Article
Cell Biology
Zhe Zhang, Qinghua Zhang, Yani Yu, Shan Su
Summary: EGCG, a bioactive component in tea, has broad anti-cancer effects on ovarian cancer by regulating FOXO3A and c-Myc.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2023)
Article
Biochemistry & Molecular Biology
Chyna S. Ortman, Jay M. Baltz
Summary: It is found that detachment of the oocyte from the zona pellucida occurs before activation of independent cell volume regulation. Metallopeptidase inhibitors partially suppress the activation of cell volume regulation, indicating the requirement of oocyte-ZP detachment. However, removal of the zona pellucida does not accelerate the activation of cell volume regulation.
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2023)
Article
Developmental Biology
Zhihao Zhou, Penghui Wang, Qing Wang, Zhangji Dong, Xu Chen, Run Zhuo, Ronghua Wu, Yan Liu, Liu Yang, Mei Liu
Summary: SASH1, a tumor suppressor gene highly expressed in the mammalian central nervous system, has been shown to play a role in brain development. In this study using zebrafish, downregulation of sash1a expression led to malformations in the embryonic brain and disorganization of glial cell marshalling. These findings highlight the importance of SASH1 in the migration of glial cells during brain development.
DEVELOPMENTAL BIOLOGY
(2023)
Article
Developmental Biology
Miguel Cifuentes Acebal, Benni Winding Hansen, Tue Sparholt Jorgensen, Louise Torp Dalgaard
Summary: This study compared the transcriptome of quiescent embryos and normal embryonic development in A. tonsa, identifying pathways and differentially regulated transcripts involved in quiescent embryogenesis. The results showed that the expression profile of quiescent embryos was not significantly different from the normal embryonic gastrulation stage, and a large proportion of annotated transcripts displayed expression values between gastrulation and organogenesis stages. Furthermore, comparison with organogenesis stage samples confirmed that a developmental arrest had been induced through quiescence, and stress response transcripts, such as the autophagy gene Sequestosome-1/p62 (SQSTM), were upregulated in quiescence. These findings provide a better understanding of the molecular mechanisms underlying the quiescent embryonic state of A. tonsa.
DEVELOPMENTAL BIOLOGY
(2023)
Article
Developmental Biology
Brianna E. Kaplan, Isabella Kasaba, Jaya Rachwani, Karen E. Adolph, Catherine S. Tamis-LeMonda
Summary: Children's learning of designed motor actions is a developmental process that can be facilitated by caregivers through attuned social information, but overhelping may hinder children's ability to perform actions themselves.
DEVELOPMENTAL PSYCHOBIOLOGY
(2023)
Article
Developmental Biology
Sally Mehanna, Satoko Arakawa, Mai Imasaka, Wenting Chen, Yuto Nakanishi, Hiroshi Nishiura, Shigeomi Shimizu, Masaki Ohmuraya
Summary: This study demonstrates the crucial role of Becn1 in pancreas development, as loss of Becn1 leads to severe defects and insufficient function in the pancreas.
DEVELOPMENTAL BIOLOGY
(2023)
Article
Developmental Biology
Anne Eskild, Irene Skau, Jostein Grytten, Camilla Haavaldsen
Summary: Placental weight increases from the first to the second delivery, with the highest increase observed at short inter-pregnancy intervals. However, the length of the inter-pregnancy interval does not affect gestational age at delivery or the placental to birthweight ratio.
Article
Developmental Biology
Rubina Shakya, Prateep Amonruttanapun, Tanapol Limboonreung, Sukumal Chongthammakun
Summary: In this study, the researchers investigated the effects of 17-beta-estradiol on neurogenic repair under inflammatory condition. They found that 17-beta-estradiol promotes the expression of differentiation marker proteins in SH-SY5Y cells by regulating microtubule stability, rather than through the canonical WNT signaling pathway. This novel mechanism provides new insight into the role of estradiol in promoting neuroregeneration in the context of chronic neuroinflammation.
CELLS & DEVELOPMENT
(2023)
Article
Developmental Biology
Amita Tiyaboonchai, Leslie Wakefield, Anne Vonada, Catherine L. May, Craig Dorrell, David Enicks, Anusha Sairavi, Klaus H. Kaestner, Markus Grompe
Summary: The current gold-standard for genetic lineage tracing in transgenic mice is based on cell-type specific expression of Cre recombinase. As an alternative, we developed a cell-type specific CRISPR/spCas9 system for lineage tracing. This method relies on RNA polymerase II promoter driven self-cleaving guide RNAs (scgRNA) to achieve tissue-specificity. The use of RNA polymerase II promoter driven scgRNAs enables the use of CRISPR/spCas9 for genetic lineage tracing.
