Biochemistry & Molecular Biology

1.8M Papers
Follow See full results
Article Biochemistry & Molecular Biology

Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2

Pengcheng Han, Linjie Li, Sheng Liu, Qisheng Wang, Di Zhang, Zepeng Xu, Pu Han, Xiaomei Li, Qi Peng, Chao Su, Baihan Huang, Dedong Li, Rong Zhang, Mingxiong Tian, Lutang Fu, Yuanzhu Gao, Xin Zhao, Kefang Liu, Jianxun Qi, George F. Gao, Peiyi Wang

Summary: The study found that the omicron variant, unlike other variants, has a similar affinity to the human receptor ACE2 as the prototype variant. Multiple mutations in the omicron variant may compensate for both immune escape and transmissibility. The complex structures of the omicron and delta variants binding to ACE2 provide insights into how specific mutations affect the binding.

CELL (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant

Yu Gao, Curtis Cai, Alba Grifoni, Thomas R. Muller, Julia Niessl, Anna Olofsson, Marion Humbert, Lotta Hansson, Anders Osterborg, Peter Bergman, Puran Chen, Annika Olsson, Johan K. Sandberg, Daniela Weiskopf, David A. Price, Hans-Gustaf Ljunggren, Annika C. Karlsson, Alessandro Sette, Soo Aleman, Marcus Buggert

Summary: This study found that SARS-CoV-2 spike-specific CD4(+) and CD8(+) T cells induced by prior infection or BNT162b2 vaccination provide extensive immune coverage against the Omicron variant. Additionally, T cells induced by BNT162b2 vaccination exhibit higher cross-reactivity to the Omicron variant compared to T cells induced by prior SARS-CoV-2 infection.

NATURE MEDICINE (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Neutralizing antibodies against the SARS-CoV-2 Delta and Omicron variants following heterologous CoronaVac plus BNT162b2 booster vaccination

Eddy Perez-Then, Carolina Lucas, Valter Silva Monteiro, Marija Miric, Vivian Brache, Leila Cochon, Chantal B. F. Vogels, Amyn A. Malik, Elena De la Cruz, Aidelis Jorge, Margarita De los Santos, Patricia Leon, Mallery Breban, Kendall Billig, Inci Yildirim, Claire Pearson, Randy Downing, Emily Gagnon, Anthony Muyombwe, Jafar Razeq, Melissa Campbell, Albert Ko, Saad B. Omer, Nathan D. Grubaugh, Sten H. Vermund, Akiko Iwasaki

Summary: The study found that a BNT162b2 mRNA vaccine booster can enhance neutralizing antibodies against the Omicron variant in individuals who received two doses of the CoronaVac vaccine, but antibody titers remain lower compared to the ancestral virus and the Delta variant.

NATURE MEDICINE (2022)

Add to Collection
Review Biochemistry & Molecular Biology

Hallmarks of aging: An expanding universe

Carlos Lopez-Otin, Maria A. Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer

Summary: Aging is driven by hallmarks that manifest with age, accelerate aging when accentuated experimentally, and can be decelerated, stopped, or reversed with therapeutic interventions. The twelve proposed hallmarks of aging include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. These hallmarks are interconnected with each other and with the recently proposed hallmarks of health.

CELL (2023)

Add to Collection
Review Biochemistry & Molecular Biology

Antibody drug conjugate: the biological missile for targeted cancer therapy

Zhiwen Fu, Shijun Li, Sifei Han, Chen Shi, Yu Zhang

Summary: Antibody-drug conjugates (ADCs) combine the highly specific targeting ability of monoclonal antibodies with the potent killing effect of cytotoxic drugs to accurately and efficiently eliminate cancer cells. Since the approval of the first ADC in 2000, 14 ADCs have been marketed worldwide, with over 100 ADC candidates currently in clinical trials. These novel cancer therapeutics, known as biological missiles, are leading the way in targeted cancer therapy.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Add to Collection
Review Biochemistry & Molecular Biology

Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

Jiaqi Liu, Qing Xiao, Jiani Xiao, Chenxi Niu, Yuanyuan Li, Xiaojun Zhang, Zhengwei Zhou, Guang Shu, Gang Yin

Summary: This article provides a comprehensive review of the Wnt/β-catenin pathway, including its origin, composition, function, and clinical trials. It also discusses the challenges and opportunities for developing small-molecule compounds targeting this signaling pathway in disease treatment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Therapeutic target database update 2022: facilitating drug discovery with enriched comparative data of targeted agents

Ying Zhou, Yintao Zhang, Xichen Lian, Fengcheng Li, Chaoxin Wang, Feng Zhu, Yunqing Qiu, Yuzong Chen

Summary: Drug discovery relies not only on knowledge of drugs and targets, but also on understanding comparative agents and targets. This study introduces a major update to the Therapeutic Target Database, providing valuable data on poor binders, non-binders, prodrug-drug pairs, co-targets, and drug-like properties, as well as additional features for advanced search and cross-links to target structures. The database is accessible without login requirement at: https://idrblab.org/ttd/.

NUCLEIC ACIDS RESEARCH (2022)

Add to Collection
Review Biochemistry & Molecular Biology

The serotonin theory of depression: a systematic umbrella review of the evidence

Joanna Moncrieff, Ruth E. Cooper, Tom Stockmann, Simone Amendola, Michael P. Hengartner, Mark A. Horowitz

Summary: The serotonin hypothesis of depression, which suggests that depression is caused by lowered serotonin activity or concentrations, lacks consistent evidence based on the synthesis and evaluation of research in this field. This umbrella review found no substantial association between serotonin and depression, while suggesting that long-term antidepressant use may reduce serotonin concentration.

MOLECULAR PSYCHIATRY (2023)

Add to Collection
Article Biochemistry & Molecular Biology

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Martin Guilliams, Johnny Bonnardel, Birthe Haest, Bart Vanderborght, Camille Wagner, Anneleen Remmerie, Anna Bujko, Liesbet Martens, Tinne Thone, Robin Browaeys, Federico F. De Ponti, Bavo Vanneste, Christian Zwicker, Freya R. Svedberg, Tineke Vanhalewyn, Amanda Goncalves, Saskia Lippens, Bert Devriendt, Eric Cox, Giuliano Ferrero, Valerie Wittamer, Andy Willaert, Suzanne J. F. Kaptein, Johan Neyts, Kai Dallmeier, Peter Geldhof, Stijn Casaert, Bart Deplancke, Peter ten Dijke, Anne Hoorens, Aude Vanlander, Frederik Berrevoet, Yves Van Nieuwenhove, Yvan Saeys, Wouter Saelens, Hans Van Vlierberghe, Lindsey Devisscher, Charlotte L. Scott

Summary: This study presents a spatial proteogenomic atlas of the liver, combining multiple omics datasets, and reveals the cellular niches and transcriptomic identities of Kupffer cells and lipid-associated macrophages. It also demonstrates the inducibility of lipid-associated macrophages by local lipid exposure and the crucial role of ALK1-BMP9/10 axis in Kupffer cell development.

CELL (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron

Zhen Cui, Pan Liu, Nan Wang, Lei Wang, Kaiyue Fan, Qianhui Zhu, Kang Wang, Ruihong Chen, Rui Feng, Zijing Jia, Minnan Yang, Ge Xu, Boling Zhu, Wangjun Fu, Tianming Chu, Leilei Feng, Yide Wang, Xinran Pei, Peng Yang, Xiaoliang Sunney Xie, Lei Cao, Yunlong Cao, Xiangxi Wang

Summary: The Omicron variant of SARS-CoV-2 is spreading rapidly worldwide due to its increased fitness, with spike structures that maintain stability for receptor recognition but compromise viral fusion efficiency. By altering amino acids and structures, it evades recognition by most antibodies, facilitating immune escape. The research sheds light on conserved regions for the development of broad-spectrum vaccines.

