Dermatology

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Article Dermatology

Efficacy and safety of abrocitinib monotherapy in adolescents and adults: a post hoc analysis of the phase 3 JAK1 atopic dermatitis efficacy and safety (JADE) REGIMEN clinical trial

Carsten Flohr, Michael J. Cork, Michael R. Ardern-Jones, Lawrence F. Eichenfield, Sebastien Barbarot, Claire Feeney, Ricardo Rojo, Irina Lazariciu, John Nesnas

Summary: The study evaluated the response to treatment with continuous/reduced-dose abrocitinib or withdrawal and reintroduction after flare in adolescents and adults with atopic dermatitis. It found that abrocitinib was effective in preventing flare in both age groups, with no significant difference in response between adolescents and adults.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Letter Dermatology

A new hope in the treatment of onychogryphosis due to acquired malalignment of great toenails: intramatrix dexpanthenol injection

Omer Kutlu, Uwe Wollina, Fatih Goktay

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Letter Dermatology

Pemphigus foliaceus treated with minocycline monotherapy or low-dose prednisolone combination therapy

Birao Fan, Xixue Chen, Xuejun Zhu, Mingyue Wang

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Progressive mucinous histiocytosis treated successfully with thalidomide: a rare case report

Reem Diab, Mohammad Shahidi Dadras, Azadeh Rakhshan, Ali Kaddah, Fahimeh Abdollahimajd

Summary: Hereditary progressive mucinous histiocytosis is a rare progressive skin disorder characterized by erythematous papules on the face and upper extremities. The cause and pathogenesis of the disease are still unknown, but it may be related to lysosomal storage disease and macrophages.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Review Dermatology

Use of autologous platelet-rich plasma in androgenetic alopecia in women: a systematic review and meta-analysis

Antonio Flavio Queiroz de Oliveira, Francisco Placido Nogueira Arcanjo, Maria Rosineida Paiva Rodrigues, Ana Augusta Rosa e Silva, Peter Richard Hall

Summary: This study conducted a systematic review and meta-analysis to examine the effectiveness of using autologous platelet-rich plasma (PRP) in treating female pattern alopecia (FPA). The analysis showed that PRP treatments can increase terminal hair density, but do not significantly increase hair thickness. No major side effects were reported during or after treatment.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Surgical experiences in pediatric pilomatricoma: punch incision and elliptical excision

Hoon Choi, Dong Hyun Shim, Chan Ho Na, Bong Seok Shin, Min Sung Kim

Summary: This retrospective study analyzed surgical methods and outcomes in patients under 19 years old who underwent surgical treatment for pilomatricoma. The results showed that punch incision and elliptical excision were commonly used surgical methods. Recurrence was not observed in the elliptical excision group, while one case of recurrence was observed in the punch incision group.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

High-fluence 1064nm Q-switched Nd:YAG laser treatment for ectopic Mongolian spot

Jun-Oh Shin, Dongyoung Roh, Kihyuk Shin, Hoon-Soo Kim, Byung-Soo Kim, Moon-Bum Kim, Hyun-Chang Ko

Summary: The present study aimed to investigate the efficacy of high-fluence 1064 nm Q-switched Nd:YAG laser in treating ectopic Mongolian spots. The results showed that this laser treatment had significant effects on improving the color and melanin content of the spots, and it was well-tolerated.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Network meta-analyses comparing the efficacy of biologic treatments for achieving complete resolution of nail psoriasis at 24-28 and 48-52 weeks

Alexander Egeberg, Lars Erik Kristensen, Luis Puig, Phoebe Rich, Saxon D. Smith, Alyssa Garrelts, Kyoungah See, Thorsten Holzkaemper, Konstantinos Fotiou, Christopher Schuster

Summary: Two network meta-analyses were conducted to compare the efficacy of biologics in treating nail psoriasis. The results showed that ixekizumab had the highest probability of achieving complete resolution of nail psoriasis.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Disease burden among patients with atopic dermatitis treated with systemic therapy for 4-12 months: results from the CorEvitas Atopic Dermatitis Registry

Jonathan I. Silverberg, Evangeline Pierce, Meghan Feely, Amber Reck Atwater, Amy Schrader, Eric A. Jones, Swapna S. Dave, Eric L. Simpson

Summary: Despite receiving systemic therapy, patients with atopic dermatitis (AD) experienced a high disease burden, with additional use of topical therapy and lesions in difficult locations. This study provides potential evidence of suboptimal treatment and highlights the need for more effective treatment options for AD.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Patients' willingness to accept adverse event and cost tradeoffs from oral nicotinamide for reduced risk of non-melanoma skin cancer

