Journal
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
Volume 95, Issue 3, Pages 505-508Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.2009.013136
Keywords
iron; hepcidin; erythropoietin; GDF15; ferritin; anemia of chronic disease
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Funding
- Hammersmith Hospitals Trustees Research Committee
- UK Medical Research Council
- NIHR Biomedical Research Centre Funding Scheme
- National Institute for Health Research [NF-SI-0507-10315] Funding Source: researchfish
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Expression of hepcidin, the key hormone governing iron transport, is reduced by anemia in a manner which appears dependent on increased bone marrow activity. The temporal associations between plasma hepcidin and other iron parameters were examined in healthy humans after erythropoietin administration and venesection. Profound hepcidin suppression appeared abruptly 24 hours after subcutaneous erythropoietin (P=0.003), and was near maximal at onset, with peak (mid-afternoon) levels reduced by 73.2%, gradually recovering over the following two weeks. Minor changes in circulating iron, soluble transferrin receptor and growth differentiation factor-15 were observed after the reduction in hepcidin. Similar but more gradual changes in these parameters were observed after reducing hematocrit by removal of 250 mL blood. These human studies confirm the importance of a rapidly responsive marrow hepcidin axis in regulating iron supply in vivo, and suggest that this axis is regulated by factors other than circulating iron, soluble transferrin receptor or growth differentiation factor-15.
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