Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Karina Genaro, Z. David Luo
Summary: Thrombospondin-4 (TSP-4) plays a crucial role in regulating various physiological and pathological processes, including cell-cell interactions, cell migration, tissue remodeling, and angiogenesis. Dysregulation of TSP-4 has been implicated in the development of disorders such as skeletal dysplasia, osteoporosis, cardiovascular diseases, and neurological disorders. Further research is needed to explore the potential of TSP-4 as a marker or therapeutic target for diagnosing and treating these conditions.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Martha Ludwig, James Hartwell, Christine A. Raines, Andrew J. Simkin
Summary: The Calvin-Benson-Bassham (CBB) cycle is found in all photosynthetic organisms and acts as the ancestral CO2 assimilation pathway. Biochemical extensions to this cycle, such as C4 photosynthesis and Crassulacean acid metabolism (CAM), allow for CO2 concentrating mechanisms. However, further research is needed to understand the integration and regulation of C4 and CAM pathways with the CBB cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Andreas Bikfalvi, Joris Guyon, Thomas Daubon
Summary: Glioblastoma is a highly aggressive and vascularized malignancy. Recent studies have shown the important role of thrombospondin-1 in the development of glioblastoma.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Sanjana Srinivasan, Xinjian He, Sarah Mirza, Jesse Mager
Summary: Exosome Complex Components 1 and 2 (EXOSC1 and 2) are essential proteins in the RNA Exosome complex that play important roles in early mammalian development. Their absence results in developmental delay and morphological abnormalities in embryos.
GENE EXPRESSION PATTERNS
(2024)
Article
Developmental Biology
Maria-del-Carmen Diaz-de-la-Loza, Brian M. Stramer
Summary: Cellular activities are traditionally considered as the main driving forces of tissue morphogenesis, while the role of extracellular matrix (ECM) is thought to be instructive. However, emerging evidence suggests that ECM may have cell-independent activity and plays an important role in directing tissue shape changes.
CELLS & DEVELOPMENT
(2024)
Article
Developmental Biology
Tom C. Karagiannis, Christian Orlowski, Katherine Ververis, Eleni Pitsillou, Gulcan Sarila, Samuel T. Keating, Laura J. Foong, Stefanie Fabris, Christina Ngo-Nguyen, Neha Malik, Jun Okabe, Andrew Hung, Theo Mantamadiotis, Assam El-Osta
Summary: This study investigates the role of phosphorylated histone H2AX (gamma H2AX) as a marker of DNA double-strand breaks (DSBs) and its implication in stem cell differentiation. The research establishes a mouse embryonic stem cell (mESC) differentiation model and examines the dynamics of gamma H2AX foci during the process. The findings reveal that gamma H2AX serves as a versatile marker of DSBs and may have a role as a biomarker in stem cell differentiation.
CELLS & DEVELOPMENT
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Kassandra J. Baron, Heth R. Turnquist
Summary: Based on successful preclinical animal transplant models, adoptive cell therapy with regulatory T cells (Tregs) shows promise in inducing allograft tolerance or reducing the need for immunosuppressive drugs in transplant recipients. Clinical evaluations have shown the ability to expand Tregs ex vivo and safely infuse them in large numbers. However, these trials have not yet achieved drug-free tolerance or significant reduction in immunosuppression needed for solid organ transplant (SOTx) rejection. Strategies to improve Treg therapy effectiveness may involve increasing Treg persistence or orchestrating Treg migration. This review discusses current clinical Treg manufacturing methods and highlights strategies to improve Treg persistence and migration in preclinical studies.
Article
Biochemistry & Molecular Biology
Hadjipanayi Ektoras, Moog Philipp, Jiang Jun, Dornseifer Ulf, Machens Hans-Guenther, F. Schilling Arndt
Summary: A new method that utilizes the regenerative power of autologous peripheral blood through hypoxia-adjusted in vitro preconditioning is proposed to treat hard-to-heal wounds. This method has shown effectiveness in managing surgical wounds with complete wound closure achieved within 135 days.
Article
Biochemistry & Molecular Biology
Jingwen Yang, Yuhan Song, Siming Xu, Shuyun Ge, Zhou Haiwen
Summary: This study evaluated the expression profiles of circular RNAs (circRNAs) in oral leukoplakia (OLK) and oral lichen planus (OLP) and explored their potential role in the pathogenesis of these diseases. High throughput sequencing technology identified significantly altered circRNAs in OLK and OLP. Validation experiments and bioinformatics analysis suggested that circHLA-C may be involved in the immune function and progression of OLK and OLP. Larger sample validation confirmed the upregulated expression of circHLA-C in OLK and OLP, and its potential diagnostic value.
Article
Biochemistry & Molecular Biology
Haichao Yuan, Senmao Li, Zhengping Zhao, Yan Wang
Summary: This study demonstrates that IFN-beta-modified hUCMSC-Exos suppress prostate cancer cell proliferation and facilitate apoptosis.
Article
Biochemistry & Molecular Biology
Makoto Hisanaga, Tomoshi Tsuchiya, Hironosuke Watanabe, Koichiro Shimoyama, Mayumi Iwatake, Yukinori Tanoue, Keizaburo Maruyama, Hiroshi Yukawa, Kazuhide Sato, Yoshimi Kato, Keitaro Matsumoto, Takuro Miyazaki, Ryoichiro Doi, Koichi Tomoshige, Takeshi Nagayasu
Summary: Decellularized scaffolds are promising biomaterials for tissue and organ reconstruction. This study investigated the effect of isogeneic abdominal adipose-derived mesenchymal stem/stromal cells (ADMSCs) on xenogeneic biomaterial-induced immunoreactions.
Review
Biochemistry & Molecular Biology
Meagan J. Makarczyk
Summary: This review discusses the application of cell therapy methods in the treatment of cartilage defects and osteoarthritis. It introduces the methods of autologous chondrocyte implantation and matrix autologous chondrocyte implantation, as well as the potential of stem cells and synthetic biology in treating osteoarthritis.
