Papers in Allergy - Peeref

Article Allergy

Sensitisation to ethylhexyl salicylate: Another piece of the frontal fibrosing alopecia puzzle

Maria Antonia Pastor-Nieto, Maria Elena Gatica-Ortega, Leopoldo Borrego

Summary: Patch testing of patients with frontal fibrosing alopecia (FFA) revealed a high prevalence of sensitization to ethylhexyl salicylate (EHS). We propose expanding the spectrum of allergens in FFA to include EHS and consider optimizing the patch test preparation.

CONTACT DERMATITIS (2023)

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Article Allergy

Efficacy outcomes in trials with prophylactic hereditary angioedema therapy: A systematic review

Remy S. Petersen, Laure M. Fijen, Danny M. Cohn

ALLERGY (2023)

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Article Allergy

Human placental extract suppresses mast cell activation and induces mast cell apoptosis

Tongqian Wu, Jingjing He, Shirong Yan, Jing Li, Ke Chen, Dingshan Zhang, Mingliang Cheng, Zou Xiang, Yu Fang

Summary: This study revealed a suppressive effect of HPE on overall mast cell activities, suggesting a potential regulatory role of HPE on the alleviation of allergic diseases through mast cells.

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY (2023)

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Article Allergy

Safety and immunopharmacology of ASP0892 in adults or adolescents with peanut allergy: two randomized trials

Brian C. Ferslew, Ronald Smulders, Tong Zhu, Mary B. Blauwet, Tomohiro Kusawake, Anna Spence, Kelly Aldridge, Hannah A. Deberg, Sugandhika Khosa, Erik Wambre, Gurunadh R. Chichili

Summary: In two phase 1 studies, ASP0892 showed good safety and moderate but not clinically relevant changes in immune responses.

ALLERGY (2023)

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Article Allergy

Hypersensitivity reactions to proton pump inhibitors. An EAACI position paper

Sevim Bavbek, Secil Kepil Ozdemir, Patrizia Bonadonna, Marina Atanaskovic-Markovic, Annick Barbaud, Knut Brockow, Jose Laguna Martinez, Alla Nakonechna, Mauro Pagani, Alessandra Arcolaci, Carla Lombardo, Maria J. Torres

Summary: This paper provides evidence-based recommendations for the diagnosis and management of hypersensitivity reactions (HSRs) to proton pump inhibitors (PPIs), and calls for further in-depth research.

ALLERGY (2023)

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Article Allergy

Quality of life is lower in food allergic adolescents compared to young children at a community educational symposium

Diem-Tran I. Nguyen, Kathleen Pitts, Kristen A. Staggers, Carla M. Davis

Summary: Adolescents with food allergies showed more concern about their disease and were more reassured by carrying epinephrine compared to younger children, possibly indicating increased autonomy and responsibility. Community events serve as an important platform for assessing quality of life and providing food allergy-related education to pediatric patients.

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY (2023)

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Article Allergy

Role of epithelial barrier function in inducing type 2 immunity following early-life viral infection

Kunyuan Tian, Prakrati Dangarh, Haina Zhang, Christian L. Hines, Andrew Bush, Hannah J. Pybus, James A. Harker, Clare M. Lloyd, Reiko J. Tanaka, Sejal Saglani

Summary: Research suggests that recurrent RSV infection in early life alters airway barrier function and promotes type 2 immunity. The study provides evidence of a causal relationship between airway barrier function and type 2 immunity.

CLINICAL AND EXPERIMENTAL ALLERGY (2023)

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Review Allergy

Systematic review and meta-analyses on the accuracy of diagnostic tests for IgE-mediated food allergy

Carmen Riggioni, Cristian Ricci, Beatriz Moya, Dominic Wong, Evi van Goor, Irene Bartha, Betul Buyuktiryaki, Mattia Giovannini, Sashini Jayasinghe, Hannah Jaumdally, Andreina Marques-Mejias, Alexandre Piletta-Zanin, Anna Berbenyuk, Margarita Andreeva, Daria Levina, Ekaterina Iakovleva, Graham Roberts, Derek Chu, Rachel Peters, George du Toit, Isabel Skypala, Alexandra F. Santos

Summary: This study conducted a systematic review and meta-analysis on diagnostic tests for IgE-mediated food allergy. It found that skin prick test and specific IgE to extracts had high sensitivity, while specific IgE to components and basophil activation test had high specificity for the diagnosis of individual food allergies.

ALLERGY (2023)

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Article Allergy

A phase 2 open-label extension study of prekallikrein inhibition with donidalorsen for hereditary angioedema

Remy S. Petersen, Laura Bordone, Marc A. Riedl, Raffi Tachdjian, Timothy J. Craig, William R. Lumry, Michael E. Manning, Jonathan A. Bernstein, Jason Raasch, Bruce L. Zuraw, Yiwen Deng, Kenneth B. Newman, Veronica J. Alexander, Cindy Lui, Eugene Schneider, Danny M. Cohn

Summary: The 2-year interim results of this phase 2 open-label extension study of donidalorsen in patients with HAE demonstrated no new safety signals. Donidalorsen was well tolerated with durable efficacy, resulting in a 96% reduction in HAE attacks.

ALLERGY (2023)

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Article Allergy

Psychometric test of the Turkish version of the Family Management Scale for Children with Asthma (FMSCA)

Tubanur Ozmen, Turkan Kadiroglu

Summary: This study evaluated the validity and reliability of the Turkish version of the Family Management Scale for Children with Asthma (FMSCA). The results showed that FMSCA had good content validity and internal consistency, making it a valid and reliable tool for evaluating family management and interventions.

