A. Kitzmiller, Kathryn A. Wikenheiser-Brokamp, Gail Deutsch, Minzhe Guo, Yina Du, Michael P. Morley, Michael J. Valdez, Haoze Yu, Kang Jin, Eric E. Bardes, Jarod A. Zepp, Terren Neithamer, Maria C. Basil, William J. Zacharias, Jamie Verheyden, Randee Young, Gautam Bandyopadhyay, Sara Lin, Charles Ansong, Joshua Adkins, Nathan Salomonis, Bruce J. Aronow, Yan Xu, Gloria Pryhuber, Jeff Whitsett, Edward E. Morrisey
Summary: The human lung plays important roles in respiration, host defense, and basic physiology. Recent technological advancements have led to the discovery of new cell types and functional properties in the lung. A comprehensive cellular census of the lung has been synthesized, with detailed information on cell types, function, markers, developmental lineages, heterogeneity, regenerative potential, disease links, and key experimental tools. This publication aims to serve as a guide for lung research and promote efforts to establish, maintain, and restore respiratory health.
DEVELOPMENTAL CELL
(2022)
Article
Cell Biology
Shaobo Zhu, Jinge Gu, Juanjuan Yao, Yichen Li, Zheting Zhang, Wencheng Xia, Zhen Wang, Xinrui Gui, Leiting Li, Dan Li, Heng Zhang, Cong Liu
Summary: This study demonstrates the role of protein liquid-liquid phase separation (LLPS) in the heat stress response in plants by discovering the LLPS of two RNA-binding proteins, RBGD2 and RBGD4. The findings suggest that manipulation of protein LLPS could be a strategy to improve plant stress resistance.
DEVELOPMENTAL CELL
(2022)
Article
Cell Biology
Wei Zhang, Wenqun Zhong, Beike Wang, Jiegang Yang, Jingbo Yang, Ziyan Yu, Zhiyuan Qin, Alex Shi, Wei Xu, Cathy Zheng, Lynn M. Schuchter, Giorgos C. Karakousis, Tara C. Mitchell, Ravi Amaravadi, Meenhard Herlyn, Haidong Dong, Phyllis A. Gimotty, George Daaboul, Xiaowei Xu, Wei Guo
Summary: This study reveals the co-localization of ICAM-1 and PD-L1 on exosomes, both of which are upregulated by interferon-y. The adhesion between TEVs and T cells mediated by ICAM-1-LFA-1 is crucial for exosomal PD-L1-mediated immune suppression.
DEVELOPMENTAL CELL
(2022)
