Journal
HAEMATOLOGICA
Volume 98, Issue 3, Pages 444-447Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.2012.069807
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Funding
- E-RARE/BMBF [01GM1005]
- Dietmar Hopp Stiftung
- German Research Foundation (DFG) [GDF15]
- National Institutes of Health [NIDDK-1R01DK090554]
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In conditions of increased erythropoiesis, expression of hepcidin, the master regulator of systemic iron homeostasis, is decreased to allow for the release of iron into the blood stream from duodenal enterocytes and macrophages. It has been suggested that hepcidin suppression is controlled by growth differentiation factor 15 (GDF15), a member of the transforming growth factor-beta superfamily of cytokines that is secreted from developing erythroblasts. In this study, we analyzed iron-related parameters in mice deficient for GDF15 under steady-state conditions and in response to increased erythropoietic activity induced by blood loss. We demonstrate that GDF15 suppresses the hepatic mRNA expression of some BMP/TGF beta target genes but not of hepcidin, and show that GDF15 is not required to balance iron homeostasis in response to blood loss.
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