Papers in Cell Biology

Article Biochemistry & Molecular Biology

Alleviation of experimental autoimmune encephalomyelitis by transferring low RelB expression tolerogenic dendritic cells

Chao Zheng, Lingling Liu, Caiyun Liu, Fengna Chu, Yue Lang, Shan Liu, Yan Mi, Jie Zhu, Tao Jin

Summary: Inducing tolerogenic dendritic cells (tDCs) with low RelB expression could effectively alleviate symptoms and reduce immune cell infiltration and demyelination in experimental autoimmune encephalomyelitis (EAE) mouse model.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2024)

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Article Biochemistry & Molecular Biology

The synergistic effect of nanocurcumin and donepezil on Alzheimer's via PI3K/AKT/GSK-3β pathway modulating

Doha M. Beltagy, Nagat F. Nawar, Tarek M. Mohamed, Ehab Tousson, Mai M. El-Keey

Summary: This study aimed to evaluate the protective role of nanocurcumin as an antioxidant and anti-inflammatory agent, and its synergistic effects with Donepezil in the treatment of Alzheimer's disease in rats. The results showed that treatment with nanocurcumin improved memory, locomotion, and neuronal differentiation by activating the PI3K/AKT/GSK-3 beta pathway.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2024)

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Article Biochemistry & Molecular Biology

Humanin ameliorates TBI-related cognitive impairment by attenuating mitochondrial dysfunction and inflammation

Pavan Thapak, Zhe Ying, Victoria Palafox-Sanchez, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla

Summary: Traumatic brain injury (TBI) impairs cellular energy demand, compromising neuronal function and plasticity. This study demonstrates that the mitochondrial activator humanin (HN) can counteract the reduction in mitochondrial bioenergetics caused by TBI, restore memory function and synaptic protein levels, and suppress inflammation and astrocyte proliferation. HN plays an integral role in normalizing fundamental aspects of TBI pathology.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2024)

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Review Biochemistry & Molecular Biology

Reactive oxygen species in colorectal cancer adjuvant therapies

Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen

Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2024)

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Article Biochemistry & Molecular Biology

Small extracellular vesicles-mediated cellular interactions between tumor cells and tumor-associated macrophages: Implication for immunotherapy

Liaoran Niu, Qi Wang, Fan Feng, Wanli Yang, Zhenyu Xie, Gaozan Zheng, Wei Zhou, Lili Duan, Kunli Du, Yiding Li, Ye Tian, Junfeng Chen, Qibin Xie, Aqiang Fan, Hanjun Dan, Jinqiang Liu, Daiming Fan, Liu Hong, Jian Zhang, Jianyong Zheng

Summary: This review provides a comprehensive summary of the interaction between cancer cells and macrophages in the tumor microenvironment, and discusses the role of small extracellular vesicles (sEVs) in this process. It also explores the various effects of macrophage-secreted sEVs on tumor malignant transformation, and addresses the therapeutic advancements and challenges associated with these vesicles.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2024)

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Article Biochemistry & Molecular Biology

Enhanced capacity for CaMKII signaling mitigates calcium release related contractile fatigue with high intensity exercise

Martin Fluck, Colline Sanchez, Vincent Jacquemond, Christine Berthier, Marie-Noelle Giraud, Daniel Jacko, Kathe Bersiner, Sebastian Gehlert, Guus Baan, Richard T. Jaspers

Summary: Enhancing CaMKII signaling improves fatigue resistance and contractile characteristics of skeletal muscle by enhancing calcium release.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2024)

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Article Biochemistry & Molecular Biology

Lanosterol elevates cytoprotective response through induced-proteasomal degradation of aberrant proteins

Sumit Kinger, Yuvraj Anandrao Jagtap, Ankur Rakesh Dubey, Prashant Kumar, Akash Choudhary, Rohan Dhiman, Vijay Kumar Prajapati, Deepak Chitkara, Krishna Mohan Poluri, Amit Mishra

Summary: Efficient protein synthesis and quality control mechanisms are crucial for maintaining proteostasis and preventing neurodegeneration. This study demonstrates that treating cells with Lanosterol can enhance the proteolytic activity of Proteasome and promote the removal of misfolded proteins, suggesting a potential therapeutic approach for abnormal protein accumulation.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2024)

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Article Biochemistry & Molecular Biology

ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis

Lan Wang, Hongmei Yuan, Wenwen Li, Peishuo Yan, Mengxia Zhao, Zhongzheng Li, Huabin Zhao, Shenghui Wang, Ruyan Wan, Yajun Li, Juntang Yang, Xin Pan, Ivan Rosas, Guoying Yu

Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease of unknown cause. Decreased expression of ACSS3 in IPF patients and mice with fibrosis was found, leading to the accumulation of lipid droplets and increased glycolysis. ACSS3 regulates the activity of alveolar epithelial cells through metabolic reprogramming, potentially serving as a therapeutic target for pulmonary fibrosis.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2024)

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Article Biochemistry & Molecular Biology

The role of RLIP76 in oxidative stress and mitochondrial dysfunction: Evidence based on autopsy brains from Alzheimer's disease patients

Chhanda Bose, Sudhir Kshirsagar, Murali Vijayan, Subodh Kumar, Sharda P. Singh, Ashly Hindle, P. Hemachandra Reddy

Summary: This study investigates the role of RLIP76 in Alzheimer's Disease (AD) by analyzing brain tissues from AD patients and control subjects. The findings show a gradual decrease in the expression of RLIP76 protein with AD progression, and its co-localization with Amyloid beta and phosphorylated tau. AD patients exhibited higher levels of lipid peroxidation, H2O2 production, and oxidative DNA damage, as well as lower ATP production compared to controls. COMET assay revealed numerous DNA strand breaks in AD patients. These results indicate that RLIP76 plays an important role in maintaining neuronal health and homeostasis, and could be a promising therapeutic target for Alzheimer's disease.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2024)

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Article Cell Biology

ZNF70 regulates IL-1β secretion of macrophages to promote the proliferation of HCT116 cells via activation of NLRP3 inflammasome and STAT3 pathway in colitis-associated colorectal cancer

Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma

Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.

CELLULAR SIGNALLING (2024)

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Article Cell Biology

Inhibition of spinal Rac1 attenuates chronic inflammatory pain by regulating the activation of astrocytes

Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li

Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.

CELLULAR SIGNALLING (2024)

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Article Biochemistry & Molecular Biology

Inhibition of autophagy initiation: A novel strategy for oral squamous cell carcinomas

Yomna S. Abd El-Aziz, Matthew J. McKay, Mark P. Molloy, Betty McDowell, Elizabeth Moon, Loretta Sioson, Amy Sheen, Angela Chou, Anthony J. Gill, Patric J. Jansson, Sumit Sahni

Summary: This study identified a novel combination of autophagy inhibitors that can effectively inhibit the proliferation of oral squamous cell carcinoma (OSCC) cells, including both chemosensitive and chemoresistant cells. This research is important for the development of new therapies for advanced OSCC tumors.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2024)

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Article Cell Biology

CircFSCN1 induces tumor progression and triggers epithelial-mesenchymal transition in bladder cancer through augmentation of MDM2-mediated p53 silencing

Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu

Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.

CELLULAR SIGNALLING (2024)

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Article Cell Biology

Knockdown of SQLE promotes CD8+T cell infiltration in the tumor microenvironment

Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li

Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.

CELLULAR SIGNALLING (2024)

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Article Biochemistry & Molecular Biology

SPOP promotes CREB5 ubiquitination to inhibit MET signaling in liver cancer

De-ao Gong, Peng Zhou, Wen-yi Chang, Jia-yao Yang, Yan-lai Zhang, Ai-long Huang, Ni Tang, Kai Wang

Summary: Liver cancer, ranked sixth globally, is a major contributor to cancer-related mortality. Metastasis is the main cause of treatment failure and deaths in liver cancer. The SPOP-CREB5-MET axis plays a significant role in liver cancer metastasis.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2024)

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Article Biochemistry & Molecular Biology

Resistance to apoptosis in complicated Crohn's disease: Relevance in ileal fibrosis

M. Seco-Cervera, D. Ortiz-Masia, D. C. Macias-Ceja, S. Coll, L. Gisbert-Ferrandiz, J. Cosin-Roger, C. Bauset, M. Ortega, B. Heras-Moran, F. Navarro-Vicente, M. Millan, J. V. Esplugues, S. Calatayud, M. D. Barrachina

Summary: The study revealed the presence of resistance to apoptosis in complicated ileal Crohn's disease, with PDGFB inducing an ETS1-mediated resistance to apoptosis associated with an inflammatory and fibrogenic pattern of expression in intestinal fibroblasts. Potential targets against ileal fibrosis include PDGFRB, IL1R1, or MCL1.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2024)

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Article Biochemistry & Molecular Biology

Paxillin/HDAC6 regulates microtubule acetylation to promote directional migration of keratinocytes driven by electric fields

Luojia Liu, Xiaoqiang Liu, Ying Chen, Meng Kong, Jinghong Zhang, Min Jiang, Hongling Zhou, Jinrui Yang, Xu Chen, Ze Zhang, Chao Wu, Xupin Jiang, Jiaping Zhang

