Papers in Allergy - Peeref

Review Allergy

Skin microbiome of atopic dermatitis

Li Fang Koh, Ruo Yan Ong, John E. Common

Summary: The skin microbiome plays a crucial role in the development of atopic dermatitis (AD). AD patients have an imbalanced skin microbiome with reduced microbial diversity and an overgrowth of pathogenic Staphylococcus aureus (S. aureus). Recent studies have highlighted the importance of establishing a proper immune response to microbes early in life and have uncovered new mechanisms of microbial community dynamics in modulating the skin microbiome. Several microbes, including S. aureus and Malassezia, are associated with AD pathogenesis. The complex relationships within the skin microbiome consortia involve various species such as Staphylococcal, Roseomonas, and Cutibacterium strains, which can inhibit S. aureus and have the potential to be probiotics for AD skin. Additionally, numerous microbes have been found to modulate the host response, improving the health and barrier function of the skin through communication with keratinocytes, specialized immune cells, and adipocytes. This increased understanding of the bioactives of skin microbiota has led to new biotherapeutic approaches targeting the skin microenvironment for AD treatment.

ALLERGOLOGY INTERNATIONAL (2022)

Add to Collection

Review Allergy

Identification of Parameters Representative of Immune Dysfunction in Patients with Severe and Fatal COVID-19 Infection: a Systematic Review and Meta-analysis

Rundong Qin, Li He, Zhaowei Yang, Nan Jia, Ruchong Chen, Jiaxing Xie, Wanyi Fu, Hao Chen, Xinliu Lin, Renbin Huang, Tian Luo, Yukai Liu, Siyang Yao, Mei Jiang, Jing Li

Summary: Abnormal immunological indicators are associated with disease severity and mortality in patients with COVID-19. This meta-analysis synthesized the findings of many studies and found that cytokine levels, white blood cell count, and inflammatory markers were significantly increased in severely ill patients or non-survivors. Conversely, lymphocyte count, monocyte count, and other indicators were significantly increased in non-severely ill patients or survivors. Impaired immune response and increased inflammation, coagulation dysfunction, and nonpulmonary organ injury were marked features of patients with poor prognosis. Parameters of immune response dysfunction combined with inflammatory, coagulated, or nonpulmonary organ injury indicators may be more sensitive to predict severe patients and non-survivors.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2023)

Add to Collection

Letter Allergy

Safety of COVID-19 vaccination in patients with polyethylene glycol allergy: A case series

Matthieu Picard, Jean-Philippe Drolet, Marie-Soleil Masse, Charles A. Filion, Faisal ALMuhizi, Michael Fein, Ana Copaescu, Ghislaine Annie C. Isabwe, Martin Blaquiere, Marie-Noel Primeau

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

Add to Collection

Article Allergy

Olfactory Outcomes With Dupilumab in Chronic Rhinosinusitis With Nasal Polyps

Joaquim Mullol, Claus Bachert, Nikhil Amin, Martin Desrosiers, Peter W. Hellings, Joseph K. Han, Roger Jankowski, Jan Vodicka, Philippe Gevaert, Nadia Daizadeh, Asif H. Khan, Siddhesh Kamat, Naimish Patel, Neil M. H. Graham, Marcella Ruddy, Heribert Staudinger, Leda P. Mannent

Summary: This study assessed the impact of dupilumab on the sense of smell in patients with severe CRSwNP. The results showed that dupilumab treatment rapidly and sustainably improved the sense of smell, alleviating a cardinal symptom of severe CRSwNP.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

Add to Collection

Article Allergy

Single-cell analysis reveals innate lymphoid cell lineage infidelity in atopic dermatitis

Natalia Alkon, Wolfgang M. Bauer, Thomas Krausgruber, Issac Goh, Johannes Griss, Vy Nguyen, Baerbel Reininger, Christine Bangert, Clement Staud, Patrick M. Brunner, Christoph Bock, Muzlifah Haniffa, Georg Stingl

Summary: This study investigates the phenotypic and molecular features of cutaneous innate lymphoid cells (ILCs) to better understand the biological role of these cells. The findings demonstrate the flexibility of the skin immune system, with ILCs in diseased skin expressing genes characteristic of different immune types. This suggests that the skin immune system can adjust its function to adapt to the environment.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Add to Collection