Marco Boeri, Maral K. Skelsey, James A. Schiro, Susan E. Dozier, Robert Glinert, Martin M. Okun

Summary: Patients with a history of multiple non-melanoma skin cancers experienced a 23% decrease in annual risk when taking oral nicotinamide supplementation. However, it is unknown how patients prioritize the risks and costs associated with nicotinamide.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Letter Dermatology

Upadacitinib for the treatment of atopic dermatitis in the elderly: an Italian case series of seven patients

Luciano Ibba

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Successful treatment of alopecia universalis with abrocitinib: a case report

Jie Zhang, Ya-Gang Zuo

Summary: Abrocitinib, a selective JAK1 inhibitor, is effective for treating moderate-to-severe atopic dermatitis (AD) and co-morbid alopecia universalis (AU). We present a case of AU following drug reaction with eosinophilia and systemic symptoms (DRESS) that responded well to abrocitinib therapy. We also reviewed AA cases after DRESS and explored the autoimmune mechanisms involved, suggesting abrocitinib as a promising option for recalcitrant AU.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Treatment of dissecting cellulitis of the scalp with erbium: YAG laser: a case series

Mengjun Xu, Suiqing Cai, Jianliang Yan

Summary: "Dissecting cellulitis of the scalp (DCS) is a rare inflammatory disease. The study found that using a 2940-nm erbium YAG laser was effective and safe for treating DCS, with no severe adverse effects."

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Safety and efficacy of Pimecrolimus in atopic dermatitis among Chinese infants: a sub-group analysis of a five-year open-label study

Xia Dou, Lingling Liu, Xuejun Zhu, Weijing Wen, Chunya Ni, Yi Zhao, Zhixin He, Hongchun Li, Qiuning Sun, Qinping Yang, Xinfen Sun, Yifeng Guo

Summary: This study evaluates the efficacy and safety of Pimecrolimus in Chinese infants with atopic dermatitis through a sub-group analysis. The results show that PIM has early and sustained efficacy in treating infants with AD in the Chinese population.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

An international expert consensus statement focusing on pre and post hair transplantation care

S. Vano-Galvan, C. N. Bisanga, P. Bouhanna, B. Farjo, V. Gambino, T. Meyer-Gonzalez, T. Silyuk, Hair Transplant Surg Expert Grp

Summary: This study aimed to reach international expert consensus on best practices in hair transplantation surgery, particularly pre- and post-transplantation care. A modified Delphi method was used and a panel of 38 hair transplantation experts assessed an 81-statement questionnaire. Two consensus rounds resulted in 59 statements (73%) reaching consensus. Expert recommendations focused on candidate selection, prior medical therapy, anesthesia, and post-transplantation care.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Letter Dermatology

Two cases of lupus miliaris disseminatus faciei successfully treated with oral tofacitinib

Xinyi Chen, Jianjun Qiao

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Letter Dermatology

Treatment of permethrin-resistant scabies with pyrethrins/piperonyl butoxide foam

Gianluca Nazzaro

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Letter Dermatology

Effectiveness and safety of baricitinib in patients with severe alopecia areata: a 36-week multicenter real-world experience

Luigi Gargiulo, Luciano Ibba, Carlo A. Vignoli, Silvia M. Ferrucci, Santo R. Mercuri, Piergiorgio Malagoli, Angelo V. Marzano, Mauro Barbareschi, Vittoria G. Bianchi, Mario Valenti, Antonio Costanzo, Alessandra Narcisi

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Article Dermatology

Engineering extracellular vesicles with macrophage membrane fusion for ameliorating imiquimod-induced psoriatic skin inflammation

Zeng Wang, Zhizhen Qin, Jiadie Wang, Xinqi Xu, Mengxin Zhang, Yuyue Liang, Yukun Huang, Zengyang Yu, Yu Gong, Luxian Zhou, Yiran Qiu, Minglu Ma, Dan Li, Bin Li

Summary: We developed an engineered extracellular vehicle (EV)-based method for ameliorating inflammatory responses in psoriasis. EVs derived from annexin A1 (ANXA1) overexpressing T cells were co-extruded with M2 macrophage membrane to obtain engineered EVs. In vitro, the effect of engineered EVs on macrophage polarization was evaluated, and the efficacy of engineered EVs in ameliorating psoriatic inflammation was evaluated in a mouse model.

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Letter Dermatology

Long-term management of pediatric psoriasis with ixekizumab: a case report

Diego Orsini, Luciano Ibba, Alessandra Narcisi, Pasquale Frascione, Alessia Pacifico, Mario Valenti, Antonio Costanzo, Luigi Gargiulo

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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