Papers in Chemistry, Analytical

Article Chemistry, Analytical

Confinement of gold nanoclusters on hydroxy double salt for versatile fluorescent sensing of bio-enzymes

Mengke Wang, Yaqing Han, Rui Huang, Zhonghao Wang, Guannan Wang

Summary: The confinement effect of AuNCs@HDS significantly improves the fluorescence properties of AuNCs and enables versatile fluorescent sensing strategy for bio-enzymes.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

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Article Chemistry, Analytical

An electrochemical metallic nanowire aptasensor for rapid and ultrasensitive detection of cardiac troponin I

Junfeng Zhang, Kai Sun, Jiangtao Ren, Han Wang, Jing Cheng

Summary: A metallic nanowire aptasensor with high sensitivity and short detection time was developed for the early diagnosis and prognostic monitoring of heart failure by detecting cardiac troponin I (cTnI). The sensor exhibited excellent detection performance, including high sensitivity, short detection time, high specificity, and good reproducibility, making it a potential application in portable devices for continuous monitoring of cardiomyocyte injury.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

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Article Chemistry, Analytical

Fluorescent probes based on quinoline and naphthidine derivatives with NIR and AIE properties for real-time monitoring mitochondrial viscosity during mitophagy

Jing-Yu Zhao, Gang Zhang, Hao-Chi Hao, Ru Sun, Yu-Jie Xu, Jian-Feng Ge

Summary: This study presents the discovery of mitochondria probes for real-time monitoring of mitophagy process. The probes showed excellent fluorescence performance and targeting capability, and were able to detect changes in mitochondrial viscosity. These probes have significant potential for investigating dynamic pathological processes related to mitophagy.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

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Article Chemistry, Analytical

Ion-selective organic electrochemical transistors for the determination of potassium in clinical samples

Marc Clua Estivill, Adil Ait Yazza, Pascal Blondeau, Francisco J. Andrade

Summary: This study presents the development and optimization of a paper-based ion-selective organic electrochemical transistor (IS-OECT) with remarkable analytical performance. The device combines thick-film transistor technology, optimal ion-selective membrane composition and thickness to achieve high sensitivities and good selectivity for detecting potassium concentrations in blood.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

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Article Chemistry, Analytical

Label-free identification of DNA single-base mutation for clinical diagnostics based on plasmonic SiNW@AgNP arrays

Han Lu, Dan Wang, Guangfei Huang, Qilin Ma, Yuan Zhang, Mingliang Jin, Lingling Shui

Summary: Surface-enhanced Raman spectroscopy (SERS) has great potential in DNA analysis, but the identification of single-base mutations is still limited. In this work, plasmonic SiNW arrays decorated with Ag nanoparticles (SiNW@AgNP arrays) were developed to address these challenges, showing excellent sensitivity and reproducibility. Under optimized conditions, SiNW@AgNP arrays enable the detection of DNA bases and the discrimination of gene mutations.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

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Article Biophysics

Plasmonic digital PCR for discriminative detection of SARS-CoV-2 variants

Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon

Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.

BIOSENSORS & BIOELECTRONICS (2024)

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Article Chemistry, Analytical

Amino acids analysis reveals serum methionine contributes to diagnosis of the Kawasaki disease in mice and children

Ruijin Geng, Mengjie Yu, Jinbiao Xu, Yuanwang Wei, Qiong Wang, Junguo Chen, Fei Sun, Kun Xu, Han Xu, Xiaohui Liu, Juhua Xiao, Xianchao Zhang, Baogang Xie

Summary: This study validated serum methionine as a potential biomarker for Kawasaki disease (KD), and found that its alteration is associated with the activation of DNMT1 in KD patients.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2024)

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Article Chemistry, Analytical

Development of integrated optical biosensors based on low-cost stereolithography fabrication and multispectral signature for Lab-On-Chip applications

Gianni Antonelli, Arianna Mencattini, Micol Massimiani, Valentina Lacconi, Joanna Filippi, Margherita Losardo, Michele 'Orazio, Paola Casti, Mario Bragaglia, Giorgia Curci, Francesca Nanni, Luisa Campagnolo, Eugenio Martinelli

Summary: Lab-On-Chips (LOCs) offer advantages in studying biological models and evaluating drug efficacy. This research presents a cost-effective technique to integrate optical biosensors into the lab-on-chip and successfully measures pH in human embryonic stem cell cultures, advancing the understanding of cell-scale metabolic mechanisms.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

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Article Chemistry, Analytical

DNA walker-powered SERS logic aptasensors for accurate imaging and identification of tumor cells

