Article
Anatomy & Morphology
Zhen He, Rong-Ge Yan, Qin-Bang Shang, Qi-En Yang
Summary: This study found that ID2 protein is expressed in spermatocytes, and forced expression of ID2 causes abnormalities in meiosis progression and defects in spermatogenesis. These results provide evidence for the important roles of ID proteins in male meiosis and spermatid development.
DEVELOPMENTAL DYNAMICS
(2023)
Article
Cell Biology
Haiyang Feng, Eric M. Thompson
Summary: The tunicate Oikopleura dioica possesses two Aurora kinases (Aurora1 and Aurora2) that play different roles in oogenic meiosis. Aurora1 is involved in spindle organization and chromosome congression, while Aurora2 is crucial for chromosome condensation and spindle assembly. In addition, Aur1 may interact with multiple proteins and participate in the regulation of microtubule motors and cohesin complexes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Mohammad I. K. Hamad, Bright Starling Emerald, Kukkala K. Kumar, Marwa F. Ibrahim, Bassam R. Ali, Mo'ath F. Bataineh
Summary: Proper growth and branching of dendrites are crucial for CNS functioning. Extrinsic factors, such as neurotransmitters and neurotrophins, play a role in regulating dendritic development. The response to these extracellular signals can have growth-promoting or growth-limiting effects, depending on various factors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Evolutionary Biology
Sergey N. Matveevsky, Oxana L. Kolomiets, Nikolay A. Shchipanov, Svetlana V. Pavlova
Summary: This study investigated the meiotic process in male hybrid shrews with complex chromosomal configurations using immunocytochemical and electron microscopy methods. Despite abnormalities in chromosome synapsis, morphologically normal spermatozoa were observed, suggesting that the impact of long meiotic configurations on fertility may be minimal.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION
(2023)
Article
Biochemistry & Molecular Biology
Nathalie Oulhen, Shumpei Morita, Cosmo Pieplow, Thomas M. Onorato, Stephany Foster, Gary Wessel
Summary: This study provides the first single cell RNA sequencing data sets of mature ovaries in echinoderms, elucidating the structure and functional biology of the ovary as well as aiding in the identification of stem cells for gamete production and understanding the evolution of reproduction in this phylum.
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2023)
Article
Biochemistry & Molecular Biology
Emma Whittington, Murielle Alund
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2023)
Article
Cell Biology
Tetsuharu Sugimoto, Chihiro Kanayama, Masateru Hiyoshi, Daisuke Kosumi, Kazufumi Takamune
Summary: In this study, we identified the expression and localization of Xenopus tudor domain containing 6/Xenopus tudor repeat (Xtdrd6/Xtr) in germ cells during oogenesis and early development. We found that XTdrd6/Xtr may interact with specific mRNAs translocating from the nucleus to the mitochondrial cloud. Furthermore, the translation of XTdrd6/Xtr protein begins at St. 47/48, suggesting its involvement in regulating the translation of mRNAs involved in new steps of germ cell differentiation.
DEVELOPMENT GROWTH & DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Bin Meng, Xiaoning Yang, Shiwei Luo, Chong Shen, Jia Qi, Haifeng Zhang, Yandong Li, Ying Xue, Juan Zhao, Pengxiang Qu, Enqi Liu
Summary: This study used proteomics analysis to construct a protein profile of the ovaries in a PCOS mouse model. The results showed significant differences in protein profile between the PCOS and control group. Differentially expressed proteins were mainly involved in lipid metabolism, oxidative stress, and immune response. This study fills the gap in PCOS ovarian proteomic data and provides an important reference for drug development and treatment of PCOS.
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2023)
Article
Cell Biology
Won-Ki Pang, Yoo-Jin Park, Myung-Geol Pang
Summary: This study investigated the potential of sperm RNA markers in assessing various aspects of sperm function and identified genes related to male fertility. The findings provide valuable insights into male infertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Maria Mangini, Nunzia Limatola, Maria Antonietta Ferrara, Giuseppe Coppola, Jong Tai Chun, Anna Chiara De Luca, Luigia Santella
Summary: In this study, the structural changes in actin filaments in fertilized eggs were investigated using Raman spectroscopy, which was consistent with live cell imaging results. The study suggests that Raman spectroscopy can serve as an alternative or advantageous method in revealing rapid subtle changes in the subplasmalemmal actin cytoskeleton.
