Papers in Allergy - Peeref

Article Allergy

Perception of burden of oral and inhaled corticosteroid adverse effects on asthma-specific quality of life

Purnadeo N. Persaud, Annie P. Tran, Donna Messner, J. Daryl Thornton, Dennis Williams, Logan J. Harper, Vickram Tejwani

Summary: This study aimed to characterize the burden of adverse effects (AEs) in oral and inhaled corticosteroids (OCS and ICS respectively) and their impact on the quality of life (QoL) of asthma patients. Quantitative surveys and qualitative interviews were conducted to identify the most burdensome AEs and explore patient views on barriers not captured in the surveys.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2023)

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Article Allergy

Fructose biphosphate aldolase: A new cassava allergen

Anne K. R. M. Ventura, Safiri de P. Alves, Roberta A. Castro, Bruno C. Rossini, Lucilense S. Delazari, Amanda M. de Oliveira, Ana I. S. Moretti, Fabio F. M. Castro, Jorge Kalil, Ariana C. Yang, Keity S. Santos

Summary: Food allergy has increased due to the consumption of processed and complex foods. This study characterized the immunogenic cassava proteins responsible for sensitizing patients allergic to it, identifying Fructose Bisphosphate Aldolase (FBA) as a highly sensitizing protein. The recombinant FBA molecule obtained in this study can produce more accurate results for in vivo diagnostic assays and desensitization protocols, avoiding secondary sensitization.

WORLD ALLERGY ORGANIZATION JOURNAL (2023)

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Article Allergy

Revision surgery versus biologic treatment with omalizumab in recurrent chronic rhinosinusitis with nasal polyps: An analysis of cost-utility and clinical outcomes

Yutong Sima, Jing Zhang, Ming Zheng, Yan Zhao, Xiangdong Wang, Luo Zhang

Summary: Both revision surgery and omalizumab treatment can improve the clinical symptoms and quality of life (QoL) of patients with recurrent CRSwNP. Patients who underwent revision surgery experienced better improvement in sinus-related symptoms. However, omalizumab treatment clearly showed a benefit in terms of economic cost and duration cost of disease-related care.

WORLD ALLERGY ORGANIZATION JOURNAL (2023)

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Review Allergy

PLACEBO/NOCEBO RESPONSES IN CLINICAL TRIALS AND PRACTICE

J. O. Warner

Summary: Clinicians have long considered the enhancement of placebo effects as an important part of medical practice. Studies have identified disease severity and treatment efficacy as key factors affecting placebo responses. The activation of endogenous opioid and dopamine pathways has been associated with placebo effects, and genetic polymorphisms may explain individual variations in placebo responsiveness. However, in asthma treatment, placebo responses primarily improve subjective symptoms with little impact on lung function. Therefore, when designing placebo-controlled clinical trials, it is crucial to consider disease severity and conduct an adequate run-in period.

CURRENT ALLERGY & CLINICAL IMMUNOLOGY (2023)

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Letter Allergy

Omalizumab in severe asthma and food allergies with IgE levels >1500 kU/L: Two-year evaluation

Giulio Dinardo, Arianna Cafarotti, Francesca Galletta, Alessandro Fiocchi, Stefania Arasi

PEDIATRIC ALLERGY AND IMMUNOLOGY (2023)

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Letter Allergy

Changes in sensitization rates for respiratory and food allergens by age

Ji Ho Choi, Jeffrey D. Suh, Intae Kim, Jin Kook Kim, Jae Hoon Cho

CLINICAL AND EXPERIMENTAL ALLERGY (2023)

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Article Allergy

Diagnostic validity of specific immunoglobulin E levels to alpha-gal in alpha-gal syndrome: a cross-sectional analysis

Adrian German-Sanchez, Ana Alonso-Llamazares, Fernando Garcia-Gonzalez, Bakai Matala-Ahmed, Ceny Solani Melgar-Reyes, Ignacio Antepara-Ercoreca

Summary: This study evaluated the diagnostic validity of sIgE levels to alpha-gal >= 0.1 kUA/L for identifying AGS. The results suggest that sIgE levels >= 0.1 kUA/L may be a useful tool for the diagnosis of AGS, although other factors and diagnostic techniques should also be considered.

