Papers in Allergy - Peeref

Article Allergy

The international EAACI/GA2LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria

Torsten Zuberbier, Amir Hamzah Abdul Latiff, Mohamed Abuzakouk, Susan Aquilina, Riccardo Asero, Diane Baker, Barbara Ballmer-Weber, Christine Bangert, Moshe Ben-Shoshan, Jonathan A. Bernstein, Carsten Bindslev-Jensen, Knut Brockow, Zenon Brzoza, Herberto Jose Chong Neto, Martin K. Church, Paulo R. Criado, Inna V. Danilycheva, Corinna Dressler, Luis Felipe Ensina, Luz Fonacier, Matthew Gaskins, Krisztian Gaspar, Asli Gelincik, Ana Gimenez-Arnau, Kiran Godse, Margarida Goncalo, Clive Grattan, Martine Grosber, Eckard Hamelmann, Jacques Hebert, Michihiro Hide, Allen Kaplan, Alexander Kapp, Aharon Kessel, Emek Kocaturk, Kanokvalai Kulthanan, Desiree Larenas-Linnemann, Antti Lauerma, Tabi A. Leslie, Markus Magerl, Michael Makris, Raisa Y. Meshkova, Martin Metz, Daniel Micallef, Charlotte G. Mortz, Alexander Nast, Hanneke Oude-Elberink, Ruby Pawankar, Paolo D. Pigatto, Hector Ratti Sisa, Maria Isabel Rojo Gutierrez, Sarbjit S. Saini, Peter Schmid-Grendelmeier, Bulent E. Sekerel, Frank Siebenhaar, Hanna Siiskonen, Angele Soria, Petra Staubach-Renz, Luca Stingeni, Gordon Sussman, Andrea Szegedi, Simon Francis Thomsen, Zahava Vadasz, Christian Vestergaard, Bettina Wedi, Zuotao Zhao, Marcus Maurer

Summary: The updated international guideline for urticaria was developed jointly by multiple international organizations, with participants from 50 countries and international societies, aiming to provide expert guidance on diagnostic and therapeutic approaches for different subtypes of urticaria.

ALLERGY (2022)

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Review Allergy

A Review of Persistent Post-COVID Syndrome (PPCS)

Bryan Oronsky, Christopher Larson, Terese C. Hammond, Arnold Oronsky, Santosh Kesari, Michelle Lybeck, Tony R. Reid

Summary: Persistent post-COVID syndrome, a pathologic entity, involves persistent physical, medical, and cognitive sequelae following COVID-19. The syndrome includes immunosuppression and organ fibrosis, and its potential long-term effects place a burden on healthcare systems, patients' families, and society.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2023)

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Article Allergy

EAACI guideline: Anaphylaxis (2021 update)

Antonella Muraro, Margitta Worm, Cherry Alviani, Victoria Cardona, Audrey DunnGalvin, Lene Heise Garvey, Carmen Riggioni, Debra de Silva, Elizabeth Angier, Stefania Arasi, Abdelouahab Bellou, Kirsten Beyer, Diola Bijlhout, Maria Beatrice Bilo, Carsten Bindslev-Jensen, Knut Brockow, Montserrat Fernandez-Rivas, Susanne Halken, Britt Jensen, Ekaterina Khaleva, Louise J. Michaelis, Hanneke N. G. Oude Elberink, Lynne Regent, Angel Sanchez, Berber J. Vlieg-Boerstra, Graham Roberts

Summary: The updated guideline on anaphylaxis emphasizes early recognition and prompt use of intramuscular adrenaline as first-line management. It also recommends comprehensive training for people at risk of anaphylaxis and improving healthcare professionals' management skills. Additionally, the urgent need for clinical trials to improve patient management in anaphylaxis is highlighted.

ALLERGY (2022)

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Article Allergy

Efficacy and safety of benralizumab in chronic rhinosinusitis with nasal polyps: A randomized, placebo-controlled trial

Claus Bachert, Joseph K. Han, Martin Y. Desrosiers, Philippe Gevaert, Enrico Heffler, Claire Hopkins, Jody R. Tversky, Peter Barker, David Cohen, Claire Emson, Ubaldo J. Martin, Vivian H. Shih, Sofia Necander, James L. Kreindler, Maria Jison, Viktoria Werkstrom

Summary: This study assessed the efficacy and safety of benralizumab in treating CRSwNP. The results showed that benralizumab significantly improved NPS and nasal blockage score, and had significant improvement on difficulty with sense of smell score. Subgroup analyses suggested influences of comorbid asthma, number of NP surgeries, sex, body mass index, and baseline blood eosinophil count on treatment effects.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Allergy