CELL (2022)

Add to Collection
Review Biochemistry & Molecular Biology

Metabolic Syndrome: Updates on Pathophysiology and Management in 2021

Gracia Fahed, Laurence Aoun, Morgan Bou Zerdan, Sabine Allam, Maroun Bou Zerdan, Youssef Bouferraa, Hazem I. Assi

Summary: Metabolic syndrome is a cluster of metabolic dysregulations associated with insulin resistance and chronic low-grade inflammation. If left untreated, it significantly increases the risk of developing diabetes and cardiovascular diseases. However, many aspects of Metabolic syndrome are still not completely understood, and many questions remain unanswered. This review provides a comprehensive overview of the historical background, epidemiology, histopathology, pathophysiology, management, and prevention of Metabolic syndrome.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022

Yongbiao Xue, Yiming Bao, Zhang Zhang, Wenming Zhao, Jingfa Xiao, Shun-min He, Guoqing Zhang, Yixue Li, Zhao Guoping, Runsheng Chen, Jingyao Zeng, Yadong Zhang, Yun-fei Shang, Jialin Mai, Shuo Shi, Mingming Lu, Congfan Bu, Zhewen Zhang, Zhenglin Du, Yinying Wang, Hongen Kang, Tianyi Xu, Lili Hao, Peilin Jia, Shuai Jiang, Qiheng Qian, Tong-tong Zhu, Yunfei Shang, Wenting Zong, Tong Jin, Yuansheng Zhang, Dong Zou, Zhang Zhang, Qiang Du, Changrui Feng, Lina Ma, Sisi Zhang, Anke Wang, Lili Dong, Yan-qing Wang, Wan Liu, Xing Yan, Yunchao Ling, Guoping Zhao, Zhihua Zhou, Wang Kang, Tao Zhang, Shuai Ma, Haoteng Yan, Zunpeng Liu, Zejun Ji, Yusheng Cai, Si Wang, Moshi Song, Jie Ren, Qi Zhou, Jing Qu, Weiqi Zhang, Guanghui Liu, Xu Chen, Tingting Chen, Zhang Sisi, Yanling Sun, Caixia Yu, Bixia Tang, Junwei Zhu, Shuang Zhai, Yubin Sun, Qiancheng Chen, Xiaoyu Yang, Xin Zhang, Zhengqi Sang, Yonggang Wang, Yilin Zhao, Huanxin Chen, Li Lan, Yanqing Wang, Yingke Ma, Yaokai Jia, Xin-chang Zheng, Meili Chen, Zou Dong, Tongtong Zhu, Chen Ming, Guangyi Niu, Rong Pan, Wei Jing, Jian Sang, Chang Liu, Yujia Xiong, Hao Lili, Mochen Zhang, Guoliang Wang, Lizhi Yi, Zhao Wei, Wenting Zong, Song Wu, Zhuang Xiong, Li Rujiao, Gong Zheng, Rujiao Li, Lin Liu, Zhao Li, Qianpeng Li, Jing Wei, Sicheng Luo, Jiajia Wang, Yirong Shi, Honghong Zhou, Peng Zhang, Tingrui Song, Yanyan Li, Fei Yang, Mengwei Li, Zhao-hua Li, Hongen Kang, Xinchang Zheng, Ru-jiao Li, Dongmei Tian, Xiaonan Liu, Cuiping Li, Xufei Teng, Shuhui Song, Yang Zhang, Guangyi Niu, Tongtong Zhu, Yuansheng Zhang, Ruru Chen, Rongqin Zhang, Feng Xu, Yifan Wang, Yunchao Ling, Chenfen Zhou, Haizhou Wang, Andrew E. Teschendorff, Yungang He, Yang Zhen, Cuiping Li, Junwei Zhu, Lun Li, Na Li, Zheng Gong, Meili Chen, Ying Cui, Guangya Duan, Jin Tong, Gangao Wu, Tianhao Huang, Enhui Jin, Wei Zhao, Hailong Kang, Zhonghuang Wang, Jingyao Zeng, Hua Chen, Mingkun Li, Wenming Zhao, Wanshan Ning, Yu Xue, Yanhu Liu, Ying Cui, Qijun Zhou, Xingyan Liu, Longlong Zhang, Bingyu Mao, Shihua Zhang, Yaping Zhang, Guodong Wang, Qianghui Zhu, Xin Li, Menghua Li, Yuanming Liu, Hong Luo, Xiaoyuan Wu, Haichun Jing, Yitong Pan, Ming Chen, Lina Ma, Leisheng Shi, Mingkun Li, Li Lan, Yiming Bao, Wen-ming Zhao, Zhixiang Zuo, Jian Ren, Xinxin Zhang, Yun Xiao, Xia Li, Dan Liu, Chi Zhang, Yu Xue, Zheng Zhao, Tao Jiang, Wanying Wu, Fangqing Zhao, Xianwen Meng, Di Peng, Hao Luo, Feng Gao, Shaofeng Lin, Chuijie Liu, Anyuan Guo, Hao Yuan, Tianhan Su, Yong E. Zhang, Yincong Zhou, Weizhi Zhang, Shanshan Fu, Xiaodan Tan, Yubin Xie, Guoji Guo, Chenwei Wang, Xingyu Liao, Xin Gao, Jianxin Wang, Guiyan Xie, Chunhui Yuan, Feng Tian, Dechang Yang, Dachao Tang, Wenyi Wu, Yujie Gou, Cheng Han, Qinghua Cui, Xiang Shang Li, Chuan-Yun Li, XiaoTong Luo, Jia Ren, Xia Li