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY (2023)

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Article Allergy

Comparing Protein and Gene Expression Signature between Nasal Polyps and Nasal Fluids in Chronic Rhinosinusitis

Yilin Hou, Changhui Chen, Zhengqi Li, Tong Lu, Lin Sun, Yi Wei, Jian Li, Weiping Wen

Summary: This study compared the protein and mRNA inflammation signatures between nasal polyps (NPs) and nasal fluids (NFs) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). The results showed that the concentration of cytokines was higher in NFs collected using NFAD compared to PVA sponge, and these cytokine levels were significantly associated with NPs. Differentially expressed proteins between NFs and NPs were significantly correlated in the eosinophilic CRSwNP subgroup. There was also a significant correlation between gene and protein expression. The levels of PDL2 in NFs were positively correlated with ECRSwNP postoperative recurrence, nasal VAS, and SNOT-22 scores.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2023)

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Article Allergy

Infantile atopic dermatitis and maternal-infant bonding: a mixed methods study

Ayel Luis Batac, Kaitlyn Merrill, Michael Golding, Manvir Bhamra, Zoe Harbottle, Isac Kopsch, Erik Wilking, Marina Jonsson, Sandra Ekstroem, Elissa Abrams, Michelle Halbrich, Elinor Simons, Leslie Roos, Jill Keddy-Grant, Thomas Gerstner, Jo-Anne St-Vincent, Jennifer Protudjer

Summary: The study investigated the association between infantile atopic dermatitis and the maternal-infant bond, finding that atopic dermatitis does not have a negative impact on maternal-infant bonding and may actually strengthen the bond in some cases.

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY (2023)

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Article Allergy

Presence of variable extrathoracic airflow limitation in patients with a negative methacholine challenge test

Zane Z. Elfessi, Sarah Zavala, Israel Rubinstein

Summary: The study reviewed electronic medical records of patients undergoing MCT at Jesse Brown VA Medical Center between January 2017 and December 2019 to determine if variable extrathoracic airflow limitation (VEAL) is observed in patients with negative MCT. A subset of patients with negative MCT were found to have increased FEF50/FIF50 values after testing, suggesting the presence of VEAL. These patients were predominantly obese, non-smoking, White males with symptoms of asthma or chronic cough.

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY (2023)

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Article Allergy

Exacerbations, treatment patterns, utilization, and costs before and after initiating of benralizumab for the treatment of severe eosinophilic asthma

Joseph L. Smith, Yen Chung, John Barron, Theodore Barlows, Bal Nepal, Donna Carstens

Summary: This study examines the effects of benralizumab on the number of exacerbations, counts of eosinophils, and asthma-related symptoms in patients with severe eosinophilic asthma. The results show that treatment with benralizumab significantly reduces exacerbations, improves asthma control, and is particularly effective for patients with high eosinophil counts.

JOURNAL OF ASTHMA (2023)

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Letter Allergy

Longitudinal asthma phenotypes by multi-trajectory analysis

Duong Duc Pham, Chaelin Hong, Ji-Hyang Lee, Hyouk-Soo Kwon, Woo-Jung Song, You Sook Cho, Ji Seon Oh, Tae-Bum Kim

ALLERGY (2023)

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Article Allergy

IgE and IgG4 epitopes of the peanut allergens shift following oral immunotherapy

Ian M. Rambo, Christina M. Kronfel, Adam R. Rivers, Lauren T. Swientoniewski, Jane K. McBride, Hsiaopo Cheng, Reyna J. Simon, Robert Ryan, Stephen A. Tilles, Jacqueline B. Nesbit, Michael D. Kulis, Barry K. Hurlburt, Soheila J. Maleki

Summary: This study assessed the changes in IgE and IgG4 binding to peanut allergens in peanut allergic participants receiving PTAH OIT. The results showed that IgE binding to Ara h 2, 3, and 6 decreased significantly post-OIT, and IgE epitopes shifted towards IgG4 binding. The increase in IgG4 was found to be more important than the decrease in IgE for achieving desensitization at the 12-month timepoint.