Summary: Our study revealed that the Paxillin/HDAC6 signaling pathway regulates microtubule acetylation in electric field-guided keratinocyte migration.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2024)

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Article Biochemistry & Molecular Biology

Relationship between cholestasis and altered progesterone metabolism in the placenta-maternal liver tandem

Paula Sanchon-Sanchez, Elisa Herraez, Rocio I. R. Macias, Maria C. Estiu, Puri Fortes, Maria J. Monte, Jose J. G. Marin, Marta R. Romero

Summary: This study investigated the relationship between cholestasis and the expression of crucial enzymes involved in progesterone metabolism in the liver and placenta. The results showed that cholestasis markedly altered the expression of these enzymes, with a more significant effect in the placenta than in the liver. These findings suggest that the excess of progesterone metabolites in the serum of ICP patients can involve both enhanced placental production and decreased hepatic clearance.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2024)

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Review Biochemistry & Molecular Biology

Arming oncolytic viruses with bispecific T cell engagers: The evolution and current status

Yunmeng Wang, Ping Cheng

Summary: Oncolytic viruses (OVs) are emerging as therapeutically relevant anticancer agents, especially when combined with genetically modified bispecific T cell engagers (BiTEs). This combination strategy can overcome the limitations of BiTEs alone and provide targeted cytotoxicity to solid tumors.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2024)

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Article Biochemistry & Molecular Biology

GK921, a transglutaminase inhibitor, strengthens the antitumor effect of cisplatin on pancreatic cancer cells by inhibiting epithelial-to-mesenchymal transition

Mengxin Li, Xuanzhong Wang, Xuyang Chen, Jinghui Hong, Ye Du, Dong Song

Summary: Pancreatic adenocarcinoma (PAAD) is a common digestive malignant tumor with limited treatment options. This study demonstrates that TGM2 may serve as a marker for treatment and prognosis in pancreatic cancer patients. Co-treatment of low dose cisplatin (DDP) and the TGM2 inhibitor GK921 effectively inhibits PAAD cell viability and proliferation in vitro and in vivo, by inhibiting epithelial-to-mesenchymal transition (EMT) induced by TGM2 and enhancing cell cycle arrest and apoptosis caused by DDP. These findings suggest that the combination of GK921 and DDP holds promise as a treatment for PAAD patients.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2024)

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Cell Biology

Alleviation of experimental autoimmune encephalomyelitis by transferring low RelB expression tolerogenic dendritic cells

The synergistic effect of nanocurcumin and donepezil on Alzheimer's via PI3K/AKT/GSK-3β pathway modulating

Humanin ameliorates TBI-related cognitive impairment by attenuating mitochondrial dysfunction and inflammation

Reactive oxygen species in colorectal cancer adjuvant therapies

Small extracellular vesicles-mediated cellular interactions between tumor cells and tumor-associated macrophages: Implication for immunotherapy

Enhanced capacity for CaMKII signaling mitigates calcium release related contractile fatigue with high intensity exercise

Lanosterol elevates cytoprotective response through induced-proteasomal degradation of aberrant proteins

ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis

The role of RLIP76 in oxidative stress and mitochondrial dysfunction: Evidence based on autopsy brains from Alzheimer's disease patients

ZNF70 regulates IL-1β secretion of macrophages to promote the proliferation of HCT116 cells via activation of NLRP3 inflammasome and STAT3 pathway in colitis-associated colorectal cancer

Inhibition of spinal Rac1 attenuates chronic inflammatory pain by regulating the activation of astrocytes

Inhibition of autophagy initiation: A novel strategy for oral squamous cell carcinomas

CircFSCN1 induces tumor progression and triggers epithelial-mesenchymal transition in bladder cancer through augmentation of MDM2-mediated p53 silencing

Knockdown of SQLE promotes CD8+T cell infiltration in the tumor microenvironment

SPOP promotes CREB5 ubiquitination to inhibit MET signaling in liver cancer

Resistance to apoptosis in complicated Crohn's disease: Relevance in ileal fibrosis

Paxillin/HDAC6 regulates microtubule acetylation to promote directional migration of keratinocytes driven by electric fields

Relationship between cholestasis and altered progesterone metabolism in the placenta-maternal liver tandem

Arming oncolytic viruses with bispecific T cell engagers: The evolution and current status

GK921, a transglutaminase inhibitor, strengthens the antitumor effect of cisplatin on pancreatic cancer cells by inhibiting epithelial-to-mesenchymal transition

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