Review
Cell Biology
Tim P. Rieseberg, Armin Dadras, Janine M. R. Fuerst-Jansen, Amra Dhabalia Ashok, Tatyana Darienko, Sophie de Vries, Iker Irisarri, Jan de Vries
Summary: Land plants have specialized metabolic pathways that produce a wide range of compounds with diverse functions. These compounds govern the growth, development, and physiology of land plants, and may have contributed to their success. Interestingly, algal relatives of land plants also possess similar specialized metabolic pathways. This study summarizes the pathways that can be traced back to early plants before they colonized land.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Tim P. Rieseberg, Armin Dadras, Janine M. R. Furst-Jansen, Amra Dhabalia Ashok, Tatyana Darienko, Sophie De Vries, Iker Irisarri, Jan De Vries
Summary: Land plants have specialized metabolic pathways that produce compounds crucial for their growth, development, and response to the environment. Surprisingly, these specialized metabolites can also be found in the algal relatives of land plants. This suggests that specialized metabolites may have played a role in the success of land plants.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Bornika Roy, Sampa Ghose, Subhrajit Biswas
Summary: Hepatocellular carcinoma (HCC) is a rapidly spreading and commonly fatal malignancy. miRNAs play a significant role in HCC progression, making miRNA-based therapeutic strategies potentially impactful in curing HCC. However, the stability of oligos and delivery systems poses substantial challenges in developing these therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Mingyue Wang, Qinan Hu, Tianhang Lv, Yuhang Wang, Qing Lan, Rong Xiang, Zhencheng Tu, Yanrong Wei, Kai Han, Chang Shi, Junfu Guo, Chao Liu, Tao Yang, Wensi Du, Yanru An, Mengnan Cheng, Jiangshan Xu, Haorong Lu, Wangsheng Li, Shaofang Zhang, Ao Chen, Wei Chen, Yuxiang Li, Xiaoshan Wang, Xun Xu, Yuhui Hu, Longqi Liu
Summary: This study utilized Stereo-seq technology to analyze the spatiotemporal transcriptome of developing Drosophila with high resolution and sensitivity. The results revealed the spatial transcriptomic characteristics of Drosophila embryos and larvae, and provided key information for the analysis of transcription factor regulons.
DEVELOPMENTAL CELL
(2022)
Review
Cell Biology
Judith Simcox, Dudley W. Lamming
Summary: This review discusses the importance of protein kinase mechanistic target of rapamycin (mTOR) in metabolic regulation, its role in regulating the metabolism of the four macromolecular building blocks of the cell, and its impact on organismal physiology and aging. It also explores the potential clinical application of mTOR inhibitors in the treatment and prevention of age-related diseases.
DEVELOPMENTAL CELL
(2022)
Article
Cell Biology
Salman F. Banani, Lena K. Afeyan, Susana W. Hawken, Jonathan E. Henninger, Alessandra Dall'Agnese, Victoria E. Clark, Jesse M. Platt, Ozgur Oksuz, Nancy M. Hannett, Ido Sagi, Tong Ihn Lee, Richard A. Young
Summary: This study comprehensively maps pathogenic mutations related to condensates and finds that these mutations may lead to condensate dysregulation, affecting a wide range of human diseases. These findings provide a foundation for researching disease mechanisms and treatments.
DEVELOPMENTAL CELL
(2022)
Article
Cell Biology
Chang Liu, Rui Li, Young Li, Xiumei Lin, Kaichen Zhao, Qun Liu, Shuowen Wang, Xueqian Yang, Xuyang Shi, Yuting Ma, Chenyu Pei, Hui Wang, Wendai Bao, Junhou Hui, Tao Yang, Zhicheng Xu, Tingting Lai, Michael Arman Berberoglu, Sunil Kumar Sahu, Miguel A. Esteban, Kailong Ma, Guangyi Fan, Yuxiang Li, Shiping Liu, Ao Chen, Xun Xu, Zhiqiang Dong, Longqi Liu
Summary: This study used Stereo-seq and scRNA-seq data to analyze the spatially resolved developmental trajectories of cell-fate transitions and molecular changes during zebrafish embryogenesis. Important interactions were identified, providing a fundamental reference for further studies on vertebrate development.
DEVELOPMENTAL CELL
(2022)
Article
Cell Biology
Shuangshuo Jia, Yue Yang, Yishu Bai, Yingliang Wei, He Zhang, Yicheng Tian, Jiabao Liu, Lunhao Bai
Summary: This study demonstrated that exercise-induced Irisin has anti-inflammatory and antipyroptosis effects on osteoarthritis chondrocytes. Moderate-intensity treadmill exercise increased the levels of Irisin, which recovered the expression of collagen II and attenuated the expression of inflammatory markers. Irisin achieved these effects by inhibiting the PI3K/Akt/NF-kappa B signaling pathway and inhibiting the activity of NLRP3/caspase-1. The findings suggest that Irisin could be a potential therapeutic target for osteoarthritis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Marcela Hernandez-Coronado, Poliana Coqueiro Dias Araujo, Pui-Leng Ip, Custodio O. Nunes, Ramin Rahni, Michael M. Wudick, Michael A. Lizzio, Jose A. Feijo, Kenneth D. Birnbaum
Summary: This study reveals that plant GLRs play a role in both defense responses and regeneration through dynamic changes in chromatin and transcription. Inhibition of GLR activity increases regeneration efficiency in multiple organ repair systems. This finding provides insights into the trade-off between defense and regeneration in plants.