FRONTIERS IN ALLERGY (2023)

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Review Allergy

Risk factors associated with uncontrolled asthma in children - a systematic review and meta-analysis

Muhammad Imran Arif, Liang Ru, Yanan Wang

Summary: This study aims to assess the risk factors of uncontrolled asthma in children and adolescents. Through a systematic review and meta-analysis of ten observational studies, it was found that past hypersensitivity reactions and incomplete controller adherence are significant risk factors for uncontrolled asthma.

JOURNAL OF ASTHMA (2023)

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Article Allergy

Sphingolipid classes and the interrelationship with pediatric asthma and asthma risk factors

Yulu Chen, Antonio Checa, Pei Zhang, Mengna Huang, Rachel S. Kelly, Min Kim, Yih-Chieh S. Chen, Kathleen A. Lee-Sarwar, Nicole Prince, Kevin M. Mendez, Sofina Begum, Priyadarshini Kachroo, Su H. Chu, Jakob Stokholm, Klaus Bonnelykke, Augusto A. Litonjua, Hans Bisgaard, Scott T. Weiss, Bo L. Chawes, Craig E. Wheelock, Jessica A. Lasky-Su

Summary: While dysregulated sphingolipid metabolism has been associated with risk of childhood asthma, the specific sphingolipid classes and mechanisms driving this relationship remain unclear. Elevations in sphingolipids were found to be deleterious overall, but ceramides were uniquely associated with increases in asthma risk factors. Modification of asthma risk factors may play an important role in regulating sphingolipid homeostasis via ceramides to affect asthma outcomes.

ALLERGY (2023)

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Article Allergy

Autophagy related gene 5 polymorphism rs17587319 (C/G) in asthmatic patients in North Indian population

Sargeet Kaur, Arpna, Durga Jha, Rajiv Khosla, Manpreet Kaur, Jyoti Parkash, Arti Sharma, Harish Changotra

Summary: The role of single nucleotide polymorphism rs17587319 (C/G) of ATG5 in asthma has not been studied so far. The study aimed to analyze this polymorphism and its association with asthma susceptibility.

JOURNAL OF ASTHMA (2023)

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Article Allergy

Does CDHR3 gene polymorphism affect paediatric asthma and its treatment response?

Joana Carneiro, Roger Tavendale, Somnath Mukhopadhyay, Patricia Soares

CLINICAL AND EXPERIMENTAL ALLERGY (2023)

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Article Allergy

Exploring the relationship between asthma, its severity and anxiety symptoms in pediatric patients: a case-control study

Mahdi Sheykhi, Ali Pourvali, Yazdan Ghandi, Anita Alaghmand, Maryam Zamanian, Tina Eslambeik, Amin Tajerian

Summary: This study highlights a significant association between asthma and heightened anxiety symptoms in children, particularly in domains such as separation anxiety, social phobia, agoraphobia, and fears related to physical injury. Children with asthma exhibited significantly higher anxiety symptoms compared to those without asthma. Furthermore, increased anxiety levels in pediatric asthma patients were associated with increased need for medication, frequency of nocturnal symptoms, and asthma severity.

JOURNAL OF ASTHMA (2023)

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Article Allergy

Immunogenicity of cephalosporin components in non-IgE-mediated cephalosporin allergy

Bodin Tuesuwan, Supranee Buranapraditkun, Weena Arjharn, Nithikan Suthumchai, Yuda Chongpison, Jettanong Klaewsongkram

CLINICAL AND EXPERIMENTAL ALLERGY (2023)

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Article Allergy

Long-term exposure from perinatal life to food-grade TiO2 alters intestinal homeostasis and predisposes to food allergy in young mice

Mohammad Issa, Chloe Michaudel, Marine Guinot, Marta Grauso-Culetto, Blanche Guillon, Jerome Lecardonnel, Luc Jouneau, Celine Chapuis, Herve Bernard, Stephane Hazebrouck, Florence Castelli, Francois Fenaille, Eric Gaultier, Gilles Riviere, Eric Houdeau, Karine Adel-Patient

Summary: This study assessed the effect of chronic perinatal exposure to food-grade titanium dioxide (fg-TiO2) on food allergy. The results showed that perinatal exposure to fg-TiO2 increased the susceptibility of male infants to develop food allergies and impaired oral tolerance to food proteins. This could be related to baseline alterations in intestinal health, gut microbiota composition, immune system, and metabolism.

ALLERGY (2023)

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