Journal
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
Volume 94, Issue 11, Pages 1581-1589Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.2009.008979
Keywords
Hodgkin's lymphoma; non-Hodgkin's lymphoma; chronic lymphocytic leukemia; lymphoplasmacytic lymphoma; Waldenstrom's macroglobulinemia; lymphoma; MGUS; multiple myeloma; familial aggregation; susceptibility; immune-related; autoimmune disease; rheumatoid arthritis; monoclonal B-cell lymphocytosis
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Funding
- Swedish Cancer Society
- Stockholm County Council
- Karolinska Institutet Foundations
- NIH
- NCI
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There are data to support a role for genetic and immune-related factors in the pathogenesis of lymphomas and plasma cell diseases. In this paper, we review our published large population-based studies and other relevant studies in Hodgkin's and non-Hodgkin's lymphomas, multiple myeloma, and the precursor condition monoclonal gammopathy of undetermined significance. We discuss the overlap in risk factors between related malignancies and explore the underlying mechanisms. Based on these studies, we provide clinical implications and discuss the relevance of these data for patient counseling and clinical follow-up. Finally, we suggest future directions for new studies designed to increase our current knowledge and to define underlying biological mechanisms of our findings.
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