Review Allergy

Multisystem Inflammatory Syndrome in Children (MIS-C)

Julisa M. Patel

Summary: This review provides an overview of the presenting features, proposed pathogenesis, suggested therapies, and outcomes of MIS-C. Patients with MIS-C present with a wide range of clinical features, with main characteristics including fever, gastrointestinal symptoms, and cardiac complications. Younger children may present with Kawasaki-like features, while older children often experience cardiogenic shock. Current treatment guidelines recommend IVIG and glucocorticoids, with biologics used in refractory cases. Most patients recover and mortality from MIS-C is rare. Prompt diagnosis and treatment are important for the best possible outcome.

CURRENT ALLERGY AND ASTHMA REPORTS (2022)

Add to Collection

Review Allergy

Frequency of food allergy in Europe: An updated systematic review and meta-analysis

Giulia C. Spolidoro, Yohannes Tesfaye Amera, Mohamed Mustafa Ali, Sungkutu Nyassi, Daniil Lisik, Athina Ioannidou, Graciela Rovner, Ekaterina Khaleva, Carina Venter, Ronald van Ree, Margitta Worm, Berber Vlieg-Boerstra, Aziz Sheikh, Antonella Muraro, Graham Roberts, Bright Nwaru

Summary: The latest estimates of food allergy prevalence and trends in Europe show an increase in self-reported food allergy and sensitization rates. This may be due to a real increase in the prevalence, increased awareness, increased evaluation of food types, or increased number of studies. Future studies need to use standardized methods, including double-blinded placebo-controlled food challenge, to minimize potential biases.

ALLERGY (2023)

Add to Collection

Article Allergy

Role of dietary fiber in promoting immune health-An EAACI position paper

Carina Venter, Rosan W. Meyer, Matthew Greenhawt, Isabella Pali-Schoell, Bright Nwaru, Caroline Roduit, Eva Untersmayr, Karine Adel-Patient, Ioana Agache, Carlo Agostoni, Cezmi A. Akdis, Mary Feeney, Karin Hoffmann-Sommergruber, Nonhlanhla Lunjani, Kate Grimshaw, Imke Reese, Peter K. Smith, Milena Sokolowska, Emilia Vassilopoulou, Berber Vlieg-Boerstra, Shriya Amara, Jens Walter, Liam O'Mahony

Summary: This review emphasizes the importance of fiber in the gut microbiome, immune regulation, and the management of allergic diseases. It highlights the significance of timing intervention and explores potential mechanisms for using fiber in the prevention and management of allergies.

ALLERGY (2022)

Add to Collection

Article Allergy

Immunogenicity and tolerability of COVID-19 messenger RNA vaccines in primary immunodeficiency patients with functional B-cell defects

Michele N. Pham, Kanagavel Murugesan, Niaz Banaei, Benjamin A. Pinsky, Monica Tang, Elisabeth Hoyte, David B. Lewis, Yael Gernez

Summary: The study assessed the immune responses in patients with PID after receiving COVID-19 mRNA vaccines. It was found that cellular immunity was stimulated in most patients, but antibody responses to the spike protein RBD were inconsistent and ineffective at ACE2 blocking in some cases.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Add to Collection

Article Allergy

Treatment of chronic or relapsing COVID-19 in immunodeficiency

Li-An K. Brown, Ed Moran, Anna Goodman, Helen Baxendale, William Bermingham, Matthew Buckland, Iman AbdulKhaliq, Hannah Jarvis, Michael Hunter, Surendra Karanam, Aisha Patel, Megan Jenkins, Alexander Robbins, Sujoy Khan, Thomas Simpson, Stephen Jolles, Jonathan Underwood, Sinisa Savic, Alex Richter, Adrian Shields, Michael Brown, David M. Lowe

Summary: This study characterized a cohort of patients with chronic or relapsing COVID-19 disease who have immunodeficiency. The findings suggest that remdesivir monotherapy is often ineffective, but the combination of remdesivir with antibody-based therapeutics shows promise.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Add to Collection

Article Allergy

World Health Organization global air quality guideline recommendations: Executive summary

Anna Goshua, Cezmi Akdis, Kari C. Nadeau

Summary: Air pollution is a major cause of death globally, particularly affecting populations in low- and middle-income countries. The World Health Organization has published updated air quality guidelines to assist in improving air quality worldwide.