Immunology of Aging: the Birth of Inflammaging

T. Fulop, A. Larbi, G. Pawelec, A. Khalil, A. A. Cohen, K. Hirokawa, J. M. Witkowski, C. Franceschi

Summary: The concept of inflammaging introduced by Prof. Franceschi in 2000 revolutionized the understanding of immune changes in response to lifelong stress. It highlights the dichotomy of the proinflammatory process, influenced by genetics and the environment, leading to either beneficial or detrimental consequences. Moreover, it elucidates the complex and systemic nature of aging, opening avenues for studying counter-processes in addition to the process itself. This concept also paves the way for potential multimodal interventions to optimize aging towards healthy longevity.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2023)

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Article Allergy

The international WAO/EAACI guideline for the management of hereditary angioedema-The 2021 revision and update

Marcus Maurer, Markus Magerl, Stephen Betschel, Werner Aberer, Ignacio J. Ansotegui, Emel Aygoeren-Puersuen, Aleena Banerji, Noemi-Anna Bara, Isabelle Boccon-Gibod, Konrad Bork, Laurence Bouillet, Henrik Balle Boysen, Nicholas Brodszki, Paula J. Busse, Anette Bygum, Teresa Caballero, Mauro Cancian, Anthony Castaldo, Danny M. Cohn, Dorrottya Csuka, Henriette Farkas, Mark Gompels, Richard Gower, Anete S. Grumach, Guillermo Guidos-Fogelbach, Michihiro Hide, Hye-Ryun Kang, Allen Phillip Kaplan, Constance Katelaris, Sorena Kiani-Alikhan, Wei-Te Lei, Richard Lockey, Hilary Longhurst, William R. Lumry, Andrew MacGinnitie, Alejandro Malbran, Inmaculada Martinez Saguer, Juan Jose Matta, Alexander Nast, Dinh Nguyen, Sandra A. Nieto-Martinez, Ruby Pawankar, Jonathan Peter, Grzegorz Porebski, Nieves Prior, Avner Reshef, Marc Riedl, Bruce Ritchie, Farrukh Rafique Sheikh, William R. Smith, Peter J. Spaeth, Marcin Stobiecki, Elias Toubi, Lilian Agnes Varga, Karsten Weller, Andrea Zanichelli, Yuxiang Zhi, Bruce Zuraw, Timothy Craig

Summary: The revision and update of the guideline on the diagnosis and management of hereditary angioedema (HAE) provides up-to-date guidance for physicians and their patients. It aims to help make rational decisions in the management of HAE, including diagnostics, treatments, goals of treatment, management for special patient groups, and disease monitoring.

ALLERGY (2022)

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Review Allergy

Epithelial barrier hypothesis: Effect of external exposome on microbiome and epithelial barriers in allergic disease

Zeynep Celebi Sozener, Betul Ozdel Ozturk, Pamir Cerci, Murat Turk, Begum Gorgulu Akin, Mubeccel Akdis, Seda Altiner, Umus Ozbey, Ismail Ogulur, Yasutaka Mitamura, Insu Yilmaz, Kari Nadeau, Cevdet Ozdemir, Dilsad Mungan, Cezmi A. Akdis

Summary: Environmental exposure plays a major role in the development of allergic diseases, including climate change, pollution, changes and loss of biodiversity, etc. The epithelial barrier hypothesis provides a mechanistic explanation of how these factors contribute to the increase in allergic and autoimmune diseases. Measures should be taken to mitigate environmental threats and decrease allergic diseases.

ALLERGY (2022)

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Article Allergy

Adult-onset autoinflammation caused by somatic mutations in UBA1: A Dutch case series of patients with VEXAS

Caspar van der Made, Judith Potjewijd, Annemiek Hoogstins, Huub P. J. Willems, Arjan J. Kwakernaak, Ruud G. L. de Sevaux, Paul L. A. van Daele, Annet Simons, Marloes Heijstek, David B. Beck, Mihai G. Netea, Pieter van Paassen, A. Elizabeth Hak, Lars T. van der Veken, Marielle E. van Gijn, Alexander Hoischen, Frank L. van de Veerdonk, Helen L. Leavis, Abraham Rutgers

Summary: A novel autoinflammatory syndrome called VEXAS has been discovered in male patients with somatic mutations in the UBA1 gene. This study retrospectively diagnosed VEXAS in previously unclassified autoinflammatory patients and described the clinical experiences with this complex disease. Through reanalysis of whole-exome sequencing data, 12 male patients with UBA1 mutations were identified. These patients experienced adult-onset autoinflammation with systemic symptoms, elevated inflammatory parameters, and multiorgan involvement, particularly affecting the skin and bone marrow. New features of VEXAS included interstitial nephritis, cardiac involvement, stroke, and intestinal perforation related to tocilizumab treatment. Despite various treatments, most patients were treatment-refractory, leading to a high mortality rate of 50%.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Allergy

Are Physicochemical Properties Shaping the Allergenic Potency of Plant Allergens?