DEVELOPMENTAL CELL
(2022)
Article
Developmental Biology
Matthew J. Shannon, Jennet Baltayeva, Barbara Castellana, Jasmin Wachter, Gina L. McNeill, Ji Soo Yoon, Jenna Treissman, Hoa T. Le, Pascal M. Lavoie, Alexander G. Beristain
Summary: This study employs single cell RNA sequencing to reveal the differentiation and maintenance processes of cells in early placental development, and identifies a potential progenitor marker and regulator.
Review
Cell Biology
Tereza Cindrova-Davies, Amanda N. Sferruzzi-Perri
Summary: The placenta plays a critical role in the health of the fetus and its mother. However, our understanding of placental development is limited due to ethical restrictions and lack of suitable models. This review discusses current knowledge of early human placental development, emphasizing the role of the maternal endometrium and fetal-maternal dialogue, and introduces the latest cell models.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Anatomy & Morphology
Agnes Desroches-Castan, Emmanuelle Tillet, Claire Bouvard, Sabine Bailly
Summary: BMPs are a group of cytokines that play diverse roles in the body. In humans, there are 15 BMP ligands that initiate cellular signaling by forming complexes with specific receptors. Certain receptors have been directly linked to rare vascular diseases.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Cell Biology
Arthur T. Molines, Joel Lemiere, Morgan Gazzola, Ida Emilie Steinmark, Claire H. Edrington, Chieh-Ting Hsu, Paula Real-Calderon, Klaus Suhling, Gohta Goshima, Liam J. Holt, Manuel Thery, Gary J. Brouhard, Fred Chang
Summary: The concentration of the cytoplasm has a linear and inverse relationship with the rates of microtubule polymerization and depolymerization, indicating that changes in cytoplasmic viscosity play a key role in modulating these reactions.
DEVELOPMENTAL CELL
(2022)
Article
Anatomy & Morphology
Wenying Zhang, Qiongwei Wu, Yu Liu, Xujie Wang, Chengbin Ma, Weipei Zhu
Summary: This study reveals the mechanism of HOTAIR involvement in cervical cancer, showing that it promotes tumor cell migration, proliferation, and chemoresistance through the miR-29b/PTEN/PI3K axis.
CELLS TISSUES ORGANS
(2022)
Article
Cell Biology
Lian-Yu Wu, Guan-Dong Shang, Fu-Xiang Wang, Jian Gao, Mu-Chun Wan, Zhou-Geng Xu, Jia-Wei Wang
Summary: This study reveals that a high auxin/cytokinin ratio environment promotes shoot regeneration in Arabidopsis by increasing the accessibility of gene loci associated with pluripotency and shoot fate determination. In addition, cytokinin signaling not only triggers shoot progenitor commitment at later stages but also maintains shoot identity genes at the priming stage. Furthermore, the study identifies regeneration cis-elements and highlights the important roles of BES1, MYC, IDD, and PIF transcription factors in shoot regeneration.
DEVELOPMENTAL CELL
(2022)
Article
Cell Biology
Xichen Nie, Sarah K. Munyoki, Meena Sukhwani, Nina Schmid, Annika Missel, Benjamin R. Emery, DonorConnect, Jan-Bernd Stukenborg, Artur Mayerhofer, Kyle E. Orwig, Kenneth Aston, James M. Hotaling, Bradley R. Cairns, Jingtao Guo
Summary: This study utilized single-cell RNA-seq to investigate the effects of aging on testicular cells in men. The results revealed age-related changes in multiple cell types, including alterations in signaling pathways, inflammation, and metabolism. The extent of dysregulation was also found to be correlated with body mass index in older men. This research provides insights into the candidate molecular mechanisms underlying testicular changes caused by aging.
DEVELOPMENTAL CELL
(2022)
Review
Cell Biology
Koning Shen, Corinne L. Pender, Raz Bar-Ziv, Hanlin Zhang, Kevin Wickham, Elizabeth Willey, Jenni Durieux, Qazi Ahmad, Andrew Dillin
Summary: Mitochondria, beyond their energy production role, have multiple functions in directing metabolism, stress responses, immunity, and cellular fate. They communicate both intracellularly and extracellularly to accomplish these tasks, providing insight into how dysfunctional mitochondria impact health in disease and aging.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
William H. Walker
Summary: This article discusses the impact of microRNAs on male fertility, specifically focusing on the regulation of gene expression in germ cells and Sertoli cells. The study highlights the importance of miRNA in differentiating spermatogonia, spermatocytes, spermatids, and Sertoli cells, and how they contribute to the overall process of spermatogenesis. Additionally, the role of miRNAs in signaling the initiation of puberty in a non-human primate model is also discussed.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Vytaute Boreikaite, Thomas S. Elliott, Jason W. Chin, Lori A. Passmore
Summary: In this study, the researchers reconstituted the 3' endonuclease activity of human CPSF and identified the protein factors required for this activity. They found that the activation and site-specific pre-mRNA cleavage by CPSF are tightly controlled. The results suggest that fidelity in mRNA processing is maintained through precise regulation of CPSF activity.
GENES & DEVELOPMENT
(2022)
Review
Cell Biology
Somarani Dash, Yasir Ahmed Syed, Mojibur R. Khan
Summary: The gut microbiome plays a significant role in early human brain development and is associated with neuropsychiatric disorders like autism. Dysbiosis of the microbiome is directly linked to exacerbated inflammatory state and functional brain deficits. Early dietary intervention may improve mental health in affected individuals.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