Review
Cell Biology
Yulia A. Nevzorova, Francisco Javier Cubero
Summary: This article reviews the role of c-Myc in obesity, highlighting its importance in regulating cell proliferation, fatty acid metabolism, inflammatory response, and intestinal dysbiosis. Therefore, c-Myc has potential value in the diagnosis and treatment of obesity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Tamir Edri, Dor Cohen, Yehuda Shabtai, Abraham Fainsod
Summary: This study demonstrates the importance of retinoic acid (RA) signaling in neural tube closure during embryogenesis. RA signaling plays an early role in the regulation of proliferation and differentiation of neural progenitors soon after gastrulation. Disruption of RA signaling leads to the misregulation of the early neuroectodermal network, resulting in increased proliferation and expansion of the neural plate, ultimately leading to the induction of neural tube defects (NTDs). Ethanol exposure induces NTDs through this mechanism involving reduced RA levels.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Zhen Jin, Zhi-Cai Zhang, Chen-Yu Xiao, Mei-Qi Li, Qian-Ru Li, Lei-Lei Gao
Summary: This study found that knocking down CRMP5 in oocytes shifts the distribution of spastin and leads to errors in microtubule-kinetochore attachment in oocyte spindles. It is speculated that this is due to the reduction of spastin distribution on chromosomes after knocking down CRMP5.
Article
Cell Biology
Yiran Lu, Ruiqing Wang, Song He, Qing Zhang, Jiahui Wei, Jinping Hu, Yu Ding
Summary: BUBR1 is highly expressed in breast cancer and is associated with poor prognosis. Knocking down BUBR1 can decrease the proliferation and metastatic ability of breast cancer cells, leading to cell cycle arrest. Additionally, the loss of BUBR1 enhances the sensitivity of breast cancer cells to cisplatin.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2023)
Article
Cell Biology
Roya Harsini, Saeed Zavareh, Meysam Nasiri, Sara Seyfi
Summary: This research investigated the effects of Coenzyme Q10 (CoQ10) on the expression of the Transcription Factor A Mitochondrial (Tfam) gene and mtDNA copy number in preantral follicles (PFs) during in vitro culture. The results showed that CoQ10 significantly improved the developmental rate of PFs, as well as the survival rate and maturity of oocytes. Furthermore, CoQ10 enhanced Tfam gene expression and increased mtDNA copy number in granulosa cells and oocytes.
Article
Cell Biology
Paola Maria da Silva Rosa, Pedro Henrique Evagelista Guedes, Joaquim Mansano Garcia, Clara Slade Oliveira
Summary: This study investigated the effects of granular cytoplasm on oocyte competence in bovine. The results showed that oocytes with granulated cytoplasm had similar efficiency for in vitro fertilization and calf production compared to oocytes with homogeneous cytoplasm.
Article
Cell Biology
Nadia Fernandez-Jimenez, Marina Martinez-Garcia, Javier Varas, Felix Gil-Dones, Juan Luis Santos, Monica Pradillo
Summary: This study investigates the function of structural components of nuclear pore complexes (NPCs) in meiotic chromosome behavior. The study reveals that mutations in several nucleoporin genes lead to chromosome fragmentation and condensation abnormalities during meiosis. The findings provide important insights into the role of nucleoporins in meiotic chromosome behavior in plants.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Evolutionary Biology
Patrick T. Rohner, Yonggang Hu, Armin P. Moczek
Summary: Static allometry is a significant component of morphological variation. This study uses geometric morphometrics to investigate the effect of functional genetic manipulations on horn shape allometry in dung beetles. The findings suggest that some genes closely align with shape allometry, indicating their role in regulating relative trait growth, while other genes are implicated in scaling-independent processes. The study highlights the importance of multivariate approaches in studying allometry and phenotypic plasticity.
EVOLUTION & DEVELOPMENT
(2023)
Article
Cell Biology
Zhaojun Geng, Yongxun Jin, Fushi Quan, Siyi Huang, Shuming Shi, Bing Hu, Zhichao Chi, Ilkeun Kong, Mingjun Zhang, Xianfeng Yu
Summary: This study found that MXC has significant effects on the development of early porcine embryos, leading to decreased cleavage rate, blastocyst rate, hatching rate, and total cell count. Moreover, MXC increases the production of reactive oxygen species, decreases mitochondrial membrane potential, and reduces mitochondrial copy number during early embryo development. Furthermore, MXC treatment leads to increased blastocyst apoptosis and DNA damage, decreased cell proliferation, and altered expression of pluripotency-related and apoptosis-related genes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Evolutionary Biology
Lucia Irazabal-Gonzalez, Daniel S. Wright, Martine E. Maan
Summary: This study documents the developmental progression of visual pigment gene expression in Lake Victoria cichlids and examines the influence of light conditions on these patterns. The results show that opsin expression profiles progress from shorter-wavelength sensitive opsins to longer-wavelength sensitive opsins with increasing age, and that these developmental trajectories respond plastically to the visual conditions. The findings suggest that developmental and environmental plasticity in opsin expression may play an important role in the evolution of cichlid visual system diversity.
EVOLUTION & DEVELOPMENT
(2023)
