4.4 Article

A T2*magnetic resonance imaging study of pancreatic iron overload in thalassemia major

Journal

HAEMATOLOGICA
Volume 93, Issue 1, Pages 116-119

Publisher

FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.11768

Keywords

magnetic resonance; thalassemia

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Funding

  1. Children Thalassaemia Foundation

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We studied the utility of pancreatic magnetic resonance imaging (MRI) in 72 thalassemia major patients (21 diabetic, 51 normoglycemic). Diabetic patients were significantly older (p<0.0001) and had smaller pancreas volume (p<0.0001). The two groups were comparable for ferritin and MRI T2* heart, liver and pancreas. Pancreatic T2* signals were abnormal in 80% of both groups, and correlated with heart T2*. In normoglycemic patients, cardiac T2* and log-pancreatic T2* values correlated with homeostatic model assessments HOMA-B (beta cell reserve), HOMA-IR (insulin resistance) and fasting insulin/C-peptide levels.This suggested that improved chelation may improve beta cell reserve and prevent pancreatic atrophy.

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