Chen Dong, Jingrong Xiong, Yeran Wang, Jing Liang, Chenlong Yan, Huiming Lv, Jingjing Zhang, Chunyuan Song, Lianhui Wang

Summary: In this study, a DNA walker-powered SERS logic aptasensor was proposed for accurate identification of tumor cells. The aptasensor can sensitively and specifically image membrane proteins on single live cells, enabling logical analysis for cancer cell classification and subtypes.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

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Article Chemistry, Analytical

Nanocasting technique for imprinting a natural leaf pattern on biomimetic polyaniline to yield an artificial hierarchical surface structure for gas sensing

Kun-Hao Luo, Yu-Han Hung, Aamna Bibi, Yi-Min Li, Chuan Hu, Jui-Ming Yeh

Summary: This study focuses on the synthesis and utilization of a novel biomimetic material, Bio-PANI, for H2S gas sensing applications. The Bio-PANI coating exhibits a larger specific surface area and better electrochemical performances compared to conventional PANI coating. The Bio-PANI-coated sensor shows higher response and better stability.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

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Article Chemistry, Analytical

Enhanced performance of electro-responsive PVC gel actuators prepared by advanced rapid thermal melting technique

Yuwei Wu, Min Yu, Chengbo Tian, David Vokoun, Runqi Hu, Hengzao Ge, Hao Zhang, Ivo Stachiv

Summary: This study proposes a new method for fabricating PVC gel using a thermal melting approach, which significantly improves its actuation performance while reducing fabrication time and cost.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

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Article Chemistry, Analytical

An APE1-mediated isothermal target cycling amplification for label-free and rapid detection of miRNA

Mengxu Sun, Yanxin Zhang, Juan Xie, Ya Zhang, Ting Huang, Minmin Li, Jin-Xiang Chen, Zong Dai, Jun Chen

Summary: This study developed a highly efficient and sensitive miRNA detection method by combining APE1-mediated isothermal target cycling amplification system with magnetic separation. The label-free and rapid detection of miRNA was achieved through the recognition and cleavage of AP probes by APE1, and the fluorescence measurement of G4/ThT. The method showed high specificity and sensitivity, and demonstrated its application in detecting miR-1246 in serum samples from breast cancer patients and normal people.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

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Article Chemistry, Analytical

Classification of circulating tumor cell clusters by morphological characteristics using convolutional neural network-support vector machine

Junhyun Park, Seongmin Ha, Jaejeung Kim, Jae-Woo Song, Kyung-A. Hyun, Tohru Kamiya, Hyo-Il Jung

Summary: In this study, a hybrid algorithm was developed for accurate classification of CTC clusters without immunofluorescence staining, providing a powerful tool for cancer diagnosis and prognosis.

SENSORS AND ACTUATORS B-CHEMICAL (2024)

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Article Chemistry, Analytical

Electrodeposited histidine-(CuCr)layered double hydroxides/carbon dots for in-tube solid-phase microextraction of chlorophenols from water, juice, and honey samples followed by HPLC-UV

Mohsen Aghaziarati, Yadollah Yamini, Maryam Shamsayei

Summary: A novel adsorbent consisting of carbon dots, CuCr-layered double hydroxides, and L-histidine was successfully applied for in-tube solid-phase microextraction of chlorophenols. Through optimization of various parameters, good separation and measurement results were achieved, enabling accurate detection of chlorophenols in water samples.

TALANTA (2024)

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Article Chemistry, Analytical

Fluorescent bacteria detection in water using cell imprinted polymer (CIP) coated microparticles in a magnetophoretic microfluidic device

Ali Doostmohammadi, Khaled Youssef, Shiva Akhtarian, Garrett Kraft, Pouya Rezai

Summary: This paper introduces a new sensor for rapid and low-cost detection of bacteria in water, which utilizes fluorescent magnetic CIP-MPs and a microfluidic channel for quick detection of Escherichia coli. The shape of the magnetic microstructures is optimized to enhance the accumulation of CIP-MPs in the microchannel. The sensor has low detection and quantification limits, and exhibits specificity towards Escherichia coli.

TALANTA (2024)

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Article Chemistry, Analytical

Microwave synthesized N-doped carbon dots for dual mode detection of Hg (II) ion and degradation of malachite green dye

Chinnu R. Thara, Beena Mathew

Summary: This study investigated the electrochemical and photochemical properties of nitrogen-doped carbon dots synthesized through microwave-assisted pyrolysis. The synthesized carbon dots exhibited high water dispersibility, stability, and biocompatibility. They showed excellent stability, sensitivity, and selectivity for mercury ion detection and were also capable of efficiently degrading malachite green dye.