JOURNAL OF ASTHMA (2023)

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Article Allergy

The utility of the necessity-concerns framework (NCF) in explaining adherence and parental beliefs about controller medication in Saudi Arabian children with asthma

Marja A. Alyami, Mohammed M. Alyami, Ahmed H. Alasimi, Jaber S. Alqahtani, Abdullah A. Alqarni, Abdulelah M. Aldhahir

Summary: The study found a significant association between parental beliefs in asthma controller medications and medication adherence. Most parents were non-adherent to their children's prescribed medications, with higher adherence reported among ambivalent parents.

JOURNAL OF ASTHMA (2023)

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Article Allergy

Perspectives and experiences of mothers of school-age children with asthma: a qualitative study

Fang Yang, Cheng Chen, Xuexue Deng, Tingting Hu, Dan Bi, Huawei Li

Summary: The study aimed to explore the perspectives and experiences of mothers of school-age children with asthma and found that caregiving stress could be alleviated more effectively by addressing psychological well-being, emphasizing family and social support, and promoting the sharing of positive experiences. In this sample, diverse and complex caregiving experiences were reflected in personal psychological aspects, family functioning, and social support.

JOURNAL OF ASTHMA (2023)

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Article Allergy

Beyond forced exhalation: impulse oscillometry as a promising tool for bronchial hyperresponsiveness evaluation

M. Corral-Blanco, R. M. Diaz Campos, A. Pelaez, C. Melero Moreno

Summary: This study investigates the relationship between impulse oscillometry (IOS) and spirometry during the methacholine test and finds a good correlation between the two. IOS shows a strong predictive value in detecting bronchial hyperreactivity.

JOURNAL OF ASTHMA (2023)

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Letter Allergy

Long-term immune response accompanies clinical outcomes in severe asthmatics treated with anti-IL-5/IL-5R biologics

C. Lorente-Sorolla, J. Bernaola, D. Sanchez-Mellado, M. Gil-Martinez, S. Naharro-Gonzalez, D. Betancor, M. Fernandez-Nieto, E. J. Pinillos-Robles, J. M. Santillan Coello, J. M. Villacampa-Auba, M. J. Rodriguez-Nieto, J. Sastre, M. Valverde-Monge, J. M. Rodrigo-Munoz, V. del Pozo

ALLERGY (2023)

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Article Allergy

Phenotypes of cough in children: A latent class analysis

Maria Christina Mallet, Eva S. L. Pedersen, Ronny Makhoul, Sylvain Blanchon, Karin Hoyler, Anja Jochmann, Philipp Latzin, Alexander Moeller, Nicolas Regamey, Myrofora Goutaki, Ben D. Spycher, Claudia E. Kuehni

Summary: In this study, four clinically relevant cough phenotypes were identified, which have different prognoses. The majority of children with cough belonged to allergy-related phenotypes.

CLINICAL AND EXPERIMENTAL ALLERGY (2023)

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Article Allergy

Circulating mast cell progenitors increase during natural birch pollen exposure in allergic asthma patients

P. Abigail Alvarado-Vazquez, Erika Mendez-Enriquez, Maya Salomonsson, Ida Waern, Christer Janson, Sara Wernersson, Andrei Malinovschi, Jenny Hallgren

Summary: This study found that the frequency of circulating MCps increases in asthma patients sensitized to birch pollen during pollen season. Patients with more severe asthma symptoms, nose or eye symptoms, or reduced asthma control had higher MCp frequency during this season. These findings provide new insight into the impact of natural allergen exposure on the expansion of MCs.

ALLERGY (2023)

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Review Allergy

Treatments of Epistaxis in Hereditary Hemorrhagic Telangiectasia: Systematic Review and Network Meta-Analysis

Wirach Chitsuthipakorn, Minh P. Hoang, Dichapong Kanjanawasee, Kachorn Seresirikachorn, Kornkiat Snidvongs

Summary: Propranolol, timolol, tranexamic acid, tamoxifen, and estriol were found to be effective treatments for managing epistaxis in HHT patients. Adverse events of tranexamic acid, tacrolimus, propranolol, and estradiol should be monitored closely.

CURRENT ALLERGY AND ASTHMA REPORTS (2023)

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Review Allergy

What is New in Alpha-Gal Syndrome?

Teresa Peralta, Gigia Roizen, Natalia Crisostomo, Raquel Aguilera-Insunza

Summary: Advances in understanding the mechanisms of AGS have led to a better understanding of this syndrome, which is challenging to diagnose and treat due to its clinical features. Future treatment strategies may involve combining anti-IgE therapy with oral desensitization to improve management outcomes.

CURRENT TREATMENT OPTIONS IN ALLERGY (2023)

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Article Allergy

Demographics, characteristics and medical treatment among adults with hand eczema in Denmark. A cross-sectional validation and registry-based study

Maria Oberlander Christensen, Yasemin Topal Yuksel, Ida Vittrup, Lea Krog Nymand, David Thein, Line Brok Norreslet, Jakob Maarbjerg Toft-Hansen, Anne Klose Janstrup, Claus Zachariae, Mette Sommerlund, Anne Bregnhoj, Alexander Egeberg, Tove Agner, Simon Francis Thomsen, Jacob Pontoppidan Thyssen

Summary: In this study, several ICD-10 codes for hand eczema (HE) were validated and important characteristics of HE patients were identified, including demographic features, disease characteristics, and medication use.

CONTACT DERMATITIS (2023)

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Review Allergy

Impact of food processing on the allergenic properties of amylase trypsin inhibitors from wheat

Peter L. Weegels, Antoine H. P. America

Summary: Amylase trypsin inhibitors (ATIs) play an important role in wheat allergies and potentially in non-coeliac wheat sensitivity. Food processing can significantly alter the properties of ATIs, potentially reducing their pathogenicity but sometimes increasing it.

FRONTIERS IN ALLERGY (2023)

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