Article
Chemistry, Applied
Hong Deng, Xue Yang, Huimin Wang, Menghan Gao, Yiyi Zhang, Runmeng Liu, Haiyan Xu, Weiqi Zhang
Summary: This study demonstrates the potential of positively charged dextran nanogels (NGs) as a promising approach for TAM targeting in cancer therapy. By utilizing a non-covalent self-assembly strategy, the researchers constructed oppositely charged NGs and compared their effects on TAM targeting. The positive NGs showed superior TAM targeting in a murine breast cancer model.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Organic
Satish Kumar Burra, Vaikunta Rao Lakinani, Raghunadh Akula, Chiranjeevi Yankkanti
Summary: A novel and green strategy for the construction of biologically relevant substituted indolyl-4H-chromenes scaffolds is reported, using L-proline as a catalyst and water as a promoter solvent. This catalytic system offers wider applicability, shorter reaction times, and high yields, making it an ideal condition for green chemistry.
SYNTHETIC COMMUNICATIONS
(2024)
Review
Chemistry, Organic
Abouelhaoul El Alami, Amine El Maraghi, Fatima Youssoufi, Assiya Atif, Hamid Sdassi
Summary: Nitrobenzimidazoles have become increasingly important in the design of new compounds in medicinal, therapeutic and chemical fields. This review provides an overview of the synthesis strategies and biological activities of nitrobenzimidazole derivatives.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Applied
Dong Fu, Yang Xie, Lili Zhou, Lili Zhang, Ting Zheng, Jun Shen
Summary: A novel triple physical cross-linking poly(ionic liquid) hydrogel was synthesized with excellent mechanical properties and other advantages. It was assembled as a multifunctional sensor to monitor joint motion, vocal cord vibration, tactile sensation, and body temperature in real time.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anita Etale, Amaka J. Onyianta, Jean-Charles Eloi, Jemma Rowlandson, Stephen J. Eichhorn
Summary: Urea and phosphoric acid are necessary for the isolation of phosphorylated cellulose nanocrystals (CNCs). This study found that a design of experiments approach allows for a lower ratio of urea to acid and the production of CNCs with high surface charge. This information is instructive for the application of phosphorylated cellulose nanomaterials in areas such as water purification and medical biomaterials.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yuma Nakata, Shinichi Kitamura, Ken Terao
Summary: By studying the synthesis and properties of partially substituted amylose n-butylcarbamate (ABC) samples, it was found that the samples were soluble in water within a certain range of degree of substitution (DS), and both LCST and UCST type phase separations were observed. Closed-loop phase diagrams for the dual thermoresponsive ABC samples in water were constructed based on turbidity measurements, and the chain conformation of ABC at different temperatures was determined through SAXS measurements.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Elham Ostadi, Naser Mohammadi
Summary: This research investigated the influence of cellulose nanocrystal (CNC)-related parameters on the mechanical and desalination performance of a cellulose diacetate (CDA) membrane system. The results showed that different types of nanoassembly were formed in the CDA when using high aspect ratio (HAR) CNCs. The nanocomposite membrane containing 0.50 wt% HAR-CNCs exhibited improved mechanical strength and reduced water permeability/salt rejection tradeoff, indicating the potential for optimizing both mechanical and desalination performance by manipulating the dispersion state of CNC rods in the CDA.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Luiz G. Greca, Ainara Azpiazu, Guillermo Reyes, Orlando J. Rojas, Blaise L. Tardy, Erlantz Lizundia
Summary: The deconstruction and valorization of chitinous biomass from crustaceans is a promising route for sustainable bioproduct development. This study introduces a mild fibrillation route to generate chitin pulp, which can be tailored to have specific properties by controlling the composition of protein and mineral components.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yifan Liu, Fengxin Zhao, Tao Song, Ming Tang, Luoqiang Tian, Tinghan He, Dongxiao Li, Yumei Xiao, Xingdong Zhang
Summary: In this study, a multifunctional dual-network hydrogel was designed to treat infectious wounds. The hydrogel, which had good injectability, stability, self-healing, and adhesion, was loaded with MgO/Icariin composite nanoparticles. In vitro and in vivo experiments showed that the nanohybrid hydrogel had multiple physiological functions and could effectively reduce bacterial infection and promote wound healing. This study provides a new paradigm for the design of multifunctional bioactive hydrogels.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Miguel Riopedre-Fernandez, Denys Biriukov, Martin Dracinsky, Hector Martinez-Seara
Summary: This study investigates the molecular motifs of hyaluronan-peptide interactions using NMR and molecular dynamics simulations. The results show that arginine-rich peptides have the strongest binding to hyaluronan, followed by lysine. Molecular simulations reveal an extended but significant interaction region, especially for arginine, which explains the enhanced binding between hyaluronan and positively charged arginine-rich proteins.