TALANTA (2024)

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Review Chemistry, Analytical

Genosensor on-chip paper for point of care detection: A review of biomedical analysis and food safety application

Lelya Hilda, Maysam Salih Mutlaq, Ibrahem Waleed, Raed H. Althomali, Mohammed H. Mahdi, Sherzod Shukhratovich Abdullaev, Rajesh Singh, Hind Ali Nasser, Yasser Fakri Mustafa, Ahmed H. R. Alawadi

Summary: Over the past decade, paper-based biosensing has gained significant attention due to its advantages such as affordability and portability. However, limitations in sensitivity and selectivity have hindered its application. The use of nanomaterials to modify paper and incorporation of bioreceptors have been proposed as strategies to overcome these limitations. Paper-based genosensors have the potential for detecting various genes related to biomedical and food safety.

TALANTA (2024)

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Article Chemistry, Analytical

Halloysite nanotubes-loaded conductive polymer as substrate and label material for sensitive detection of amyloid-β protein by electrochemical immunosensor

Sujie Ye, Ping Wang, Yang Li, Wenzhong Wang, Qing Liu, Yueyun Li

Summary: This study utilized various nanomaterials, including Ni/PdH NDs, mHNT, and PANI@eHNT, to enhance the sensitivity and signal amplification of the electrochemical immunosensor, with the anticipation of aiding in the early detection of AD.

TALANTA (2024)

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Article Chemistry, Analytical

In situ analysis of metabolic changes under hypoxic-ischemic encephalopathy via MALDI mass spectrometry imaging

Huihui Liu, Ting Xie, Jiyun Wang, Xiao Wang, Jing Han, Zhihua Huang, Lixia Jiang, Zongxiu Nie

Summary: HIE is a major cause of neurological disability and fetal or neonatal asphyxia death. The study found significant changes in metabolites involved in multiple metabolic pathways during the HIE period, including the accumulation of neutral TGs in the ischemic region.

TALANTA (2024)

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Article Chemistry, Analytical

Enhancing electrochemiluminescence by modifying Fe3CuO4 and CdS@ZnS: A novel ECL sensor for highly sensitive detection of permethrin

Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu

Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.

TALANTA (2024)

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Chemistry, Analytical

Confinement of gold nanoclusters on hydroxy double salt for versatile fluorescent sensing of bio-enzymes

An electrochemical metallic nanowire aptasensor for rapid and ultrasensitive detection of cardiac troponin I

Fluorescent probes based on quinoline and naphthidine derivatives with NIR and AIE properties for real-time monitoring mitochondrial viscosity during mitophagy

Ion-selective organic electrochemical transistors for the determination of potassium in clinical samples

Label-free identification of DNA single-base mutation for clinical diagnostics based on plasmonic SiNW@AgNP arrays

Plasmonic digital PCR for discriminative detection of SARS-CoV-2 variants

Amino acids analysis reveals serum methionine contributes to diagnosis of the Kawasaki disease in mice and children

Development of integrated optical biosensors based on low-cost stereolithography fabrication and multispectral signature for Lab-On-Chip applications

DNA walker-powered SERS logic aptasensors for accurate imaging and identification of tumor cells

Nanocasting technique for imprinting a natural leaf pattern on biomimetic polyaniline to yield an artificial hierarchical surface structure for gas sensing

Enhanced performance of electro-responsive PVC gel actuators prepared by advanced rapid thermal melting technique

An APE1-mediated isothermal target cycling amplification for label-free and rapid detection of miRNA

Classification of circulating tumor cell clusters by morphological characteristics using convolutional neural network-support vector machine

Electrodeposited histidine-(CuCr)layered double hydroxides/carbon dots for in-tube solid-phase microextraction of chlorophenols from water, juice, and honey samples followed by HPLC-UV

Fluorescent bacteria detection in water using cell imprinted polymer (CIP) coated microparticles in a magnetophoretic microfluidic device

Microwave synthesized N-doped carbon dots for dual mode detection of Hg (II) ion and degradation of malachite green dye

Genosensor on-chip paper for point of care detection: A review of biomedical analysis and food safety application

Halloysite nanotubes-loaded conductive polymer as substrate and label material for sensitive detection of amyloid-β protein by electrochemical immunosensor

In situ analysis of metabolic changes under hypoxic-ischemic encephalopathy via MALDI mass spectrometry imaging

Enhancing electrochemiluminescence by modifying Fe3CuO4 and CdS@ZnS: A novel ECL sensor for highly sensitive detection of permethrin

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