ALLERGY (2022)

Add to Collection

Article Allergy

Mepolizumab for chronic rhinosinusitis with nasal polyps: Treatment efficacy by comorbidity and blood eosinophil count

Claus Bachert, Ana R. Sousa, Joseph K. Han, Rodney J. Schlosser, Leigh J. Sowerby, Claire Hopkins, Jorge F. Maspero, Steven G. Smith, Oliver Kante, Despina E. Karidi-Andrioti, Bhabita Mayer, Robert H. Chan, Steve W. Yancey, Adam M. Chaker

Summary: Mepolizumab demonstrates efficacy in reducing nasal polyp size and nasal obstruction in patients with chronic rhinosinusitis with nasal polyps, regardless of comorbid asthma or aspirin-exacerbated respiratory disease.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Add to Collection

Article Allergy

Hsa_circ_0004287 inhibits macrophagemediated inflammation in an N6-methyladenosine-dependent manner in atopic dermatitis and psoriasis

Lan Yang, Jinrong Fu, Xiao Han, Caiyan Zhang, Li Xia, Ronghui Zhu, Saihua Huang, Wenfeng Xiao, Hongmiao Yu, Yajing Gao, Qiuyan Liang, Wei Li, Yufeng Zhou

Summary: This study identified a functional unknown circRNA hsa_circ_0004287 that is upregulated in peripheral blood mononuclear cells of both AD and psoriasis patients and mainly expressed by macrophages under inflammatory conditions. Hsa_circ_0004287 reduces the stability of its host gene MALAT1 and inhibits M1 macrophage activation, thereby alleviating skin inflammation in AD and psoriasis.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Add to Collection

Review Allergy

Rhinovirus Infections and Their Roles in Asthma: Etiology and Exacerbations

David J. Jackson, James E. Gern

Summary: Rhinovirus infections can cause wheezing illnesses, especially in preschool children, and increase the risk of developing asthma. Specific risk factors and mechanisms for rhinovirus wheezing have been identified, providing potential targets and strategies for reducing the risk of rhinovirus-induced wheezing and exacerbations of asthma.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

Add to Collection

Article Allergy

IL-33 signaling in sensory neurons promotes dry skin itch

Anna M. Trier, Madison R. Mack, Avery Fredman, Masato Tamari, Aaron M. Ver Heul, Yonghui Zhao, Changxiong J. Guo, Oshri Avraham, Zachary K. Ford, Landon K. Oetjen, Jing Feng, Carina Dehner, Dean Coble, Asima Badic, Satoru Joshita, Masato Kubo, Robert W. Gereau, Jennifer Alexander-Brett, Valeria Cavalli, Steve Davidson, Hongzhen Hu, Qin Liu, Brian S. Kim

Summary: IL-33 signaling may play a critical role in the development of chronic itch, depending on the tissue microenvironment.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Add to Collection

Article Allergy

Benralizumab improves symptoms of patients with severe, eosinophilic asthma with a diagnosis of nasal polyposis

Giorgio Walter Canonica, Tim W. Harrison, Pascal Chanez, Francesco Menzella, Renaud Louis, Borja G. Cosio, Njira L. Lugogo, Arjun Mohan, Annie Burden, Esther Garcia Gil

Summary: The study showed that benralizumab can improve symptoms of NP and asthma outcomes in patients with severe, eosinophilic asthma and NP, with better effects observed in patients with high baseline SNOT-22 scores.

ALLERGY (2022)

Add to Collection

Article Allergy

Impact of Allergic Rhinitis and Asthma on COVID-19 Infection, Hospitalization, and Mortality

Jianjun Ren, Wendu Pang, Yaxin Luo, Danni Cheng, Ke Qiu, Yufang Rao, Yongbo Zheng, Yijun Dong, Jiajia Peng, Yao Hu, Zhiye Ying, Haopeng Yu, Xiaoxi Zeng, Zhiyong Zong, Geoffrey Liu, Deyun Wang, Gang Wang, Wei Zhang, Wei Xu, Yu Zhao