Joana Costa, Simona Lucia Bavaro, Sara Benede, Araceli Diaz-Perales, Cristina Bueno-Diaz, Eva Gelencser, Julia Klueber, Colette Larre, Daniel Lozano-Ojalvo, Roberta Lupi, Isabel Mafra, Gabriel Mazzucchelli, Elena Molina, Linda Monaci, Laura Martin-Pedraza, Cristian Piras, Pedro M. Rodrigues, Paola Roncada, Denise Schrama, Tanja Cirkovic-Velickovic, Kitty Verhoeckx, Caterina Villa, Annette Kuehn, Karin Hoffmann-Sommergruber, Thomas Holzhauser

Summary: This research searched for evidence on how different physicochemical properties affect the allergenicity of food proteins, and found consistent effects on protein allergenicity within the same protein family. Molecular stability was identified as the most common characteristic promoting plant protein allergenicity. However, there is still a lack of systematic approach to link physicochemical properties with clinical allergenicity.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2022)

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Review Allergy

Asthma and risk of infection, hospitalization, ICU admission and mortality from COVID-19: Systematic review and meta-analysis

Anthony P. Sunjaya, Sabine M. Allida, Gian Luca Di Tanna, Christine Jenkins

Summary: This study found that the prevalence of asthma among COVID-19 patients is similar to the global prevalence of asthma. Overall findings suggest that people with asthma have a lower risk than those without asthma for acquiring COVID-19 and have similar clinical outcomes.

JOURNAL OF ASTHMA (2022)

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Article Allergy

Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?

Joana Costa, Caterina Villa, Kitty Verhoeckx, Tanja Cirkovic-Velickovic, Denise Schrama, Paola Roncada, Pedro M. Rodrigues, Cristian Piras, Laura Martin-Pedraza, Linda Monaci, Elena Molina, Gabriel Mazzucchelli, Isabel Mafra, Roberta Lupi, Daniel Lozano-Ojalvo, Colette Larre, Julia Klueber, Eva Gelencser, Cristina Bueno-Diaz, Araceli Diaz-Perales, Sara Benede, Simona Lucia Bavaro, Annette Kuehn, Karim Hoffmann-Sommergruber, Thomas Holzhauser

Summary: Physicochemical parameters play a crucial role in shaping the allergenicity of animal proteins. However, there are significant knowledge gaps in understanding protein allergenicity from both animal and plant origins, necessitating further comprehensive research and data integration in the future.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2022)

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Review Allergy

Comparative efficacy and safety of monoclonal antibodies and aspirin desensitization for chronic rhinosinusitis with nasal polyposis: A systematic review and network meta-analysis

Paul Oykhman, Fernando Aleman Paramo, Jean Bousquet, David W. Kennedy, Romina Brignardello-Petersen, Derek K. Chu

Summary: Multiple biologics and ASA-D effectively improve patient-important outcomes, with variations in effects among different agents. Dupilumab stands out as the most beneficial treatment for all studied outcomes.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Editorial Material Allergy

Comparative efficacy and safety of monoclonal antibodies and aspirin desensitization for chronic rhinosinusitis with nasal polyposis: A systematic review and network meta-analysis

[Anonymous]

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Review Allergy

The ingenious mast cell: Contemporary insights into mast cell behavior and function

Joakim S. Dahlin, Marcus Maurer, Dean D. Metcalfe, Gunnar Pejler, Ronit Sagi-Eisenberg, Gunnar Nilsson

Summary: Mast cells play a crucial role in maintaining homeostasis and surveillance of the human body, releasing various mediators that affect both immune and non-immune cells. Research using animal models has contributed to a better understanding of mast cell function in health and disease.