Summary: The National Genomics Data Center (NGDC) of China National Center for Bioinformation (CNCB) provides database resources to support global research, with a focus on single-cell omics and precision medicine. They continuously scale up and update core database resources, daily update SARS-CoV-2 genome data, and establish OpenLB and update Database Commons.

NUCLEIC ACIDS RESEARCH (2022)

Add to Collection
Review Biochemistry & Molecular Biology

A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory Environments, and Future Perspectives

Peng Liu, Guiliang Chen, Jingchen Zhang

Summary: Liposomes have been widely recognized as promising drug carriers due to their superior properties. This review discusses the liposomal drug products approved by FDA and EMA, providing valuable information on their critical chemistry and pharmaceutical technologies. Moreover, it summarizes the current regulatory guidance and future perspectives related to liposomal products.

MOLECULES (2022)

Add to Collection
Article Biochemistry & Molecular Biology

MODOMICS: a database of RNA modification pathways. 2021 update

Pietro Boccaletto, Filip Stefaniak, Angana Ray, Andrea Cappannini, Sunandan Mukherjee, Elzbieta Purta, Malgorzata Kurkowska, Niloofar Shirvanizadeh, Eliana Destefanis, Paula Groza, Gulben Avsar, Antonia Romitelli, Pinar Pir, Erik Dassi, Silvestro G. Conticello, Francesca Aguilo, Janusz M. Bujnicki

Summary: MODOMICS database, established since 2006, has evolved from containing basic chemical structures of modified ribonucleosides to a comprehensive resource with new functionalities such as a catalog of RNA modifications linked to human diseases. The database, which is extensively linked to RCSB Protein Data Bank, provides users with an enhanced tool for research on RNA modification.

NUCLEIC ACIDS RESEARCH (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Effectiveness of COVID-19 booster vaccines against COVID-19-related symptoms, hospitalization and death in England

Nick Andrews, Julia Stowe, Freja Kirsebom, Samuel Toffa, Ruchira Sachdeva, Charlotte Gower, Mary Ramsay, Jamie Lopez Bernal

Summary: This study examined the relative and absolute effectiveness of mRNA booster vaccination against COVID-19. The results showed that the booster dose of BNT162b2 or mRNA-1273 had a relative effectiveness ranging from 85% to 95% against symptomatic disease, and an absolute effectiveness ranging from 94% to 97%. For hospitalization or death, the absolute effectiveness of the BNT162b2 booster ranged from 97% to 99% in all age groups. The study provides real-world evidence of significantly increased protection from the booster vaccine dose against mild and severe disease.