Summary: Allergic rhinitis (AR) and asthma may act as protective factors against COVID-19 infection, while asthma increases the risk of hospitalization. However, long-term medication for AR and/or asthma does not have a significant association with COVID-19 outcomes.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

Add to Collection

Review Allergy

Epidemiology of Chronic Rhinosinusitis: Prevalence and Risk Factors

Ahmad R. Sedaghat, Edward C. Kuan, Glenis K. Scadding

Summary: Knowledge of the epidemiology of chronic rhinosinusitis (CRS) is essential for patient care, including accurate diagnosis and treatment decisions. The current evidence suggests that the prevalence of CRS is consistently less than 5%, with about one-third of CRS patients having nasal polyps. The classification of CRS endotypes, mainly related to type 2 or non-type 2 inflammation, varies significantly by region. The epidemiology of CRS is influenced by various risk factors, such as genetics, demographics, environment, and comorbid diseases. Understanding these relationships can improve the diagnosis and treatment of CRS.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

Add to Collection

Article Allergy

Development and validation of combined symptom-medication scores for allergic rhinitis*

Bernardo Sousa-Pinto, Luis Filipe Azevedo, Marek Jutel, Ioana Agache, G. Walter Canonica, Wienczyslawa Czarlewski, Nikolaos G. Papadopoulos, Karl-Christian Bergmann, Philippe Devillier, Daniel Laune, Ludger Klimek, Aram Anto, Josep M. Anto, Patrik Eklund, Rute Almeida, Anna Bedbrook, Sinthia Bosnic-Anticevich, Helen A. Brough, Luisa Brussino, Victoria Cardona, Thomas Casale, Lorenzo Cecchi, Denis Charpin, Tomas Chivato, Elisio M. Costa, Alvaro A. Cruz, Stephanie Dramburg, Stephen R. Durham, Giulia De Feo, Roy Gerth van Wijk, Wystke J. Fokkens, Bilun Gemicioglu, Tari Haahtela, Maddalena Illario, Juan Carlos Ivancevich, Violeta Kvedariene, Piotr Kuna, Desiree E. Larenas-Linnemann, Michael Makris, Eve Mathieu-Dupas, Erik Melen, Mario Morais-Almeida, Ralph Moesges, Joaquim Mullol, Kari C. Nadeau, Nhan Pham-Thi, Robyn O'Hehir, Frederico S. Regateiro, Sietze Reitsma, Boleslaw Samolinski, Aziz Sheikh, Cristiana Stellato, Ana Todo-Bom, Peter Valentin Tomazic, Sanna Toppila-Salmi, Antonio Valero, Arunas Valiulis, Maria Teresa Ventura, Dana Wallace, Susan Waserman, Arzu Yorgancioglu, Govert Vries, Michiel Eerd, Petra Zieglmayer, Torsten Zuberbier, Oliver Pfaar, Joao Almeida Fonseca, Jean Bousquet

Summary: This study used real-life data to generate and validate combined symptom-medication scores (CSMSs). The cluster analysis-based CSMS showed the best performance, with medium-high validity, reliability, and accuracy.

ALLERGY (2022)

Add to Collection

Review Allergy

Neuroimmune communication regulating pruritus in atopic dermatitis

Martin Steinhoff, Fareed Ahmad, Atul Pandey, Angeliki Datsi, Ayda AlHammadi, Sara Al-Khawaga, Aysha Al-Malki, Jianghui Meng, Majid Alam, Joerg Buddenkotte

Summary: Atopic dermatitis is a common chronic inflammatory skin disease, and its pathogenesis involves the dysregulation of neuroimmune circuits. Abnormal neuroimmune circuits can lead to inflammation, pruritus, pain, and skin barrier dysfunction. Understanding neuroimmune circuits and neuronal signaling is crucial for controlling the pathological mechanisms of atopic dermatitis.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Add to Collection

«
1
2
3
4
5
»

See full results

Related Categories

Anatomy & Morphology (60.4K) Andrology (20.9K) Behavioral Sciences (170.8K) Cardiac & Cardiovascular Systems (1.1M) Nutrition & Dietetics (363.1K) Pathology (375.2K) Public, Environmental & Occupational Health (1M) Substance Abuse (127.4K)

© Peeref 2019-2024. All rights reserved.