ALLERGY (2022)

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Article Allergy

Drug allergy: A 2022 practice parameter update

David A. Khan, Aleena Banerji, Kimberly G. Blumenthal, Elizabeth J. Phillips, Roland Solensky, Andrew A. White, Jonathan A. Bernstein, Derek K. Chu, Anne K. Ellis, David B. K. Golden, Matthew J. Greenhawt, Caroline C. Horner, Dennis Ledford, Jay A. Lieberman, John Oppenheimer, Matthew A. Rank, Marcus S. Shaker, David R. Stukus, Dana Wallace, Julie Wang

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Allergy

External Environmental Pollution as a Risk Factor for Asthma

Jose Chatkin, Liana Correa, Ubiratan Santos

Summary: Air pollution is a concerning risk factor for global morbidity and mortality, playing a special role in respiratory conditions. Pollutants induce various respiratory symptoms and significantly impact asthma outcomes. Factors such as modern lifestyle, socioeconomic status, and age play different roles in environmental exposure and health impacts.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2022)

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Review Allergy

Endotypes of chronic rhinosinusitis: Relationships to disease phenotypes, pathogenesis, clinical findings, and treatment approaches

Atsushi Kato, Anju T. Peters, Whitney W. Stevens, Robert P. Schleimer, Bruce K. Tan, Robert C. Kern

Summary: The study of chronic rhinosinusitis (CRS) has shifted from phenotype-based classification to endotype-based classification, identifying three main endotypes that orchestrate the expression of different gene sets. The development of improved methods for endotyping disease is expanding the use of biological therapies, targeting Type 2 inflammation and potentially other inflammatory endotypes in the future.

ALLERGY (2022)

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Review Allergy

Subtypes of atopic dermatitis: From phenotype to endotype

Yoshiki Tokura, Satoshi Hayano

Summary: Atopic dermatitis (AD) is a heterogeneous disorder that can be classified into different types, including the IgE-high, extrinsic subtype and the IgE-normal, intrinsic subtype. Recent research has shown that different populations have different AD subtypes, which differ in immune regulation, skin barrier, and cytokine activation. Therefore, personalized or precision medicine is crucial for the treatment of AD targeting each subtype.

ALLERGOLOGY INTERNATIONAL (2022)

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Article Allergy

Optimizing investigation of suspected allergy to polyethylene glycols

Maria Anna Bruusgaard-Mouritsen, Bettina Margrethe Jensen, Lars K. Poulsen, Jeanne Duus Johansen, Lene Heise Garvey

Summary: This study evaluated the reactivity of different molecular weight PEGs in skin prick tests and investigated cross-sensitization patterns in PEG allergy. The results showed that skin test reactivity to PEG can decrease over time, but titrated SPT with increasing concentrations of PEG 20,000 can be diagnostic.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Allergy

Therapeutic options for CTLA-4 insufficiency

David Egg, Ina Caroline Rump, Noriko Mitsuiki, Jessica Rojas-Restrepo, Maria-Elena Maccari, Charlotte Schwab, Annemarie Gabrysch, Klaus Warnatz, Sigune Goldacker, Virginia Patino, Daniel Wolff, Satoshi Okada, Seiichi Hayakawa, Yoshiaki Shikama, Kenji Kanda, Kohsuke Imai, Manabu Sotomatsu, Makoto Kuwashima, Takahiro Kamiya, Tomohiro Morio, Kazuaki Matsumoto, Takeshi Mori, Yuri Yoshimoto, Ingunn Dybedal, Maria Kanariou, Zeynep Yesim Kucuk, Hugo Chapdelaine, Lenka Petruzelkova, Hanns-Martin Lorenz, Kathleen E. Sullivan, Jennifer Heimall, Michel Moutschen, Jiri Litzman, Mike Recher, Michael H. Albert, Fabian Hauck, Suranjith Seneviratne, Jana Pachlopnik Schmid, Antonios Kolios, Gary Unglik, Christian Klemann, Scott Snapper, Lisa Giulino-Roth, Michael Svaton, Craig D. Platt, Sophie Hambleton, Olaf Neth, Geraldine Gosse, Steffen Reinsch, Dirk Holzinger, Yae-Jean Kim, Shahrzad Bakhtiar, Faranaz Atschekzei, Reinhold Schmidt, Georgios Sogkas, Shanmuganathan Chandrakasan, William Rae, Beata Derfalvi, Hanne Vibeke Marquart, Ahmet Ozen, Ayca Kiykim, Elif Karakoc-Aydiner, Pavlina Kralickova, Godelieve de Bree, Dimitra Kiritsi, Markus G. Seidel, Robin Kobbe, Jennifer Dantzer, Laia Alsina, Thais Armangue, Vassilios Lougaris, Philipp Agyeman, Sofia Nystrom, David Buchbinder, Peter D. Arkwright, Bodo Grimbacher

Summary: Heterozygous germline mutations in cytotoxic T lymphocyte-associated antigen-4 (CTLA4) can lead to life-threatening autoimmune and lymphoproliferative complications. Treatment options include systemic immunosuppressants, immunoglobulin replacement, and stem cell transplantation for potential cure.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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