NATURE MEDICINE (2022)

Add to Collection
Review Biochemistry & Molecular Biology

PANTHER: Making genome-scale phylogenetics accessible to all

Paul D. Thomas, Dustin Ebert, Anushya Muruganujan, Tremayne Mushayahama, Laurent-Philippe Albou, Huaiyu Mi

Summary: PANTHER is a user-focused knowledgebase that stores results of extensive phylogenetic reconstruction pipelines and provides manual review and annotation of function evolution events, aiding in protein sequence analysis tasks.

PROTEIN SCIENCE (2022)

Add to Collection
Review Biochemistry & Molecular Biology

Thirty years of resistance: Zig-zag through the plant immune system

Bruno Pok Man Ngou, Pingtao Ding, Jonathan D. G. Jones

Summary: Understanding the plant immune system is crucial for protecting crops from diseases. Plants have a two-tiered innate immune system to resist pathogens. Over the last 30 years, significant progress has been made in identifying immune receptors and understanding the signaling pathways and interactions between different components of the immune system.

PLANT CELL (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer

Aikun Fu, Bingqing Yao, Tingting Dong, Yongyi Chen, Jia Yao, Yu Liu, Hang Li, Huiru Bai, Xiaoqin Liu, Yue Zhang, Chunhui Wang, Yajing Guo, Nan Li, Shang Cai

Summary: Tumor-resident intracellular microbiota plays an important role in promoting cancer metastasis, enhancing host-cell survival by increasing resistance to fluid shear stress. Furthermore, administration of intratumor bacteria can also promote tumor metastasis.

CELL (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies

Timothee Bruel, Jerome Hadjadj, Piet Maes, Delphine Planas, Aymeric Seve, Isabelle Staropoli, Florence Guivel-Benhassine, Francoise Porrot, William-Henry Bolland, Yann Nguyen, Marion Casadevall, Caroline Charre, Helene Pere, David Veyer, Matthieu Prot, Artem Baidaliuk, Lize Cuypers, Cyril Planchais, Hugo Mouquet, Guy Baele, Luc Mouthon, Laurent Hocqueloux, Etienne Simon-Loriere, Emmanuel Andre, Benjamin Terrier, Thierry Prazuck, Olivier Schwartz

Summary: There are differences in neutralizing activity of therapeutic antibodies against the SARS-CoV-2 Omicron BA.1 and BA.2 sublineages, and immunocompromised individuals treated with antibodies show elevated antibody levels but reduced neutralization against Omicron. Breakthrough infections with the Omicron variant are observed in some immunocompromised individuals despite antibody treatment.

NATURE MEDICINE (2022)

Add to Collection
Review Biochemistry & Molecular Biology

Glioma targeted therapy: insight into future of molecular approaches

Keyang Yang, Zhijing Wu, Hao Zhang, Nan Zhang, Wantao Wu, Zeyu Wang, Ziyu Dai, Xun Zhang, Liyang Zhang, Yun Peng, Weijie Ye, Wenjing Zeng, Zhixiong Liu, Quan Cheng

Summary: Gliomas are common brain tumors originating from glial cells. Treatment and prognosis differ significantly depending on the type of glioma. Traditional targeted therapy approaches have faced challenges, while new methods such as immunotherapy and the tumor microenvironment are gaining interest. More clinical trials are needed to evaluate the feasibility of personalized targeted therapy.

MOLECULAR CANCER (2022)

Add to Collection
See full results
Related Categories

Top Journals

NATURE MEDICINE
NATURE MEDICINE
CELL
CELL
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Molecular Cancer
Molecular Cancer
Molecular Plant
Molecular Plant
NUCLEIC ACIDS RESEARCH
NUCLEIC ACIDS RESEARCH
Molecular Cell
Molecular Cell
TRENDS IN MICROBIOLOGY
TRENDS IN MICROBIOLOGY
PROGRESS IN LIPID RESEARCH
PROGRESS IN LIPID RESEARCH
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.