DEVELOPMENTAL BIOLOGY
(2023)
Editorial Material
Developmental Biology
Roberto Mayor
CELLS & DEVELOPMENT
(2023)
Review
Cell Biology
Louisiane Perrin, Danijela Matic Vignjevic
Summary: The intestinal epithelium plays a dual role in absorbing nutrients and water while forming a barrier against pathogens. Precise control of tissue integrity, renewal, cell polarity, and force generation/transmission is essential for maintaining intestinal homeostasis. This review highlights the role of the cell cytoskeleton in cell-cell and cell-matrix junctions, intracellular trafficking, and tissue renewal in the intestinal epithelium.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Michael Klutstein, Nitzan Gonen
Summary: The process of aging involves physiological changes to an organism over time, affecting DNA, proteins, metabolism, cells, and organs. Epigenetic changes play a significant role in the aging of gametes, impacting reproductive capabilities in both females and males. Oocyte quality declines at an early age, while sperm count, motility, and fecundity are affected by aging.
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2023)
Article
Developmental Biology
Carolina Burnay, David I. Anderson, Chris Button, Rita Cordovil
Summary: These two studies show that the number of swimming sessions infants participate in is related to their behavior when confronted with bodies of water. Infants who participated in more sessions were more likely to avoid falling into the water but entered the water more if they could access it via a slope. This finding suggests that experience in infant swimming programs can promote more adaptive behaviors, but slope entries may increase drowning risks for young children.
DEVELOPMENTAL PSYCHOBIOLOGY
(2023)
Article
Developmental Biology
Stefania V. Vacaru, Anna M. Parenteau, Sydney Yi, Jennifer A. Silvers, Camelia E. Hostinar, Carolina de Weerth
Summary: This study examined adolescents' physiological stress responses to the COVID-19 pandemic and the role of attachment. The results showed that there were nonsignificant changes in hair cortisol and a nonsignificant effect of attachment in both Dutch and US samples, after accounting for age. However, a significant effect of sex emerged in the Dutch sample, with girls showing a significant cortisol increase during the pandemic that was not explained by puberty.
DEVELOPMENTAL PSYCHOBIOLOGY
(2023)
Editorial Material
Developmental Biology
John J. Williamson
CELLS & DEVELOPMENT
(2023)
Article
Developmental Biology
Michal Kovo, Erez Berman, Hind Odeh, Oded Luria, Ron Beloosesky, Jacob Bar
Summary: The study found that inflammatory stimuli can increase the vasoconstrictive response of placental blood vessels to angiotensin II, potentially compromising vascular function.
Review
Cell Biology
Bernat Corominas-Murtra, Edouard Hannezo
Summary: Homeostatic balance in the intestinal epithelium relies on coordination between biochemical signalling, mechanical forces, and organ geometry. Existing models offer different perspectives on cell renewal, tissue shape maintenance, and stem fate choices. Integration of these models across scales provides new insights into the dynamics of cell renewal in complex tissues.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Claudia A. Rivera, Ana-Maria Lennon-Dumenil
Summary: This article introduces the intestine as the body's largest proportion of immune cells, continuously exposed to new antigens and immune stimuli from the diet, microbiota, and intestinal pathogens. It describes the main populations of immune cells present in the intestine from both the innate and adaptive immune system. The article later discusses how the intestinal niches significantly impact the phenotype and function of gut immune populations during steady state and infection.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Article
Developmental Biology
Ayaka Ohashi, Suzuno Terai, Saya Furukawa, Sakiya Yamamoto, Rena Kashimoto, Akira Satoh
Summary: Studying the regenerative ability of axolotls may provide insights into effective treatment for severe muscle injuries. This study focuses on understanding the mechanisms underlying the high regenerative capacity in axolotls and the role of TN-C-enriched ECM in promoting muscle satellite cell migration. The results suggest the importance of maintaining TN-C expression for better muscle regeneration in mammals.
DEVELOPMENTAL BIOLOGY
(2023)
Review
Developmental Biology
Kim-Chi T. Pham, Kimberly S. Chiew
Summary: Air pollution is a major public health concern that has led to an increase in death rates and negative effects on neurocognitive function and development. People of color and lower socioeconomic status are more likely to be exposed to elevated levels of air pollution as a result of systemic racism and classism. The adverse effects of air pollution on neurocognitive health are worsened among individuals with marginalized identities due to disparities in access to healthcare and other stressors.
DEVELOPMENTAL PSYCHOBIOLOGY
(2023)