CARBOHYDRATE POLYMERS
(2024)
Correction
Chemistry, Applied
Yanjun Liu, Panpan Li, Wenjie Pan, Juan Zhao, Chen Guang Olnood, Yuanfa Liu, Yong-Jiang Xu
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian-Han Xiao, Ze-Zhi Li, Li Ren, Shu-Yao Wang, Xiao-Qiang Li, Hong-Xin Bai, Rui-Zhi Qiao, Na Tang, Wen-Juan Liu, Jing-Mei Wang, Guang-Yuan Ma, Dian-Chao Dong, Ke-Han Wu, Wei Cao
Summary: This study optimized the derivatives of alpha-D-glucan binding to ALDOA and found that the sulfated modification demonstrated the highest affinity with ALDOA, which could effectively inhibit the proliferation of HCC cells by blocking ALDOA.
CARBOHYDRATE POLYMERS
(2024)
Article
Biochemistry & Molecular Biology
Simone Giovannuzzi, Anna Nikitjuka, Bruna Rafaela Pereira Resende, Michael Smietana, Alessio Nocentini, Claudiu T. Supuran, Jean-Yves Winum
Summary: Boron-based compounds have been extensively studied in medicinal chemistry, playing a crucial role in designing small molecule drugs for various diseases. Boron is particularly valuable in developing inhibitors for metalloenzymes carbonic anhydrases, and it can modulate ligand recognition ability and selectivity. Recent advancements have led to the discovery of novel boron-based inhibitors that can inhibit carbonic anhydrases through a Lewis acid-base mechanism. Further research is needed to fully explore the potential of boron-based inhibitors and advance their clinical applications.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinxin Liu, Lei Chen, Ze Chen
Summary: This study developed a nanostructured photosensitizer loaded with oxygen-throttling drug and demonstrated its enhanced cytotoxicity against tumor cells under hypoxic conditions. Animal experiments showed the enhanced tumor targeting capability of the photosensitizer and its inhibitory effect on tumor growth.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xiao-Dong Wang, Yong-Si Liu, Ming-Hao Hu
Summary: In this study, a selffolded fluorescent probe was designed to selectively illuminate G4s by unfolding its intramolecular aggregation mediated by G4 binding. This probe showed more controllable background emission and promising ability to track G4 forming dynamics compared to previous disaggregation-induced emission (DIE) probes.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Xiang, Zhuo Yuan, Qichuan Deng, Linshen Xie, Dongke Yu, Jianyou Shi
Summary: This review provides a brief description of the diagnosis, pathogenesis, and potential therapeutic inhibitors for renal fibrosis. Currently, there are no clear therapeutic targets or drugs for renal fibrosis; however, some natural products may have potential efficacy for treating renal fibrosis.
BIOORGANIC CHEMISTRY
(2024)
Article
Chemistry, Organic
Terungwa H. Iorkula, Bryce A. Tolman, Scott R. Burt, Matt A. Peterson
Summary: A new method for synthesizing C-6 substituted products has been discovered in this study, which utilizes lower doses of fluoride and CsF as a catalyst, with high reaction yields and cost-effectiveness under suitable conditions.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Preethi Dhanapal, S. L. Manju
Summary: Thiazole based Schiff base scaffolds have become an integral part of drug development in recent years, playing a versatile role as building blocks for lead drug molecules. This study presents a facile one pot synthetic method for producing novel 4-aryl thiazoles with high yield, shorter reaction time, and milder conditions, without the need for catalysts or purification techniques.
SYNTHETIC COMMUNICATIONS
(2024)
